enzyme Name streptomycin 3kinase EC number 2.7.1.87 CAS number 39391 15 6 IUBMB EC number 2 7 1 87 GO code 0050299 image width caption In enzymology , a streptomycin 3kinase EC number 2.7.1.87 is an enzyme that catalysis catalyzes the chemical reaction ATP streptomycin math rightleftharpoons math ADP streptomycin 3 phosphate Thus, the two substrate biochemistry substrates of this enzyme are adenosine triphosphate ATP and streptomycin , whereas its two product chemistry products are adenosine diphosphate ADP and streptomycin 3 phosphate . This enzyme belongs to the family of transferase s, specifically those transferring phosphorus containing groups phosphotransferase s with an alcohol group as acceptor. The systematic name of this enzyme class is ATP streptomycin 3 phosphotransferase . Other names in common use include streptomycin 3kinase phosphorylating , and streptomycin 3 phosphotransferase . References reflist 1 cite journal author Walker JB, Skorvaga M year 1973 title Phosphorylation of streptomycin and dihydrostreptomycin by Streptomyces. Enzymatic synthesis of different diphosphorylated derivatives journal J. Biol. Chem. volume 248 pages 2435&ndash 40 pmid 4121456 issue 7 Category EC 2.7.1 Category Enzymes of unknown structure enzyme stub ... more details
enzyme Name dihydrostreptomycin 6 phosphate 3 alpha kinase EC number 2.7.1.88 CAS number 39391 14 5 IUBMB EC number 2 7 1 88 GO code 0047333 image width caption In enzymology , a dihydrostreptomycin 6 phosphate 3 alpha kinase EC number 2.7.1.88 is an enzyme that catalysis catalyzes the chemical reaction ATP dihydrostreptomycin 6 phosphate math rightleftharpoons math ADP dihydrostreptomycin 3 alpha,6 bisphosphate Thus, the two substrate biochemistry substrates of this enzyme are adenosine triphosphate ATP and dihydrostreptomycin 6 phosphate , whereas its two product chemistry products are adenosine diphosphate ADP and dihydrostreptomycin 3 alpha,6 bisphosphate . This enzyme belongs to the family of transferase s, specifically those transferring phosphorus containing groups phosphotransferase s with an alcohol group as acceptor. The systematic name of this enzyme class is ATP dihydrostreptomycin 6 phosphate 3 alpha phosphotransferase . Other names in common use include dihydrostreptomycin 6 phosphate kinase phosphorylating , and ATP dihydrostreptomycin 6 P 3 alpha phosphotransferase . References reflist 1 cite journal author Walker JB, Skorvaga M date 1973 title Phosphorylation of streptomycin and dihydrostreptomycin by Streptomyces. Enzymatic synthesis of different diphosphorylated derivatives journal J. Biol. Chem. volume 248 pages 2435&ndash 40 pmid 4121456 issue 7 enzyme stub Category EC 2.7.1 Category Enzymes of unknown structure ... more details
Janus kinase3 deficiency or JAK3 deficiency is a defect in the body s cytokine receptors and their signaling. ref name Bolognia cite book author Rapini, Ronald P. Bolognia, Jean L. Jorizzo, Joseph L. title Dermatology 2 Volume Set publisher Mosby location St. Louis year 2007 pages 820 isbn 1 4160 2999 0 oclc doi accessdate 2009 12 17 ref JAK3 encodes Janus kinase3, a tyrosine kinase that belongs to the Janus family. JAK3 functions in signal transduction and interacts with members of the STAT signal transduction and activators of transcription family. The cause of JAK3 deficiency. ref cite web url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 3718 title JAK3 Janus kinase3 Homo sapiens work NCBI publisher Department of Health & Human Services accessdate 17 December 2009 ref The deficiency causes the near absence of T lymphocytes and Natural killer cells and normal or elevated B lymphocytes due to an autosomal recessive variant of severe combined immunodeficiency SCID ref cite web url http bioinf.uta.fi xml idr ff FF9.xml title JAK3 deficiency work ImmunoDeficiency Resource IDR publisher IMT Bioinformatics accessdate 17 December 2009 ref See also List of cutaneous conditions References reflist Cutaneous condition stub Category Cytokine receptors Category Noninfectious immunodeficiency related cutaneous conditions ... more details
K, et al. title ik3 1 Cables is a substrate for cyclin dependent kinase3 cdk 3 . journal Eur. J. Biochem ... kinase in vascular smooth muscle cells. journal J. Biol. Chem. volume 271 issue 14 pages 8345 51 ... T, et al. title Investigation of the cell cycle regulation of cdk3 associated kinase activity and the role ... volume 127 issue 3 pages 635 48 year 2006 pmid 17081983 doi 10.1016 j.cell.2006.09.026 cite journal ... 6 issue 3 pages 537 47 year 2007 pmid 17192257 doi 10.1074 mcp.T600062 MCP200 refend External links ... dependent kinase 03 Category Cell cycle Category Proteins ... more details
summary text JAK3 encodes Janus kinase3, a tyrosine kinase that belongs to the Janus family. JAK3 functions ... Janus kinase3 function cause an autosomal SCID severe combined immunodeficiency disease . ref cite web title Entrez Gene JAK3 Janus kinase3 a protein tyrosine kinase, leukocyte url http ... of the Jak 3 Janus kinase in response to interleukin 2 journal Nature volume 370 issue 6485 ... 10925257 doi ref Interactions Janus kinase3 has been shown to Protein protein interaction interact ... of the Jak 3 Janus kinase in response to interleukin 2 journal Nature volume 370 issue 6485 pages 151 ... author Witthuhn BA title Involvement of the Jak 3 Janus kinase in signalling by interleukins ... Staples first9 JE cite journal author Verbsky JW title Expression of Janus kinase3 in human endothelial ... PDB Gallery geneid 3718 External links MeshName Janus Kinase3 Tyrosine kinases JAK STAT signaling ...PBB geneid 3718 Tyrosine protein kinase JAK3 is an enzyme that in humans is encoded by the JAK3 gene ... A display authors 3 last4 De Saint Basile first4 Genevieve last5 Savoldi first5 Gianfranco last6 Cranston ... author separator , author2 Tayebi N author3 Nakajima H display authors 3 last4 Riedy ... 3 last4 Sun first4 XJ last5 White first5 MF last6 Oakes first6 SA last7 Pierce first7 JH last8 ... Johnston JA author3 Linnekin D display authors 3 last4 Varesio first4 L last5 Rowe first5 TK last6 O ... D author3 Beckmann P display authors 3 last4 Galanaud first4 P last5 Richard first5 Y cite journal author Lai KS title A kinase deficient splice variant of the human JAK3 is expressed in hematopoietic ... 3 last4 Witthuhn first4 BA last5 Ihle first5 JN last6 Liu first6 ET cite journal author Macchi P title Mutations of Jak 3 gene in patients with autosomal severe combined immune deficiency SCID ... , author2 Villa A author3 Giliani S display authors 3 last4 Sacco first4 Maria G. last5 Frattini ... Johnston JA author3 Noguchi M display authors 3 last4 Kawamura first4 M last5 Bacon first5 C. last6 ... more details
Lipopolysaccharide Induces Anandamide Synthesis in Macrophages via CD14 MAPK Phosphoinositide3Kinase ... BS, Cantley LC title Purification and characterization of phosphoinositide3kinase from rat liver ... through the lipid products of phosphoinositide3 OH kinase journal Nature volume 387 issue ... are broad Phosphoinositide3kinase inhibitor inhibitors against PI 3 kinases and a number of unrelated ...Pfam box Symbol PI3 PI4 kinase Name Phosphatidylinositol 3 and 4 kinase image PI3kinase.png width caption ... and colleagues began with their identification of a previously unknown phosphoinositidekinase ... properties of the products of the lipid kinase, leading to the discovery that this phosphoinositidekinase had the unprecedented ability to phosphorylate phosphoinositides on the 3 position of the inositol .... The phosphoinositol 3kinase family is divided into three different classes Class I PI 3 kinases Class I , Class II PI 3 kinases Class II , and Class III PI 3kinase Class III . The classifications ... phosphoinositide3 kinases the lipids take centre stage journal Current Opinion in Cell Biology volume ... Genetic analysis of a phosphatidylinositol 3kinase SH2 domain reveals determinants of specificity ... PI 3kinase III PI3K are differentiated from the Class I by their structure and function. Class II comprises ... polypeptide PI3K C2 rowspan 3 Phosphatidylinositol 4 phosphate 3kinase 2.7.1.154 PIK3C2B PI3K, class ..., class 3 Vps34 Phosphatidylinositol 3kinase 2.7.1.137 rowspan 4 class 1 catalytic P110 PIK3CA PI3K, catalytic, alpha polypeptide p110 rowspan 4 Phosphatidylinositol 4,5 bisphosphate 3kinase 2.7.1.153 ... of class I PI 3 kinases to activate protein kinase B PKB, aka Akt as in the PI3K AKT mTOR pathway ... by activated PI 3kinase. ref cite journal author Franke TF, Kaplan DR, Cantley LC, Toker A title ... protein kinase 1 Phosphoinositide dependent kinase 1 PDK1 or, rarely referred to as PDPK1 also contains ... it to also translocate to the plasma membrane upon activation of PI 3kinase. The colocalization of activated ... more details
enzyme Name phosphoinositide 5 phosphatase EC number 3.1.3.36 CAS number 9036 01 5 IUBMB EC number 3 1 3 36 GO code 0004439 image width caption In enzymology , a phosphoinositide 5 phosphatase EC number 3.1.3.36 is an enzyme that catalysis catalyzes the chemical reaction 1 phosphatidyl 1D myo inositol 4,5 bisphosphate H sub 2 sub O math rightleftharpoons math 1 phosphatidyl 1D myo inositol 4 phosphate phosphate Thus, the two substrate biochemistry substrates of this enzyme are 1 phosphatidyl 1D myo inositol 4,5 bisphosphate and water H sub 2 sub O , whereas its two product chemistry products are 1 phosphatidyl 1D myo inositol 4 phosphate and phosphate . This enzyme belongs to the family of hydrolase s, specifically those acting on phosphoric ester monoester bonds. The systematic name of this enzyme class is phosphatidyl myo inositol 4,5 bisphosphate 4 phosphohydrolase . Other names in common use include type II inositol polyphosphate 5 phosphatase , triphosphoinositide phosphatase , IP3 phosphatase , PtdIns 4,5 P2 phosphatase , triphosphoinositide phosphomonoesterase , diphosphoinositide phosphatase , inositol 1,4,5 triphosphate 5 phosphomonoesterase , inositol triphosphate 5 phosphomonoesterase , phosphatidylinositol bisphosphatase , phosphatidyl myo inositol 4,5 bisphosphate phosphatase , phosphatidylinositol 4,5 bisphosphate phosphatase , polyphosphoinositol lipid 5 phosphatase , and phosphatidyl inositol bisphosphate phosphatase . This enzyme participates in inositol phosphate metabolism and phosphatidylinositol signaling system . Structural studies As of late 2007, 4 tertiary structure structures have been solved for this class of enzymes, with Protein Data Bank PDB accession codes PDB link 1UFW , PDB link 1W80 , PDB link 2DNR , and PDB link 2QV2 . References reflist 1 cite journal author Dawson RM, Thompson W date 1964 title The triphosphoinositide phosphomonoesterase of brain tissue journal Biochem. J. volume 91 pages 244&ndash 50 pmid 4284485 issue 2 pmc 1202879 ... more details
Image Phosphate formula.svg thumb Phosphate In chemistry and biochemistry , a kinase ref name pmid12471243 cite journal author Manning G, Whyte DB. et al. title The protein kinase complement of the human genome journal Science volume 298 issue 5600 pages 1912 1934 year 2002 pmid 12471243 doi 10.1126 science.1075762 url ref is a type of enzyme that transfers phosphate groups from High energy phosphate high energy donor molecules, such as adenosine triphosphate ATP , ref http nobelprize.org nobel prizes chemistry laureates 1997 illpres history.html History of ATP research milestones from an ATP related chemistry Nobel Prize site. ref to specific Substrate biochemistry substrate s, a process referred to as phosphorylation . Kinases are part of the larger family of phosphotransferase s. Kinases are not to be confused with phosphorylase s, which carry out phosphorolysis , the breaking of a bond using an inorganic phosphate group or with phosphatase s, which remove phosphate groups. Types One of the largest groups of kinases are protein kinase s, which act on and modify the activity of specific proteins. Kinases are used extensively to transmit signals and control complex processes in cells. More than five hundred different kinases have been identified in humans. Their enormous diversity, as well as their role in signaling, makes them an object of study. Various other kinases act on small molecules such as lipid s, carbohydrate s, amino acid s, and nucleotide s, either for signaling ... Reflist 2 See also Cyclin dependent kinase Ca2 calmodulin dependent protein kinase Ca sup 2 sup calmodulin dependent protein kinase Signal transduction G protein coupled receptor Kinases Category EC 2.7.1 an Quinasa ca Quinasa cs Kin za de Kinase es Quinasa fa fr Kinase gl Quinase ko io Kinazo id Kinase it Chinasi he nl Kinase ja oc Quinasa pl Kinazy pt Cinase ru sr Kinaza fi Kinaasi sv Kinas ta uk vi Kinase zh ... more details
PBB geneid 5170 In the field of biochemistry , 3phosphoinositide dependent protein kinase 1 , also known ... protein kinase 1 by 3phosphoinositide dependent protein kinase 1 journal Biochem. Biophys. Res ... Fujita Naoya, Tsuruo Takashi year 2002 month Oct. title Regulation of kinase activity of 3phosphoinositide dependent protein kinase 1 by binding to 14 33 journal J. Biol. Chem. volume 277 issue 42 ... SR, Downes CP, et al. title Characterization of a 3phosphoinositide dependent protein kinase which ... author Alessi DR, Deak M, Casamayor A, et al. title 3Phosphoinositide dependent protein kinase 1 ... and by 3phosphoinositide dependent protein kinase 1 in vitro comparison with protein kinase B alpha ... and localization of 3phosphoinositide dependent protein kinase 1. journal Biochem. J. volume 337 Pt ... 3kinase is mediated by 3phosphoinositide dependent protein kinase 1 PDK1 and PDK2 ... for the activity of 3phosphoinositide dependent protein kinase 1 identification of five sites of phosphorylation ... doi pmc 1220463 refend External links MeshName 3phosphoinositide dependent protein kinase PDB ... at the membrane. Interactions Phosphoinositide dependent kinase 1 has been shown to Protein protein ... inducible kinase SGK is a target of the PI 3kinase stimulated signaling pathway journal ... Biondi R M, Cheung P C, Casamayor A, Deak M, Alessi D R year 2000 month Jul. title A 3phosphoinositide ..., Cohen P, Parker P J year 1998 month Sep. title Protein kinase C isotypes controlled by phosphoinositide3kinase through the protein kinase PDK1 journal Science journal Science volume 281 issue 5385 ... jbc.272.48.30491 cite journal author Alessi DR, Kozlowski MT, Weng QP, et al. title 3Phosphoinositide ... author Le Good JA, Ziegler WH, Parekh DB, et al. title Protein kinase C isotypes controlled by phosphoinositide3kinase through the protein kinase PDK1. journal Science volume 281 issue 5385 pages 2042 ... kinase SGK is a target of the PI 3kinase stimulated signaling pathway. journal EMBO J. volume ... more details
A Phosphoinositide3kinase inhibitor PI3K inhibitor is a potential medical drug that functions by inhibiting a Phosphoinositide3kinase enzyme which is part of the PI3K AKT mTOR pathway , which plays a key role in cancer. Inhibiting this pathway often suppresses tumor growth. ref name Neri discuss ... Capitani first8 S last9 Martelli first9 AM title The phosphoinositide3kinase AKT1 pathway involvement ... MCR volume 1 issue 3 pages 234 46 year 2003 pmid 12556562 ref There are a number of different classes and isoform s of Phosphoinositide3kinase PI3K s. ref name Ito Class I PI 3 kinases Class 1 PI3K ... ref name Stein cite journal last1 Stein first1 R. title Prospects for phosphoinositide3kinase inhibition as a cancer treatment journal Endocrine Related Cancer volume 8 issue 3 pages 237 48 year ... cancer drugs Category Phosphoinositide3kinase inhibitors Category Drug discovery antineoplastic ... of phosphatidylinositol 3kinase inhibitors in inflammatory respiratory disease journal The Journal ... 3kinase inhibitor, PX 866, is a potent inhibitor of cancer cell motility and growth in three ... dual phosphatidylinositol 3kinase mammalian target of rapamycin inhibitor, elicits multifaceted ... 3, 2010 ref ref ClinicalTrialsGov NCT00907205 A Dose Escalation Study of SF1126, a PI3 Kinase PI3K Inhibitor ... title Form and flexibility in phosphoinositide3 kinases journal Biochemical Society Transactions ... Announces Initiation of Phase 2 Trial of Delta Isoform Selective PI3 Kinase Inhibitor CAL 101 in Combination ... articles press patients chronic lymphocytic leukemia,1508350.html accessdate November 3, 2010 ref .... ref ref cite press release title Semafore s PI3 Kinase Inhibitor SF1126 Is A Vascular Targeted Conjugate ... Kinase Inhibitor GDC 0941 in Combination With Paclitaxel and Carboplatin With or Without Bevacizumab ... cite journal url http stke.sciencemag.org cgi content abstract 3 147 ra81 title Akt and Autophagy Cooperate ... Oakes first9 SA volume 3 issue 147 pages ra81 pmc 3001107 journal Science signaling ref SAR245408 , SAR245409 ... more details
MAP kinasekinasekinase or MAP3K or MEKK is a serine threonine specific protein kinase which acts upon MAP kinasekinase . In humans there are at least 19 genes MAP3K1 aka MEKK1 MAP3K2 MAP3K3 aka MAP3K3 MEKK3 MAP3K4 MAP3K5 aka ASK1 MAP3K6 aka ASK2 MAP3K7 aka MAP3K7 MEKK7 aka TAK1 MAP3K8 aka TPL2 or Tpl2 MAP3K9 MAP3K10 MAP3K11 aka MAP3K11 MEKK11 aka MLK3 MAP3K12 aka MUK MAP3K13 aka LZK MAP3K14 MAP3K15 MAP3K16 aka TAO1 or TAOK1 MAP3K17 aka TAO2 or TAOK2 RAF1 BRAF ARAF ZAK aka MLTK Perhaps the best characterized MAP3K are the members of the oncogenic RAF family RAF1, BRAF, ARAF , which are effectors of mitogenic ras signaling and which activate the MAPK ERK pathway ERK1 2 MAPK3 MAPK1 pathway , through activation of MEK1 MAP2K1 and MEK2 MAP2K2 . MEKK1 activates C Jun N terminal kinases MAPK8 JNK by phosphorylation of its activator SEK1 MAP2K4 . ref cite journal author Yan M title Activation of stress activated protein kinase by MEKK1 phosphorylation of its activator SEK1 year 1994 journal Nature volume 372 pages 798 800 pmid 7997270 issue 6508 author separator , display authors 1 last2 Dai first2 T last3 Deak first3 JC last4 Kyriakis first4 JM last5 Zon first5 LI last6 Woodgett first6 JR last7 Templeton first7 DJ doi 10.1038 372798a0 ref MAP3K3 directly regulates the C Jun N terminal kinases MAPK8 JNK and MAPK ERK pathway extracellular signal regulated protein kinase ERK pathways by activating SEK and MEK1 2 respectively it does not regulate the p38 mitogen activated protein kinases p38 pathway. ref cite journal author Ellinger Ziegelbauer H title Direct activation of the stress activated protein kinase SAPK and extracellular signal regulated protein kinase ERK pathways by an inducible mitogen activated protein Kinase ERK kinasekinase3 MEKK derivative year 1997 journal J ... names. gallery External links MeshName MAP KinaseKinase Kinases EC number 2.7.11.25 References Reflist biochemistry stub MAP kinase activation Serine threonine specific protein kinases es MAP quinasa ... more details
The myeloid based model CLP s. ref name Paul0808 In B cell signaling, PI 3kinase is recruited to the BCR ...enzyme Name phosphoinositide phospholipase C EC number 3.1.4.11 CAS number 37213 51 7 IUBMB EC number 3 1 4 11 GO code 0004435 image width caption Pfam box Symbol PI PLC X Name Phosphatidylinositol specific ... 195 PDB3 1t6m B 57 195 Refimprove date July 2011 Phosphoinositide phospholipase C PLC EC number 3.1.4.11 ... triphosphate IP sub 3 sub and diglyceride diacylglycerol DAG . The chemical reaction may be expressed ... IP sub 3 sub , inositol triphosphate . PLCs catalyze the reaction in two sequential steps. The first ... IP sub 3 sub intermediate. At this point, DAG is generated. However, in the second phosphodiesterase ... of water, resulting in a final acyclic IP sub 3 sub product. It should be mentioned that bacterial ... of different phosphoinositide s and their affinity for different regulatory proteins ... inositol triphosphate IP sub 3 sub and diglyceride diacylglycerol DAG . These molecules then go ... to its hydrophobic character, where it recruits protein kinase C PKC , which becomes activated in conjunction ... of calcium sensitive proteins such as Calmodulin . Further reading Function of protein kinase C Domain ... tyrosine kinase activity has been reported. In addition, members of the Ras superfamily of small ... isozymes preferring phosphoinositol 3 phosphate or neutral membranes. Members of the Rho GTPase ... 4,5 bisphosphate into PIP sub 3 sub Phosphatidylinositol 3,4,5 trisphosphate Phosphatidylinositol 3,4,5 trisphosphate . The increase in concentration of PIP sub 3 sub recruits PLC 2 to the BCR complex which binds to BLNK on the BCR scaffold and membrane PIP sub 3 sub . PLC 2 is then phosphorylated by Syk on one site and Bruton s tyrosine kinase Btk on two sites. PLC 2 then competes with PI 3K for PIP sub 2 sub which it hydrolyzes into Inositol trisphosphate IP sub 3 sub inositol 1,4,5 triphosphate ... portions of the Protein kinase C PKC family. Because PLC 2 competes for PIP sub 2 sub with the original ... more details
Mitogen activated protein kinasekinasekinasekinase MAP4K is a family of proteins involved in cellular signal transduction . Expand list date May 2011 MAP4K1 aka HPK1 MAP4K2 aka GCK MAP4K3 MAP4K4 MAP4K5 Additional images gallery File Signal transduction pathways.svg Some signal transduction pathways. MAP4K s not labelled. File MAPKpathway.jpg MAPK pathway. Some or all of the MAP4K s in this image are labelled by other names, such as HPK1 and GCK. gallery See also Signal transduction MAP kinase MAP kinasekinase MAP kinasekinasekinase References references MAP kinase activation Serine threonine specific protein kinases biochemistry stub ... more details
p70S6 kinase or p70S6K is a serine threonine kinase that acts downstream of Phosphatidylinositol 3,4,5 trisphosphate PIP3 and phosphoinositide dependent kinase 1 in the Phosphoinositide3kinase PI3 kinase pathway. ref Cite journal journal Nature title PDGF and insulin dependent pp70S6k activation mediated by phosphatidylinositol 3 OH kinase volume 370 issue 6484 year 1994 authors Chung J, Grammer TC, Lemon KP, Kazlauskas A, Blenis J. page 71 75 doi 10.1038 370071a0 PMID 8015612 ref As the name suggests, its target Substrate biochemistry substrate is the Ribosomal protein s6 S6 ribosomal protein . ref Cite journal journal Cell title Rapamycin FKBP specifically blocks growth dependent activation of and signaling by the 70 kd S6 protein kinases. authors Chung J, Kuo CJ, Crabtree GR, Blenis J. volume 69 issue 7 year 1992 page 1227 1236 doi 10.1016 0092 8674 92 90643 Q PMID 1377606 ref Phosphorylation of S6 induces protein synthesis at the ribosome. mTOR P70S6 kinase is in a signaling pathway that includes mTOR the mammalian target of rapamycin . mTOR can be activated in distinct ways, thereby activating p70S6K. For example, branched chain amino acid s such as leucine are sufficient to activate mTOR, resulting in an increase in p70S6K phosphorylation and thereby activating it . mTOR is also in a pathway downstream of the kinase Akt . Akt is typically activated upon stimulation of a cell with a growth factor such as IGF 1 . Akt then activates mTOR by inhibiting the Tsc complex , leading to p70S6K activation. Physical exercise activates protein synthesis via phosphorylation activation of p70S6K in a pathway that is dependent on mTOR. This has been demonstrated by using an inhibitor of mTOR, rapamycin, to block an increase in muscle mass, despite increases in load e.g., exercise . Exercise has been shown to increase levels of IGF 1 in muscle, thus inducing the IGF 1 PI3K Akt ... Reflist Serine threonine specific protein kinases DEFAULTSORT P70s6 Kinase Category Protein ... more details
of hamster 3 hydroxy 3 methylglutaryl CoA reductase prevents phosphorylation by AMP activated kinase ...enzyme Name dephospho reductase kinasekinase EC number 2.7.11.3 CAS number 72060 33 4 IUBMB EC number 2 7 11 3 GO code 0047848 image width caption In enzymology , a dephospho reductase kinasekinase EC number 2.7.11.3 is an enzyme that catalysis catalyzes the chemical reaction ATP dephospho hydroxymethylglutaryl CoA reductase NADPH kinase math rightleftharpoons math ADP hydroxymethylglutaryl CoA reductase NADPH kinase Thus, the two substrate biochemistry substrates of this enzyme are adenosine triphosphate ATP and dephospho hydroxymethylglutaryl CoA reductase NADPH kinase , whereas its two product chemistry products are adenosine diphosphate ADP and hydroxymethylglutaryl CoA reductase NADPH kinase . This enzyme belongs to the family of transferase s, specifically those transferring a phosphate ... threonine kinase s . The systematic name of this enzyme class is ATP dephospho hydroxymethylglutaryl CoA reductase NADPH kinase phosphotransferase . Other names in common use include AMP activated kinase , AMP activated protein kinasekinase , hydroxymethylglutaryl coenzyme A reductase kinasekinase , hydroxymethylglutaryl coenzyme A reductase kinasekinase , phosphorylating , reductase kinase , reductase kinasekinase , and STK30 . References reflist 1 cite journal author Beg ZH, Stonik JA, Brewer HB Jr year 1979 title Characterization and regulation of reductase kinase, a protein kinase that modulates the enzymic activity of 3 hydroxy 3 methylglutaryl coenzyme A reductase journal Proc. Natl ... 3 hydroxy 3 methylglutaryl coenzyme A reductase and modulation of its enzymic activity by calcium activated and phospholipid dependent protein kinase journal J. Biol. Chem. volume 260 pages 1682&ndash 7 pmid 3155737 issue 3 cite journal author Clarke PR, Hardie DG year 1990 title Regulation of HMG CoA reductase identification of the site phosphorylated by the AMP activated protein kinase in vitro ... more details
Infobox protein family Symbol DAGK cat Name Diacylglycerol kinase catalytic domain image width caption crystal structure of diacylglycerol kinase dgkb in complex with adp and mg Pfam PF00781 Pfam clan CL0240 InterPro IPR001206 SMART DAGKc PROSITE MEROPS SCOP TCDB OPM family OPM protein CAZy CDD File Soluble diacylglycerol kinase DgkB from Staphylococcus aureus.png thumb left x125px DgkB, soluble DAGK from Staphylococcus aureus . helices in red, strands in yellow, coils in green. Infobox protein family Symbol DAGK acc Name Diacylglycerol kinase accessory domain image width caption Pfam PF00609 Pfam clan InterPro IPR000756 SMART DAGKa PROSITE MEROPS SCOP TCDB OPM family OPM protein CAZy CDD Infobox protein family Symbol DAGK prokar Name Prokaryotic diacylglycerol kinase image width caption nmr solution structure of e. coli diacylglycerol kinase dagk in dpc micelles Pfam PF01219 Pfam clan InterPro IPR000829 SMART PROSITE PDOC00820 MEROPS SCOP TCDB OPM family OPM protein CAZy CDD Diacylglycerol kinase DGK or DAGK is a family of enzymes that catalyzes the conversion of diglyceride diacylglycerol DAG to phosphatidic acid PA utilizing Adenosine triphosphate ATP as a source of the phosphate. In non stimulated cells, DGK activity is low allowing DAG to be used for glycerophospholipid biosynthesis but on receptor activation of the phosphoinositide pathway, DGK activity increases driving the conversion of DAG to PA. As both lipids are thought to function as bioactive lipid signaling molecules with distinct cellular targets, DGK therefore occupies an important position, effectively ... diacylglycerol kinase journal J. Bacteriol. volume 176 issue 17 pages 5459 65 year 1994 month September ... transmembrane domains. Some Gram positive bacteria also encode a soluble diacylglycerol kinase capable ... Type 2 DGK , DGK contain a pleckstrin homology domain Type 3 DGK has specificity for arachidonate ... links MeshName Diacylglycerol Kinase EC number 2.7.1.107 Kinases Phospholipid metabolism Category Integral ... more details
File PhK 1QL6 gamma small.png thumb 250px Catalytic gamma subunit of phosphorylase kinase. Phosphorylase kinase PhK is a serine threonine specific protein kinase which activates glycogen phosphorylase ... s catalysis, but phosphorylation of both these subunits by protein kinase A PKA, or Cyclic adenosine monophosphate cAMP dependent protein kinase reduces their respective inhibitory activities. The ... conformational change that activates the kinase s activity by binding to a complementary hydrophobic ... PHKG1 , PHKG2 History Phosphorylase kinase was the first protein kinase to be isolated and characterized ... in fact activating phosphorylase kinase via the regulatory subunit, leading to the phosphorylation ... P loop protein kinases such as protein kinase A PKA, cAMP dependent kinase . In contrast to these other ... serine . ref name Skamnaki1999 Structure Phosphorylase kinase is a 1.3 MDa hexadecameric ... function and regulation File PhK diagram.png thumb 250px Overview of phosphorylase kinase regulation. Physiologically, phosphorylase kinase plays the important role of stimulating glycogen breakdown ..., binding to the subunits of phosphorylase kinase, and partly activating enzyme activity. This binding partly stabilizes the protein in the active form. The phosphorylase kinase is completely activated when the and subunits are phosphorylated by protein kinase A and the delta subunit has bound ... adrenergic receptor to trigger a phosphoinositide cascade, resulting in the release of Ca sup 2 ... kinase genes can result in physiological symptoms classified under the broad heading ... in the PHKA2 gene, which codes for the subunit of phosphorylase kinase. In the case of XLG ... kinase the complexity of its regulation is reflected in the complexity of its structure journal Front ... journal Biol Chem volume 391 issue 2 3 pages 131 137 year 2010 pmid 20030590 doi 10.1515 ... affecting the activity of muscle phosphorylase b kinase journal J Biol Chem volume 234 issue pages ... more details
enzyme Name glycerate kinase EC number 2.7.1.31 CAS number 9026 61 3 IUBMB EC number 2 7 1 31 GO code 0008887 image width caption Pfam box Symbol Glyc kinase Name Glycerate kinase Pfam PF02595 InterPro IPR004381 PROSITE PDB PDB 1to6 In enzymology , a glycerate kinase EC number 2.7.1.31 is an enzyme that catalysis catalyzes the chemical reaction ATP R glycerate math rightleftharpoons math ADP 3 phospho R glycerate Thus, the two substrate biochemistry substrates of this enzyme are adenosine triphosphate ATP and R glycerate , whereas its two product chemistry products are adenosine diphosphate ADP and 3 phospho R glycerate . This enzyme belongs to the family of transferase s, specifically those transferring phosphorus containing groups phosphotransferase s with an alcohol group as acceptor. The systematic name of this enzyme class is ATP R glycerate 3 phosphotransferase . Other names in common use include glycerate kinase phosphorylating , D glycerate 3kinase , D glycerate kinase , glycerate 3kinase , GK , D glyceric acid kinase , and ATP D glycerate 2 phosphotransferase . This enzyme participates in 3 metabolism metabolic pathways serine glycine threonine metabolism, glycerolipid metabolism, and glyoxylate dicarboxylate metabolism. Structural studies As of late 2007, 3 tertiary structure structures have been solved for this class of enzymes, with Protein Data Bank PDB accession codes PDB link 1TO6 , PDB link 1X3L , and PDB link 2B8N . References reflist 1 cite journal author Doughty CC, Hayashi JA, Guenther HL date 1966 title Purification and properties of D glycerate 3kinase from Escherichia coli journal J. Biol. Chem. volume 241 pages 568&ndash 72 pmid 5325263 issue 3 cite journal author ICHIHARA A, GREENBERG DM date 1957 title Studies on the purification and properties of D glyceric acid kinase of liver journal J. Biol. Chem. volume 225 pages 949&ndash 58 pmid 13416296 issue 2 enzyme stub Category EC 2.7.1 Category Enzymes of known structure ... more details
enzyme Name Polo kinase EC number 2.7.11.21 CAS number IUBMB EC number 2 7 11 21 GO code image width caption In enzymology , a polo kinase EC number 2.7.11.21 is a kinase enzyme i.e. one that catalysis catalyzes the chemical reaction ATP a protein math rightleftharpoons math ADP a phosphoprotein Thus, the two substrate biochemistry substrates of these enzymes are adenosine triphosphate ATP and protein , whereas their two product chemistry products are adenosine diphosphate ADP and phosphoprotein . These enzymes belong to the family of transferase s, specifically those transferring a phosphate group to the sidechain oxygen atom of serine or threonine residues in protein s protein serine threonine kinase s . The systematic name of this polo like kinase enzyme class is ATP protein phosphotransferase Spindle apparatus spindle pole dependent . Examples and other names in common use include Cdc5 , Cdc5p , Plk , PLK , PLK1 Plk1 , Plo1 , POLO kinase , polo serine threonine kinase , polo like kinase , polo like kinase 1 , serine threonine specific Drosophila kinase polo , and STK21 . These enzymes participate in 3 metabolism metabolic pathways cell cycle , cell cycle yeast , and progesterone mediated oocyte maturation . Structural studies As of late 2007, 5 tertiary structure structures have been solved for this class of enzymes, with Protein Data Bank PDB accession codes PDB link 2OGQ , PDB link 2OJS , PDB link 2OJX , PDB link 2OU7 , and PDB link 2OWB . References reflist 1 cite journal author C, Karess RE, Glover DM, Sunkel CE date 1991 title polo encodes a protein kinase homolog required ... of a protein kinase encoding mouse gene, Plk, related to the polo gene of Drosophila 1993 cite ... and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle ... like kinase Plo1 to the spindle pole body and a functional spindle assembly checkpoint journal J. Cell ... author Ohkura H date 2003 title Phosphorylation polo kinase joins an elite club journal Curr. Biol ... more details
enzyme Name deoxyguanosine kinase EC number 2.7.1.113 CAS number 39471 28 8 IUBMB EC number 2 7 1 113 GO code 0004138 image width caption In enzymology , a deoxyguanosine kinase EC number 2.7.1.113 is an enzyme that catalysis catalyzes the chemical reaction ATP deoxyguanosine math rightleftharpoons math ADP dGMP Thus, the two substrate biochemistry substrates of this enzyme are adenosine triphosphate ATP and deoxyguanosine , whereas its two product chemistry products are adenosine diphosphate ADP and deoxyguanosine monophosphate dGMP . This enzyme belongs to the family of transferase s, specifically those transferring phosphorus containing groups phosphotransferase s with an alcohol group as acceptor. The systematic name of this enzyme class is ATP deoxyguanosine 5 phosphotransferase . Other names in common use include deoxyguanosine kinase phosphorylating , dihydroxypropoxymethyl guanine kinase , 2 deoxyguanosine kinase , and NTP deoxyguanosine 5 phosphotransferase . This enzyme participates in purine metabolism . Structural studies As of late 2007, 4 tertiary structure structures have been solved for this class of enzymes, with Protein Data Bank PDB accession codes PDB link 2JAQ , PDB link 2JAS , PDB link 2JAT , and PDB link 2OCP . Clinical Mutations in this gene have been linked to inherited mitochondrial DNA depletion syndromes, neonatal liver failure, nystagmus and hypotonia . References reflist 1 cite journal author Barker J, Lewis RA date 1981 title Deoxyguanosine kinase of neonatal mouse skin tissue journal Biochim. Biophys. Acta. volume 658 pages 111&ndash 23 pmid 6260206 issue 1 cite journal author Gower WR Jr, Carr MC, Ives DH date 1979 title Deoxyguanosine kinase. Distinct molecular forms in mitochondria and cytosol journal J. Biol. Chem. volume 254 pages 2180&ndash 3 pmid 218928 issue 7 enzyme stub Category EC 2.7.1 Category Enzymes of known structure ... more details
Image Ch4 kinases.jpg thumb 250px right Protein phosphorylation A protein kinase is a kinase enzyme that modifies ... genome contains about 500 protein kinase genes and they constitute about 2 of all human genes. ref name pmid12471243 cite journal author Manning G, Whyte DB. et al. title The protein kinase complement ... to 30 of all human proteins may be modified by kinase activity, and kinases are known to regulate the majority ... hydrogen H white . The chemical activity of a kinase involves transferring a phosphate group from a nucleoside ... dual specificity kinase s act on all three. ref cite journal author Dhanasekaran N, Premkumar ... protein kinases that phosphorylate other amino acids, including histidine kinase s that phosphorylate ... histidine kinases journal Int. J. Biochem. Cell Biol. volume 35 issue 3 pages 297 309 year 2003 ... is highly regulated. Kinases are turned on or off by phosphorylation sometimes by the kinase ... in the cell relative to their substrates. Structure main Protein kinase domain The catalytic subunits ... name pmid12734000 cite journal author Hanks SK title Genomic analysis of the eukaryotic protein kinase ... kinase superfamily kinase catalytic domain structure and classification journal FASEB J. volume ... long&pmid 7768349 issn ref ref name pmid1835513 cite journal author Hunter T title Protein kinase classification journal Meth. Enzymol. volume 200 issue pages 3 37 year 1991 pmid 1835513 doi 10.1016 ... Protein kinase catalytic domain sequence database identification of conserved features of primary ... kinase journal Science volume 253 issue 5018 pages 407 14 year 1991 month July pmid 1862342 doi 10.1126 science.1862342 url issn ref Protein kinase groups The human protein kinase family is divided into the following groups AGC kinases containing Protein kinase A PKA , Protein kinase c PKC and Protein kinase g PKG . CaM Kinase CaM kinases containing the calcium calmodulin dependent protein kinases. Ck1 CK1 containing the casein kinase 1 group. CMGC containing Cyclin dependent kinase CDK , MAPK ... more details
Image MAPKpathway.jpg right thumb 300px The mitogen activated protein kinase MAPK pathway. ref name pmid10558990 cite journal author Rossomando AJ, Payne DM, Weber MJ, Sturgill TW title Evidence that pp42, a major tyrosine kinase target protein, is a mitogen activated serine threonine protein kinase journal Proc Natl Acad Sci USA volume 86 issue 18 pages 6940 3 year 1989 pmid 2550926 doi 10.1073 pnas.86.18.6940 issn pmc 297966 ref ref name pmid2550926 cite journal author Bonni A, Brunet A, West AE, Datta SR, Takasu MA, Greenberg ME title Cell survival promoted by the Ras MAPK signaling pathway by transcription dependent and independent mechanisms journal Science volume 286 issue 5443 pages 1358 ... kinasekinasekinase MEKK1 by the Ste20p homologue GCK and the adapter protein TRAF2 journal Mol. Cell. Biol. volume 22 issue 3 pages 737 49 year 2002 pmid 11784851 doi 10.1128 MCB.22.3.737 749.2002 issn pmc 133545 ref ref name pmid11242034 cite journal author Chang L, Karin M title Mammalian MAP kinase ... N terminal kinase pathway and apoptotic signaling review journal Int. J. Oncol. volume 16 issue 4 pages .... Rev. Mol. Cell Biol. volume 3 issue 1 pages 30 40 year 2002 pmid 11823796 doi 10.1038 nrm715 issn ... A, Zanke BW, Lassam N, Pawson T, Woodgett JR, Iscove NN title HPK1, a hematopoietic protein kinase .... MAP kinase signaling specificity journal Science volume 296 issue 5577 pages 2345 7 year ... of the diagram. Raf kinases are a family of three serine threonine specific protein kinase s that are related .... Res. Commun. volume 399 issue 3 pages 313 7 year 2010 month August pmid 20674547 doi 10.1016 j.bbrc.2010.07.092 ... a Raf kinase related oncogene that enhances fibrosarcoma induction. The acronym RAF is derived from ... Raf kinases participate in the Ras subfamily RAS RAF mitogen activated protein kinasekinase MEK extracellular ... pathway mitogen activated protein kinase MAPK cascade . ref name pmid20674547 Activation of RAF kinases requires interaction with Ras subfamily RAS GTPases . The three RAF kinase family members are ARAF ... more details
enzyme Name hydroxylysine kinase EC number 2.7.1.81 CAS number 9073 58 9 IUBMB EC number 2 7 1 81 GO code 0047992 image width caption In enzymology , a hydroxylysine kinase EC number 2.7.1.81 is an enzyme that catalysis catalyzes the chemical reaction GTP 5 hydroxy L lysine math rightleftharpoons math GDP 5 phosphonooxy L lysine Thus, the two substrate biochemistry substrates of this enzyme are guanosine triphosphate GTP and 5 hydroxy L lysine , whereas its two product chemistry products are guanosine diphosphate GDP and 5 phosphonooxy L lysine . This enzyme belongs to the family of transferase s, specifically those transferring phosphorus containing groups phosphotransferase s with an alcohol group as acceptor. The systematic name of this enzyme class is GTP 5 hydroxy L lysine O phosphotransferase . Other names in common use include hydroxylysine kinase phosphorylating , and guanosine triphosphate 5 hydroxy L lysine O phosphotransferase . This enzyme participates in lysine degradation . References reflist 1 cite journal author Hiles RA, Henderson LM date 1972 title The partial purification and properties of hydroxylysine kinase from rat liver journal J. Biol. Chem. volume 247 pages 646&ndash 51 pmid 4621658 issue 3 enzyme stub Category EC 2.7.1 Category Enzymes of unknown structure ... more details
kinase? journal Trends Biochem. Sci. volume 17 issue 3 pages 99 year 1992 month March pmid 1329277 ...enzyme Name guanylate kinase EC number 2.7.4.8 CAS number 9026 59 9 IUBMB EC number 2 7 4 8 GO code 0004385 image width caption Infobox protein family Symbol Guanylate kin Name guanylate kinase image PDB 1gky EBI.jpg width caption Structure of Guanylate Kinase. ref name pmid1314905 cite journal author Stehle T, Schulz GE title Refined structure of the complex between guanylate kinase and its substrate GMP at 2.0 A resolution journal J. Mol. Biol. volume 224 issue 4 pages 1127 41 year 1992 month April pmid 1314905 doi 10.1016 0022 2836 92 90474 X url ref Pfam PF00625 InterPro IPR008144 SMART PROSITE PDOC00670 SCOP 1gky TCDB OPM family OPM protein PDB PDB2 1ex6 , PDB2 1ex7 , PDB2 1gky , PDB2 1jxm , PDB2 1jxo , PDB2 1kgd , PDB2 1kjw , PDB2 1lvg , PDB2 1s4q , PDB2 1s96 , PDB2 1xzp , PDB2 1xzq , PDB2 1z6g , PDB2 1z8f , PDB2 1znw , PDB2 1znx , PDB2 1zny , PDB2 1znz , PDB2 2an9 , PDB2 2anb , PDB2 2anc , PDB2 2f3r , PDB2 2f3t , PDB2 2qor In enzymology , a guanylate kinase EC number 2.7.4.8 is an enzyme that catalysis catalyzes the chemical reaction Adenosine triphosphate ATP Guanosine monophosphate ... participates in purine metabolism . Guanylate kinase catalyzes the ATP dependent phosphorylation ... of the complex between guanylate kinase and its substrate GMP at 2.0 A resolution journal J. Mol ... kinase and to the product of a Drosophila tumor suppressor gene journal Cell volume 68 issue ... determination of guanylate kinase from pig brain journal Eur. J. Biochem. volume 213 issue 1 pages ... d GMP phosphotransferase . Other names in common use include deoxyguanylate kinase, 5 GMP kinase, GMP kinase, guanosine monophosphate kinase, and ATP GMP phosphotransferase. References reflist Further ... pages 49&ndash 61 pmid 4307347 doi 10.1016 0003 9861 69 90337 3 issue 1 cite journal author Hiraga ... and properties of guanylate kinase from Escherichia coli journal J. Biol. Chem. volume 241 pages 5452 ... more details
shikimate 3 phosphotransferase . Other names in common use include shikimate kinase phosphorylating , and shikimate kinase II . This enzyme participates in phenylalanine, tyrosine and tryptophan biosynthesis ...enzyme Name shikimate kinase EC number 2.7.1.71 CAS number 9031 51 0 IUBMB EC number 2 7 1 71 GO code 0004765 image width caption Pfam box Symbol SKI Name Shikimate kinase image 1e6c opm.gif width caption Shikimate kinase of Erwinia chrysanthemi Pfam PF01202 Pfam clan CL0023 InterPro IPR000623 SMART PROSITE PDOC00868 SCOP 2shk TCDB OPM family OPM protein 1e6c PDB PDB3 1l4y A 11 167 PDB3 1we2 A 11 167 PDB3 1l4u A 11 167 PDB3 1u8a A 11 167 PDB3 2shk B 11 169 PDB3 1shk A 11 169 PDB3 1e6c B 11 169 PDB3 1kag A 13 171 PDB3 2IYQ PDB3 2IYR PDB3 2IYS PDB3 2IYT PDB3 2IYU PDB3 2IYV PDB3 2IYW PDB3 2IYX PDB3 2IYY PDB3 2IYZ In enzymology , a shikimate kinase EC number 2.7.1.71 is an enzyme that catalysis catalyzes the chemical reaction ATP shikimate math rightleftharpoons math ADP shikimate 3 phosphate Thus, the two substrate biochemistry substrates of this enzyme are adenosine triphosphate ATP and shikimate , whereas its two product chemistry products are adenosine diphosphate ADP and shikimate 3 phosphate . This is fifth step in the biosynthesis of aromatic amino acids from chorismate the so called shikimate pathway . ref name PUB00001125 cite journal author Gasson MJ, Griffin HG title The gene aroK encoding shikimate kinase I from Escherichia coli journal DNA Seq. volume 5 issue 3 pages 195 197 year 1995 pmid 7612934 ref The protein is found in bacteria, plants and fungi where it is part of a multifunctional ... year 1968 title Shikimate kinase isoenzymes in Salmonella typhimurium journal J. Biol. Chem. volume 243 pages 676&ndash 7 pmid 4866525 issue 3 cite journal author Hartmann MD, Bourenkov GP, Oberschall ... kinase from Mycobacterium tuberculosis. journal J. Mol. Biol. volume 364 pages 411&ndash 23 pmid 17020768 doi 10.1016 j.jmb.2006.09.001 issue 3 enzyme stub Category EC 2.7.1 Category Enzymes of known ... more details
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