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Encyclopedia results for Protein kinase R

Protein kinase R





Encyclopedia results for Protein kinase R

  1. Protein kinase R

    PBB geneid 5610 Protein kinase RNA activated also known as protein kinase R PKR , interferon induced, double stranded RNA activated protein kinase , or eukaryotic translation initiation factor 2 alpha ... Protein kinase R has been shown to Protein protein interaction interact with ASK1 , ref name pmid12473108 ... reverse the protein kinase R inhibition of HIV 1 long terminal repeat expression journal J. Biol ... stranded RNA dependent protein kinase, PKR, to regulate its autophosphorylation and activity journal ... for the double stranded RNA dependent protein kinase, PKR journal Biochemistry volume 38 ... and regulator of the eukaryotic initiation factor 2 kinase double stranded RNA activated protein kinase ... protein, is phosphorylated by the interferon induced protein kinase, PKR journal J. Biol. Chem ... of the dsRNA dependent protein kinase PKR by the cellular glycoprotein p67 journal Biochemistry ... The double stranded RNA activated protein kinase PKR physically associates with the tumor suppressor ... binding of the catalytic subunit of protein phosphatase 1 to the PKR protein kinase is necessary ... of double stranded RNA dependent protein kinase PKR journal Biochem. J. volume 366 issue Pt 1 pages ... protein kinase, PKR journal EMBO J. volume 17 issue 15 pages 4379 90 year 1998 month August pmid ... Physical association between STAT1 and the interferon inducible protein kinase PKR and implications ... protein kinase and TAR RNA binding protein form homo and heterodimers in vivo journal Proc. Natl ..., Meurs EF, Esteban M title The dsRNA protein kinase PKR virus and cell control. journal Biochimie ..., and regulation of the interferon induced, RNA dependent P1 eIF 2 alpha protein kinase from human ... P1 eIF 2 alpha protein kinase. journal Virology volume 188 issue 1 pages 47 56 year 1992 pmid 1373554 ... RNA activated protein kinase induced by interferon. journal Cell volume 62 issue 2 pages 379 90 year ... MG, Parkin NT, et al. title Control of the interferon induced 68 kilodalton protein kinase by the HIV ...   more details



  1. Protein kinase A

    R, Li H, et al. title AMP activated protein kinase inhibits alkaline pH and PKA induced apical vacuolar ...In cell biology , Protein kinase A PKA refers to a family of enzyme s whose activity is dependent on cellular levels of cyclic AMP cAMP . PKA is also known as cAMP dependent protein kinase EC number 2.7.11.11 . Protein kinase A has several functions in the cell, including regulation of glycogen , sugar , and lipid metabolism . It should neither be confused with AMP activated protein kinase which, although ... can be down regulated by phosphorylation. Downregulation of protein kinase A occurs by a feedback mechanism ... of cAMP that can activate protein kinase A. Anchorage The 2 regulatory subunits of protein kinase A are important for localizing the kinase inside the cell. With the aid of A kinase anchoring protein A kinase anchor protein AKAP , AKAP binds both to the regulatory subunits and to either a component ... subcellular compartment. The catalytic function of protein kinase A would sometimes couple with the AKAP ... Adrenaline and glucagon affect the activity of protein kinase A by changing the levels of cAMP in a cell via the G protein mechanism, using adenylate cyclase . Protein Kinase A acts to phosphorylate many enzymes important in metabolism. For example, protein kinase A phosphorylates acetyl CoA carboxylase ... 2010 05 22 ref See also Protein kinase Signal transduction G protein coupled receptor Serine threonine specific protein kinase Myosin light chain kinase cAMP dependent pathway References references ... pka c1.htm Drosophila cAMP dependent protein kinase 1 The Interactive Fly Serine threonine specific ... fr Prot ine kinase A it Protein chinasi A he A ru A sr Proteinska kinaza ... regulatory and two catalyst catalytic Protein subunit subunit s. Under low levels of cAMP, the holoenzyme ..., activation of adenylate cyclase s by G protein coupled receptor s coupled to Gs alpha subunit G sub ... catalytic subunits can then catalyse the transfer of ATP terminal phosphates to protein substrate biochemistry ...   more details



  1. Protein kinase

    Image Ch4 kinases.jpg thumb 250px right Protein phosphorylation A protein kinase is a kinase enzyme that modifies ... genome contains about 500 protein kinase genes and they constitute about 2 of all human genes. ref name pmid12471243 cite journal author Manning G, Whyte DB. et al. title The protein kinase complement ... protein kinases that phosphorylate other amino acids, including histidine kinase s that phosphorylate ... in the cell relative to their substrates. Structure main Protein kinase domain The catalytic subunits ... name pmid12734000 cite journal author Hanks SK title Genomic analysis of the eukaryotic protein kinase ... long&pmid 7768349 issn ref ref name pmid1835513 cite journal author Hunter T title Protein kinase ... Protein kinase catalytic domain sequence database identification of conserved features of primary ... 10.1126 science.1862342 url issn ref Protein kinase groups The human protein kinase family is divided into the following groups AGC kinases containing Protein kinase A PKA , Protein kinase c PKC and Protein kinase g PKG . CaM Kinase CaM kinases containing the calcium calmodulin dependent protein ... Calcium calmodulin dependent protein kinase II CaMKII is an example of a serine threonine specific protein kinase. main Serine threonine specific protein kinases Serine threonine protein kinases EC number ... group of protein kinases are the MAP kinase s acronym from mitogen activated protein kinases . Important ... kinases main Tyrosine kinase Tyrosine specific protein kinases EC number 2.7.10.1 and EC number ... kinase is Janus kinase JAK , many of whose effects are mediated by STAT protein s. See JAK STAT pathway . Histidine specific protein kinases main Histidine kinase Histidine kinase s are structurally ... on a receiver domain on a different protein, or sometimes on the kinase itself. The aspartyl phosphate .... Mixed kinases Some kinases have mixed kinase activities. For example, Mitogen activated protein ... and tyrosine kinase and, hence, is a dual specificity kinase . Inhibitors main Protein kinase ...   more details



  1. Tau-protein kinase

    enzyme Name tau protein kinase EC number 2.7.11.26 CAS number 111694 09 8 IUBMB EC number 2 7 11 26 GO code 0050321 image width caption In enzymology , a tau protein kinase EC number 2.7.11.26 is an enzyme that catalysis catalyzes the chemical reaction ATP tau protein math rightleftharpoons math ADP O phospho tau protein Thus, the two substrate biochemistry substrates of this enzyme are adenosine triphosphate ATP and tau protein , whereas its two product chemistry products are adenosine diphosphate ADP and O phospho tau protein . This enzyme belongs to the family of transferase s, specifically those transferring a phosphate group to the sidechain oxygen atom of serine or threonine residues in protein s protein serine threonine kinase s . This enzyme participates in 14 metabolism metabolic pathways ... cell carcinoma . Nomenclature The systematic name of this enzyme class is ATP tau protein O phosphotransferase . Other names in common use include ATP tau protein O hosphotransferase , brain protein kinase PK40erk , cdk5 p20 , CDK5 p23 , glycogen synthase kinase 3beta , GSK , protein tau kinase , STK31 , tau kinase , tau protein kinase , tau protein kinase I , tau protein kinase II , tau tubulin kinase , TPK , TPK I , TPK II , and TTK . Structural studies As of late 2007, 3 tertiary structure structures have been solved for this class of enzymes, with Protein Data Bank PDB accession codes PDB link 2JDO , PDB link 2JDR , and PDB link 2UW9 . Examples Human genes encoding proteins with Tau protein kinase activity include BRSK1 BRSK2 GSK3A GSK3B References reflist 1 cite journal author Ishiguro K, Ihara Y, Uchida T, Imahori K date Tokyo title A novel tubulin dependent protein kinase forming ... issue 3 cite journal author Lund ET, McKenna R, Evans DB, Sharma SK, Mathews WR date 2001 title Characterization of the in vitro phosphorylation of human tau by tau protein kinase II cdk5 p20 using ... title Expression, purification and crystallization of human tau protein kinase I glycogen synthase kinase ...   more details



  1. Kinase binding protein CGI-121

    Orphan date July 2011 Infobox protein family Symbol CGI 121 Name CGI 121 image PDB 1zd0 EBI.jpg width caption crystal structure of pfu 542154 conserved hypothetical protein Pfam PF08617 Pfam clan InterPro IPR013926 SMART PROSITE MEROPS SCOP 1zd0 TCDB OPM family OPM protein CAZy CDD In molecular biology, the kinase binding protein CGI 121 family of proteins includes the kinase binding protein CGI 121 and its Homology biology homologues . CGI 121 has been shown to Molecular binding bind to the p53 related protein kinase PRPK . ref name pmid12659830 cite journal author Miyoshi A, Kito K, Aramoto T, Abe Y, Kobayashi N, Ueda N title Identification of CGI 121, a novel PRPK p53 related protein kinase binding protein journal Biochem. Biophys. Res. Commun. volume 303 issue 2 pages 399 405 year 2003 month April pmid 12659830 doi 10.1016 S0006 291X 03 00333 4 url ref CGI 121 is part of a conserved protein complex, KEOPS. The KEOPS Protein complex complex is involved in telomere uncapping and telomere elongation. ref name pmid16564010 cite journal author Downey M, Houlsworth R, Maringele L, Rollie A, Brehme M, Galicia S, Guillard S, Partington M, Zubko MK, Krogan NJ, Emili A, Greenblatt JF, Harrington L, Lydall D, Durocher D title A genome wide screen identifies the evolutionarily conserved KEOPS complex as a telomere regulator journal Cell volume 124 issue 6 pages 1155 68 year 2006 month March pmid 16564010 doi 10.1016 j.cell.2005.12.044 url ref Interestingly, this family of proteins also include archaeal homology biology homologues . References reflist InterPro content IPR013926 DEFAULTSORT Kinase Binding Protein Cgi 121 Category Protein domains ...   more details



  1. Myotonin-protein kinase

    PBB geneid 1760 Myotonin protein kinase MT PK also known as myotonic dystrophy protein kinase MDPK or dystrophia myotonica protein kinase DMK is an enzyme that in humans is encoded by the DMPK gene . ref ... doi 10.1126 science.1546326 ref ref name entrez Function Myotonin protein kinase is a serine threonine specific protein kinase serine threonine kinase that is closely related to other kinases that interact ... protein kinase url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 1760 accessdate ref Interactions Myotonic dystrophy protein kinase has been shown to Protein protein ... month Mar. title MKBP, a novel member of the small heat shock protein family, binds and activates the myotonic dystrophy protein kinase journal J. Cell Biol. volume 140 issue 5 pages 1113 24 publisher ... 1 kinases, components of distinct signaling pathways, activate myotonic dystrophy protein kinase journal ... of the myotonin protein kinase gene in discrete areas of human brain. journal Biochem. Biophys. Res ... al. title Expression of a novel human myotonin protein kinase MtPK cDNA clone which encodes a protein ... protein kinase DMPK mRNA as a result of a triplet repeat expansion in myotonic dystrophy. journal ... S, et al. title Decreased expression of myotonin protein kinase messenger RNA and protein in adult ... the myotonic dystrophy protein kinase. journal J. Cell Biol. volume 140 issue 5 pages 1113 ..., Lam LT, Morris GE title Localization of myotonic dystrophy protein kinase in human and rabbit tissues ... specific protein kinases DEFAULTSORT Myotonin Protein Kinase Category EC 2.7.1 Category Human proteins ... cite journal last Sugiyama first Y authorlink coauthors Suzuki A, Kishikawa M, Akutsu R, Hirose T, Waye ... heat shock protein complex composed of MKBP HSPB2 and HSPB3 during myogenic differentiation journal ... multiple protein isoform encoding mRNAs. journal Nat. Genet. volume 1 issue 4 pages 261 6 year 1993 ... dystrophy expansion of a trinucleotide CTG repeat at the 3 end of a transcript encoding a protein ...   more details



  1. Protein kinase D1

    PBB geneid 5587 Serine threonine protein kinase D1 is an enzyme that in humans is encoded by the PRKD1 ... K title PKCu is a novel, atypical member of the protein kinase C family journal J Biol Chem ... cite journal author Owczarek CM, Portbury KJ, Kola I, Hertzog PJ title Assignment of protein kinase ... 000015624 ref ref name entrez cite web title Entrez Gene PRKD1 protein kinase D1 url http www.ncbi.nlm.nih.gov .... PBB Summary section title summary text Members of the protein kinase C PKC family function in many .... supplied by OMIM ref name entrez Interactions Protein kinase D1 has been shown to Protein protein ... with and is phosphorylated by isoforms of protein kinase C journal Biochem. Biophys. Res. Commun ... Protein kinase C micro is regulated by the multifunctional chaperon protein p32 journal J. Biol. Chem ... month Apr. title Protein kinase C mu is negatively regulated by 14 3 3 signal transduction proteins ... with protein kinase C mu journal FEBS Lett. volume 461 issue 1 2 pages 68 72 publisher location NETHERLANDS ... by tat requires protein kinase C journal EMBO J. volume 9 issue 4 pages 1165 70 year 1990 pmid ... in both NF kappa B binding and protein kinase C activity in primary human astrocytes journal J. Virol ... SP, Law CL, Klaus SJ, et al. title Protein kinase C mu PKC mu associates with the B cell antigen ... phosphorylation of human immunodeficiency virus type 1 Tat protein by protein kinase C evidence for the phosphorylation ... of protein kinase C PKC alpha, and epsilon and zeta isoforms in PC12 cells journal Biochem ... protein induces interleukin 6 mRNA expression in human brain endothelial cells via protein kinase C and cAMP dependent protein kinase pathways journal AIDS Res. Hum. Retroviruses volume 14 issue 10 pages ... T, Rozengurt E title The pleckstrin homology domain of protein kinase D interacts preferentially with the eta isoform of protein kinase C journal J. Biol. Chem. volume 274 issue 14 pages 9224 30 year ... al. title Protein kinase C mu is negatively regulated by 14 3 3 signal transduction proteins journal ...   more details



  1. Rho-associated protein kinase

    protein Name ROCK image 3d9v bio r 500.jpg width caption Crystal structure of human ROCK I Symbol Rho associated protein kinase AltSymbols Rho kinase AltSymbols Rho associated, coiled coil containing protein kinase ATC prefix ATC suffix ATC supplemental CAS number CAS supplemental DrugBank EntrezGene ... Rho associated protein kinase ROCK is a kinase belonging to the AGC PKA PKG PKC family of Serine threonine specific protein kinase serine threonine kinases . It is mainly involved in regulating the shape ... and ROCK II, two isoforms of Rho associated coiled coil forming protein serine threonine kinase in mice ... Rho associated, coiled coil containing protein kinase 2 caption image width HGNCid 10252 Symbol ROCK2 ... dystrophy kinase Myotonin protein kinase DMPK , DMPK related cell division control protein ... signaling peptides and proteins DEFAULTSORT Rho Associated Protein Kinase Category Cell cycle ... of the small GTPase RhoA . Mammalian ROCK consists of a kinase domain, a coiled coil region and a Pleckstrin homology PH domain, which reduces the kinase activity of ROCKs by an autoinhibitory intramolecular ... 0189 x author Hahmann C, Schroeter T year 2010 title Rho kinase inhibitors as therapeutics from pan ... binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton ... 0014 5793 96 00811 3 url ref . Function File ROCK protein function.svg thumb 400px Fig.1 Role and Regulation ... effector protein of the small GTPase Rho , which is one of the major regulators of the cytoskeleton ... as follows Different substrates can be phosphorylated by ROCKs, including LIM kinase , myosin light ... the depolymerisation of actin filaments indirectly ROCK phosphorylates and activates LIM kinase , which ... T, Boku S, et al. title Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM kinase journal Science volume 285 issue 5429 pages 895 8 year 1999 month August pmid 10436159 ... of the motor protein myosin II by two different mechanisms Firstly, phosphorylation of the myosin light ...   more details



  1. Protein kinase domain

    the protein kinase domain ref name pmid12471243 Cite journal author Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S title The protein kinase complement of the human genome journal Science ...Pfam box Symbol Pkinase Name Protein kinase domain image PDB 1apm EBI.jpg width caption Structure of the catalytic subunit of cAMP dependent protein kinase. ref name pmid15299526 Cite journal author Knighton ... dependent protein kinase complexed with a peptide inhibitor and detergent journal Acta Crystallogr ... 1csn 12 237 PDB3 1cki B 9 247 PDB3 1ckj B 9 247 PDB3 1lhx A 9 276 The protein kinase domain is a structurally ... kinase s. ref name pmid1956325 Cite journal author Hanks SK, Quinn AM title Protein kinase catalytic ... 10.1016 0076 6879 91 00126 H url chapter 2 Protein kinase catalytic domain sequence database Identification ... T title Protein kinases 6. The eukaryotic protein kinase superfamily kinase catalytic domain structure ... author Scheeff ED, Bourne PE title Structural evolution of the protein kinase like superfamily journal ..., T. Hunter, S. Sudarsanam, The Protein Kinase Complement of the Human Genome , Science 6 December ... to substrate specificity serine threonine specific protein kinase serine threonine specific and tyrosine ... AM title The protein kinase family conserved features and deduced phylogeny of the catalytic domains ... ref Function Protein kinase function has been evolutionarily conserved from Escherichia coli ... G, Plowman GD, Hunter T, Sudarsanam S title Evolution of protein kinase signaling from yeast to man ... author Hanks SK, Hunter T title Protein kinases 6. The eukaryotic protein kinase superfamily kinase ... date June 2010 ref ref name pmid1835513 Cite journal author Hunter T title Protein kinase classification ... 91 00125 G url chapter 1 Protein kinase classification series Methods in Enzymology isbn 9780121821012 ... protein kinase journal Science volume 253 issue 5018 pages 407 14 year 1991 month July pmid 1862342 ... DAPK3 DCLK1 DCLK2 DCLK3 DDR1 DDR2 gene DDR2 Myotonic dystrophy protein kinase DMPK DYRK1A DYRK1B ...   more details



  1. Protein-histidine pros-kinase

    enzyme Name protein histidine pros kinase EC number 2.7.13.1 CAS number 99283 67 7 IUBMB EC number 2 7 13 1 GO code 0008256 image width caption In enzymology , a protein histidine pros kinase EC number 2.7.13.1 is an enzyme that catalysis catalyzes the chemical reaction ATP protein small L small histidine math rightleftharpoons math ADP protein N sup &pi sup phospho small L small histidine Thus, the two substrate biochemistry substrates of this enzyme are adenosine triphosphate ATP and protein L histidine , whereas its two product chemistry products are adenosine diphosphate ADP and protein Npi phospho L histidine . This enzyme belongs to the family of transferase s, specifically those transferring a phosphate group to the sidechain of histidine residues in protein s protein histidine kinases . The systematic name of this enzyme class is ATP protein L histidine Npi phosphotransferase . Other names in common use include ATP protein L histidine N pros phosphotransferase , histidine kinase ambiguous , histidine protein kinase ambiguous , protein histidine kinase ambiguous , protein kinase histidine ambiguous , and HK2 . References reflist 1 cite journal author Fujitaki JM, Fung G, Oh EY, Smith RA year 1981 title Characterization of chemical and enzymatic acid labile phosphorylation of histone H4 using phosphorus 31 nuclear magnetic resonance journal Biochemistry. volume 20 pages 3658&ndash 64 pmid 7196259 doi 10.1021 bi00515a055 issue 12 cite journal author Huebner VD, Matthews HR year 1985 title Phosphorylation of histidine in proteins by a nuclear extract of Physarum polycephalum plasmodia journal J. Biol. Chem. volume 260 pages 16106&ndash 13 pmid 4066704 issue 30 Kinases Category EC 2.7.13 Category Enzymes of unknown structure enzyme stub ...   more details



  1. Protein-histidine tele-kinase

    enzyme Name protein histidine tele kinase EC number 2.7.13.2 CAS number 99283 67 7 IUBMB EC number 2 7 13 2 GO code 0008257 image width caption In enzymology , a protein histidine tele kinase EC number 2.7.13.2 is an enzyme that catalysis catalyzes the chemical reaction ATP protein small L small histidine math rightleftharpoons math ADP protein N sup &tau sup phospho small L small histidine Thus, the two substrate biochemistry substrates of this enzyme are adenosine triphosphate ATP and protein L histidine , whereas its two product chemistry products are adenosine diphosphate ADP and protein Ntau phospho L histidine . This enzyme belongs to the family of transferase s, specifically those transferring a phosphate group to the sidechain of histidine residues in protein s protein histidine kinases . The systematic name of this enzyme class is ATP protein L histidine Ntau phosphotransferase . Other names in common use include ATP protein L histidine N tele phosphotransferase , histidine kinase ambiguous , histidine protein kinase ambiguous , protein histidine kinase ambiguous , protein kinase histidine ambiguous , and HK3 . References reflist 1 cite journal author Fujitaki JM, Fung G, Oh EY, Smith RA date 1981 title Characterization of chemical and enzymatic acid labile phosphorylation of histone H4 using phosphorus 31 nuclear magnetic resonance journal Biochemistry. volume 20 pages 3658&ndash 64 pmid 7196259 doi 10.1021 bi00515a055 issue 12 cite journal author Huebner VD, Matthews HR date 1985 title Phosphorylation of histidine in proteins by a nuclear extract of Physarum polycephalum plasmodia journal J. Biol. Chem. volume 260 pages 16106&ndash 13 pmid 4066704 issue 30 enzyme stub Kinases Category EC 2.7.13 Category Enzymes of unknown structure ...   more details



  1. Tyrosine-protein kinase BLK

    PBB geneid 640 Tyrosine protein kinase BLK also known as B lymphocyte kinase is an enzyme that in humans is encoded by the BLK gene . ref name pmid7845672 cite journal author Drebin JA, Hartzell SW, Griffin ... homologue of a B lymphocyte specific protein tyrosine kinase blk journal Oncogene volume 10 issue ... The tyrosine protein kinase BLK has been shown to Protein protein interaction interact with UBE3A ... of sites on the Src family protein tyrosine kinases p55blk, p59fyn, and p56lyn which interact with the effector molecules phospholipase C gamma 2, microtubule associated protein kinase, GTPase activating protein, and phosphatidylinositol 3 kinase. journal Mol. Cell. Biol. volume 13 issue 9 pages ... BLK B lymphoid tyrosine kinase url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 640 accessdate ref The PBB Summary template is automatically maintained by Protein ... family tyrosine kinase Blk through E6AP mediated ubiquitination journal Proc. Natl. Acad. Sci. U.S.A. ... author Dymecki SM, Niederhuber JE, Desiderio SV title Specific expression of a tyrosine kinase gene ... tyrosine kinase related to murine Blk. journal J. Immunol. volume 154 issue 3 pages 1265 72 year 1995 pmid 7822795 doi cite journal author Donovan JA, Wange RL, Langdon WY, Samelson LE title The protein product of the c cbl protooncogene is the 120 kDa tyrosine phosphorylated protein in Jurkat cells ... P, et al. title In vivo and in vitro specificity of protein tyrosine kinases for immunoglobulin G ... bbrc.1997.6638 cite journal author Hegde R, Srinivasula SM, Ahmad M, et al. title Blk, a BH3 containing mouse protein that interacts with Bcl 2 and Bcl xL, is a potent death agonist. journal J. Biol ... journal author Oda H, Kumar S, Howley PM title Regulation of the Src family tyrosine kinase Blk through ... kinases The PBB Controls template provides controls for Protein Box Bot, please see Template PBB Controls for details. PBB Controls update page yes require manual inspection no update protein box ...   more details



  1. Protein kinase N1

    PBB geneid 5585 Serine threonine protein kinase N1 is an enzyme that in humans is encoded by the PKN1 ... S, Jockusch H, Ono Y title The protein kinase N PKN gene PRKCL1 Prkcl1 maps to human chromosome 19p12 ... ref name entrez cite web title Entrez Gene PKN1 protein kinase N1 url http www.ncbi.nlm.nih.gov sites ... name entrez Interactions Protein kinase N1 has been shown to Protein protein interaction interact with Phospholipase ... dependent kinase 1 , ref name pmid10764742 cite journal last Balendran first A authorlink coauthors Biondi R M, Cheung P C, Casamayor A, Deak M, Alessi D R year 2000 month Jul. title A 3 phosphoinositide dependent protein kinase 1 PDK1 docking site is required for the phosphorylation of protein ... RH, Ridden J, Parker PJ title Cloning and expression patterns of two members of a novel protein kinase ... of DBK, a novel putative serine threonine protein kinase from human endothelial cells ... PJ title Identification of multiple, novel, protein kinase C related gene products journal FEBS Lett ... author Mukai H, Ono Y title A novel protein kinase with leucine zipper like sequences its catalytic domain is highly homologous to that of protein kinase C journal Biochem. Biophys. Res. Commun. volume ... target for Rho as the serine threonine kinase protein kinase N journal Science volume 271 ... Sequential phosphorylation of Tau by glycogen synthase kinase 3beta and protein kinase A at Thr212 ... maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3 phosphoinositide dependent protein kinase 1 PDPK1 PDK1 is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase ...   more details



  1. Wee1-like protein kinase

    a nuclear protein, which is a tyrosine kinase belonging to the Ser Thr family of protein kinases. This protein catalyzes the inhibitory tyrosine phosphorylation of Cdk1 CDC2 cyclin B kinase, and appears ... ref Interactions Wee1 like protein kinase has been shown to Protein protein interaction interact ... M, Elder RT title HIV 1 viral protein R Vpr & host cellular responses. journal Indian J. Med. Res. volume ...see also Wee1 PBB geneid 7465 WEE1 homolog S. pombe , also known as WEE1 , is a protein which in humans ... cytoplasmically activated CDC2 kinase. ref name entrez cite web title Entrez Gene WEE1 WEE1 homolog ..., Hook K E, Duan H, Booher R N, Sun Y year 2000 month Apr. title Binding of 14 3 3beta to the carboxyl terminus of Wee1 increases Wee1 stability, kinase activity, and G2 M cell population journal Cell ... External links MeshName WEE1 protein, human Further reading refbegin 2 PBB Further reading citations cite journal author Kino T, Pavlakis GN title Partner molecules of accessory protein Vpr of the human ... virus type 1 accessory protein Vpr a causative agent of the AIDS related insulin resistance ... protein from HIV 1 distinct roles along the viral life cycle. journal Retrovirology volume 2 issue pages ... author Baldin V, Ducommun B title Subcellular localisation of human wee1 kinase is regulated during ... 15 kinase during the cell cycle. journal EMBO J. volume 14 issue 9 pages 1878 91 year 1995 pmid ... journal author Kharbanda S, Yuan ZM, Taneja N, et al. title p56 p53lyn tyrosine kinase activation ... 1994 pmid 8084605 doi cite journal author Heald R, McLoughlin M, McKeon F title Human wee1 maintains mitotic timing by protecting the nucleus from cytoplasmically activated Cdc2 kinase. journal Cell ... author McGowan CH, Russell P title Human Wee1 kinase inhibits cell division by phosphorylating p34cdc2 ... author Booher RN, Holman PS, Fattaey A title Human Myt1 is a cell cycle regulated kinase that inhibits ..., kinase activity, and G2 M cell population. journal Cell Growth Differ. volume 11 issue 4 pages 211 ...   more details



  1. AMP-activated protein kinase

    R, Li H, Gong F, Smolak C, Neumann D, Pastor Soler NM title AMP activated protein kinase inhibits ...Expert subject Biochemistry date September 2009 5 AMP activated protein kinase or AMPK or 5 adenosine monophosphate activated protein kinase is an enzyme that plays a role in cellular energy homeostasis ... cells . ref name pmid10409121 It should not be confused with cyclic AMP activated protein kinase protein kinase A , which, although being of similar nature, may have opposite effects. ref name pmid19211918 .... year 2002 title Metformin increases AMP activated protein kinase activity in skeletal muscle of subjects ... For over a decade it has been known that calmodulin dependent protein kinase kinase beta ... protein kinase phosphorylating the subunit of AMPK at Thr 172. ref name pmid8910387 ref name pmid10642499 ... of AMP activated protein kinase isoforms in rat muscles journal Am. J. Physiol. Endocrinol. Metab ... intensity dependent activation of 5 AMP activated protein kinase in human skeletal muscle ... LJ title Exercise induces isoform specific increase in 5 AMP activated protein kinase activity in human ... protein kinase journal Nat. Med. volume 8 issue 11 pages 1288 95 year 2002 month November pmid ... Mammalian AMP activated protein kinase subfamily journal J. Biol. Chem. volume 271 issue 2 pages ... protein kinase beta subunit isoform that is highly expressed in skeletal muscle journal J. Biol ... DG, Carling D title Characterization of AMP activated protein kinase gamma subunit isoforms and their role .... A specific method for activating AMP activated protein kinase in intact cells? journal Eur ... activated protein kinase journal FASEB J. volume 9 issue 7 pages 541 6 year 1995 month April pmid 7737463 ... G title Stimulation of rat liver AMP activated protein kinase by AMP analogues journal Biochim. Biophys ... with AICAR, a cell permeable activator of AMP activated protein kinase journal FEBS Lett. volume ... CL, Lamb JD, Winder WW title AMP activated protein kinase kinase activity and phosphorylation of AMP ...   more details



  1. CGMP-dependent protein kinase

    protein Name PRKG1 protein kinase, cGMP dependent, type I caption X ray crystallography Biological macromolecular crystallography Crystallographic structure of the leucine zipper domain of human cGMP dependent protein kinase I beta. ref name pmid20826808 PDB 3NMD cite journal author Casteel DE, Smith Nguyen EV, Sankaran B, Roh SH, Pilz RB, Kim C title A crystal structure of the cyclic GMP dependent protein kinase I beta dimerization docking domain reveals molecular details of isoform specific anchoring ... 10 Arm q Band 11.2 LocusSupplementaryData protein Name protein kinase, cGMP dependent, type ... title cGMP dependent protein kinase cGMP dependent protein kinase or Protein Kinase G PKG is a serine threonine specific protein kinase that is activated by cyclic guanosine monophosphate cGMP . It phosphorylates ... cAMP dependent protein kinase References reflist External links EC number 2.7.11.12 http circres.ahajournals.org cgi content full 93 10 907 Cyclic GMP Dependent Protein Kinases and the Cardiovascular System MeshName cGMP Dependent Protein Kinases Serine threonine specific protein kinases Intracellular signaling peptides and proteins Category Protein kinases Category EC 2.7.11 ... identical protein subunit subunits 75 kDa and 85 kDa, respectively and share common structural ... domain that mediates homodimerization, suppression of the kinase activity in the absence of cGMP, and interactions with other proteins including protein substrates 2 a regulatory domain that contains two non identical cGMP binding sites 3 a kinase domain that catalyzes the phosphate transfer from Adenosine triphosphate ATP to the hydroxyl group of a serine threonine side chain of the target protein ... and inhibits the Myosin light chain kinase which normally phosphorylates the myosin light chains ... V, Berger FG, Browning DD title Expression of cyclic guanosine monophosphate dependent protein kinase in metastatic colon carcinoma cells blocks tumor angiogenesis journal Cancer volume 112 issue ...   more details



  1. Protein kinase inhibitor

    A protein kinase inhibitor is a type of enzyme inhibitor that specifically blocks the action of one or more protein kinase s. Hence, they can be subdivided or characterised by the amino acid s whose phosphorylation is inhibited most kinases act on both serine and threonine, the tyrosine kinase s act on tyrosine, and a number dual specificity kinase s act on all three. There are also protein kinases that phosphorylate other amino acids, including histidine kinase s that phosphorylate histidine residues ... novel DNA dependent protein kinase inhibitor NU7441 journal Cancer Res. volume 66 issue 10 ... Vemurafenib BRAF Roche Small molecule 2011 Aug Melanoma See also Tyrosine kinase inhibitor amino acid References reflist External links MeshName Protein kinase inhibitors http www.reactionbiology.com ... Protein kinase inhibitors biochem stub ... cgi pmidlookup?view long&pmid 16707462 ref Clinical use Kinase inhibitors such as dasatinib ... kinase inhibitor PLX5568 is currently in clinical trials for treatment of polycystic kidney disease ... ref Some of the kinase inhibitors used in treating cancer are inhibitors of tyrosine kinase s. ref name urlDefinition of tyrosine kinase inhibitor NCI Dictionary of Cancer Terms cite web url http www.cancer.gov templates db alpha.aspx?CdrID 44833 title Definition of tyrosine kinase inhibitor NCI Dictionary of Cancer Terms format work accessdate ref The effectiveness of kinase inhibitors on various ... v8 n9 full nrd2871.html title Factors underlying sensitivity of cancers to small molecule kinase inhibitors ... protein kinases and the receptors that activate them class sortable wikitable Name Target Company ... Mar SCCHN Crizotinib Anaplastic lymphoma kinase ALK c Met Met Pfizer Small molecule 2011 Aug NSCLC ... endothelial growth factor VEGF Genentech Monoclonal antibody 2006 AMD Ruxolitinib Janus kinase JAK Incyte ... T1.html Chemical structures and known kinase targets for clinically approved kinase inhibitors ...   more details



  1. Mitogen-activated protein kinase

    enzyme Name Mitogen activated protein kinase EC number 2.7.11.24 CAS number 142243 02 5 IUBMB EC number ... thumb 300px The mitogen activated protein kinase MAPK pathway. ref name pmid10558990 cite journal author Rossomando AJ, Payne DM, Weber MJ, Sturgill TW title Evidence that pp42, a major tyrosine kinase target protein, is a mitogen activated serine threonine protein kinase journal Proc Natl Acad Sci ... JM title Direct Activation of Mitogen Activated Protein Kinase Kinase Kinase MEKK1 by the Ste20p Homologue GCK and the Adapter Protein TRAF2 journal Mol. Cell. Biol. volume 22 issue 3 pages ... NN title HPK1, a hematopoietic protein kinase activating the SAPK JNK pathway journal EMBO J. volume ... protein MAP kinases EC number 2.7.11.24 are serine threonine specific protein kinase s that respond ... protein MAP kinase pathways regulation and physiological functions journal Endocr. Rev. volume ... section date July 2011 MAP kinases are activated within the protein kinase cascades called MAPK cascade . Each one consists of three enzymes, MAP kinase, MAP kinase kinase MKK, MEK, or MAP2K and MAP kinase kinase kinase MKKK, MEKK or MAP3K that are activated in series. A MAP3K that is activated ... of the atypical MAPK ERK4 and its activation of the MAPK activated protein kinase MK5 journal ... of Ras with GTP. GTP Ras bind Raf 1 and B Raf, two protein kinases. Consequently, Raf protein kinase ... via a Ca sup 2 sup increase. G Protein coupled receptors The MAP kinase cascade can also be activated by certain heterotrimeric G proteins. Protein kinase C Protein kinase C PKC is used by many ... Fly Signaling proteins MAP kinase activation Serine threonine specific protein kinases Category Protein ... cite journal author Chang L, Karin M title Mammalian MAP kinase signaling cascades journal Nature ... cite journal author Chen YR, Tan TH title The c Jun N terminal kinase pathway and apoptotic signaling ... DG, Davis RJ title Signal transduction. MAP kinase signaling specificity journal Science volume 296 ...   more details



  1. Protein kinase C

    Other uses PKC disambiguation infobox enzyme Name Protein kinase C EC number 2.7.11.13 CAS number 141436 78 4 IUBMB EC number 2 7 11 13 GO code 0004702 image width caption Protein kinase C also known as PKC EC 2.7.11.13 is a family of protein kinase enzyme s that are involved in controlling the function .... ref name pmid9601053 cite journal author Mellor H, Parker PJ title The extended protein kinase .... ref name pmid7737456 cite journal author Nishizuka Y title Protein kinase C and lipid signaling ... hand, atypical a PKCs including protein kinase M and isoforms require neither Ca sup 2 sup nor diacylglycerol for activation. The term protein kinase C usually refers to the entire family of isoforms ... neither Ca sup 2 sup nor DAG for activation PRKCI PKC Gene PRKCI Protein kinase C, zeta PKC Gene ... degree, among the catalytic region of other serine threonine specific protein kinase serine threonine ... region, discussed below. Catalytic The catalytic region or kinase core of the protein kinase A PKA ... identical Selbie et al., 1993 . Of the over 30 protein kinase structures whose crystal structure has ... dependent protein kinase 1 PDK1 is the upstream kinase responsible for initiating the process ... kinase 1 PDK1 docking site is required for the phosphorylation of protein kinase Czeta PKCzeta and PKC ... July pmid 10764742 doi 10.1074 jbc.M000421200 ref The consensus sequence of protein kinase C enzymes is similar to that of protein kinase A , since it contains basic amino acids close to the Ser Thr to be phosphorylated. Their substrates are, e.g., MARCKS protein s, MAP kinase , transcription factor ... growth factor receptor . Activation Upon activation, protein kinase C enzymes are translocated ... kinase C proteins . The protein kinase C enzymes are known for their long term activation They remain ... may also play a role in long term activation. Function Function of Protein kinase C redirects here ... Phosphorylation of Activation Transcription Factor 2 at Serine 121 by Protein Kinase C Controls c Jun ...   more details



  1. Protein kinase M zeta/Protein kinase C zeta

    PBB geneid 5590 Protein kinase C, zeta PKC also known as PRKCZ is an enzyme that in humans is encoded ... M, Libien JM, Weinstein G, Tcherapanov A, Sacktor TC title Protein kinase M zeta synthesis from a brain mRNA encoding an independent protein kinase C zeta catalytic domain. Implications for the molecular ... of protein kinase C PKC and, lacking an autoinhibitory regulatory domain of the full length PKC ... thought of as being a cleavage product of full length PKC , an atypical isoform of protein kinase ... author Ling D, Benardo L, Serrano P, Blace N, Kelly M, Crary J, Sacktor T title Protein kinase Mzeta ... by protein kinase Mzeta maintains late phase long term potentiation journal J Neurosci volume ... title Atypical protein kinase C in neurodegenerative disease I PKMzeta aggregates with limbic neurofibrillary ... alpha 1 associates with and is phosphorylated by isoforms of protein kinase C journal Biochem. Biophys ... A 3 phosphoinositide dependent protein kinase 1 PDK1 docking site is required for the phosphorylation of protein kinase Czeta PKCzeta and PKC related kinase 2 by PDK1 journal J. Biol. Chem. volume ... Sep. title Protein kinase C isotypes controlled by phosphoinositide 3 kinase through the protein ... protein complex Par6 Par3 protein kinase Czeta PKCzeta and regulates PKCzeta activity journal Mol. Cell ... that links the small GTPases Rac and Cdc42 to atypical protein kinase C journal Genes Cells ... protein kinase C interacting protein journal Mol. Cell Biol. Res. Commun. volume 2 issue 1 pages 28 ... year 2002 month Jul. title Protein kinase Czeta phosphorylates nuclear factor of activated T cells ... facilitate coupling of protein kinase C zeta to Raf 1 negative regulation by 14 3 3 phosphorylation ... substrate for protein kinase Czeta journal Biochem. Biophys. Res. Commun. volume 317 issue 3 pages ... of PDK2 activity against protein kinase B gamma journal Biochemistry volume 41 issue 32 pages ... elegans UNC 76 protein involved in axonal outgrowth is a protein kinase C zeta interacting ...   more details



  1. Mitogen-activated protein kinase kinase

    otheruses2 MKK sic Mitogen activated protein kinase kinase also known as MAP2K is a kinase enzyme which Phosphorylation phosphorylates mitogen activated protein kinase MAPK . MAP2K is classified as EC number 2.7.12.2 . There are seven genes Gene MAP2K1 aka MEK1 Gene MAP2K2 aka MEK2 Gene MAP2K3 aka MKK3 Gene MAP2K4 aka MKK4 Gene MAP2K5 aka MKK5 Gene MAP2K6 aka MKK6 Gene MAP2K7 aka MKK7 The activators of p38 mitogen activated protein kinases p38 MKK3 and MKK6 , C Jun N terminal kinases JNK MKK4 and MKK7 , and Extracellular signal regulated kinases ERK MEK1 and MEK2 define independent Mitogen activated protein kinase MAP kinase signal transduction pathways. ref cite journal author D rijard B, et al. title Independent human MAP kinase signal transduction pathways defined by MEK and MKK isoforms year 1995 journal Science volume 267 issue 5198 pages 682 5 doi 10.1126 science.7839144 pmid 7839144 ref References Reflist External links MeshName Mitogen Activated Protein Kinase Kinases MAP kinase activation Kinases Serine threonine specific protein kinases Category Protein kinases Category Article Feedback 5 biochemistry stub es MAP quinasa quinasa ...   more details



  1. Cyclin-dependent kinase inhibitor protein

    activated protein kinase signaling pathway in human tumors journal Oncogene volume 18 issue 3 ...Pfam box Symbol CDI Name Cyclin dependent kinase inhibitor image PDB 1jsu EBI.jpg width caption Structure of the p27Kip1 cyclin dependent kinase inhibitor bound to the cyclin A Cdk2 complex. ref name pmid8684460 cite journal author Russo AA, Jeffrey PD, Patten AK, Massagu J, Pavletich NP title Crystal structure of the p27Kip1 cyclin dependent kinase inhibitor bound to the cyclin A Cdk2 complex journal Nature volume 382 issue 6589 pages 325 31 year 1996 month July pmid 8684460 doi 10.1038 382325a0 url ref Pfam PF02234 InterPro IPR003175 SMART Prosite SCOP 1jsu TCDB OPM family OPM protein PDB PDB3 1jsu C 30 80 PDB3 1h27 E 30 35 about the cell cycle protein the medical therapy CDK inhibitor A cyclin dependent kinase inhibitor protein is a protein which inhibits cyclin dependent kinase . Several function as tumor suppressor gene s. Cell cycle progression is negatively controlled by cyclin dependent kinases inhibitors called CDIs, CKIs or CDKIs . CDIs are involved in cell cycle restriction point arrest at the G1 phase G sub 1 sub phase . Examples class wikitable sortable border 1 Protein Gene Interacts with p16 gene p16 CDKN2A Cyclin dependent kinase 4 , Cyclin dependent kinase 6 CDKN2B p15 CDKN2B Cyclin dependent kinase 4 CDKN2C p18 CDKN2C Cyclin dependent kinase 4 , Cyclin dependent kinase 6 CDKN2D p19 CDKN2D Cyclin dependent kinase 4 , Cyclin dependent kinase 6 p21 p21 WAF1 CDKN1A ref name pmid9989833 cite journal author Hoshino R, Chatani Y, Yamori T, Tsuruo T, Oka H, Yoshida ... Cyclin dependent kinase 2 CDKN1B p27 CDKN1B Cyclin D3 Cyclin dependent kinase 4 , Cyclin E1 Cyclin dependent kinase 2 Cyclin dependent kinase inhibitor 1C p57 CDKN1C Cyclin E1 Cyclin dependent kinase 2 CDKN3 Cyclin dependent kinase 2 References reflist External links MeshName Cyclin Dependent Kinase Inhibitor Proteins protein stub Cell cycle proteins Category Protein domains ...   more details



  1. Receptor protein serine/threonine kinase

    enzyme Name Receptor protein serine threonine kinase EC number 2.7.11.30 CAS number 146702 86 5 IUBMB EC number 2 7 11 30 GO code image width caption In enzymology , a receptor protein serine threonine kinase EC number 2.7.11.30 is an enzyme that catalysis catalyzes the chemical reaction ATP receptor protein math rightleftharpoons math ADP receptor protein phosphate Thus, the two substrate biochemistry substrates of this enzyme are adenosine triphosphate ATP and receptor protein , whereas its two product chemistry products are adenosine diphosphate ADP and receptor protein phosphate . This enzyme belongs to the family of transferase s, to be specific those transferring phosphorus containing groups protein serine threonine kinases. The systematic name of this enzyme class is ATP receptor protein phosphotransferase . Other names in common use include activin receptor kinase , receptor type I serine threonine protein kinase , receptor type II serine threonine protein kinase , STK13 , TGF beta kinase , and receptor serine threonine protein kinase . This enzyme participates in 7 metabolism metabolic pathways mapk signaling pathway , cytokine cytokine receptor interaction , tgf beta signaling pathway , adherens junction , colorectal cancer , pancreatic cancer , and chronic myeloid leukemia . Structural studies As of late 2007, 5 tertiary structure structures have been solved for this class of enzymes, with Protein Data Bank PDB accession codes PDB link 2GOO , PDB link 2H62 , PDB link 2H64 , PDB link 2HLQ , and PDB link 2HLR . References reflist 1 refbegin cite journal author Wrana JL, Attisano L, Wieser R, Ventura F, Massague J date 1994 title Mechanism of activation of the TGF beta receptor journal Nature. volume 370 pages 341&ndash 7 pmid 8047140 doi 10.1038 370341a0 issue 6488 ... Bloch first3 S last4 Ajmera first4 R last5 Roberts first5 AB last6 Lechleider first6 RJ issue 21 refend enzyme stub Serine threonine specific protein kinases Enzyme linked receptors Category EC 2.7.11 ...   more details



  1. G protein-coupled receptor kinase

    enzyme Name G protein coupled receptor kinase EC number 2.7.11.16 CAS number IUBMB EC number 2 7 11 16 GO code 0004703 image Gprotein coupled receptor kinase.png width caption Crystal structure of G protein coupled receptor kinase 1 rhodopsin kinase GRK1 bound to adenosine triphosphate ATP . ref name ... of rhodopsin kinase in different ligand states reveal key elements involved in G protein coupled receptor kinase activation journal J. Biol. Chem. volume 283 issue 20 pages 14053 62 year 2008 month May pmid 18339619 pmc 2376226 doi 10.1074 jbc.M708974200 url issn ref G protein coupled receptor kinases GRKs , GPCRKs are a protein family family of protein kinase s which regulate the activity of G protein coupled receptors GPCRs by phosphorylation phosphorylating their intracellular domains after their associated G proteins have been released and activated. In other words, these protein ... Gene OMIM G protein coupled receptor kinase 1 Rhodopsin kinase Gene GRK1 OMIM2 180381 G protein coupled receptor kinase 2 beta adrenergic receptor kinase &beta Adrenergic receptor kinase 1 BARK1 Gene ADRBK1 GRK2 OMIM2 109635 G protein coupled receptor kinase 3 beta adrenergic receptor kinase &beta Adrenergic receptor kinase 2 BARK2 Gene ADRBK2 GRK3 OMIM2 109636 G protein coupled receptor kinase 4 ... 600870 G protein coupled receptor kinase 6 Knockout mice are supersensitive to dopaminergic s ref ... supersensitivity in G protein coupled receptor kinase 6 deficient mice journal Neuron journal Neuron ... GRK6 OMIM2 600869 G protein coupled receptor kinase 7 Cone opsin kinase Gene GRK7 OMIM2 606987 See also Downregulation and upregulation G protein coupled receptor Phosphorylation Protein kinase References ... The G protein coupled receptor kinase GRK interactome role of GRKs in GPCR regulation and signaling ... and deactivation. Defects in GRK1 result in Oguchi disease 2. ref cite web title GRK1 G protein coupled receptor kinase 1 Homo sapiens url http www.ncbi.nlm.nih.gov gene 6011 publisher National Center ...   more details



  1. Mitogen-activated protein kinase 9

    R J year 1999 month Oct. title The JIP Group of Mitogen Activated Protein Kinase Scaffold Proteins ...PBB geneid 5601 Mitogen activated protein kinase 9 is an enzyme that in humans is encoded by the MAPK9 ... maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act ... Entrez Gene MAPK9 mitogen activated protein kinase 9 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 5601 accessdate ref Interactions Mitogen activated protein kinase 9 has been shown to Protein protein interaction interact with TOB1 , ref name pmid12151396 cite journal ... R, Yuan Z M, Kharbanda S, Kufe D year 1995 month Dec. title Involvement of stress activated protein kinase in the cellular response to 1 beta D arabinofuranosylcytosine and other DNA damaging agents ..., a Novel Jun N Terminal Protein Kinase JNK Binding Protein That Functions as a Scaffold Factor in the JNK ... Activated Protein Kinase Signaling Module with the Neuronal Protein JIP3 journal Mol. Cell. Biol. volume ... 1 cite journal author Chu Y title The mitogen activated protein kinase phosphatases PAC1, MKP 1 ... Selective interaction of JNK protein kinase isoforms with transcription factors journal EMBO J ... Claire cite journal author Janknecht R, Hunter T title Convergence of MAP kinase pathways on the ternary ... MAP kinase activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates journal EMBO J. volume 16 issue 8 pages 1921 33 year 1997 pmid 9155018 ..., Moore G, Davis R, Karin M title JNK2 contains a specificity determining region responsible for efficient ... processes such as proliferation, differentiation, transcription regulation and development. This kinase .... This gene and MAPK8 are also known as c Jun N terminal kinases. This kinase blocks the ubiquitination .... title Identification of the Anti proliferative protein Tob as a MAPK substrate journal J. Biol. Chem ...   more details




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