- Transthyretin
PBB geneid 7276 Transthyretin TTR is a blood plasma serum and cerebrospinal fluid carrier of the thyroid hormone thyroxine T4 and retinol binding protein bound to retinol. This is how transthyretin gained its name, trans ports thy roxine and retin ol. The liver secretes transthyretin into the blood, and the choroid plexus secretes TTR into the cerebrospinal fluid . TTR was originally called prealbumin ref MeshName Prealbumin ref because it ran faster than albumin on electrophoresis gels. Binding affinities It functions in concert with two other thyroid hormone binding proteins in the serum class wikitable Protein Binding strength Plasma concentration thyroxine binding globulin TBG highest lowest transthyretin TTR lower higher albumins poorest much higher In cerebrospinal fluid TTR is the primary carrier of T4, as albumin is not present. TTR also acts as a carrier of retinol vitamin A through its association with retinol binding protein RBP in the blood and the CSF. Less than 1 of TTR s T4 binding sites are occupied in blood, which is taken advantage of below to prevent TTRs dissociation, misfolding and aggregation which leads to the degeneration of post mitotic tissue. Numerous other small molecules are known to bind in the thyroxine binding sites, including many natural products such as resveratrol , drugs Tafamidis , ref name pmid12820260 cite journal author Razavi H, Palaninathan SK, Powers ET, Wiseman RL, Purkey HE, Mohamedmohaideen NN, Deechongkit S, Chiang KP, Dendle MT, Sacchettini JC, Kelly JW title Benzoxazoles as transthyretin amyloid fibril inhibitors synthesis, evaluation, and mechanism of action journal Angew. Chem. Int. Ed. Engl. volume 42 issue 24 pages 2758 61 year 2003 month June pmid 12820260 doi 10.1002 anie.200351179 ref or Vyndaqel, diflunisal ref name pmid17107884 cite journal author Sekijima Y, Dendle MA, Kelly JW title Orally administered diflunisal stabilizes transthyretin against dissociation required for amyloidogenesis journal Amyloid vol ... more details
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