Chembox verifiedrevid 444077628 ImageFile Pyrophosphate anion.png ImageSize 150px ImageFile1 Pyrophosphate 3D balls.png ImageSize1 150px ImageAlt1 ImageName1 Pyrophosphate anion IUPACName OtherNames Diphosphate Section1 Chembox Identifiers ChemSpiderID Ref chemspidercite correct chemspider ChemSpiderID 559142 InChI 1 H4O7P2 c1 8 2,3 7 9 4,5 6 h H2,1,2,3 H2,4,5,6 p 4 InChIKey XPPKVPWEQAFLFU XBHQNQODAI StdInChI Ref stdinchicite correct chemspider StdInChI 1S H4O7P2 c1 8 2,3 7 9 4,5 6 h H2,1,2,3 H2,4,5,6 p 4 StdInChIKey Ref stdinchicite correct chemspider StdInChIKey XPPKVPWEQAFLFU UHFFFAOYSA J CASNo ... . Pyrophosphates are good complexing agents and have many uses in industrial chemistry. Pyrophosphate is the first member of an entire series of polyphosphate s. The term pyrophosphate is also the name ... with inorganic phosphate as for dimethylallyl pyrophosphate . This bond is also referred to as a high energy phosphate bond. The synthesis of tetraethyl pyrophosphate was first described in 1854 ..., when a nucleotide is incorporated into a growing DNA or RNA strand by a polymerase , pyrophosphate ... pyrophosphate reacts with the 3 nucleotidemonophosphate NMP or dNMP , which is removed from the oligonucleotide to release the corresponding triphosphate dNTP from DNA, or NTP from RNA . The pyrophosphate ... reactions of simple polyphosphates such as pyrophosphate, linear triphosphate, Adenosine diphosphate ... cite journal author Huebner PWA, Milburn RM title Hydrolysis of pyrophosphate to orthophosphate ... Bone Calcium pyrophosphate Calcium pyrophosphate dihydrate deposition disease Catalysis DNA High energy ... monophosphate RNA Sodium pyrophosphate Structural phosphate Superphosphate Thiamine pyrophosphate Tooth Zinc pyrophosphate Div col end References reflist 2 Further reading cite journal author Schr der ... bcm 0296.pdf External links Wiktionary diphosphate pyrophosphate MeshName Pyrophosphates footer templates ... fr Pyrophosphate gl Pirofosfato it Pirofosfato hu Difoszf tok nl Pyrofosfaat pl Pirofosforany ... more details
Unreferenced stub auto yes date December 2009 Chembox verifiedrevid 424660305 ImageFile Farnesyl pyrophosphate.png ImageSize 220px ImageName Skeletal formula ImageFile1 Farnesyl pyrophosphate 3D balls.png ImageSize1 250px ImageName1 Ball and stick model IUPACName OtherNames Section1 Chembox Identifiers CASNo Ref cascite correct ?? CASNo 13058 04 3 PubChem 706 SMILES MeSHName farnesyl pyrophosphate Section2 Chembox Properties Formula C sub 15 sub H sub 28 sub O sub 7 sub P sub 2 sub MolarMass 382.326 Appearance Density MeltingPt BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition Farnesyl pyrophosphate FPP , also known as farnesyl diphosphate FDP , is an intermediate in the HMG CoA reductase pathway used by organisms in the biosynthesis of terpene s, terpenoid s, and sterol s. It is the immediate precursor of squalene via the enzyme squalene synthase , dehydrodolichol diphosphate a precursor of dolichol , and geranylgeranyl pyrophosphate GGPP . Biosynthesis Farnesyl pyrophosphate synthase a prenyl transferase catalyzes sequential condensation reactions of dimethylallyl pyrophosphate with 2 units of 3 isopentenyl pyrophosphate to form farnesyl pyrophosphate, as is shown in the following two steps Dimethylallyl pyrophosphate reacts with 3 isopentenyl pyrophosphate to form geranyl pyrophosphate Image Cholesterol Synthesis Reaction8.png Geranyl pyrophosphate then reacts with another molecule of 3 isopentenyl pyrophosphate to form farnesyl pyrophosphate Image Cholesterol Synthesis Reaction9.png Regulation The above reactions are inhibited by bisphosphonate s used for osteoporosis . Related compounds Farnesene Farnesol Geranyl pyrophosphate Geranylgeranyl pyrophosphate Cholesterol metabolism intermediates DEFAULTSORT Farnesyl Pyrophosphate Category Organophosphates Category Sesquiterpenes Biochem stub fi Farnesyylipyrofosfaatti zh ... more details
chembox verifiedrevid 403176984 ImageFile undecaprenyl pyrophosphate.png ImageSize 280px ImageName Skeletal formula of C55 isoprenyl pyrophosphate ImageFile1 C55 isoprenyl pyrophosphate 3D balls.png ImageSize1 280px ImageName1 Ball and stick model of C55 isoprenyl pyrophosphate IUPACName phosphono 2 E ,6 E ,10 E ,14 E ,18 E ,22 E ,26 E ,30 E ,34 E ,38 E 3,7,11,15,19,23,27,31,35,39,43 undecamethyltetratetraconta 2,6,10,14,18,22,26,30,34,38,42 undecaenyl hydrogen phosphate IUPACName hidden yes OtherNames C55 undecaprenyl pyrophosphate Undecaprenyl pyrophosphate Pyrophosphoryl undecaprenol Undecaisoprenyl pyrophosphate Undecaprenyl diphosphate Section1 Chembox Identifiers CASNo 31867 59 1 PubChem 5280604 SMILES CC CCC C C CC C C CC C C CC C C CC C C CC C C CC C C CC C C CC C C CC C C COP O O OP O O O C C C C C C C C C C C Section2 Chembox Properties C 55 H 92 O 7 P 2 Appearance Density MeltingPt BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition C55 isoprenyl pyrophosphate undecaprenyl pyrophosphate is an essential molecule involved in construction of the bacterial peptidoglycan cell wall . organic compound stub microbiology stub Category Organophosphates Category Terpenes and terpenoids ... more details
food s containing sodium pyrophosphate include chicken nugget s, marshmallows , pudding , crab ... common baking powder s. In toothpaste and dental floss, sodium pyrophosphate acts as a Calculus ... them from being deposited on teeth . Sodium pyrophosphate is sometimes used in household detergent ... of water , promoting algae growth. Calcium pyrophosphate is the crystal deposited in joints in the medical ... de Tetranatriumdiphosphat fr Pyrophosphate de sodium it Pirofosfato di sodio pt Pirofosfato ... more details
chembox verifiedrevid 451189391 ImageFile IPP.png ImageSize 210px ImageName Skeletal formula of IPP ImageFile1 Isopentenyl pyrophosphate 3D balls.png ImageSize1 220px ImageName1 Ball and stick model of IPP IUPACName hydroxy 3 methylbut 3 enoxy phosphoryl oxyphosphonic acid OtherNames Section1 Chembox Identifiers ChemSpiderID Ref chemspidercite correct chemspider ChemSpiderID 13115335 InChI 1 C5H12O7P2 c1 5 2 3 4 11 14 9,10 12 13 6,7 8 h1,3 4H2,2H3, H,9,10 H2,6,7,8 p 3 InChIKey NUHSROFQTUXZQQ DFZHHIFOAI StdInChI Ref stdinchicite correct chemspider StdInChI 1S C5H12O7P2 c1 5 2 3 4 11 14 9,10 12 13 6,7 8 h1,3 4H2,2H3, H,9,10 H2,6,7,8 p 3 StdInChIKey Ref stdinchicite correct chemspider StdInChIKey NUHSROFQTUXZQQ UHFFFAOYSA K CASNo Ref cascite correct ?? CASNo 358 71 4 PubChem 15983957 ChEBI Ref ebicite correct EBI ChEBI 128769 SMILES CC C CCOP O O OP O O O MeSHName isopentenyl pyrophosphate Section2 Chembox Properties Formula C sub 5 sub H sub 12 sub O sub 7 sub P sub 2 sub MolarMass 246.092 Appearance Density MeltingPt BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition Isopentenyl pyrophosphate IPP is an intermediate in the classical, HMG CoA reductase pathway used by organisms in the biosynthesis of terpene s and terpenoid s. IPP is formed from acetyl CoA via mevalonic acid . IPP can then be isomerized to dimethylallyl pyrophosphate by the enzyme isopentenyl pyrophosphate isomerase . Image Mevalonate pathway.png 350px thumb center Mevalonate pathway Image Sterol synthesis.svg thumb center 350px Simplified version of the steroid synthesis pathway with the intermediates isopentenyl pyrophosphate IPP , dimethylallyl pyrophosphate DMAPP , geranyl pyrophosphate GPP and squalene shown. Some intermediates are omitted. IPP can be synthesized via the alternative, non mevalonate pathway of isoprenoid biosynthesis instead, where it is formed from E 4 hydroxy 3 methyl but 2 enyl pyrophosphate HMB PP by the enzyme HMB PP reductase LytB, IspH . The non m ... more details
Chembox Watchedfields changed verifiedrevid 443835762 ImageFile Geranylgeranyl pyrophosphate.png ImageSize IUPACName OtherNames Section1 Chembox Identifiers ChemSpiderID Ref chemspidercite correct chemspider ChemSpiderID 394418 InChI 1 C20H36O7P2 c1 17 2 9 6 10 18 3 11 7 12 19 4 13 8 14 20 5 15 16 26 29 24,25 27 28 21,22 23 h9,11,13,15H,6 8,10,12,14,16H2,1 5H3, H,24,25 H2,21,22,23 b18 11 ,19 13 ,20 15 InChIKey OINNEUNVOZHBOX QIRCYJPOBR StdInChI Ref stdinchicite correct chemspider StdInChI 1S C20H36O7P2 c1 17 2 9 6 10 18 3 11 7 12 19 4 13 8 14 20 5 15 16 26 29 24,25 27 28 21,22 23 h9,11,13,15H,6 8,10,12,14,16H2,1 5H3, H,24,25 H2,21,22,23 b18 11 ,19 13 ,20 15 StdInChIKey Ref stdinchicite correct chemspider StdInChIKey OINNEUNVOZHBOX QIRCYJPOSA N CASNo 6699 20 3 PubChem 447277 ChEBI Ref ebicite correct EBI ChEBI 48861 SMILES O P O O OP O O OC C C CC C C C CC C C C CC C C C C C MeSHName geranylgeranyl pyrophosphate Section2 Chembox Properties C 20 H 36 O 7 P 2 Appearance Density MeltingPt BoilingPt Section3 Chembox Hazards Solubility MainHazards FlashPt Autoignition Geranylgeranyl pyrophosphate is an intermediate in the HMG CoA reductase pathway used by organisms in the biosynthesis of terpene s and terpenoid s. ref http www.rpi.edu dept bcbp molbiochem MBWeb mb2 part1 cholesterol.htm Cholesterol Synthesis , Rensselaer Polytechnic Institute ref In plants it is also the precursor to carotenoid s, gibberellin s, tocopherol s, and chlorophyll s. It is also a precursor to geranylgeranylation geranylgeranylated proteins. Related compounds Geranylgeraniol Geranyl pyrophosphate Farnesyl pyrophosphate References reflist Cholesterol metabolism intermediates DEFAULTSORT Geranylgeranyl Pyrophosphate Category Organophosphates Category Diterpenes Biochem stub ja fi Geranyyligeranyylipyrofosfaatti ... more details
Unreferenced stub auto yes date December 2009 Chembox verifiedrevid 443496302 ImageFile calcium pyrophosphate.png ImageSize 200px IUPACName Calcium diphosphate OtherNames Diphosphoric acid, calcium salt 1 2 Section1 Chembox Identifiers ChemSpiderID Ref chemspidercite correct chemspider ChemSpiderID 23034 UNII Ref fdacite correct FDA UNII X69NU20D19 InChI 1 2Ca.H4O7P2 c 1 8 2,3 7 9 4,5 6 h H2,1,2,3 H2,4,5,6 q2 2 p 4 InChIKey JUNWLZAGQLJVLR XBHQNQODAN StdInChI Ref stdinchicite correct chemspider StdInChI 1S 2Ca.H4O7P2 c 1 8 2,3 7 9 4,5 6 h H2,1,2,3 H2,4,5,6 q2 2 p 4 StdInChIKey Ref stdinchicite correct chemspider StdInChIKey JUNWLZAGQLJVLR UHFFFAOYSA J CASNo 7790 76 3 CASNo Ref cascite correct CAS PubChem 24632 ChEBI Ref ebicite correct EBI ChEBI 32598 SMILES Ca 2 . Ca 2 . O P O O OP O O O MeSHName Calcium pyrophosphate Section2 Chembox Properties Formula Ca sub 2 sub O sub 7 sub P sub 2 sub MolarMass 254.053 g mol Appearance Density 3.09 g cm sup 3 sup MeltingPt 1230 C BoilingPt Solubility insoluble Section3 Chembox Hazards EUIndex Not listed NFPA H 2 NFPA F 0 NFPA R 0 NFPA O FlashPt Non flammable Section8 Chembox Related OtherAnions Calcium phosphate OtherCations Magnesium pyrophosphate br Sodium pyrophosphate Calcium pyrophosphate Ca sub 2 sub O sub 7 sub P sub 2 sub is a chemical compound that can be formed by the reaction of pyrophosphoric acid and a calcium base or by strongly heating calcium phosphate or calcium ammonium phosphate. It is commonly used as a mild abrasive agent in toothpastes . Deposition of CPPD in articular joints causes an arthritis condition called pseudogout . See also Calcium pyrophosphate deposition disease Calcium compounds DEFAULTSORT Calcium Pyrophosphate Category Calcium compounds Category Pyrophosphates Inorganic compound stub ar ja sr Kalcijum pirofosfat zh ... more details
chembox verifiedrevid 402890942 Name Zinc pyrophosphate Reference ref name hand Citation last Lide first David R. author link last2 first2 author2 link publication date date year 1998 title Handbook of Chemistry and Physics edition 87 volume series publication place Boca Raton, FL place publisher CRC Press id isbn 0 8493 0594 2 doi oclc pages 4 96 url accessdate ref ImageFile Zinc pyrophosphate.png ImageSize ImageName Zinc pyrophosphate OtherNames Section1 Chembox Identifiers ChemSpiderID Ref chemspidercite correct chemspider ChemSpiderID 56393 PubChem 62641 InChI 1 H4O7P2.2Zn c1 8 2,3 7 9 4,5 6 h H2,1,2,3 H2,4,5,6 q 2 2 p 4 InChIKey OMSYGYSPFZQFFP XBHQNQODAA SMILES Zn 2 . Zn 2 . O P O O OP O O O StdInChI Ref stdinchicite correct chemspider StdInChI 1S H4O7P2.2Zn c1 8 2,3 7 9 4,5 6 h H2,1,2,3 H2,4,5,6 q 2 2 p 4 StdInChIKey Ref stdinchicite correct chemspider StdInChIKey OMSYGYSPFZQFFP UHFFFAOYSA J CASNo 7446 26 6 Section2 Chembox Properties Formula Zn sub 2 sub P sub 2 sub O sub 7 sub MolarMass 304.72 g mol Appearance white crystalline powder Density 3.75 g cm sup 3 sup MeltingPt BoilingPt Solubility insoluble SolubleOther soluble in dilute acid s Section3 Chembox Structure CrystalStruct Section7 Chembox Hazards EUClass Zinc pyrophospate Zn sub 2 sub P sub 2 sub O sub 7 sub is an inorganic chemical compound . It is useful in gravimetric analysis of zinc. Zinc pyrophosphate is obtained by precipitating zinc as a phosphate, then heating over 1123 K. Fact date May 2009 References Reflist Zinc compounds Category Pyrophosphates Category Zinc compounds inorganic compound stub el ... more details
Chembox verifiedrevid 457790064 ImageFile Tetraethyl pyrophosphate.png ImageSize IUPACName tetraethyl diphosphate OtherNames Section1 Chembox Identifiers CASNo Ref cascite correct CAS CASNo 107 49 3 ChEMBL Ref ebicite correct EBI ChEMBL 293787 PubChem 7873 ChemSpiderID Ref chemspidercite correct chemspider ChemSpiderID 7585 SMILES O P OP O OCC OCC OCC OCC InChI 1 C8H20O7P2 c1 5 11 16 9,12 6 2 15 17 10,13 7 3 14 8 4 h5 8H2,1 4H3 InChIKey IDCBOTIENDVCBQ UHFFFAOYAI StdInChI Ref stdinchicite correct chemspider StdInChI 1S C8H20O7P2 c1 5 11 16 9,12 6 2 15 17 10,13 7 3 14 8 4 h5 8H2,1 4H3 StdInChIKey Ref stdinchicite correct chemspider StdInChIKey IDCBOTIENDVCBQ UHFFFAOYSA N Section2 Chembox Properties C 8 H 20 O 7 P 2 Appearance Density MeltingPt BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition Tetraethyl pyrophosphate , abbreviated TEPP, is an organophosphate compound . It is used as a pesticide . This compound is a clear, colorless liquid. It is soluble in water, but hydrolyzes rapidly. ref Ullmann s doi 10.1002 14356007.a14 263 title Insect Control author Robert L. Metcalf ref It was first synthesized by Philippe de Clermont . This compound may be prepared by two equivalents of diethyl chlorophosphate with one equivalent of water in the presence of pyridine to scavenge the hydrogen chloride formed ref cite journal doi 10.1021 ja01191a104 journal J. Am. Chem. Soc. year 1948 last1 Toy first1 A. D. F. volume 70 issue 11 pages 3882 title The Preparation of Tetraethyl Pyrophosphate and Other Tetraalkyl Pyrophosphates ref File Synthesis of tetraethyl pyrophosphate.png 400px References References Category Pyrophosphates sr Tetraetil pirofosfat fi Tetraetyylipyrofosfaatti ... more details
, which is in turn connected to a pyrophosphate diphosphate functional group . The part of TPP molecule ... The TPP thiazolium ring can be deprotonated at C2 to become an ylid. Image Thiamine pyrophosphate ... Thiazoles Category Pyrimidines Category B vitamins de Thiaminpyrophosphat fr Thiamine pyrophosphate ... more details
chembox verifiedrevid 386736811 ImageFile Phosphoribosyl N formylglycineamide.svg ImageSize IUPACName OtherNames Formylglycinamide ribonucleotide, br Formylglycinamide ribotide, br FGAR Section1 Chembox Identifiers CASNo 349 34 8 PubChem 130805 SMILES MeSHName Phosphoribosyl N formylglycineamide Section2 Chembox Properties Formula C sub 8 sub H sub 15 sub N sub 2 sub O sub 9 sub P MolarMass 314.187 g mol Appearance Density MeltingPt BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition Phosphoribosyl N formylglycineamide or FGAR is a ribonucleotide derivative. Nucleotide metabolism intermediates Category Nucleotides biochem stub ... more details
enzyme Name phosphoribosyl ATP diphosphatase EC number 3.6.1.31 CAS number 69553 55 5 IUBMB EC number 3 6 1 31 GO code 0004636 image width caption In enzymology , a phosphoribosyl ATP diphosphatase EC number 3.6.1.31 is an enzyme that catalysis catalyzes the chemical reaction 1 5 phosphoribosyl ATP H sub 2 sub O math rightleftharpoons math 1 5 phosphoribosyl AMP diphosphate Thus, the two substrate biochemistry substrates of this enzyme are 1 5 phosphoribosyl ATP and water H sub 2 sub O , whereas its two product chemistry products are 1 5 phosphoribosyl AMP and diphosphate . This enzyme belongs to the family of hydrolase s, specifically those acting on acid anhydrides in phosphorus containing anhydrides. The systematic name of this enzyme class is 1 5 phosphoribosyl ATP diphosphohydrolase . Other names in common use include phosphoribosyl ATP pyrophosphatase , and phosphoribosyladenosine triphosphate pyrophosphatase . This enzyme participates in histidine metabolism . It employs one cofactor biochemistry cofactor , Hydron chemistry H . Structural studies As of late 2007, 4 tertiary structure structures have been solved for this class of enzymes, with Protein Data Bank PDB accession codes PDB link 1Y6X , PDB link 1YVW , PDB link 1YXB , and PDB link 2A7W . References reflist 1 cite journal author Smith DWE and Ames BN date 1965 title Phosphoribosyladenosine monophosphate, an intermediate in histidine biosynthesis journal J. Biol. Chem. volume 240 pages 3056&ndash 3063 pmid 14342333 hydrolase stub Category EC 3.6.1 Category Enzymes of known structure ... more details
enzyme Name phosphoribosyl AMP cyclohydrolase EC number 3.5.4.19 CAS number 37289 22 8 IUBMB EC number 3 5 4 19 GO code 0004635 image width caption In enzymology , a phosphoribosyl AMP cyclohydrolase EC number 3.5.4.19 is an enzyme that catalysis catalyzes the chemical reaction 1 5 phosphoribosyl AMP H sub 2 sub O math rightleftharpoons math 1 5 phosphoribosyl 5 5 phosphoribosylamino methylideneamino imidazole 4 carboxamide Thus, the two substrate biochemistry substrates of this enzyme are 1 5 phosphoribosyl AMP and water H sub 2 sub O , whereas its two product chemistry products are 1 5 phosphoribosyl 5 5 and phosphoribosylamino methylideneamino imidazole 4 carboxamide . This enzyme belongs to the family of hydrolase s, those acting on carbon nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is 1 5 phospho D ribosyl AMP 1,6 hydrolase . Other names in common use include PRAMP cyclohydrolase , and phosphoribosyladenosine monophosphate cyclohydrolase . This enzyme participates in histidine metabolism . Structural studies As of late 2007, only one tertiary structure structure has been solved for this class of enzymes, with the Protein Data Bank PDB accession code PDB link 1ZPS . References reflist 1 cite journal author Minson AC, Creaser EH date 1969 title Purification of a trifunctional enzyme, catalysing three steps of the histidine pathway, from Neurospora crassa journal Biochem. J. volume 114 pages 49&ndash 56 pmid 4309307 issue 1 pmc 1184794 hydrolase stub Category EC 3.5.4 Category Enzymes of known structure ... more details
DISPLAYTITLE E 4 Hydroxy 3 methyl but 2 enyl pyrophosphate chembox verifiedrevid 456493945 Name E 4 Hydroxy 3 methyl but 2 enyl pyrophosphate ImageFile HMB PP.PNG ImageSize 190px ImageName Chemical structure of HMB PP ImageFile1 HMBPP 3D balls.png ImageSize1 240px ImageName1 Ball and stick model, shown here as a 3 ion IUPACName E 4 hydroxy 3 methylbut 2 enoxy oxidophosphoryl phosphate OtherNames E 4 hydroxy dimethylallyl pyrophosphate br HDMAPP br E 4 Hydroxy 3 methyl but 2 enyl diphosphate br HMBDP Section1 Chembox Identifiers ChemSpiderID Ref chemspidercite correct chemspider ChEBI Ref ebicite correct EBI ChEBI 15664 ChemSpiderID 4445244 InChI 1 C5H12O8P2 c1 5 4 6 2 3 12 15 10,11 13 14 7,8 9 h2,6H,3 4H2,1H3, H,10,11 H2,7,8,9 b5 2 InChIKey MDSIZRKJVDMQOQ GORDUTHDBB SMILES1 O P OP O O O OC C C CO C O StdInChI Ref stdinchicite correct chemspider StdInChI 1S C5H12O8P2 c1 5 4 6 2 3 12 15 10,11 13 14 7,8 9 h2,6H,3 4H2,1H3, H,10,11 H2,7,8,9 b5 2 StdInChIKey Ref stdinchicite correct chemspider StdInChIKey MDSIZRKJVDMQOQ GORDUTHDSA N CASNo Ref cascite correct ?? CASNo ChEMBL Ref ebicite correct EBI ChEMBL 145233 PubChem 21597501 SMILES CC CCOP O O OP O O O CO Section2 Chembox Properties C 5 H 12 O 8 P 2 Appearance Density MeltingPt BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition E 4 Hydroxy 3 methyl but 2 enyl pyrophosphate HMBPP or HMB PP is an intermediate of the non mevalonate pathway of isoprenoid biosynthesis. ref name Rohmer cite journal last1 Rohmer first1 M title The discovery of a mevalonate independent pathway for isoprenoid biosynthesis in bacteria, algae and higher plants journal Natural product reports volume 16 issue 5 pages 565 74 year 1999 pmid 10584331 doi 10.1039 a709175c last2 Rohmer first2 Michel ref ref name Poulter cite journal ... pyrophosphate IPP and dimethylallyl pyrophosphate DMAPP by HMB PP reductase LytB, IspH . HMB ... links MeshName 4 hydroxy 3 methylbut 2 enyl pyrophosphate DEFAULTSORT Hydroxymethylbutenyl pyrophosphate ... more details
enzyme Name Ribose phosphate diphosphokinase EC number 2.4.2.17 CAS number 9031 46 3 IUBMB EC number 2 4 2 17 GO code 0003879 image width caption protein Name phosphoribosyl pyrophosphate synthetase 1 caption image width HGNCid 9462 Symbol PRPS1 AltSymbols EntrezGene 5631 OMIM 311850 RefSeq NM 002764 UniProt P60891 PDB ECnumber 2.4.2.17 Chromosome X Arm q Band 21 LocusSupplementaryData q27 protein Name phosphoribosyl pyrophosphate synthetase 2 caption image width HGNCid 9465 Symbol PRPS2 AltSymbols EntrezGene 5634 OMIM 311860 RefSeq NM 002765 UniProt P11908 PDB ECnumber 2.4.2.17 Chromosome X Arm p Band ter LocusSupplementaryData q21 Ribose phosphate diphosphokinase or phosphoribosyl pyrophosphate synthetase is an enzyme that converts ribose 5 phosphate into phosphoribosyl pyrophosphate . It is classified under EC number 2.7.6.1 . External Links http www.ncbi.nlm.nih.gov books NBK1876 GeneReviews NIH NCBI UW entry on Charcot Marie Tooth Neuropathy X Type 5 http www.ncbi.nlm.nih.gov omim 311860,611566,311070,311850,311070,311850 OMIM entries on on Charcot Marie Tooth Neuropathy X Type 5 http www.ncbi.nlm.nih.gov bookshelf br.fcgi?book gene&part arts GeneReviews NCBI NIH UW entry on Arts Syndrome http www.ncbi.nlm.nih.gov bookshelf br.fcgi?book gene&part prs GeneReviews NIH NCBI UW entry on Phosphoribosylpyrophosphate Synthetase PRS Superactivity http www.ncbi.nlm.nih.gov books NBK57098 GeneReviews NCBI NIH UW entry on DFNX1 Nonsyndromic Hearing Loss and Deafness MeshName Phosphoribosyl Pyrophosphate Synthetase transferase stub Kinases Nucleotide metabolism enzymes de Ribosephosphat Diphosphokinase es Ribosa fosfato difosfoquinasa ja ... more details
PBB geneid 5636 Phosphoribosylpyrophosphate synthetase associated protein 2 is a protein that in humans is encoded by the PRPSAP2 gene . ref name entrez cite web title Entrez Gene phosphoribosylpyrophosphate synthetase associated protein 2 url http www.ncbi.nlm.nih.gov sites entrez?db gene&cmd retrieve&list uids 5636 accessdate 2011 08 30 ref Function The enzyme ribose phosphate diphosphokinase phosphoribosylpyrophosphate synthetase PRS catalyzes the formation of phosphoribosylpyrophosphate which is a substrate for synthesis of purine and pyrimidine nucleotides, histidine , tryptophan and nicotinamide adenine dinucleotide NAD . PRS exists as a complex with two catalytic subunits and two associated subunits. This gene encodes a non catalytic associated subunit of PRS. ref name entrez cite web title Entrez Gene phosphoribosylpyrophosphate synthetase associated protein 2 url http www.ncbi.nlm.nih.gov sites entrez?db gene&cmd retrieve&list uids 5636 accessdate 2011 08 30 ref References reflist Further reading refbegin 2 cite journal author Katashima R, Iwahana H, Fujimura M, et al. title Molecular cloning of a human cDNA for the 41 kDa phosphoribosylpyrophosphate synthetase associated protein. journal Biochim. Biophys. Acta volume 1396 issue 3 pages 245 50 year 1998 pmid 9545573 doi cite journal author Stelzl U, Worm U, Lalowski M, et al. title A human protein protein interaction network a resource for annotating the proteome. journal Cell volume 122 issue 6 pages 957 68 year 2005 pmid 16169070 doi 10.1016 j.cell.2005.08.029 cite journal author Olsen JV, Blagoev B, Gnad F, et al. title Global, in vivo, and site specific phosphorylation dynamics in signaling networks. journal Cell volume 127 issue 3 pages 635 48 year 2006 pmid 17081983 doi 10.1016 j.cell.2006.09.026 cite journal author Katashima R, Iwahana H, Fujimura M, et al. title Assignment of the human phosphoribosylpyrophosphate synthetase associated protein 41 gene PRPSAP2 to 17p11.2 p12. journal Genomics volume ... more details
A salvage pathway is a Metabolic pathway pathway in which nucleotide s purine and pyrimidine are synthesized from intermediates in the degradative pathway for nucleotides. Salvage pathways are used to recover bases and nucleosides that are formed during biodegradation degradation of RNA and DNA . This is important in some organs because some tissues cannot undergo de novo synthesis . The salvaged bases and nucleosides can then be converted back into nucleotides. Substrates The salvage pathway requires distinct substrates Pyrimidines Uridine phosphorylase adds ribose 1 phospate to the free base uracil, forming uridine monophosphate. Uridine kinase then phosphorylates this nucleoside into its diphosphate and triphosphate forms. Deoxythymidine phosphorylase adds deoxyribose 1 phosphate to thymine, forming deoxythymidine monophosphate. Thymidine kinase can then phosphorylate this compound to deoxythymidine diphosphate and triphosphate. Image Pyrimidine Ribonucleotide Salvage.png thumb none 400px The salvage of pyrimidine ribonucleotides. Purines Phosphoribosyltransferases add activated ribose 5 phosphate called phosphoribosyl pyrophosphate or PRPP to bases, creating nucleotide monophosphates. There are two types of phosphoribosyltransferases adenine phosphoribosyltransferase APRT and hypoxanthine guanine phosphoribosyltransferase HGPRT . Lesch Nyhan syndrome is associated with a deficiency of HGPRT. class wikitable Nucleoside Enzyme Nucleotide hypoxanthine hypoxanthine guanine phosphoribosyl transferase HGPRT Inosine monophosphate IMP guanine hypoxanthine guanine phosphoribosyl transferase HGPRT Guanosine monophosphate GMP adenine adenine phosphoribosyltransferase APRT Adenosine monophosphate AMP External links http www.chem.brandeis.edu pochapsky research.html Enzymes in the methionine salvage pathway structure and function at Brandeis University Category Genetics genetics stub Protein metabolism Nucleotide metabolism ca Salvament de nucle tids de Salvage Pathway ja ... more details
chembox verifiedrevid 416365529 ImageFile Phosphoribosylamine.svg ImageSize IUPACName OtherNames Section1 Chembox Identifiers CASNo 14050 66 9 PubChem 3082052 SMILES C C1C C C O1 N O O OP O O O MeSHName Phosphoribosylamine Section2 Chembox Properties Formula C sub 5 sub H sub 12 sub NO sub 7 sub P MolarMass 229.125 g mol Appearance Density MeltingPt BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition Phosphoribosylamine 5PRA is an intermediate in purine metabolism . It is a precursor to Inosine monophosphate IMP . It is generated from Phosphoribosyl pyrophosphate PRPP . Image Nucleotides syn1.png thumb center 300px div style border width 0px border bottom 1px solid black text align left The synthesis of IMP . div The color scheme is as follows span style font weight bold span style color blue enzymes span , span style color rgb 219,155,36 coenzymes span , span style color rgb 151,149,45 substrate names span , span style color rgb 227,13,196 metal ions span , span style color rgb 128,0,0 inorganic molecules span span See also Amidophosphoribosyltransferase Phosphoribosyl pyrophosphate Nucleotide metabolism intermediates biochem stub Category Organophosphates Category Amino sugars es Fosforribosilamina ja ... more details
chembox verifiedrevid 395738406 ImageFile Orotidine monophosphate.svg ImageSize IUPACName 3 2R,3R,4S,5R 3,4 dihydroxy 5 & 8203 phosphonooxymethyl oxolan 2 yl & 8203 2,6 dioxo pyrimidine 4 carboxylic acid OtherNames Orotidylic acid, br OMP Section1 Chembox Identifiers CASNo 2149 82 8 PubChem 968 SMILES C1 C N C O NC1 O C2C C C O2 COP O O O O O C O O MeSHName Orotidine 5 monophosphate Section2 Chembox Properties Formula C sub 10 sub H sub 13 sub N sub 2 sub O sub 11 sub P MolarMass 368.191 g mol Appearance Density MeltingPt BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition Orotidine 5 monophosphate OMP , also known as orotidylic acid, is a pyrimidine nucleotide which is the last intermediate in the biosynthesis of uridine monophosphate . OMP is formed from orotic acid orotate and phosphoribosyl pyrophosphate by the enzyme Orotate phosphoribosyltransferase In humans, the enzyme UMP synthase converts OMP into uridine 5 monophosphate . If UMP synthase is defective, orotic aciduria can result. Nucleotide metabolism intermediates Category Nucleotides Category Pyrimidinediones biochem stub ja 5 sr Orotidin 5 monofosfat ... more details
enzyme Name Orotate phosphoribosyltransferase EC number 2.4.2.10 CAS number 9030 25 5 IUBMB EC number 2 4 2 10 GO code 0004588 image 2PSI orotate phosphoribosyltransferase bound to substrates S cerevisiae.png width caption S. cerevisiae orotate phosphoribosyl transferase bound to its substrates. From PDB file 2PSI. ref name Gonz lez Segura cite journal author Gonz lez Segura L, Witte JF, McClard RW, Hurley TD title Ternary complex formation and induced asymmetry in orotate phosphoribosyltransferase journal Biochemistry volume 46 issue 49 pages 14075 86 year 2007 month December pmid 18020427 doi 10.1021 bi701023z url ref Orotate phosphoribosyltransferase is an enzyme involved in pyrimidine biosynthesis . It catalyzes the formation of orotidine 5 monophosphate OMP from orotic acid orotate and phosphoribosyl pyrophosphate . ref name Gonz lez Segura In yeast and bacteria , orotate phospohribosyltransferase is an independent enzyme with a unique gene coding for the protein, whereas in mammals and other multicellular organisms , the catalytic function is carried out by a domain of the bifunctional enzyme uridine monophosphate synthetase UMP synthase . ref cite journal author Yablonski MJ, Pasek DA, Han BD, Jones ME, Traut TW. year 1996 title Intrinsic activity and stability of bifunctional human UMP synthase and its two separate catalytic domains, orotate phosphoribosyltransferase and orotidine 5 phosphate decarboxylase. journal J Biol Chem. volume 271 issue 18 pages 10704 10708 pmid 8631878 doi 10.1074 jbc.271.18.10704 ref References reflist Category EC 2.4.2 ... more details
Orphan date February 2009 PBB geneid 5635 Phosphoribosylpyrophosphate synthetase associated protein 1 is an enzyme that in humans is encoded by the PRPSAP1 gene . ref name pmid8660991 cite journal author Ishizuka T, Ahmad I, Kita K, Sonoda T, Ishijima S, Sawa K, Suzuki N, Tatibana M title The human phosphoribosylpyrophosphate synthetase associated protein 39 gene PRPSAP1 is located in the chromosome region 17q24 q25 journal Genomics volume 33 issue 2 pages 332 4 year 1997 month Jan pmid 8660991 pmc doi 10.1006 geno.1996.0207 ref ref name entrez cite web title Entrez Gene PRPSAP1 phosphoribosylpyrophosphate synthetase associated protein 1 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 5635 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text References reflist Further reading refbegin 2 PBB Further reading citations cite journal author Tatibana M, Kita K, Taira M, et al. title Mammalian phosphoribosylpyrophosphate synthetase. journal Adv. Enzyme Regul. volume 35 issue pages 229 49 year 1995 pmid 7572345 doi 10.1016 0065 2571 94 00017 W cite journal author Kita K, Ishizuka T, Ishijima S, et al. title A novel 39 kDa phosphoribosylpyrophosphate synthetase associated protein of rat liver. Cloning, high sequence similarity to the catalytic subunits, and a negative regulatory role. journal J. Biol. Chem. volume 269 issue 11 pages 8334 40 year 1994 pmid 8132556 doi cite journal author Ishizuka T, Kita K, Sonoda T, et al. title Cloning and sequencing of human complementary DNA for the phosphoribosylpyrophosphate synthetase associated protein 39. journal Biochim. Biophys. Acta volume 1306 issue 1 pages 27 30 year 1996 pmid 8611620 doi cite journal author Ishijima S, Asai T, Kita K, et al. title Partial reconstitution of mammalian phosphoribosylpyrophosphate synthetase in Escherichia coli cells. Coexpression of catalytic subunits ... more details
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