enzyme Name phosphoribosylaminoimidazolecarboxamide formyltransferase EC number 2.1.2.3 CAS number 9032 03 5 IUBMB EC number 2 1 2 3 GO code 0004643 image width caption In enzymology , a phosphoribosylaminoimidazolecarboxamide formyltransferase EC number 2.1.2.3 , also known by the shorter name AICAR transformylase , is an enzyme that catalysis catalyzes the chemical reaction 10 formyltetrahydrofolate AICAR math rightleftharpoons math tetrahydrofolate FAICAR Thus, the two substrate biochemistry substrates of this enzyme are 10 formyltetrahydrofolate and AICAR , whereas its two product chemistry products are tetrahydrofolate and FAICAR . This enzyme participates in purine metabolism and one carbon pool by folate . Nomenclature This enzyme belongs to the family of transferase s that transfer one carbon groups, specifically the hydroxymethyl , formyl and related transferases. The systematic name of this enzyme class is 10 formyltetrahydrofolate 5 phosphoribosyl 5 amino 4 imidazole carb oxamide N formyltransferase. Other names in common use include div col colwidth 30em 10 formyltetrahydrofolate 5 phosphoribosyl 5 amino 4 imidazolecarboxamide formyltransferase 5 amino 1 ribosyl 4 imidazolecarboxamide 5 phosphate, 5 amino 4 imidazolecarboxamide ribonucleotide transformylase, 5 amino 4 imidazolecarboxamide ribotide transformylase, 5 phosphoribosyl 5 amino 4 imidazolecarboxamide formyltransferase, AICAR formyltransferase, AICAR transformylase, aminoimidazolecarboxamide ribonucleotide transformylase, and transformylase. Div col end Structural studies As of late 2007, 11 tertiary structure structures have been solved for this class of enzymes, with Protein Data Bank PDB accession codes PDB link 1G8M , PDB link 1M9N , PDB link 1OZ0 , PDB link 1P4R , PDB link 1PKX , PDB link 1PL0 , PDB link 1THZ , PDB link 2B1G , PDB link 2B1I , PDB link 2IU0 , and PDB link 2IU3 . References reflist 1 cite journal author HARTMAN SC, BUCHANAN JM date 1959 title Biosynthesis of the purines. XXVI ... more details
enzyme Name methionyl tRNA formyltransferase EC number 2.1.2.9 CAS number 9015 76 3 IUBMB EC number 2 1 2 9 GO code 0004479 image width caption In enzymology , a methionyl tRNA formyltransferase EC number 2.1.2.9 is an enzyme that catalysis catalyzes the chemical reaction 10 formyltetrahydrofolate small L small methionyl tRNA sup fMet sup H sub 2 sub O math rightleftharpoons math tetrahydrofolate N formylmethionyl tRNA sup fMet sup The 3 substrate biochemistry substrates of this enzyme are 10 formyltetrahydrofolate , fMet small L small methionyl tRNA sup fMet sup , and water H sub 2 sub O , whereas its two product chemistry products are tetrahydrofolate and fMet N formylmethionyl tRNA sup fMet sup . This enzyme belongs to the family of transferase s that transfer one carbon groups, specifically the hydroxymethyl , formyl and related transferases. The systematic name of this enzyme class is 10 formyltetrahydrofolate L methionyl tRNA N formyltransferase . Other names in common use include N10 formyltetrahydrofolic methionyl transfer ribonucleic , transformylase , formylmethionyl transfer ribonucleic synthetase , methionyl ribonucleic formyltransferase , methionyl tRNA Met formyltransferase , methionyl tRNA transformylase , methionyl transfer RNA transformylase , methionyl transfer ribonucleate methyltransferase , and methionyl transfer ribonucleic transformylase . This enzyme participates in 3 metabolism metabolic pathways methionine metabolism , one carbon pool by folate , and aminoacyl tRNA biosynthesis . Structural studies As of late 2007, two tertiary structure structures have been solved for this class of enzymes, with Protein Data Bank PDB accession codes PDB link 1FMT and PDB link 2FMT . References reflist 1 cite journal author Dickerman HW, Steers E Jr, Redfield BG, Weissbach H date 1967 title Methionyl soluble ribonucleic acid transformylase. I. Purification and partial characterization journal J. Biol. Chem. volume 242 pages 1522&ndash 5 pmid 5337045 issue 7 ... more details
enzyme Name formylmethanofuran tetrahydromethanopterin N formyltransferase EC number 2.3.1.101 CAS number 105669 83 8 IUBMB EC number 2 3 1 101 GO code 0030270 image width caption Infobox protein family Symbol FTR Name FTR image PDB 1m5s EBI.jpg width caption formylmethanofuran tetrahydromethanopterin fromyltransferase from methanosarcina barkeri Pfam PF01913 Pfam clan InterPro IPR022667 SMART PROSITE MEROPS SCOP 1ftr TCDB 9.A.17 OPM family OPM protein CAZy CDD Infobox protein family Symbol FTR C Name FTR, proximal lobe image PDB 1m5h EBI.jpg width caption formylmethanofuran tetrahydromethanopterin formyltransferase from archaeoglobus fulgidus Pfam PF02741 Pfam clan InterPro IPR002770 SMART PROSITE MEROPS SCOP 1ftr TCDB OPM family OPM protein CAZy CDD In enzymology , a formylmethanofuran tetrahydromethanopterin N formyltransferase EC number 2.3.1.101 is an enzyme that catalysis catalyzes the chemical reaction formylmethanofuran 5,6,7,8 tetrahydromethanopterin math rightleftharpoons math methanofuran 5 formyl 5,6,7,8 tetrahydromethanopterin Thus, the two substrate biochemistry substrates of this enzyme are formylmethanofuran and 5,6,7,8 tetrahydromethanopterin , whereas its two product chemistry products are methanofuran and 5 formyl 5,6,7,8 tetrahydromethanopterin . This enzyme belongs ... 5 formyltransferase . Other names in common use include formylmethanofuran tetrahydromethanopterin formyltransferase , formylmethanofuran tetrahydromethanopterin formyltransferase , N formylmethanofuran CHO MFR tetrahydromethanopterin H4MPT , formyltransferase , FTR , formylmethanofuran 5,6,7,8 tetrahydromethanopterin , and N5 formyltransferase . This enzyme participates in folate ..., Merckel M, Thauer R, Shima S title Formylmethanofuran tetrahydromethanopterin formyltransferase from ... JA title Generation of formate by the formyltransferase hydrolase complex Fhc from Methylobacterium ... of formylmethanofuran tetrahydromethanopterin formyltransferase in methanogenesis from carbon dioxide ... more details
GART can refer to Graphics address remapping table , a memory management unit used in computer graphics cards Groupement des autorit s responsables de transport , a French trade association for public transport providers The Great American Road Trip , a reality television series on NBC A symbol for phosphoribosylglycinamide formyltransferase disambiguation ... more details
PRGS may refer to Frederick S. Pardee RAND Graduate School , an American higher education institution Progress Software Corporation , an American software company with Nasdaq index PRGS Phosphoribosylglycinamide formyltransferase , an enzyme Pok mon Ranger Guardian Signs , a video game in the Pok mon series See also PRG disambiguation disambig ... more details
, GARS is part of a trifunctional enzyme in conjunction with AIRS and with phosphoribosylglycinamideformyltransferase GART , forming GARS AIRS GART. Nomenclature The systematic name of this enzyme class is 5 phospho D ribosylamine glycine ligase ADP forming . Other names in common use include phosphoribosylglycinamide ..., 5 phosphoribosylglycinamide synthetase, and GAR. Structural studies As of late 2007, 3 tertiary ... more details
enzyme Name formate dihydrofolate ligase EC number 6.3.4.17 CAS number 123303 25 3 IUBMB EC number 6 3 4 17 GO code 0047897 image width caption In enzymology , a formate dihydrofolate ligase EC number 6.3.4.17 is an enzyme that catalysis catalyzes the chemical reaction ATP formate dihydrofolate math rightleftharpoons math ADP phosphate 10 formyldihydrofolate The 3 substrate biochemistry substrates of this enzyme are adenosine triphosphate ATP , formate , and dihydrofolate , whereas its 3 product chemistry products are adenosine diphosphate ADP , phosphate , and 10 formyldihydrofolate . This enzyme belongs to the family of ligase s, specifically those forming generic carbon nitrogen bonds. The systematic name of this enzyme class is formate dihydrofolate ligase ADP forming . Other names in common use include formyltransferase, dihydrofolate , dihydrofolate formyltransferase , and formyl dihydrofolate synthase . References reflist 1 Further reading refbegin cite journal author Drake JC, Baram J, Allegra CJ date 1990 title Isolation and characterization of a novel dihydrofolate formylating enzyme from human MCF 7 breast cancer cells journal Biochem. Pharmacol. volume 39 pages 615&ndash 8 pmid 2306274 doi 10.1016 0006 2952 90 90073 T issue 3 refend ligase stub Category EC 6.3.4 Category Enzymes of unknown structure ... more details
chembox Watchedfields changed verifiedrevid 399191626 ImageFile 10 formyl tetrahydrofolic acid.svg ImageSize IUPACName 2 S 2 4 2 amino 4 oxo 5,6,7,8 tetrahydro 1 H pteridin 6 yl br methyl formyl amino benzoyl amino pentanedioic acid OtherNames 10 CHO THF Section1 Chembox Identifiers ChemSpiderID Ref chemspidercite correct chemspider ChemSpiderID 9 InChI 1 C20H23N7O7 c21 20 25 16 15 18 32 26 20 23 11 7 22 16 8 27 9 28 12 3 1 10 2 4 12 17 31 24 13 19 33 34 5 6 14 29 30 h1 4,9,11,13,23H,5 8H2, H,24,31 H,29,30 H,33,34 H4,21,22,25,26,32 InChIKey AUFGTPPARQZWDO UHFFFAOYAK SMILES1 O C O C NC O c1ccc cc1 N C O CC3N C2 C N C N C2 O N NC3 CCC O O StdInChI Ref stdinchicite correct chemspider StdInChI 1S C20H23N7O7 c21 20 25 16 15 18 32 26 20 23 11 7 22 16 8 27 9 28 12 3 1 10 2 4 12 17 31 24 13 19 33 34 5 6 14 29 30 h1 4,9,11,13,23H,5 8H2, H,24,31 H,29,30 H,33,34 H4,21,22,25,26,32 StdInChIKey Ref stdinchicite correct chemspider StdInChIKey AUFGTPPARQZWDO UHFFFAOYSA N CASNo 2800 34 2 PubChem 10 SMILES C1C NC2 C N1 NC NC2 O N CN C O C3 CC C C C3 C O NC CCC O O C O O MeSHName 10 formyl tetrahydrofolate Section2 Chembox Properties Formula C sub 20 sub H sub 23 sub N sub 7 sub O sub 7 sub MolarMass 473.44 g mol Appearance Density MeltingPt BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition 10 Formyltetrahydrofolate 10 CHO THF is form of tetrahydrofolate that acts as a donor of formyl group s in anabolism . In these reactions 10 CHO THF is used as a Substrate biochemistry substrate in formyltransferase reactions. This is important in purine biosynthesis , where 10 CHO THF is a substrate for phosphoribosylaminoimidazolecarboxamide formyltransferase , as well as in the formylation of the methionyl initiator tRNA fMet tRNA , when 10 CHO THF is a substrate for methionyl tRNA formyltransferase . Biosynthesis 10 CHO THF is produced either by the enzyme methenyltetrahydrofolate cyclohydrolase via the reaction 5,10 methenyltetrahydrofolate H sub 2 sub O math right ... more details
peptide G Group specific antigen GAG gamma globulin gamma interferon ganglion Phosphoribosylglycinamideformyltransferase GART gastrointestinal GI gene gene therapy genetic engineering genital ulcer ... more details
Image Methanofuran a b c.svg thumb 400px Structure of the methanofurans Methanofuran describes a family of chemical compound s found in methanogen ic archaea . ref cite journal author Thauer RK title Biochemistry of methanogenesis a tribute to Marjory Stephenson. 1998 Marjory Stephenson Prize Lecture journal Microbiology volume 144 issue Pt 9 pages 2377 406 year 1998 month September pmid 9782487 url http mic.sgmjournals.org cgi pmidlookup?view long&pmid 9782487 doi 10.1099 00221287 144 9 2377 ref These species feature a 2 aminomethyl furan linked to phenoxy group. At least three different end groups are recognized R tricarboxyheptanoyl methanofuran , glutamic acid glutamyl glutamyl methanofuran b , tricarboxy 2 hydroxyheptanoyl methanofuran c, see picture . Formylation of MFR Methanofuran converts to formyl methanofuran in an early stage of methanogenesis. The enzyme formylmethanofuran dehydrogenase List of EC numbers EC 1 EC 1.2.99.5 formylates methanofuran using chem CO 2 , the primary C1 source in methanogenesis. ref cite journal author Vorholt JA, Thauer RK title The active species of chem CO 2 utilized by formylmethanofuran dehydrogenase from methanogenic Archaea journal Eur. J. Biochem. volume 248 issue 3 pages 919 24 year 1997 month September pmid 9342247 url http onlinelibrary.wiley.com resolve openurl?genre article&sid nlm pubmed&issn 0014 2956&date 1997&volume 248&issue 3&spage 919 doi 10.1111 j.1432 1033.1997.00919.x ref Deformylation of MFR The enzyme formylmethanofuran tetrahydromethanopterin formyltransferase catalysis catalyzes the transfer of the formyl group from formylmethanofuran to N5 on tetrahydromethanopterin, H 4 MPT . This enzyme has been crystallized it contains no prosthetic group . ref cite journal author Acharya P, Warkentin E, Ermler U, Thauer RK, Shima S title The structure of formylmethanofuran tetrahydromethanopterin formyltransferase in complex with its coenzymes journal J. Mol. Biol. volume 357 issue 3 pages 870 9 year 2006 month Ma ... more details
For other categories, see List of MeSH codes . This is the fourth part of the list of the D codes for MeSH . It is a product of the United States National Library of Medicine . Source for content is http www.nlm.nih.gov mesh filelist.html here . File 2006 MeSH Trees . MeshNumber D08 Enzymes and Coenzymes enzymes and coenzymes MeshNumber D08.211 Coenzymes coenzymes MeshNumber D08.211.090 Biopterin biopterin MeshNumber D08.211.090.500 Neopterin neopterin MeshNumber D08.211.096 Biotin biotin MeshNumber D08.211.175 Cobamides cobamides MeshNumber D08.211.211 Coenzyme A coenzyme a MeshNumber D08.211.211.300 Acyl Coenzyme A acyl coenzyme a MeshNumber D08.211.211.300.075 Acetyl Coenzyme A acetyl coenzyme a MeshNumber D08.211.211.300.500 Malonyl Coenzyme A malonyl coenzyme a MeshNumber D08.211.211.300.700 Palmitoyl Coenzyme A palmitoyl coenzyme a MeshNumber D08.211.474 Flavins flavins MeshNumber D08.211.474.650 Riboflavin riboflavin MeshNumber D08.211.474.650.249 Flavin Adenine Dinucleotide flavin adenine dinucleotide MeshNumber D08.211.474.650.500 Flavin Mononucleotide flavin mononucleotide MeshNumber D08.211.589 NAD nad MeshNumber D08.211.625 NADP nadp MeshNumber D08.211.682 PQQ Cofactor pqq cofactor MeshNumber D08.211.740 Pyridoxal Phosphate pyridoxal phosphate MeshNumber D08.211.790 Sphingolipid Activator Proteins sphingolipid activator proteins MeshNumber D08.211.790.249 G M2 Activator Protein g m2 activator protein MeshNumber D08.211.790.500 Saposins saposins MeshNumber D08.211.840 Tetrahydrofolates tetrahydrofolates MeshNumber D08.211.840.300 Formyltetrahydrofolates formyltetrahydrofolates MeshNumber D08.211.840.300.500 Leucovorin leucovorin MeshNumber D08.211.878 Thiamine Pyrophosphate thiamine pyrophosphate MeshNumber D08.211.906 Thioctic Acid thioctic acid MeshNumber D08.211.935 Ubiquinone ubiquinone MeshNumber D08.244 Cytochromes cytochromes MeshNumber D08.244.175 Cytochrome a Group cytochrome a group MeshNumber D08.244.175.249 Cytochromes a cytochromes a MeshNumb ... more details
EC number 2.1.2.1 glycine hydroxymethyltransferase EC number 2.1.2.2 phosphoribosylglycinamideformyltransferase EC number 2.1.2.3 phosphoribosylaminoimidazolecarboxamide formyltransferase EC number ... 2.1.2.8 deoxycytidylate 5 hydroxymethyltransferase EC number 2.1.2.9 methionyl tRNA formyltransferase ... formyltransferase EC number 2.3.1.102 N6 hydroxylysine O acetyltransferase EC number 2.3.1.103 sinapoylglucose ... more details
PBB geneid 471 Bifunctional purine biosynthesis protein PURH is a protein that in humans is encoded by the ATIC gene . ref name pmid8567683 cite journal author Rayl EA, Moroson BA, Beardsley GP title The human purH gene product, 5 aminoimidazole 4 carboxamide ribonucleotide formyltransferase IMP cyclohydrolase. Cloning, sequencing, expression, purification, kinetic analysis, and domain mapping journal J Biol Chem volume 271 issue 4 pages 2225 33 year 1996 month Mar pmid 8567683 pmc doi 10.1074 jbc.271.4.2225 ref ref name pmid9378707 cite journal author Sugita T, Aya H, Ueno M, Ishizuka T, Kawashima K title Characterization of molecularly cloned human 5 aminoimidazole 4 carboxamide ribonucleotide transformylase journal J Biochem volume 122 issue 2 pages 309 13 year 1997 month Nov pmid 9378707 pmc doi ref ref name entrez cite web title Entrez Gene ATIC 5 aminoimidazole 4 carboxamide ribonucleotide formyltransferase IMP cyclohydrolase url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 471 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text ATIC encodes an enzyme which generates inosine monophosphate from aminoimidazole carboxamide ribonucleotide . It has two functions EC number 2.1.2.3 5 aminoimidazole 4 carboxamide ribonucleotide formyltransferase EC number 3.5.4.10 IMP cyclohydrolase References reflist Further reading refbegin 2 PBB Further reading citations cite journal author Rasmussen HH title Microsequences of 145 proteins recorded in the two dimensional gel protein database of normal human epidermal keratinocytes journal Electrophoresis volume 13 issue 12 pages 960 9 year 1993 pmid 1286667 doi 10.1002 elps.11501301199 author separator , author2 van Damme J author3 Puype M display authors 3 last4 Gesser first4 Borbala last5 Celis first5 Julio E. last6 Vandekerckhove first6 Jo l cite journal author Yamauchi M title I ... more details
PBB geneid 123263 Mitochondrial methionyl tRNA formyltransferase is a protein that in humans is encoded by the MTFMT gene . ref name entrez cite web title Entrez Gene Mitochondrial methionyl tRNA formyltransferase url http www.ncbi.nlm.nih.gov sites entrez?db gene&cmd retrieve&list uids 123263 accessdate 2011 09 20 ref The protein encoded by this nuclear gene localizes to the mitochondrion, where it catalyzes the formylation of methionyl tRNA. ref name entrez cite web title Entrez Gene Mitochondrial methionyl tRNA formyltransferase url http www.ncbi.nlm.nih.gov sites entrez?db gene&cmd retrieve&list uids 123263 accessdate 2011 09 20 ref . Recessive type mutations in MTFMT have been shown to cause mitochondrial disease ref name MitoExomeMTFMT cite web title Mutations in MTFMT Underlie a Human Disorder of Formylation Causing Impaired Mitochondrial Translation url http www.cell.com cell metabolism abstract S1550 4131 11 00304 4 accessdate 2012 01 03 ref Model organisms class wikitable sortable collapsible collapsed border 1 cellpadding 2 style float right Mtfmt knockout mouse phenotype Characteristic Phenotype Homozygote viability bgcolor C40000 Abnormal Recessive lethal study bgcolor C40000 Abnormal Fertility bgcolor 488ED3 Normal Body weight bgcolor 488ED3 Normal Open Field animal test Anxiety bgcolor 488ED3 Normal Neurological assessment bgcolor 488ED3 Normal Grip strength bgcolor 488ED3 Normal Hot plate test Hot plate bgcolor 488ED3 Normal Dysmorphology bgcolor 488ED3 Normal Indirect calorimetry bgcolor 488ED3 Normal Glucose tolerance test bgcolor 488ED3 Normal Auditory brainstem response bgcolor 488ED3 Normal Dual energy X ray absorptiometry DEXA bgcolor 488ED3 Normal Radiography bgcolor 488ED3 Normal Body temperature bgcolor 488ED3 Normal Eye morphology bgcolor 488ED3 Normal Clinical chemistry bgcolor 488ED3 Normal Blood plasma Plasma immunoglobulin s bgcolor 488ED3 Normal Haematology bgcolor 488ED3 Normal Peripheral blood lymphocyte s bgcolor 488ED3 Normal Micronucleus ... more details
TS , dihydrofolate reductase DHFR , and glycinamide ribonucleotide formyltransferase ref Cite journal ... of the Glycinamide Ribonucleotide Formyltransferase Inhibitor AG2034 journal Clinical Cancer Research ... more details
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