- Protofection
Wikify date January 2012 Protofection is a term that refers to the transfection of foreign mitochondrial DNA to replace the original energy generators within cells. As mitochondria are damaged with age, this would be a method of rejuvenating them to original states. This technology could similarly be applied to modified or artificial mitochondria. The intent being designing ones that do not produce as many preferably zero free radicals while staying as, or more efficient in generating energy in the cell. While not invulnerable to free radical damage, having less free radicals would also make such generators have longer lifespans if they could still renew at an identical rate, or at least enough to keep more healthy ones at a given time. External links http www.fightaging.org archives 000539.php FightAging.org Article responding to developments. http www.longevitymeme.org news view news item.cfm?news id 1932 LongevityMeme.org reports developments. Category Molecular biology Cell biology stub ... more details
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- Mitochondrial myopathy
Refimprove date February 2008 Infobox Disease Name PAGENAME Image Animal mitochondrion diagram en edit .svg Caption Simplified structure of a typical mitochondrion DiseasesDB ICD10 ICD10 G 71 3 g 70 ICD9 ICDO OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID D017240 Mitochondrial myopathy is a type of myopathy associated with mitochondrial disease . On biopsy, the muscle tissue of patients with this disease usually demonstrate ragged red muscle fibers. These ragged red fibers contain mild accumulations of glycogen and neutral lipids, and may show an increased reactivity for succinate dehydrogenase and a decreased reactivity for cytochrome c oxidase . Inheritance is maternal Non Mendelian inheritance Extranuclear inheritance non Mendelian extranuclear . There are several subcategories of mitochondrial myopathies. Treatment Although no cure currently exists, there is hope in treatment for this class of hereditary disease s with the use of an embryotic Protofection mitochondrial transplant . ref Name BBC 5 February 2008 cite web title Three parent embryo formed in lab work Scientists believe they have made a potential breakthrough in the treatment of serious disease by creating a human embryo with three separate parents. publisher BBC News date 5 February 2008 , 11 13 GMT url http news.bbc.co.uk 2 hi health 7227861.stm format web doi accessdate 2008 02 08 ref anchor Variations of the Disease Signs and symptoms Signs and symptoms include Mitochondrial encephalomyopathy, lactic acidosis, and stroke like syndrome MELAS Varying degrees of cognitive impairment and dementia Lactic acidosis Stroke s Transient ischemic attack s Hearing loss Weight loss Myoclonic epilepsy and ragged red fibers MERRF Progressive myoclonic epilepsy Clumps of diseased mitochondria accumulate in muscle fibers and appear as ragged red fibers when muscle is stained with modified G m ri trichrome stain Short stature Kearns Sayre syndrome KSS External ophthalmoplegia Cardiac conduction defects Senso ... more details
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- Transfection
for cells, and its suspected effect on the expression of other genes proteins. See also Protofection ... more details
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- Mitochondrial disease
News ref Embryo nic mitochondrial transplant and protofection have been proposed as a possible treatment ... more details
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- Artificial gene synthesis
, Transduction genetics transduction and protofection have been a standard research practice for many ... more details
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- Mycoplasma laboratorium
genetics transduction and protofection have been a standard research practice for many years ... more details
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