About the drug the musical about a person with thalidomide disability Thalidomide A Musical drugbox verifiedrevid 420478187 drug name Thalidomide IUPAC name RS 2 2,6 dioxopiperidin 3 yl 1 H isoindole 1,3 2 H dione image Thalidomide 2D skeletal wavy.svg imagename 1 1 mixture racemate width 200px CASNo ... cite journal author Ando Y, Fuse E, Figg WD title Thalidomide metabolism by the CYP2C subfamily journal ... US Rx only legal status Rx only routes of administration oral Thalidomide pron en l d ma d was introduced ... and Peripheral neuropathy neuropathy . There is now a growing clinical interest in thalidomide ... of a Primary Target of Thalidomide Teratogenicity. Science 327, 1345 1350. ref rabbit s and primate ... http drugsafetysite.com thalidomideThalidomide Drug safety during pregnancy and breastfeeding DRUGSAFETYSITE.COM Bot generated title ref Thalidomide was sold in a number of countries across the world ... url http www.bbc.co.uk science horizon 2004 thalidomide.shtml title Thalidomide A Second Chance? programme ... Freak last Anon work Happy Birthday Thalidomide publisher Channel 4 accessdate 2009 05 01 ref Since then thalidomide has been found to be a valuable treatment for a number of medical conditions and it is being ... its testing in the developing world. ref cite web title Prudence and the Pill Testing Thalidomide ... A. date January 14, 2011 ref ref cite web url http www.healthyforms.com health news 2006 03 thalidomide controversial treatment.php date March 10, 2006 title Thalidomide controversial treatment for multiple ... null&offset 0&page 1 title Can thalidomide ever be trusted? last Bowditch first Gillian date March ... London ref The thalidomide tragedy led to much stricter testing being required for drugs and pesticides ... Thalidomide was developed by German pharmaceutical company Gr nenthal in Stolberg Rhineland near ..., director of the Thalidomide Trust in the United Kingdom, mentioned evidence found by Argentinian ... during the war years, Astra AB , which held the Swedish licence to distribute thalidomide, and IG ... more details
Deleted image removed Image Thalidomide Chicago.jpg thumb right Thalidomide stars Anna Winslet and Mat Fraser. Thalidomide A Musical is a United Kingdom British Musical theatre musical written and composed by Mat Fraser , who was born disabled as a result of the drug thalidomide being taken during his mother s pregnancy. Fraser and Anna Winslet play all the roles in the show. The musical premiered at the London Battersea Arts Centre s Octoberfest in 2005 and has since played across Britain and at festivals in Cardiff and Versailles, France . The production tells the story of a love affair between Glyn, a thalidomide victim Fraser and an able bodied woman, Katie Crawford Winslet , attracted by his phocomelia . Fraser calls the story a cartoon version of his own life. Winslet won the role in part because she did not shirk at an audition request to mimic Fraser himself. ref http arts.guardian.co.uk features story 0,11710,1636104,00.html Mat Fraser on why he felt compelled to write Thalidomide A Musical Guardian Unlimited Arts Bot generated title ref Musical numbers Monster Babies I ll Be His Arms It s Hard To Hitch Down Life s Highway With No Thumbs Talk to the Flipper Cause the Face Don t Care Reception The Daily Telegraph summarized the show as sharp and original, but not for the squeamish . ref http www.telegraph.co.uk arts main.jhtml?xml arts 2006 02 03 btthal03.xml&sSheet arts 2006 02 03 ixartleft.html Sharp and original, but not for the squeamish Telegraph Bot generated title ref One Wolverhampton councilor, Malcolm Gwinnett, criticised the show, arguing that, To exploit people in this way is, frankly, sick , while Fraser said that, It makes Jerry Springer The Opera Jerry Springer look tame . References references External links http www.thalidomide a musical.com Official site Category 2005 musicals Category British plays ... more details
Copy to Wikimedia Commons Summary structural drawing of thalidomide Created with ISIS Draw 2.5 and Paint Shop Pro 8.1 by Catbar. User Catbar Brian Rock 03 54, 27 Jan 2004 UTC Licensing GFDL migration relicense ... more details
Summary Miller, Marylin T. Thalidomide Embryopathy A Model for the Study of Congenital Incomitant Horizontal Strabismus. Transaction of the American Ophthalmological Society 1991 81 623 674. http www.pubmedcentral.nih.gov articlerender.fcgi?artid 1298636&rendertype figure&id F2 Licensing PD USGov NIH ... more details
TWCleanup2 Unreferenced stub auto yes date December 2009 Transplacental refers to the ability of a toxin or pathogen to cross the physical and biological barriers of the placenta separating the mother and fetus , to whom such substances may be dangerous. This would include, for example, HIV and the drug thalidomide . Category Obstetrics Human repro stub ... more details
Summary Miller, Marylin T. Thalidomide Embryopathy A Model for the Study of Congenital Incomitant Horizontal Strabismus. Transaction of the American Ophthalmological Society 1991 81 623 674. http www.pubmedcentral.nih.gov articlerender.fcgi?artid 1298636&rendertype figure&id F2 Licensing PD USGov NIH ... more details
Summary Miller, Marylin T. Thalidomide Embryopathy A Model for the Study of Congenital Incomitant Horizontal Strabismus. Transaction of the American Ophthalmological Society 1991 81 623 674. http www.pubmedcentral.nih.gov articlerender.fcgi?artid 1298636&rendertype figure&id F3 Licensing PD USGov NIH ... more details
Widukind Lenz 1919&ndash 1995 was a distinguished Germany German pediatrician , medical genetics medical geneticist and dysmorphology dysmorphologist who was among the first to recognize the thalidomide thalidomide syndrome in 1961 and alert the world to the dangers of limb and other malformations due to the mother s exposure to this drug during pregnancy. In the ensuing years, Lenz did much important work on the thalidomide syndrome http www.tierversuchsgegner.org Contergan contergan history.html . He also did work of value in clinical genetics and cytogenetics . He described a number of malformation syndromes, several of which bear his name today. http www.whonamedit.com doctor.cfm 1002.html He was an editor of the journal Human Genetics and published a textbook of medical genetics. Lenz studied medicine from 1937 to 1943. He was a physician in Luftwaffe hospitals during World War II and then in a prisoner of war camp in England. After stints in biochemistry in G ttingen and medicine in Kiel , he became physician in chief of the University Medical Center Hamburg Eppendorf Eppendorfer Kinderklinik in 1952 and was named to the chair of pediatrics at the University of Hamburg in 1961. Lenz became director of the Institute of Human Genetics in M nster in 1965. Widukind Lenz was the son of Fritz Lenz , also a geneticist, but one of an entirely different stripe. Fritz Lenz espoused eugenics and influenced the racial hygiene policies of the Third Reich . Widukind Lenz died respected as an eminent physician and a humanitarian. External links http www.tierversuchsgegner.org Contergan contergan history.html Dr. Widukind Lenz History of Contergan Thalidomide Extract from a lecture by Widukind Lenz on the history of Contergan Thalidomide given at the 1992 UNITH Congress with a photograph of Widukind Lenz http www.whonamedit.com doctor.cfm 1002.html Information on the life and contributions of Widukind Lenz and the thalidomide syndrome , by Ole Daniel Enersen on the http www.w ... more details
are valued at up to 30,000 per project. Thalidomide According to Gr nenthal, the company invented and marketed Thalidomide Contergan or Softenon in the 1950s. The drug was responsible for teratogenic ... . Recent research however, originating from different sources, suggest that the history of Thalidomide might stretch past 1953 to the World War II . It has been claimed that Thalidomide was actually ... licence to distribute Thalidomide , and IG Farben , the German pharmaceutical firm, seem to confirm the alternative past of the product. Furthermore, a relation has been suggested between testing Thalidomide and the Nazi death camps . ref The Sunday Times, Daniel Foggo , February 8, 2009 , Thalidomide ... between Gr nenthal and Rh ne Poulenc for the development of Contergan thalidomide. Three Gr nenthal employees discovered thalidomide and Gr nenthal is the sole inventor on the patent. According to Gr nenthal, Dr. Heinrich M ckter was one of those responsible for inventing Thalidomide . Other sources ... Foggo , February 8, 2009 , Thalidomide was created by the Nazis http www.timesonline.co.uk tol ... with the goal of finding new compounds which Chemie Gr nenthal might use. Gr nenthal contended that Thalidomide ... Thalidomide and all compounds containing it from the market on November 26, 1961. A study published ... all but five women had taken Thalidomide between the thirtieth and fiftieth day after their last ... the drug between the twenty eighth and forty second day after conception. ref Thalidomide , New York ... from her physician. The lawsuit alleged that Chemie Gr nenthal was negligent in not testing the Thalidomide preparation, and failing to warn of its effects on unborn children. ref Thalidomide Maker ... executives were tried for involuntary manslaughter . By this time the company stated that Thalidomide ... to mean that Thalidomide was safe during the final stage of pregnancy only. This is a fallacious form ... conception . ref name mide Suffer The Children The Story of Thalidomide , The Insight ... more details
s medal Bibliography Sheskin, J. 1975 . http dx.doi.org 10.1111 j.1365 4362.1975.tb00145.x Thalidomide ... 10.1111 j.1365 4362.1978.tb06052.x Study with nine thalidomide derivatives in the lepra reaction ... of Thalidomide and Its Revival as a Vital Medicine&dq 22Dark Remedy The Impact of Thalidomide and Its Revival as a Vital Medicine Dark remedy The impact of thalidomide and its revival as a vital ... rx thalidomide .html Thalidomide and Cancer . 3quarksdaily. Azra Raza Raza, A. February, 2002 . http www.biochemist.org bio 02401 0021 024010021.pdf The third coming Thalidomide and a final goodbye . The Biochemist ... The return of thalidomide BBC Inside Out . Sol J. Barer Barer, S. 2007 . http chemheritage.org ... leda data 351 Lutz.rtf From tragedy to triumph The approval of thalidomide . Gerson Oliveira ... en Thalidomide in the treatment of erythema nodosum leprosum ENL Systematic review of clinical ... of thalidomide in leprosy . Unpublished dissertation, Louisiana State University. European Symposium ... more details
Directive 65 65 EEC1 was the first European pharmaceutical directive. The directive was a reaction to the Thalidomide tragedy in the early 1960s, when thousands of babies were born with deformities as a result of their mothers taking the drug during pregnancy. The directive aimed at harmonising standards for the approval of medicines within the then European Economic Community and required that medicines could not be marketed within the community without prior authorisation of the competent authority of at least one member state. See also EudraLex Kefauver Harris Amendment Regulation of therapeutic goods European Medicines Agency References Maio G., On the history of the Contergan thalidomide catastrophe in the light of drug legislation , Dtsch Med Wochenschr. 2001 Oct 19 126 42 1183 6. Shah RR., Thalidomide, drug safety and early drug regulation in the UK, Adverse Drug React Toxicol Rev. 2001 Dec 20 4 199 255. External links http eur lex.europa.eu LexUriServ LexUriServ.do?uri CELEX 31965L0065 EN HTML Directive 65 65 EEC1 http www.euractiv.com en health new medicines legislation article 117531 New medicines legislation overview Category Clinical research Category Pharmaceuticals policy Category European Union directives by number 65 65 Category 1965 in law Category 1965 in the European Economic Community health stub ... more details
Unreferenced stub auto yes date December 2009 Orphan date December 2009 Extended physiological proprioception EPP is a concept pioneered by D.C. Simpson 1972 to describe the ability to perceive at the tip of the tool, in this case a prosthetic limb. The work was based on pneumatic prosthesis developed in response to disabilities incurred by infants as the result of use of the drug, thalidomide , by mothers from 1957 to 1962. Category Prosthetics DEFAULTSORT Extended Physiological Proprioception Psych stub ... more details
Unreferenced date March 2007 Orphan date February 2009 Meromelia is the birth defect of lacking one or more arms or legs with the presence of a hand or foot. It results in a shrunken and deformed extremity. See also Amelia birth defect Phocomelia Polymelia Thalidomide Amniotic Band Syndrome Category Congenital disorders Category Musculoskeletal disorders disease stub pt Meromelia ... more details
A Leprostatic agent is a drug that interferes with proliferation of the bacterium that causes leprosy . ref http cancerweb.ncl.ac.uk cgi bin omd?leprostatic Definition leprostatic from Online Medical Dictionary Bot generated title ref ref MeshName Leprostatic agents ref The following agents are leprostatic agents ref MeshPharmaList 82007917 ref acedapsone clofazimine dapsone desoxyfructo serotonin diucifon ethionamide rifampin rifapentine sulfameter thalidomide References reflist Major drug groups Antimycobacterials Category Leprosy antiinfective drug stub ... more details
thumb Phocomelia manifest as aural abnormalities. Image thalidomide affects.jpg thumb right 300px Cases of severe thalidomide induced phocomelia. Image phocomelia1.jpg thumb 200px Eyesight limitation ... Zimmer coauthors title Answers Begin to Emerge on How Thalidomide Caused Defects url http www.nytimes.com ... cause phocomelia, the prominent roots come from the drug use of thalidomide and from genetic inheritance ... of a pregnant woman taking thalidomide during pregnancy and prosthesis. Although operations ... structures. Causes ThalidomideThalidomide was released into the market in 1957 in West Germany under the label of Contergan. Primarily prescribed as a sedative or hypnotic, thalidomide also claimed to cure anxiety, insomnia, gastritis, and tension. ref Miller, Marylin T. Thalidomide Embryopathy ... morning sickness in pregnant women. Thalidomide became an over the counter drug in Germany around ... in the 60 s, cases of severe phocomelia amplified the direct cause was linked to thalidomide. ref ... children had taken thalidomide during the first trimester of pregnancy. ref Cuthbert, Alan. Thalidomide. The Oxford Companion to the Body. Oxford University Press, 2001, 2003. Answers.com 06 Dec. 2007. http www.answers.com topic thalidomide. ref Throughout Europe, Australia, and the United ... Cuthbert, Alan. Thalidomide. The Oxford Companion to the Body. Oxford University Press, 2001, 2003. Answers.com 06 Dec. 2007. http www.answers.com topic thalidomide. ref Thalidomide became effectively linked to death or severe disabilities among babies. Those subjected to thalidomide while in the womb ..., along with blindness and deafness. ref Cuthbert, Alan. Thalidomide. The Oxford Companion to the Body. Oxford University Press, 2001, 2003. Answers.com 06 Dec. 2007. http www.answers.com topic thalidomide ... Malformations in the kidney and heart Shortened neck Abnormalities in the urethra Thalidomide syndrome ... as thalidomide syndrome. The symptoms of thalidomide syndrome are defined by absent or shortened ... more details
notable achievement, with Dr P H Huang, was the discovery that thalidomide caused malformations by interacting ..., which showed that thalidomide may inhibit cell division in rapidly dividing cells of malignant tumors ... His theory that damage caused by thalidomide can be passed to offspring has proven highly controversial ... in 1993 for deliberately falsifying data. ref http www.newscientist.com article mg13718620.800 thalidomide hero found guilty of scientific fraud .html Thalidomide hero found guilty of scientific fraud ... PA92&dq thalidomide mcbride prize&source bl&ots hTtawra2MC&sig 1CV s8U5hC3JCx17Eu7H8qxygFc&hl en&ei ... more details
backing of The Thalidomide Trust. The aim of the campaign is to secure the release of Billy ... international Battle for jailed Thalidomide man.6310174.jp Yorkshire Post br http www.theaustralian.com.au news world thalidomide victim billy burton may die in jail for cannabis smuggling ... MP offers hope to jail.6327875.jp North Yorkshire News External http www.thalidomide.org.uk The Thalidomide ... more details
Anna Melissa Winslet born 1972 is an England English actress . She was born in Reading, Berkshire and is the elder sister of Kate Winslet Kate and Beth Winslet . She performed alongside actor Mat Fraser in Thalidomide A Musical . Filmography Red Rose 2004 Rear View Mirror 2000 The Cater Street Hangman 1998 TV uncredited Double Vision 1992 TV Theatre Happy Savages 1998 Same Hole Deeper 1998 Show of Strength 1998 Thalidomide A Musical 2005 present External links imdb name id 0935472 name Anna Winslet Persondata Metadata see Wikipedia Persondata . NAME Winslet, Anna ALTERNATIVE NAMES SHORT DESCRIPTION DATE OF BIRTH 1972 PLACE OF BIRTH DATE OF DEATH PLACE OF DEATH DEFAULTSORT Winslet, Anna Category 1972 births Category English Anglicans Category English film actors Category English musical theatre actors Category English stage actors Category English television actors Category Living people Category People from Reading, Berkshire England film actor stub ... more details
coauthors title Answers Begin to Emerge on How Thalidomide Caused Defects url http www.nytimes.com ... of Science, a protein known as cereblon latched on tightly to the thalidomide. work New York Times ... web url http www.rsc.org chemistryworld News 2010 March 11031001.asp title Thalidomide binding protein ... urlResearchers Gain New Insights into the Mystery of Thalidomide Caused Birth Defects Scientific American cite web url http www.scientificamerican.com article.cfm?id thalidomide target identified title Researchers Gain New Insights into the Mystery of Thalidomide Caused Birth Defect author Moisse K ... archivedate quote accessdate 2010 03 11 ref Thalidomide was used as a treatment for morning sickness ... birth defects. ref cite web url http www.bbc.co.uk science horizon 2004 thalidomide.shtml title Thalidomide ... Thalidomide publisher Channel 4 accessdate 2009 05 01 ref Mental retardation Mutations in the CRBN gene ... more details
industry. Most notably, Distillers was responsible for the manufacture of the drug Thalidomide ... Financial Future for Thalidomide Survivors url http staging.diageo.com en row NewsAndMedia PressReleases ... Thalidomide, DCBL was never very successful, despite producing the first oral penicillin. In July 1957 DCBL signed a sixteen year contract with Grunenthal to market Thalidomide, rather than ... of pure substance for animal experiments and formulation . Thalidomide was marketed in England ... safety, using phrases such as non toxic and no known toxicity. Later Thalidomide was marketed under the names Asmaval, Tensival, Valgis, and Valgraine. ref Suffer The Children The Story of Thalidomide ... more details
Foundation 41 was a medical research organisation, principally investigating the causes of mental and physical handicap in babies, and was based at the Crown Street Women s Hospital, Sydney Crown Street Women s Hospital , Sydney, New South Wales Sydney , Australia . It was founded in 1971 by Dr William McBride doctor William McBride . ref http catalogue.nla.gov.au Record 1501964 Papers of William McBride, ca. 1953 1996 , National Library of Australia , accessed 26 July 2010 ref The name Foundation 41 derives from the normal duration of Human gestation Duration human gestation 40 weeks plus the first week of life after birth. Funding McBride created Foundation 41 using prize money given by France s L Institut de la Vie in connection with his discovery that Thalidomide N phthalimidoglutarimide caused malformations by interacting with the DNA of dividing embryo nic cells. Ongoing funding was by public philanthropy . This essentially ceased with the Debenox case. Debenox McBride s later involvement with Debenox is less illustrious, and had a marked effect on Foundation 41. ref cite book author Grant J title Corrupted Science publisher Facts, Figures & Fun, 2007 isbn 13 9871904332732 page 49f ref In 1981 McBride published a paper indicating that the drug Debenox marketed in the US as Bendectin caused birth defects. His coauthors noted that the published paper contained manipulated data and protested ref http www.abc.net.au austory transcripts s248519.htm The Insider , Australian Story , 22 February 2001, accessed 26 July 2010 ref but their voices went unheard. Multiple lawsuits were undertaken by patients and McBride was a willing witness for the claimants. Eventually, the research was investigated and, as a result, McBride was struck off the Australian medical register in 1993 for deliberately falsifying data. ref http www.newscientist.com article mg13718620.800 thalidomide hero found guilty of scientific fraud .html Thalidomide hero found guilty of scientific fraud & ... more details
body, thalidomide undergoes racemization even if only one of the two stereoisomers is ingested, the other one is produced. Thalidomide is currently used as a treatment for leprosy and must ... more details
for the U.S. Food and Drug Administration FDA who refused to authorize thalidomide for market because ... that thalidomide caused serious birth defect s. Kelsey s career intersected with the passage of laws ... , where she taught until 1957. ref name heirloom Work at the FDA and thalidomide Image Kelsey 01.jpg ... by Marion Merrell Dow Richardson Merrell for the drug thalidomide under the tradename Kevadon as a tranquiliser ... further studies . ref name heirloom Despite pressure from thalidomide s manufacturer, Kelsey persisted ... was dramatically vindicated when the births of deformed infants in Europe were linked to thalidomide ... that the thalidomide crossed the placenta l barrier and caused serious birth defect s in infants ... to marketing. ref name fda3 As a result of her blocking American approval of thalidomide, Kelsey was awarded ... on thalidomide work The Washington Post author Lyndsey Layton date September 13, 2010 ref Legacy and awards ... 1962 07 15 cite journal first Maureen last Rouhi date 2005 06 20 title Top Pharmaceuticals Thalidomide ... ritn Thalidomide index.html title Research in the News Thalidomide accessdate 2009 08 15 archiveurl ... ritn Thalidomide index.html archivedate 2007 08 22 cite journal last year 1981 month June title ... Thalidomide.Html The Right Lesson to Learn from Thalidomide . Mintz, Morton 1965 The therapeutic nightmare ... .M55&Search Code CALL &PID 3698 Library of Congress catalog entry McFadyen, R.E. 1976 . Thalidomide ... III first Anthony J coauthor Hsu MD, Sylvia title A review of thalidomide s history and current dermatological applications url http dermatology.cdlib.org 93 reviews thalidomide hsu.html journal Dermatology ... Lisa A. coauthor Warren, Noreen title Frances Kelsey & Thalidomide in the US A Case Study Relating ... examiner who prevented thalidomide from coming to market in the United States DATE OF BIRTH 1914 ... more details
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