Refimprove date January 2009 A proteinisoform is any of several different forms of the same protein . Different forms of a protein may be produced from related genes , or may arise from the same gene by alternative splicing . A large number of isoforms are caused by single nucleotide polymorphisms or SNPs, small genetic differences between alleles of the same gene. These occur at specific individual nucleotide positions within a gene. The discovery of isoforms partly explains the apparently small number of coding regions genes revealed by the human genome project the ability to create categorically different proteins from the same gene increases the diversity of the proteome . Isoforms are readily described and discovered by microarray studies and cDNA libraries. Glycoforms A glycoform is an isoform of a protein that differs only with respect to the number or type of attached glycan . Glycoproteins often consist of a number of different glycoforms, with alterations in the attached saccharide or oligosaccharide . These modifications may result from differences in biosynthesis during the process of glycosylation , or due to the action of glycosidases or glycosyltransferases . Glycoforms may be detected through detailed chemical analysis of separated glycoforms, but more conveniently detected through differential reaction with lectins , as in lectin affinity chromatography and lectin ... varying number of isoforms, with a single isoform in yeasts and multiple at least six in mammals in eukaryotes ... External links Wiktionary isoform http www.ncbi.nlm.nih.gov entrez query.fcgi?cmd Retrieve&db mesh&list uids 68020033&dopt Full MeSH entry protein isoforms http ghr.nlm.nih.gov glossary isoforms Definitions Isoform DEFAULTSORT ProteinIsoform Category Molecular biology Category Proteins protein stub ca Isoforma de Isoform es Isoforma fr Isoforme it Isoforma proteica nl Prote ne isovorm pl Polimorfizm bia ek simple Isoform sr Proteinska izoforma ... more details
Pfam box Symbol SpA Name Protein A image Protein A 1DEE 1L6X.png width caption Structure of a domain of protein A as a three helix bundle binding to the heavy variable chain of a VH3 human Fab ref name ... JB, Silverman GJ. title Crystal structure of a Staphylococcus aureus protein A domain complexed with the Fab ... month May pmid 10805799 doi pmc 25840 ref left. Minimized protein A bound to Fc fragment of Rituximab ... April pmid 10754313 doi ref Pfam InterPro SMART PROSITE SCOP 1DEE TCDB OPM family OPM protein PDB PDB2 1dee , PDB2 1l6x Protein A is a 40 60 Atomic mass unit kDa MSCRAMM surface protein originally found ... opsonization and phagocytosis . Protein A antibody binding Protein A binds with high affinity to human IgG1 and IgG2 as well as mouse IgG2a and IgG2b. Protein A binds with moderate affinity to human ... or IgD , nor will it react to mouse IgM, IgA or IgE. The capacity of protein A to bind antibodies .... The protein A used for production of antibodies in bio pharmaceuticals is most commonly bound to a stationary phase chromatography resin. Other antibody binding proteins In addition to Protein A, other immunoglobulin binding bacterial proteins such as Protein G , Protein A G and Protein L ... Staphylococcus aureus utilizes Protein A, along with a host of other proteins and surface factors to aid its survival and, thus, virulence. Protein A helps inhibit phagocytic engulfment and acts as an immunological disguise. Mutants of S. aureus lacking protein A are more efficiently phagocytosed ... toxin. J. Exp. Med. 2003 197 1125 1139. ref Research Recombinant Staphylococcal Protein ... form of Protein A is called MabSelect ref http www.gelifesciences.com aptrix upp00919.nsf Content 17D93C2E6A580E57C1257628001CE677 file 18114994AE.pdf ref . Protein A is often coupled to other molecules ... beads. Protein A is often immobilized onto a solid support and used as reliable method for purifying total IgG from crude protein mixtures such as blood serum serum or ascites fluid, or coupled with one ... more details
PBB geneid 5627 Protein S is a vitamin K dependent plasma glycoprotein synthesized in the endothelium. In the circulation, Protein S exists in two forms a free form and a complex form bound to complement system complement protein C4b. In humans, protein S is encoded by the PROS1 gene . ref name pmid2944113 ... J, Wydro R title Isolation and sequence of the cDNA for human protein S, a regulator of blood coagulation ... in Seattle , Washington first discovered protein S and arbitrarily named it after the city ... , and protein S journal Biochemistry volume 16 issue 4 pages 698 706 year 1977 month February pmid ... Characterization of protein S, a gamma carboxyglutamic acid containing protein from bovine and human ... 10.1021 bi00572a026 ref Function The best characterized function of Protein S is its role in the anti coagulation pathway, where it functions as a cofactor to Protein C in the inactivation of factor ... cite journal author Castoldi E, Hackeng TM title Regulation of coagulation by protein S journal Curr ... MOH.0b013e328309ec97 url ref Protein S can bind to negatively charged phospholipids via the carboxylated Gla domain GLA domain . This property allows Protein S to function in the removal of cells which ... . Protein S can bind to the negatively charged phospholipids and function as a bridging molecule between the apoptotic cell and the phagocyte. The bridging property of Protein S enhances the phagocytosis ... such as inflammation occurring. Pathology Mutations in the PROS1 gene can lead to Protein S deficiency ... of, and molecular defects underlying, inherited protein S deficiency in the general population ... P, Fuentes Prior P, Hurtado B, Sala N title Molecular basis of protein S deficiency journal Thromb ... Protein S has been shown to Proteinprotein interaction interact with Factor V . ref name pmid10593904 ... Y, Rosing J, Tans G, Griffin J H year 1999 month Dec. title C terminal residues 621 635 of protein ... of protein S to factor Va associated with inhibition of prothrombinase that is independent of activated ... more details
About a class of molecules protein as a nutrient Protein nutrient other uses pp semi indef File Myoglobin.png thumb right A representation of the 3D structure of the protein myoglobin showing colored alpha helix alpha helices . This protein was the first to have its structure solved by X ray crystallography ... into a globular protein globular or fibrous protein fibrous form, facilitating a biological function ... sequence sequence of amino acids in a protein is defined by the DNA sequence sequence of a gene , which ... . Shortly after or even during synthesis, the residues in a protein are often chemically ... stable protein complex es. One of the most distinguishing features of polypeptides is their ability ... to be single structure. Other proteins undergo large rearrangements from one protein conformation ... signaling event . Thus, the structure of a protein serves as a medium through which to regulate either the function of a protein or activity of an enzyme. Not all proteins require a folding process ... protein into free amino acids that are then used in metabolism. Proteins were first described ... Berzelius in 1838. Early nutritional scientists such as the German Carl von Voit believed that protein ... urease was in fact a protein. ref name Sumner1926 The first protein to be protein sequencing .... The first protein structure s to be solved were hemoglobin and myoglobin , by Max Perutz and John ... be protein purification purified from other cellular components using a variety of techniques such as ultracentrifugation .... Methods commonly used to study protein structure and function include immunohistochemistry , site ... protein folding the statistical analysis techniques employed to calculate a protein s probable tertiary ... chains in a protein that ultimately determines its three dimensional structure and its chemical reactivity ... linked in the protein chain, an individual amino acid is called a residue, and the linked series of carbon, nitrogen, and oxygen atoms are known as the main chain or protein backbone. ref Murray ... more details
enzyme Name protein xylosyltransferase EC number 2.4.2.26 CAS number 55576 38 0 IUBMB EC number 2 4 2 26 GO code 0030158 image width caption In enzymology , a protein xylosyltransferase EC number 2.4.2.26 is an enzyme that catalysis catalyzes the chemical reaction in which a beta D xylose xylosyl residue is transferred from UDP D xylose to the sidechain oxygen atom of a serine residue in a protein . This enzyme belongs to the family of glycosyltransferase s, specifically the pentosyltransferases. The systematic name of this enzyme class is UDP D xylose protein beta D xylosyltransferase . Other names in common use include UDP D xylose core protein beta D xylosyltransferase , UDP D xylose core protein xylosyltransferase , UDP D xylose proteoglycan core protein beta D xylosyltransferase , UDP xylose core protein beta D xylosyltransferase , uridine diphosphoxylose core protein beta xylosyltransferase , and uridine diphosphoxylose protein xylosyltransferase . This enzyme participates in the biosynthesis of chondroitin sulfate and glycan structures. References reflist 1 cite journal author Stoolmiller AC, Horwitz AL, Dorfman A date 1972 title Biosynthesis of the chondroitin sulfate proteoglycan. Purification and properties of xylosyltransferase journal J. Biol. Chem. volume 247 pages 3525&ndash 32 pmid 5030630 issue 11 cite journal author Gotting C, Kuhn J, Zahn R, Brinkmann T, Kleesiek K date 2000 title Molecular cloning and expression of human UDP d Xylose proteoglycan core protein beta d xylosyltransferase and its first isoform XT II journal J. Mol. Biol. volume 304 pages 517&ndash 28 pmid 11099377 doi 10.1006 jmbi.2000.4261 issue 4 enzyme stub Category EC 2.4.2 Category Enzymes of unknown structure ... more details
Confusing date January 2009 Unreferenced date July 2007 Fetal proteins are simply protein s present at highest levels at the fetus stage. Often related proteins assume similar roles after birth or in the embryo , in which case the fetal varieties are called fetal isoform s. Sometimes the gene s coding fetal isoforms occur adjacent to their adult homology biology homologues in the genome , and in those cases a locus control region often coordinates the transition from fetal to adult forms. In other cases fetal isoforms can be produced by alternate splicing using fetal exon s to produce proteins that differ in only a portion of their amino acid sequence. In some situations the reexpression or continuing expression of fetal forms can reveal the presence of a disease condition or serve as a treatment for diseases such as sickle cell anemia . Some well known examples include Alpha fetoprotein , the predominant serum protein of the fetus which gives way to albumin in the adult. Fetal hemoglobin , the fetal version of hemoglobin . Fetal Troponin T and Troponin I isoforms. protein stub Category Developmental biology ... more details
Protein database may refer to Any protein structure database Any protein sequence database Exact names Protein NIH Protein database of the National Institute of Health Protein Database of Bio Synthesis, Inc. disambig ... more details
Protein supplement may refer to Dietary supplement s Bodybuilding supplement Protein Bodybuilding supplement Protein bar See also Protein Disambig ... more details
forms a proteinprotein interaction with the ribonuclease protein. The contacts between the two proteins are shown as coloured patches. 250px Proteinprotein interactions occur when two or more protein s bind together, often to carry out their function biology biological function . Many ... molecular machines that are built from a large number of protein components organised by their proteinprotein interactions. Protein interactions have been studied from the perspectives of biochemistry ... or genetic epigenetic graph theory networks . Indeed, proteinprotein interactions are at the core ... cell are mediated to the inside of that cell by proteinprotein interactions of the signaling molecules ... and in many diseases e.g. cancer s . Proteins might interact for a long time to form part of a protein complex , a protein may be carrying another protein for example, from cytoplasm to cell nucleus nucleus or vice versa in the case of the nuclear pore importins , or a protein may interact briefly with another protein just to modify it for example, a protein kinase will add a phosphate to a target protein . This modification of proteins can itself change proteinprotein interactions. For example ..., proteinprotein interactions are of central importance for virtually every process in a living cell ... for new therapeutic approaches. Methods to investigate proteinprotein interactions Main Methods to investigate proteinprotein interactions As proteinprotein interactions are so important there are a multitude ... such as yeast two hybrid screening can be used to detect novel proteinprotein interactions. There are also ... methods. ref Mashaghi A et al. Investigation of a protein complex network EUROPEAN PHYSICAL JOURNAL ... of the human interactome where each point represents a protein and each blue line between them is an interaction. 200px Visualization of proteinprotein interaction networks is a popular application of scientific visualization techniques. Although protein interaction diagrams are common ... more details
PBB geneid 2038 Erythrocyte membrane protein band 4.2 is a protein that in humans is encoded by the EPB42 ... CM, Lux SE title The murine pallid mutation is a platelet storage pool disease associated with the protein ... membrane protein band 4.2 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 2038 accessdate ref Protein 4.2 is a cytoskeleton protein found in red blood cells . The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text Erythrocyte membrane protein band 4.2 is an ATP binding protein which may regulate the association of protein 3 with ankyrin. It probably has a role in erythrocyte ... doi 10.1034 j.1600 0749.2002.1r082.x cite journal author Sung LA title Human erythrocyte protein 4.2 isoform expression, differential splicing, and chromosomal assignment journal Blood volume ... protein 4.2, a high copy number membrane protein, is N myristylated journal J. Biol. Chem. volume ... to threonine substitution in protein 4.2 cDNA is associated with a Japanese form of hereditary hemolytic anemia protein 4.2NIPPON journal Blood volume 79 issue 7 pages 1846 54 year 1992 pmid 1558976 ... author Sung LA title Molecular cloning of human protein 4.2 a major component of the erythrocyte membrane ... erythrocyte protein 4.2 maps to chromosome 15q15 journal Am. J. Hum. Genet. volume 50 issue 1 pages ... CM title Organization of the gene for human erythrocyte membrane protein 4.2 structural similarities ... Korsgren C title Complete amino acid sequence and homologies of human erythrocyte membrane protein ... of erythrocyte membrane protein 4.2 journal Biochem. J. volume 309 Pt 2 issue pages 677 81 year 1995 pmid 7626035 doi pmc 1135783 cite journal author Hayette S title A point mutation in the protein ... first9 C. M. cite journal author Hayette S title A deletional frameshift mutation in protein 4.2 ... in the erythrocyte protein 4.2 gene of Japanese patients with hereditary spherocytosis protein ... more details
A binding protein is any protein that acts as an agent to Molecular binding bind two or more molecules together. Examples include DNA binding protein Single strand binding protein Telomere binding protein RNA binding protein Poly A binding protein Nuclear cap binding protein complex CREB binding protein Calcium binding protein Calcium binding protein 1 S100 calcium binding protein A1 TATA binding protein Actin binding protein Penicillin binding proteins Retinol binding protein Retinol binding protein 4 EP300 Binding immunoglobulin protein Odorant binding protein Lipopolysaccharide binding protein C4b binding protein Rap GTP binding protein Calmodulin binding proteins Iron binding proteins Thyroxine binding proteins Folate binding protein Sterol regulatory element binding protein GTP binding protein Retinaldehyde binding protein 1 Ccaat enhancer binding proteins Androgen binding protein Maltose binding protein Phosphatidylethanolamine binding protein 1 Syntaxin binding protein 3 Insulin like growth factor binding protein Methyl CpG binding domain protein 2 Growth hormone binding protein Vitamin D binding protein Syntaxin binding protein 2 Oxysterol binding protein E3 binding protein Iron responsive element binding protein Polypyrimidine tract binding protein Fatty acid binding protein Myosin binding protein C, cardiac CPE binding protein Category Proteins biochem stub ... more details
Proteinprotein interaction prediction is a field combining bioinformatics and structural biology in an attempt ... proteinprotein interaction s is important for the investigation of intracellular signaling pathways, modelling of protein complex structures and for gaining insights into various biochemical ... of experimental techniques, including yeast two hybrid screening two hybrid systems, protein fragment complementation assays PCA , affinity purification mass spectrometry , protein microarray s, fluorescence ... in other organisms. In addition, a number of bound protein complexes have been structurally solved ... pairs of protein families with similar patterns of presence or absence across large numbers of species ... imply physical interaction. Prediction of co evolved protein pairs based on similar phylogenetic ... protein in the hypothesized interacting pair. If the matrices are sufficiently similar as measured ... ref Ogmen builds a library of known proteinprotein interfaces from the Protein Data Bank PDB , where ... a known structure i.e. present in the Protein Data Bank PDB . Bayesian network modelling Bayesian ... potential protein interaction is a true positive result. These methods are useful because ... circumstantial evidence that a particular pair of proteins might interact. 3D template based protein complex modelling This method ref Aloy ref Chen ref Fukuhara ref Kittichotirat makes use of known protein complex structures to predict as well as structurally model interactions between query protein ... to search for protein complex structures that are homologous to the query sequences. These known ... sequences. This method has the advantage of not only inferring protein interactions but also suggests ... is limited to a relatively small number of known protein complex structures. Supervised learning problem ... the known protein interactions supervise the estimation of a function that can predict whether an interaction .... . Relationship to docking methods The field of proteinprotein interaction prediction is closely related ... more details
The screening of proteinprotein interactions refers to the identification of protein interactions with high ... for new therapeutic approaches. Methods to screen proteinprotein interactions Though there are many methods to detect proteinprotein interactions, the majority of these methods such as Co immunoprecipitation ... approaches. Ex vivo or in vivo methods Methods that screen proteinprotein interactions ... of proteinprotein interactions and their modulators. ref cite journal author Lu JP, Beatty LK, Pinthus ... screening and verification of protein interactions in living cells journal Nature Precedings ... of a protein without bias. However, the method has a notoriously high false positive rate, which makes ... requires two successive steps of protein purification, and thus can not readily detect transient proteinprotein interactions. Recent genome wide TAP experiments were performed by Krogan et al., 2006 and Gavin et al., 2006, providing updated protein interaction data for yeast organisms check my plural the singular looked very wrong . cross link Chemical crosslinking is often used to fix protein .... ref cite journal author Chen CS, Zhu H year 2006 volume 40 issue 4 pages 423, 425, 427 title Protein microarrays journal Biotechniques pmid 16629388 doi 10.2144 06404TE01 ref See also Proteinprotein interaction BiFC References Reflist External links External links date August 2010 Proteinprotein interaction databases http hprd.org HPRD Human Protein Reference Database , a manually curated database of human protein information with visualization tools http www.ebi.ac.uk intact IntAct Interaction ... INTeraction Database , a tool that focuses on experimentally verified protein interactions mined from the literature by curators http mips.gsf.de proj ppi MIPS Mammalian ProteinProtein Interaction Database , the MIPS mammalian proteinprotein interaction database http www.thebiogrid.org BioGRID genomics footer Biology footer DEFAULTSORT ProteinProtein Interaction Screening Category Signal transduction ... more details
wiktionarypar proteinProtein is an organic compound made of amino acids. Protein may also refer to Protein nutrient Protein band See also List of topics related to protein disambig es Prote na desambiguaci n lv Prote ni noz mju atdal ana ... more details
Protein K may refer to Protein K porin , a porin expressed in pathogenic strains of E. coli Protein K gene expression , a DNA and RNA binding protein expressed in the nucleus of eukaryotes disambig ... more details
Citrullinated protein may refer to Any protein having undergone citrullination The proteins often cyclic ones being the targets of anti citrullinated protein antibody anti citrullinated protein antibodies disambig ... more details
Infobox protein family Symbol 14 3 3 Name 14 3 3 image PDB 1ib1 EBI.jpg width caption Crystal structure of the 14 3 3 zeta seretonin N acetyltransferase complex. Pfam PF00244 Pfam clan InterPro IPR000308 SMART 14 3 3 PROSITE PDOC00633 MEROPS SCOP 1a4o TCDB OPM family OPM protein CAZy CDD 14 3 3 proteins are a family of conserved regulatory molecule s expressed in all eukaryote eukaryotic cells. 14 3 3 protein s have the ability to bind a multitude of functionally diverse signal transduction signaling proteins , including kinase s, phosphatase s, and transmembrane receptor s. More than 100 signaling proteins have been reported as 14 3 3 ligands. The name 14 3 3 refers to the particular elution and migration pattern of these proteins on DEAE cellulose chromatography and starch gel electrophoresis . The 14 3 3 proteins eluted in the 14th fraction of bovine brain homogenate and were found on positions 3.3 of subsequent electrophoresis by Moore and Perez 1967 . Elevated amounts of 14 3 3 proteins are found in the cerebrospinal fluid of patients with Creutzfeldt Jakob disease . ref name pmid10548598 cite journal author Takahashi H title Increased levels of epsilon and gamma isoforms of 14 3 3 proteins in cerebrospinal fluid in patients with Creutzfeldt Jakob disease journal Clin. Diagn ... first9 K ref Image 14 3 3dimer.png thumb right Molecular structure of a 14 3 3 protein dimer .... Protists have at least one. Eukaryotes can tolerate the loss of an 14 3 3 isoform if multiple isoforms ... and deposited in the public domain. 14 3 3 proteins play an isoform specific role in class switch recombination. They are believed to interact with the protein Activation Induced Cytidine Deaminase ... LIG 14 3 3 1 ELM LIG 14 3 3 2 ELM LIG 14 3 3 3 MeshName 14 3 3 Protein http www.rcsb.org pdb explore.do?structureId 2BTP Three dimensional structure of 14 3 3 Protein Theta Human complexed with a peptide ... Fly Adaptor proteins Category Programmed cell death Category Proteins Category Protein families ... more details
PBB geneid 6497 The Ski protein is a nuclear Oncogene protooncoprotein that is associated with tumors ... where the protein was initially discovered. Structure Gene The SKI proto oncogene is located at a region ... 24 issue 2 pages 265 72 year 2005 month June pmid 15986136 doi 10.1007 s10555 005 1576 x ref Protein ... url ref The SKI protein has a 728 amino acid sequence, with multiple protein domain domain s and is expressed ... SnoN protein. The different domains have different functions, with the primary domains interacting with Smad proteins. The protein has a helix turn helix structural motif motif , a cysteine and histidine ... zipper . All these domains, including a proline rich region, are consistent with the fact that the protein must have domains that allow it to interact with other proteins. ref name Reed The protein ... WE, Lin K title Competition between Ski and CREB binding protein for binding to Smad proteins ... a domain similar to the Dachshund protein. The SKI Dachshund homology domain SKI DHD contains the helix turn helix domains of the protein and the beta alpha beta turn motifs. ref name Wilson Function ... fibroblast s depend on the SKI protein as a transcription co regulator inducing transformation. ref name Reed The aforementioned DHD region is specifically employed for proteinprotein interactions ... that the SKI protein in cancerous cells acts as a suppressor, inhibiting TGF beta signaling pathway transforming growth factor TFG signaling . TFG is a protein which regulates cell growth . Signaling ... and embryonic cell s at low levels, however an over expression of the protein is characteristic of tumor cells. ref name Chen It is thought that high levels of SKI protein inactivate tumor suppression ... Reed The SKI protein and the CPB protein compete for binding with the Smad proteins, specifically competing with the Mothers against decapentaplegic homolog 3 Smad 3 and CREB CReB binding protein interactions ... studied area of the protein s link to cancer. Currently it is thought that the SKI protein prevents ... more details
. Thus, in the human brain, the tau proteins constitute a family of six Proteinisoform isoforms with the range ...PBB geneid 4137 Tau proteins are proteins that microtubule associated protein stabilize microtubules ... is designated MAPT microtubule associated protein tau . ref name pmid3131773 cite journal ... encoding a core protein of the paired helical filament of Alzheimer disease identification as the microtubule associated protein tau journal Proc. Natl. Acad. Sci. U.S.A. volume 85 issue 11 pages ... isoforms of human microtubule associated protein tau sequences and localization in neurofibrillary ..., Lockwood AH, Hwo SY, Kirschner MW title A protein factor essential for microtubule assembly journal ... 432646 doi 10.1073 pnas.72.5.1858 ref Function Tau protein is a highly soluble microtubule associated protein MAP . In humans, these proteins are mostly found in neurons compared to non neuronal cells ... of mice lacking tau protein journal Nature volume 369 issue 6480 pages 488 91 year 1994 month June ... tubulin assembly into microtubules. Tau has two ways of controlling microtubule stability proteinisoform isoforms and phosphorylation . Six tau isoforms exist in human brain tissue, and they are distinguished by their number of binding protein domain domains . Three isoforms have three binding ... end carboxy terminus of the protein and are positively charged allowing it to bind to the negatively ... Thr phosphorylation sites on the longest tau isoform. Phosphorylation has been reported on approximately ... ML, Kincaid RL title Regulated phosphorylation and dephosphorylation of tau protein effects on microtubule ... is regulated by a host of kinase s, including PKN, a Protein kinase Serine.2Fthreonine specific protein ... to tau affects tau s association with MTs. Genetics The MAPT gene for encoding tau protein is located on chromosome Chromosome 17 human 17 q21, containing 16 exon s. The major tau protein in the human ... part exon 10 missing. So, the longest isoform in the Central nervous system CNS has four repeats ... more details
is a 70 k Da protein. There are 10 known isoform s of human merlin molecule the full molecule being ...PBB geneid 4771 Merlin also called Neurofibromin 2 or schwannomin is a cytoskeletal protein . In humans, it is a tumor suppressor gene tumor suppressor protein involved in Neurofibromatosis type II . ref ... membrane organizing protein causes neuro fibromatosis type 2 journal Nature volume 363 issue 6429 ... reveal its similarity to the ERM protein family . The name merlin is an acronym for Moesin Ezrin Radixin Like Protein . Genes Homo sapiens Human merlin is coded by the gene NF2 in Chromosome 22 . Mus ... encodes a highly conserved merlin protein with alternative forms journal Hum. Mol. Genet. volume ... is a member of the ERM family of proteins including ezrin , moesin, and radixin, which are in the protein ... year 2002 pmid 11756419 doi 10.1074 jbc.M109979200 ref Merlin can protein dimer dimer ize with itself ... scaffolding protein, i.e. linking actin filaments to cell membrane or membrane glycoprotein ... Alfthan K, Heiska L, Gr nholm M, Renkema GH, Carp n O title Cyclic AMP dependent protein kinase phosphorylates ... growth controlling molecules, including eIF3c, CD44 , protein kinase A and p21 activated kinase ... doi 10.1093 hmg ddl021 ref Interactions Merlin protein has been shown to Proteinprotein interaction ..., Gutmann D H, Pulst S M year 2000 month Jul. title The neurofibromatosis 2 tumor suppressor protein ... of the neurofibromatosis 2 tumor suppressor protein merlin and the ERM protein ezrin journal J ... H, Fan X, Lagani re J, Chishti A H, Rouleau G A year 2001 month Aug. title Schwannomin isoform 1 interacts ... Magicin, a novel cytoskeletal protein associates with the NF2 tumor suppressor merlin and Grb2 journal ... .bin fbidq.html?FBgn0013951 FlyBase synopsis of gene Mer UMichOPM protein pdbid 1gc6 Calculated ... proteins Hippo signaling pathway The PBB Controls template provides controls for Protein Box Bot, please ... protein box yes update summary no update citations no PDB Gallery geneid 4771 Category Cytoskeleton ... more details
Orphan date February 2009 Unreferenced date February 2009 MASP is a protein name abbreviation of Mannan binding lectin MBL associated serine protease. See also MASP2 protein Category Human proteins protein stub ... more details
, protein stability, response to stress, and progression through the cell cycle ref cite journal ... protein. SUMO family members often have dissimilar names the SUMO homologue in yeast , for example, is called ... HSUMO1 1A5R nmr ribbons.png thumb 300px right Structure schematic of human SUMO1 protein made with iMol and based on PDB file 1A5R, an NMR structure the backbone of the protein is represented as a ribbon ... the shape of the protein human SUMO1, PDB file 1A5R Function SUMO modification of proteins has many functions. Among the most frequent and best studied are protein stability, cell nucleus nuclear cytosol ... of a given protein is SUMOylated and this modification is rapidly reversed by the action of deSUMOylating ... modulates the partitioning of the Ran GTPase activating protein RanGAP1 between the cytosol and the nuclear ... ubiquitin related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2 ... protein hNinein promotes hNinein nuclear localization journal Life Sci. volume 78 issue 10 ... homolog 1 S. cerevisiae ref , to find out more. There are 3 confirmed SUMO isoform s in humans SUMO1 ... of small ubiquitin related protein modifiers SUMO 1 versus SUMO 2 3 journal J Biol Chem ... members and depends on which organism the protein comes from. Although SUMO has very little sequence ... of human SUMO1 is depicted on the right. It shows SUMO1 as a globular protein with both ends of the amino acid chain shown in red and blue sticking out of the protein s centre. The spherical core consists of an alpha helix and a beta sheet . The diagrams shown are based on an NMR analysis of the protein ... Ubc9 . Finally, one of a small number of E3 ligating proteins attaches it to the protein. In yeast ... External links http www.lifesensors.com product expression systems.php LifeSensors SUMO based Protein ... http www.rockefeller.edu labheads chua ulp.php Nam Hai Chua s lab plants, protein modification ... in your protein by Abgent Protein posttranslational modification Posttranslational modification Category ... more details
M protein may refer to M protein Streptococcus M protein Streptococcus , a virulence factor of the bacterium Streptococcus pyogenes Another name for paraprotein , an abnormal protein in the urine or blood, often seen in multiple myeloma or Monoclonal gammopathy of undetermined significance MGUS disambiguation ... more details
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