The pluripotency of biological compounds describes the ability of certain substances to produce several distinct biological responses. For example, in immunology many cytokines are pluripotent, in that each of these compounds can activate specific behavior in some cell types and inhibit other behavior in other cell types. Interferon gamma represents an excellent example of pluripotency. In most somatic cells it inhibits growth and upregulates expression of major histocompatibility complex Major Histocompatibility Complex MHC antigens in a general anti viral response. In B lymphocytes B cells it stimulates antibody class switching, and in natural killer cell Natural Killer NK cells this protein hormone stimulates maturation. In macrophages it activates intracellular killing. Pluripotent cells have the ability to phagocytize bacterial cells and lyse red blood cells. Victims with the disease Typhoid Lymphoma have a defect in the beta nucleotide in the nucleus of the pluripotent cell. This causes the cell to lyse red blood cells, eventually leading to a death by suffocation due to the lack of oxygen in the blood. Category biology biology stub ... more details
Orphan date February 2009 PBB geneid 151871 Developmental pluripotency associated protein 2 is a protein that in humans is encoded by the DPPA2 gene . ref name pmid15583978 cite journal author Du J, Lin G, Nie ZY, Lu GX title Molecular cloning and characterization analysis of HPESCRG1, a novel gene expressed specifically in human embryonic stem cell. journal Zhonghua Yi Xue Yi Chuan Xue Za Zhi volume 21 issue 6 pages 542 7 year 2004 month Dec pmid 15583978 pmc doi ref ref name entrez cite web title Entrez Gene DPPA2 developmental pluripotency associated 2 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 151871 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text References reflist Further reading refbegin 2 PBB Further reading citations cite journal author Strausberg RL, Feingold EA, Grouse LH, et al. title Generation and initial analysis of more than 15,000 full length human and mouse cDNA sequences. journal Proc. Natl. Acad. Sci. U.S.A. volume 99 issue 26 pages 16899 903 year 2003 pmid 12477932 doi 10.1073 pnas.242603899 pmc 139241 cite journal author Gerhard DS, Wagner L, Feingold EA, et al. title The status, quality, and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC . journal Genome Res. volume 14 issue 10B pages 2121 7 year 2004 pmid 15489334 doi 10.1101 gr.2596504 pmc 528928 cite journal author Rual JF, Venkatesan K, Hao T, et al. title Towards a proteome scale map of the human protein protein interaction network. journal Nature volume 437 issue 7062 pages 1173 8 year 2005 pmid 16189514 doi 10.1038 nature04209 refend gene 3 stub The PBB Controls template provides controls for Protein Box Bot, please see Template PBB Controls for details. PBB Controls update page yes require manual inspection no update protein box yes update summary yes update citations yes ... more details
Fbx15 , otherwise known as Fbxo15 , is a protein expressed in un differentiate cellular differentiate d embryonic stem cell s. It is expressed during coexpression of Oct3 4 and SOX2 , two genes identified to be important in embryonic stem cell self renewal and differentiation repression. There is an enhancer site upstream of the Fbx15 encoding transcription gene that contains an octamer like binding motif and a Sox like binding motif. Lacking of Fbx15 leads to normal embryonic development, but it is often used as a downstream identifier to check for stem cell pluripotency and also Oct3 4 activation, as Oct3 4 deactivation leads to a complete lack of Fbx15 expression. Category Proteins protein stub ... more details
The pluriblast is a Pluripotency pluripotent population of Cell biology cells in the early mammal ian conceptus that is distinct from the trophoblast , and gives rise to the germ layer s of the embryo proper , as well as extraembryonic endoderm and extraembryonic mesoderm . Both the pluriblast and trophoblast arise from the Totipotency totipotent cells of the early conceptus. By definition, the pluriblast does not give rise to trophoblast cells during normal development, although it may retain this potential under experimental conditions. In most eutheria n mammals the pluriblast is termed the inner cell mass , as it forms a mass of cells within the fluid filled blastocyst , bounded by the trophoblast. However in metatherian marsupial mammals, and indeed in a small number of eutherian mammals, the pluriblast forms part of the blastocyst wall and no structure exists that can be described as an inner cell mass. Inner cell mass is thus a morphological term peculiar to the majority of eutherian mammals, whereas pluriblast is a functional term more widely applicable to conserved aspects of mammalian development. References Johnson MH and Selwood L 1996 . Nomenclature of early development in mammals. Reproduction, Fertility and Development. 8 759 764. Category Developmental biology ... more details
Orphan date February 2009 PBB geneid 359787 Developmental pluripotency associated protein 3 is a protein that in humans is encoded by the DPPA3 gene . ref name entrez cite web title Entrez Gene DPPA3 developmental pluripotency associated 3 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 359787 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text This gene encodes a protein that in mice may function as a maternal factor during the preimplantation stage of development. In mice, this gene may play a role in transcriptional repression, cell division, and maintenance of cell pluripotentiality. In humans, related intronless loci are located on chromosomes 14 and X. ref name entrez cite web title Entrez Gene DPPA3 developmental pluripotency associated 3 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 359787 accessdate ref References reflist Further reading refbegin 2 PBB Further reading citations cite journal author Nakamura T, Arai Y, Umehara H, et al. title PGC7 Stella protects against DNA demethylation in early embryogenesis. journal Nat. Cell Biol. volume 9 issue 1 pages 64 71 year 2007 pmid 17143267 doi 10.1038 ncb1519 cite journal author Elliman SJ, Wu I, Kemp DM title Adult tissue specific expression of a Dppa3 derived retrogene represents a postnatal transcript of pluripotent cell origin. journal J. Biol. Chem. volume 281 issue 1 pages 16 9 year 2006 pmid 16291741 doi 10.1074 jbc.C500415200 cite journal author Gerhard DS, Wagner L, Feingold EA, et al. title The status, quality, and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC . journal Genome Res. volume 14 issue 10B pages 2121 7 year 2004 pmid 15489334 doi 10.1101 gr.2596504 pmc 528928 cite journal ... RP, James K, Koopman P title Dppa3 is a marker of pluripotency and has a human homologue that is expressed ... more details
, a pluripotency sustaining factor in embryonic stem cells journal Cell volume 113 issue 5 pages ... pluripotency . NANOG is thought to function in concert with other factors such as Oct 4 ... to maintain pluripotency. In other words, these cells have the ability to become virtually ... that understanding the mechanisms that maintain a cell s pluripotency is critical for researchers to understand ... of arrested embryos demonstrated that embryos express pluripotency marker genes such as Oct 4 POU5F1 , NANOG and REX1. Derived human ESC lines also expressed specific pluripotency markers TRA ... and pluripotency in mouse embryonic stem cells journal Biochem. Soc. Trans. volume 33 issue Pt 6 pages ... S, Graem N, Skakkebaek NE, Leffers H, Rajpert De Meyts E title Stem cell pluripotency factor NANOG ... M, Chow CW, Robb L title The pluripotency homeobox gene NANOG is expressed in human germ cell ... in embryonic stem cell pluripotency. journal Cell Res. volume 17 issue 1 pages 42 9 year 2007 ... The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells ... of Nanog, a pluripotency sustaining factor in embryonic stem cells. journal Cell volume 113 issue ... analysis of the pluripotency promoting Nanog genes in mouse and human. journal Dev. Dyn ... pluripotency factor NANOG is expressed in human fetal gonocytes, testicular carcinoma in situ and germ ... more details
of pluripotency, thereby increasing the potential use of iPS cells in human diseases. ref ... pluripotency. ref name urlGeneration of Induced Pluripotent Stem Cells Using Recombinant Proteins ... Dedifferentiation to totipotency or pluripotency an overview of methods. Various methods exist to revert adult somatic cells to pluripotency or totipotency. In the case of totipotency, reprogramming ... methods support reversion to pluripotency though, vehicles and biotypes vary considerably in efficiencies ... to pluripotency through retroviral or DNA viral routes but carries the onus of insertional inactivation ... transduction supports reprogramming adult cells to pluripotency, the method is cumbersome and requires ... or pluripotency, but many examples exist that improve the overall efficiency of the process ... es to transduce mouse fibroblasts with a selection of those genes. Eventually, four key pluripotency ... is a major determinant of cellular pluripotency. ref cite journal last1 Takahashi first1 K last2 ... ref name nature Cite web last Baker first Monya title Adult cells reprogrammed to pluripotency ... pluripotency. ref name urlGeneration of Induced Pluripotent Stem Cells Using Recombinant Proteins The expression of pluripotency induction genes can also be increased by treating somatic cells with Basic ... pluripotency. The absence of Oct 3 4 in Oct 3 4 sup sup cells, such as blastomere s and embryonic ... gives rise to the pluripotency and differentiation potential of embryonic stem cells. Various other ... family of genes is associated with maintaining pluripotency similar to Oct 3 4, although it is associated ..., is necessary in promoting pluripotency. Therefore, it was surprising when Yamanaka et al. reported ... respects, thus confirming the identity, authenticity, and pluripotency of iPSCs to naturally ... human telomerase reverse transcriptase , a necessary component in the telomerase protein complex. Pluripotency ... typically are of only one cell type. Teratoma formation is a landmark test for pluripotency. Embryoid ... more details
Pluripotency Image Human embryonic stem cells.png thumb 250px Human embryo nic stem cells br A Cell ... to produce several distinct biological responses see Pluripotency biological compounds Main Stem Cell In cell biology, pluripotency refers to a stem cell that has the potential to cellular differentiation ... the potential to contribute to extraembryonic tissue, such as the placenta . Induced pluripotency ... Baker first Monya title Adult cells reprogrammed to pluripotency, without tumors journal Nature Reports ... pluripotency of somatic cell s into cellular differentiation undifferentiated induced pluripotent ... more details
Image MuensterMPI.jpg thumb Building of the institute at the R ntgenstrasse in M nster. The Max Planck Institute for Molecular Biomedicine was founded on 1 April 2001 in M nster , North Rhine Westphalia , Germany . It is part of the Max Planck Society . The managing director is Prof. Dr. Ralf H. Adams. History The Institute was founded on the 1st August 2001 in M nster , Germany . Founding director was Prof. Dr. Dietmar Vestweber. In 2004 another department was added Prof. Dr. Hans Robert Sch ler . In the same year, the institute got its current name Max Planck Institute for Molecular Biomedicine. In 2006 the institute moved to a new and modern building offering more space and equipment. At the end of 2007 another department was added Prof. Dr. Ralf H. Adams . This department moved from the Cancer Research UK London Research Institute to the MPI. Departments Department 1 Prof. Dr. Dietmar Vestweber Vascular Cell Biology Department 2 Prof. Dr. Hans Robert Sch ler Cell and Developmental Biology Department 3 Prof. Dr. Ralf H. Adams Tissue Morphogenesis Research Department 1 Department 1 Vascular Cell Biology is concentrating its research on leukocyte migration into inflammatory sites. Department 2 Department 2 Cell and Developmental Biology works on germline development and pluripotency. Department 3 Department 3 Tissue Morphogenesis works on how cells make tissue, in particular blood vessels. Degree programme The MPI for Molecular Biomedicine offers a Master of Science and a PhD in Molecular Biomedicine together with the University of M nster . Both degree programmes are taught in English. External links http www.mpi muenster.mpg.de en Official site http www.imprs mbm cedad.mpg.de International Max Planck Research School Molecular Biomedicine IMPRS MBM coord 51 58 5 N 7 35 27 E type landmark display title Category Max Planck Society Molecular Biomedicine Category Research institutes in Germany Category Molecular biology institutes Category 2001 establishments med org ... more details
The Wellcome Trust Centre for Stem Cell Research often referred to as the CSCR at the University of Cambridge is a research centre on the nature and potential medical uses of stem cell s. It is located on Tennis Court Road in Central Cambridge. The Centre is funded by the Wellcome Trust as well as the Medical Research Council UK Medical Research Council . The director is Austin Smith biologist Austin Smith , and the Deputy Director is Fiona Watt . ref name cscr home cite web url http www.cscr.cam.ac.uk title Wellcome Trust Centre for Stem Cell Research accessdate November 13, 2009 ref The main areas of study include pluripotent and neural stem cells, ref cite news url http business.timesonline.co.uk tol business specials stemcell research article3904020.ece work The Times location London title Incredible discoveries hint at wonder of scientific mysteries yet to be unravelled date May 10, 2008 ref as well as Epidermis skin epidermal stem cells. ref cite news url http www.bbc.co.uk news health 10722943 work BBC News title Skin the key to medical cures? date July 24, 2010 ref ref http www.cscr.cam.ac.uk research fwatt.html ref Key advances in stem cell science at the centre include the elucidation of the role of the nanog protein in pluripotency ref http www.fiercebiotech.com press releases new research gives insight how stems cells develop other types cells ref and work on inhibiting cellular differentiation . ref cite news url http www.telegraph.co.uk science science news 3342823 Scientists uncover secret of eternal youth.html work The Daily Telegraph location London title Scientists uncover secret of eternal youth date May 23, 2008 ref It also conducts human embryo work as approved by the Human Fertilisation and Embryology Authority . ref http www.hfea.gov.uk 1584.html ref References reflist External links http www.cscr.cam.ac.uk Official website Category Stem cells Category Health in the United Kingdom Category Science and technology in the United Kingdom Category ... more details
The tetraploid complementation assay is a technique in biology in which cells of two mammal ian embryo s are combined to form a new embryo. ref http dev.biologists.org cgi content full 130 25 6155 Mouse embryonic chimeras tools for studying mammalian development , Development 130, 6155 6163 2003 ref It is used to construct genetically modified organism s, to study the consequences of certain mutations on embryonal development, and in the study of pluripotency pluripotent stem cells . Procedure Normal mammalian somatic cell s are diploid each chromosome and thus every gene is present in duplicate. The assay starts with producing a tetraploid cell in which every chromosome exists fourfold. This is done by taking an embryo at the two cell stage and fusing the two cells by applying an electrical current. The resulting tetraploid cell will continue to divide, and all daughter cells will also be tetraploid. Such a tetraploid embryo can develop normally to the blastocyst stage and will Implantation human embryo implant in the wall of the uterus . The tetraploid cells can form the extra embryonic tissue placenta etc. , however a proper fetus will rarely develop. In the tetraploid complementation assay, one now combines such a tetraploid embryo either at the morula or blastocyst stage with normal diploid embryonic stem cell s ES from a different organism. The embryo will then develop normally the fetus is exclusively derived from the ES cell, while the extra embryonic tissues are exclusively derived from the tetraploid cells. Applications Foreign genes or mutations can be introduced into ES cells rather easily, and these ES cells can then be grown into whole animals using the tetraploid complementation assay. By introducing targeted mutations into the tetraploid cells and or into the ES cells, one can study which genes are important for fetal development and which ones are important for development of the extra embryonic tissues. The tetraploid complementation assay is also ... more details
or external direction. Inside cells express high levels of Oct4 which maintains pluripotency and suppresses ... Oct4 . Oct4 Oct4 is expressed in the ICM and participate in maintaining its pluripotency, a role ... pluripotency. In contrast with Oct4 , studies of Nanog null mice do not show the reversion of the ICM ... transcription factor, Eomes, these genes act to suppress pluripotency genes like Oct4 and Nanog ... maintain pluripotency generate the ICM and eventually the rest of the embryo proper. Although this dichotomy ... more details
pluripotency and differentiate into trophectoderm. Therefore, the level of Oct 4 expression in mice is vital for regulating pluripotency and early cell differentiation since one of its main functions ... endoderm and mesoderm. In contrast, repression of Oct 4 induces loss of pluripotency and dedifferentiation ... that their findings established a role for Oct 4 as a master regulator of pluripotency that controls ... BK, Zaehres M, Sch ler HR title Oct4 Induced Pluripotency in Adult Neural Stem Cells journal Cell ... Lengner CJ, Welstead GG, Jaenisch R title The pluripotency regulator Oct4 a role in somatic stem ... self renewal and pluripotency journal Stem Cells volume 23 issue 1 pages 124 33 year 2005 pmid 15625129 ... more details
protein Name coactivator associated arginine methyltransferase 1 caption image width HGNCid 23393 Symbol CARM1 AltSymbols EntrezGene 10498 OMIM 603934 RefSeq XM 032719 UniProt Q86X55 PDB ECnumber 2.1.1.125 Chromosome 19 Arm p Band 13.2 LocusSupplementaryData protein Name coactivator associated arginine methyltransferase 1 like caption image width HGNCid 23392 Symbol CARM1L AltSymbols EntrezGene 256280 OMIM RefSeq XM 171224 UniProt Q5SZY8 PDB ECnumber Chromosome 9 Arm p Band 24.2 LocusSupplementaryData CARM1 coactivator associated arginine methyltransferase 1 is an enzyme EC number 2.1.1.125 encoded by the gene CARM1 gene found in human beings, as well as many other mammals. ref name pmid10381882 cite journal author Chen D, Ma H, Hong H, Koh SS, Huang SM, Schurter BT, Aswad DW, Stallcup MR title Regulation of transcription by a protein methyltransferase journal Science volume 284 issue 5423 pages 2174 7 year 1999 pmid 10381882 doi 10.1126 science.284.5423.2174 issn ref CARM1 is a secondary coactivator genetics coactivator through its association with p160 family SRC 1 , GRIP1 , Nuclear receptor coactivator 3 AIB of coactivators. It is responsible for moving cells toward the inner cell mass in developing blastocysts. ref name pmid17215844 cite journal author Torres Padilla ME, Parfitt DE, Kouzarides T, Zernicka Goetz M title Histone arginine methylation regulates pluripotency in the early mouse embryo journal Nature volume 445 issue 7124 pages 214 8 year 2007 pmid 17215844 doi 10.1038 nature05458 issn ref This gene also plays an important role in androgen receptors and may play a role in prostate cancer progression. ref name pmid15221992 cite journal author Hong H, Kao C, Jeng MH, Eble JN, Koch MO, Gardner TA, Zhang S, Li L, Pan CX, Hu Z, MacLennan GT, Cheng L title Aberrant expression of CARM1, a transcriptional coactivator of androgen receptor, in the development of prostate carcinoma and androgen independent status journal Cancer volume 101 issue 1 pages 83 9 year ... more details
Prostasomes were discovered in 1978 as submicrometre membranous Vesicle biology vesicles 40 500 nm in diameter secreted by the prostate gland epithelial cells into seminal fluid ref cite journal author Ronquist G, Brody I title The prostasome its secretion and function in man. journal Biochim Biophys Acta volume 822 issue 2 pages 203 18 year 1985 pmid 2992593 doi 10.1016 0304 4157 85 90008 5 url ref . They possess an unusual lipid composition and a tight and highly ordered structure of their lipoprotein membranes resembling lipid raft . The physiological role of prostasomes implicates improvement of sperm motility and protection against attacks from the female immune defense during the passage to the egg ref cite journal author Burden HP, Holmes CH, Persad R, Whittington K title Prostasomes their effects on human male reproduction and fertility. journal Hum Reprod Update volume 12 issue 3 pages 283 92 year 2006 pmid 16373403 doi 10.1093 humupd dmi052 url http humupd.oxfordjournals.org cgi content full 12 3 283 ref . Investigations have shown that cancerous prostate cells and prostate cells with low differentiation continue to produce and secrete prostasomes ref cite journal title The Janus faced nature of prostasomes their pluripotency favours the normal reproductive process and malignant prostate growth. journal Prostate Cancer Prostatic Dis volume 7 issue 1 pages 21 31 year 2004 pmid 14999234 doi 10.1038 sj.pcan.4500684 url author Ronquist G, Nilsson BO ref . The high incidence of prostate cancer in elderly men could take advantage of the immune protective activities supported by the prostasomes. Immune regulating proteins found in prostasomes include amino peptidase N CD13 dipeptidyl peptidase IV CD26 enkephalinase neutral endopeptidase, CD10 angiotensin converting enzyme ACE, CD143 tissue factor TF CD142 , thromboplastin decay accelerator factor CD55 protectin CD59 , inhibitor of MAC and complement regulatory membrane cofactor protein CD46 ref Ronquist, G., Jin, ... more details
Orphan date December 2010 New unreviewed article source ArticleWizard date December 2010 Infobox Company company name Gemini Somatics company type Private Corporation location Riverside, Columbia County, Oregon Riverside, OR key people Joseph Cavendish Chairman Edward Darmos Dr. Edward Darmos Executive Director of Synthetic Somatology industry Biotechnology products Somatic synthesis technologies ref http www.pressbox.co.uk cgi bin links page.cgi?g detailed 2F574970.html t snap d ARRAY 280x86921d4 29 Gemini Somatics Acquires Significant Funding , Press release, Oregon , 12 November 2010, Retrieved on 22 December 2010. ref Scientific consultancy homepage http www.geminisomatics.com www.geminisomatics.com Gemini Somatics is a biotechnology company located in Riverside, Columbia County, Oregon Riverside, Oregon , working primarily in the field of synthetic somatology, which is an emerging science developed by Edward Darmos Dr Edward Darmos . ref http www.geminisomatics.com Gemini Somatics corporate web site. ref . Research Gemini Somatics focuses its efforts on synthetic somatology, which is an adaptation of synthetic biology using Pluripotent stem cell Pluripotency pluripotent stem cells and artificially generated genomes in order to adapt human life to potential future conditions ref Darmos, Edward. http www.scribd.com doc 43784991 An Introduction to Synthetic Somatology An Introduction to Synthetic Somatology . ref . Their work is based on the developments surrounding Mycoplasma mycoides ref Henderson, Mark. http www.timesonline.co.uk tol news science biology evolution article7132299.ece Scientists create artificial life in laboratory , The Times, London. 21 May 2010. ref and Mycoplasma laboratorium , as well as taking advantage of technological advancements including the Bioreactor NASA tissue cloning bioreactor NASA bioreactor and the DARPA REMIND programme ref Golder, D. http www.sfx.co.uk 2010 12 06 the clone ranger 2 ixzz18eCLGR7f The Clone Ranger , SFX magazin ... more details
body body . Pluripotency distinguishes embryonic stem cells from adult stem cell s found in adult s while ... potential pluripotency led to the use of EC cells as the in vitro model for early mouse ... to maintain the pluripotency of actively dividing stem cells. The problem was discovered when non ... Myc are essential for ESC self renewal and pluripotency, ref Varlakhanova, et al. myc maintains embryonic stem cell pluripotency and self renewal Differentiation doi 10.1016 j.diff.2010.05.001 ... that pluripotency pluripotent stem cell s highly similar to embryonic stem cells can be generated ... more details
A progenitor cell is a cell biology biological cell that, like a stem cell , has a tendency to differentiate into a specific type of cell, but is already more specific than a stem cell and is pushed to differentiate into its target cell. The most important difference between stem cells and progenitor cells is that stem cells can replicate indefinitely, whereas progenitor cells can only divide a limited number of times. Controversy about the exact definition remains and the concept is still evolving. The terms progenitor cell and stem cell are sometimes equated. ref DorlandsDict nine 100009804 progenitor cell ref Properties Most progenitors are described as Oligopotency oligopotent . In this point of view, they may be compared to adult stem cells. But progenitors are said to be in a further stage of cell differentiation. They are in the center between stem cells and fully differentiated cells. The kind of potency they have depends on the type of their parent stem cell and also on their niche. Like stem cells, mostly, they are formed and transported in a colony, with the right conditions for them to grow and differentiate into their target tissues. In contrast, some progenitor cells were found during research, and were isolated. After their marker was found, it was proven that these progenitor could move through the body and migrate towards the tissue where they are needed. Many properties are shared by adult stem cells and progenitor cells. But still, controversy remains because embryonic stem cells are true stem cells in that they are Pluripotency pluripotent and show unlimited capacity for self renewal. In contrast, many cells termed adult stem cell s would be better defined as progenitor cells, as their capacities for unlimited self renewal and plasticity have not been comprehensively demonstrated. Progenitor cells are found in adult organisms and they act as a repair system for the body. They replenish special cells, but also maintain the blood, skin and intestin ... more details
The Dolans are Bioship living spaceships which the authors of the Perry Rhodan fictional universe introduced in 1967. While the concept of a largely organic spacegoing vessel had been put forward earlier, the Dolan represents the first example of the class of Biological engineering bioengineered , highly integrated combat capable starships that have become a frequent feature in current science fiction. In the storyline, the Dolans served as all purpose vessels and weapons for their commanders, the Oscillation Sentinels also known as the Second Conditioned who were products of the same synthetic biology , designed and bred as agents for their elusive masters, the Prime Oscillation Power . These entities monitored spacetime for the telltale hyperdimensional signatures of temporal experiments, which they regarded as forbidden. Biology Unless signatures of Time travel causality manipulations were detected, Dolans concealed themselves on remote uninhabited planets and stayed in Stasis fiction stasis , resembling a deflated balloon hull. In its active state, a Dolan became a reddish or black and outwardly almost featureless sphere of about 100 meters diameter. Its body consisted mainly of matrix tissue built from structural cells that could adapt to almost any function including absorption of nutrients and could undergo multiple rounds of local cell division whenever this was called for therefore, few dedicated organs were required. Within minutes, this tissue could undergo a Phase transformations in solids solid phase transformation to harden its structure to a Polycrystal polycristalline steel like quality. Limited mobility on planetary surfaces could be achieved by growing tentacle like legs. Completely engulfed by this Pluripotency pluripotent biological matrix were four decks and a central cylinder of 20 meters length. These non biological internal support structures held the drive unit, power sources, weapons and other equipment that closely interfaced with the Dola ... more details
Catherine Verfaillie born 1957 is a Belgium Belgian molecular biologist and professor at the Katholieke Universiteit Leuven Leuven , Belgium . Her work on the ability of adult stem cells to differentiate to different cell types is considered highly controversial leading to accusations of poor laboratory practices and fabrication of data by members of her laboratory. ref http www.nytimes.com 2007 02 28 science 28stem.html? r 1&scp 1&sq catherine 20verfaillie&st cse ref Education Born in Ypres , she obtained an M.D.from the Katholieke Universiteit Leuven in 1982, after which she specialized in internal medicine and became interested in hematology and leukemia . Career In 1987 she departed for the United States U.S. as a research fellow to the University of Minnesota. She worked in the lab of Dr. Phillip McGlave in hematopoiesis and stromal control of hematopoietic stem cells, in 1991 becoming a professor in the Department of Medicine, becoming a full professor in 1997. ref Eckfeldt CE, Mendenhall EM, Verfaillie CM., The Molecular Repertoire of the Almighty Stem Cell, Nature Rev Mol Cell Biol, 6, 726 737 2005 ref Catherine Verfaillie was Director of the Stem Cell Institute at the University of Minnesota United States U.S. from 1998 until 2006. In a widely noted paper in 2002, she claimed that a specific type of adult derived stem cells termed multipotent adult progenitor cells MAPC ,. ref Jiang Y, Jahagirdar BN, Reinhardt RL, Schwartz RE, Keene CD, Ortiz Gonzalez XR, Reyes M, Lenvik T, Lund T, Blackstad M, Du J, Aldrich S, Lisberg A, Low WC, Largaespada DA, Verfaillie CM., Pluripotency of mesenchymal stem cells derived from adult marrow, Nature, 2002 Jul 4 418 6893 41 9 ref ref Yuehua Jiang, Balkrishna N. Jahagirdar, R. Lee Reinhardt, Robert E. Schwartz, C. Dirk Keene, Xilma R. Ortiz Gonzalez, Morayma Reyes, Todd Lenvik, Troy Lund, Mark Blackstad, Jingbo Du, Sara Aldrich, Aaron Lisberg, Walter C. Low, David A. Largaespada & Catherine M. Verfaillie, Pluripotency of mese ... more details
stem cells to be either totipotency totipotent or pluripotency pluripotent to be able to give rise ... divisions of the fertilized egg are also totipotent. ref cite journal title Totipotency, pluripotency ... volume 114 pages 185 99 pmid 19343304 pmc 2752493 doi 10.1007 10 2008 45 ref Pluripotency Pluripotent ..., a pluripotency sustaining factor in embryonic stem cells journal Cell volume 113 issue 5 pages ... of pluripotency. ref cite journal author Boyer LA, Lee TI, Cole MF, et al. title Core transcriptional ... and pluripotency, embryonic stem cells remain a theoretically potential source for regenerative .... ref cite journal author Jiang Y, Jahagirdar BN, Reinhardt RL, et al. title Pluripotency of mesenchymal ... ref ref cite journal journal Nature date 2009 03 01 title Virus free induction of pluripotency and subsequent ... more details
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