Chembox verifiedrevid 410484218 ImageFile Phosphatidylinositol 3,4,5 trisphosphate.svg ImageSize IUPACName OtherNames PI 3,4,5 P sub 3 sub , PtdIns 3,4,5 P sub 3 sub Section1 Chembox Identifiers CASNo Ref cascite correct ?? CASNo PubChem SMILES Section2 Chembox Properties Formula C sub 47 sub H sub 86 sub O sub 22 sub P sub 4 sub MolarMass 1126.46 g mol, neutral with fatty acid composition 18 0, 20 4 Appearance Density MeltingPt BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition Phosphatidylinositol 3,4,5 triphosphate PtdIns 3,4,5 P sub 3 sub , abbreviated PIP sub 3 sub , is the product of the class I phosphoinositide 3 kinases PI 3 kinases phosphorylation on phosphatidylinositol 4,5 bisphosphate PIP sub 2 sub . Discovery In the mid 1980s, Lewis C. Cantley published a series of papers describing the discovery of a novel type of phosphoinositide kinase with the unprecedented ability to phosphorylate the 3 position of the inositol ring. ref name Whitman cite journal author Whitman M, Downes CP, Keeler M, Keller T, Cantley L title Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol 3 phosphate journal Nature volume 332 issue 6165 pages 644 6 year 1988 month April pmid 2833705 doi 10.1038 332644a0 url ref Subsequent studies demonstrated that in vivo the enzyme prefers PtdIns 4,5 P2 as a substrate, producing the product PIP3. ref name Auger cite journal author Auger KR, Serunian LA, Soltoff SP, Libby P, Cantley LC title PDGF dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells journal Cell volume 57 issue 1 pages 167 75 year 1989 month April pmid 2467744 doi 10.1016 0092 8674 89 90182 7 url ref PIP3 had been previously identified in human neutrophils following stimulation with chemotactic peptide ref name Traynor Kaplan cite journal author Traynor Kaplan AE ... SH2 containing inositol phosphatase on the 5 position of the inositol ring, producing phosphatidylinositol ... more details
. The inositol can be phosphorylated to form phosphatidylinositol phosphate PIP , phosphatidylinositol bisphosphate PIP sub 2 sub and Phosphatidylinositol 3,4,5 trisphosphatephosphatidylinositoltrisphosphate ... Hazards MainHazards FlashPt Autoignition Phosphatidylinositol abbreviated PtdIns, or PI is a negatively .... Biosynthesis Image Biosynthesis of Phosphatidylinositol.jpg thumb Biosynthesis of phosphatidylinositol catalyzed by phosphatidylinositol synthase. Figure adapted from Christopher, K. van Holde, K.E. ... Holde, K.E. Ahern, Kevin G., date 2005 ref . The synthesis of phosphatidylinositol is catalyzed by phosphatidylinositol ... research topic. Phosphatidylinositol is classified as a glycerophospholipid that contains a glycerol ... as the most acidic phospholipid. Phosphoinositides Phosphorylated forms of phosphatidylinositol ... of the following phosphoinositides have been found in animals Phosphatidylinositol monophosphates Phosphatidylinositol 3 phosphate , also known as PtdIns3 P or PI 3 P Phosphatidylinositol 4 phosphate , also known as PtdIns4 P or PI 4 P Phosphatidylinositol 5 phosphate , also known as PtdIns5 P or PI 5 P Phosphatidylinositol bisphophosphates Phosphatidylinositol 3,4 bisphosphate , also known as PtdIns 3,4 P or PI 3,4 P sub 2 sub Phosphatidylinositol 3,5 bisphosphate , also known as PtdIns 3,5 P or PI 3,5 P sub 2 sub Phosphatidylinositol 4,5 bisphosphate , also known as PtdIns 4,5 P , PI 4,5 P sub 2 sub or often simply referred to as PIP sub 2 sub Phosphatidylinositol trisphophosphate Phosphatidylinositol 3,4,5 trisphosphate , also known as PtdIns 3,4,5 P or PI 3,4,5 P sub 3 sub These phosphoinositides ... B first Pical C coauthors , date 2002 ref . References references See also commonscat Phosphatidylinositol PI 3 kinase Inositol phosphate Phosphatidylinositol 3 phosphate Phosphatidylinositol 4 phosphate Phosphatidylinositol 5 phosphate Phosphatidylinositol 3,4 bisphosphate Phosphatidylinositol 3,5 bisphosphate Phosphatidylinositol 4,5 bisphosphate Inositol 1,4,5 triphosphate Phosphatidylinositol ... more details
Use mdy dates date February 2011 Year dab 345 Year nav 345 M1 year in topic NOTOC Year 345 Roman numerals CCCXLV was a common year starting on Tuesday link will display the full calendar of the Julian calendar . At the time, it was known as the Year of the Consulship of Amantius and Albinus or, less frequently, year 1098 Ab urbe condita . The denomination 345 for this year has been used since the early medieval period, when the Anno Domini calendar era became the prevalent method in Europe for naming years. Events onlyinclude By place India The merchant Knai Thomman visits the Malabar Coast in Kerala India and assists the church there. onlyinclude Births Evagrius Ponticus , Christian monk and Asceticism ascetic d. 399 Flavius Afranius Syagrius , Roman politician and administrator Quintus Aurelius Symmachus , Roman Roman consul consul and intellectual d. 402 Tyrannius Rufinus Tyrannius of Aquileia , List of historians historian and Theology theologian approximate date Deaths References Reflist DEFAULTSORT 345 Category 345 af 345 am 345 . . . ar 345 an 345 ast 345 az 345 bn map bms 345 be 345 be x old 345 bh bs 345 br 345 bg 345 ca 345 cv 345 cs 345 co 345 cy 345 da 345 de 345 et 345 el 345 es 345 eo 345 eu 345 fa fr 345 fy 345 gd 345 gl 345 gan 345 ko 345 hy 345 hr 345. io 345 bpy id 345 os 345 it 345 he 345 jv 345 ka 345 kk 345 sw 345 ht 345 almanak jilyen la 345 lb 345 lt 345 m. lmo 345 hu 345 mk 345 mr . . ms 345 nah 345 nl 345 new ja 345 nap 345 no 345 nn 345 oc 345 or uz 345 pa pi pnb 345 nds 345 pl 345 pt 345 ro 345 qu 345 ru 345 sa sq 345 scn 345 sk 345 sl 345 sr 345 sh 345 su 345 fi 345 sv 345 tl 345 tt 345 th . . 888 tr 345 tk 345 uk 345 ur 345 vec 345 vi 345 vo 345 war 345 yo 345 zh 345 ... more details
Image Inositol 1,4,5 trisphosphate.svg thumb The inositol trisphosphate trianion Inositol trisphosphate or inositol 1,4,5 trisphosphate also commonly known as triphosphoinositol abbreviated InsP sub 3 sub or IP sub 3 sub , together with diglyceride diacylglycerol DAG , is a secondary messenger molecule used in signal transduction and lipid signaling in cell biology biological cell s. While DAG stays inside the membrane, IP sub 3 sub is soluble and diffuses through the cell. It is made by hydrolysis of phosphatidylinositol 4,5 bisphosphate PIP sub 2 sub , a phospholipid that is located in the plasma membrane , by phospholipase C PLC . Properties of IP3 Chemical Formula and Molecular Weight IP sub 3 sub is a polyatomic ion with a molecular mass of 420.10 g mol. Its empirical formula is C sub 6 sub H sub 15 sub O sub 15 sub P sub 3 sub . It is composed of an inositol ring with three phosphate groups bound at the 1, 4, and 5 carbon positions, and three hydroxyl groups bound at positions 2, 3, and 6. ref Pubmed. 2011 . Inostiol 1,4,5 Trisphosphate Compound Summary. Retrieved from http pubchem.ncbi.nlm.nih.gov summary summary.cgi?cid 439456&loc ec rcs ref Chemical proprieties of phosphate group and IP sub 3 sub Phosphate groups can exist in three different forms depending on a solution s pH . Phosphorous atoms can bind three oxygen atoms with single bonds and a fourth oxygen atom using a double bond. The pH of the solution, and thus the form of the phosphate group determines its ability ..., which is called the inositol trisphosphate receptor Ins3PR , was first studied using deletion mutagenesis ... P phosphate was incorporated into the phosphatidylinositol of pancreas slices when stimulated with acetylcholine ... last1 Worley first1 PF last2 Baraban first2 JM last3 Snyder first3 SH title Inositol 1,4,5 trisphosphate ... Purkinje neurons at the inositol trisphosphate receptor journal J. Neurosci. volume 28 issue 1 pages ... 1,4,5 Trisphosphate Lipid signaling Calcium signaling Phospholipids DEFAULTSORT Inositol Triphosphate ... more details
Phosphatidylinositol bisphosphate may refer to Phosphatidylinositol 3,4 bisphosphate Phosphatidylinositol 3,5 bisphosphate Phosphatidylinositol 4,5 bisphosphate disambig es Fosfatidilinositol bifosfato sr Fosfatidilinozitol bisfosfat ... more details
Phosphatidylinositol phosphate may refer to Phosphatidylinositol 3 phosphate , also known as PI 3 P Phosphatidylinositol 4 phosphate , also known as PI 4 P Phosphatidylinositol 5 phosphate , also known as PI 5 P disambig Category Phospholipids ... more details
Image Phosphatidylinositol 3,5 bisphosphate.jpg thumb right 250px Chemical structure of sn 1 stearoyl 2 arachidonoyl phosphatidylinositol 3,5 bisphosphate Phosphatidylinositol 3,5 bisphosphate PtdIns 3,5 P sub 2 sub or PI 3,5 P sub 2 sub is a minor phospholipid component of cell membranes, yet important in distinguishing cell compartments. The generation of PtdIns 3,5 P sub 2 sub in intracellular membranes by the lipid kinase PIKFYVE PIKfyve recruits a number of important proteins involved in regulating intracellular trafficking ref cite journal author Michell RH, Heath VL, Lemmon MA, Dove SK title Phosphatidylinositol 3,5 bisphosphate metabolism and cellular functions journal Trends Biochem. Sci. volume 31 issue 1 pages 52 63 year 2006 month January pmid 16364647 doi 10.1016 j.tibs.2005.11.013 url ref . PtdIns 3,5 P sub 2 sub is dephophosphorylated at the 5 position by the phosphatase FIG4 , and by members of the myotubularin lipid phosphatase family at the 3 position of the inositol ring generating Phosphatidylinositol 5 phosphate PtdIns5 P . The phosphoinositide binding domain in a number of proteins binds to PtdIns 3,5 P sub 2 sub , including the PH domain in centaurin 2 Citation needed date January 2011 , the PX domain of SNX1 Citation needed date January 2011 , and a WD40 repeat domain in Atg18p ref cite journal author Dove SK, Piper RC, McEwen RK, et al. title Svp1p defines a family of phosphatidylinositol 3,5 bisphosphate effectors journal EMBO J. volume 23 issue 9 pages 1922 33 year 2004 month May pmid 15103325 pmc 404323 doi 10.1038 sj.emboj.7600203 url ref . References Reflist External links MeshName phosphatidylinositol 3,5 bisphosphate Category Phospholipids Cell biology stub Phospholipids es Fosfatidilinositol 3,5 bifosfato pl 3,5 Bisfosforan fosfatydyloinozytolu ... more details
Unreferenced stub auto yes date December 2009 Chembox verifiedrevid 402031007 ImageFile Phosphatidylinositol 3 phosphate.svg ImageSize IUPACName OtherNames sn 1 stearoyl 2 arachidonoyl phosphatidylinositol 3 phosphate Section1 Chembox Identifiers CASNo Ref cascite correct ?? CASNo PubChem 6857403 SMILES Section2 Chembox Properties Formula C sub 11 sub H sub 20 sub O sub 16 sub P sub 2 sub MolarMass 470.214 g mol, neutral with fatty acid composition 18 0, 20 4 Appearance Density MeltingPt BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition Phosphatidylinositol 3 phosphate PtdIns3 P or PI3P is a phospholipid found in cell membranes that helps to recruit a range of proteins, many of which are involved in protein trafficking, to the membranes. It is the product of both the class II and III phosphoinositide 3 kinases PI 3 kinases activity on phosphatidylinositol . PtdIns3 P is dephophosphorylated by the myotubularin family of phosphatase s, on the D3 position of the inositol ring, and can be converted to Phosphatidylinositol 3,5 bisphosphate PtdIns 3,5 P sub 2 sub by the lipid kinase PIKFYVE PIKfyve . Both FYVE domains and PX domain s &ndash found in proteins such as SNX1 , Hrs , and EEA1 &ndash bind to PtdIns3 P . The majority of PtdIns3 P appears to be constitutively synthesised by the class III PI 3 kinase , Vps34, at endocytic membranes. Class II PI 3 kinases also appear to synthesise PtdIns3 P , their activity however appears to be regulated by a range of stimuli, including growth factors. This suggests that specific pools of PtdIns3 P may be synthesised upon cell stimulation. Phospholipids DEFAULTSORT Phosphatidylinositol 3 Phosphate Category Phospholipids Category EC 2.7.1 Transferase stub ru 3 ... more details
Unreferenced stub auto yes date December 2009 Image 1 Phosphatidyl 1D myo Inositol 4,5 bisphosphat.svg thumb General structure Image Phosphatidylinositol 3,4 bisphosphate.svg thumb right 250px Chemical structure of sn 1 stearoyl 2 arachidonoyl phosphatidylinositol 3,4 bisphosphate Phosphatidylinositol 3,4 bisphosphate PtdIns 3,4 P sub 2 sub is a minor phospholipid component of cell membranes, yet an important second messenger . The generation of PtdIns 3,4 P sub 2 sub at the plasma membrane activates a number of important cell signaling pathways. PtdIns 3,4 P sub 2 sub is dephophosphorylated by the phosphatase INPP4B on the 4 position of the inositol ring and by the TPTE transmembrane phosphatases with tensin homology family of phosphatases on the 3 position of the inositol ring. The PH domain in a number of proteins binds to PtdIns 3,4 P sub 2 sub including the PH domain in PKB . The generation of PtdIns 3,4 P sub 2 sub at the plasma membrane upon the activation of class I PI 3 kinases and SHIP phosphatases causes these proteins to translocate to the plasma membrane, thereby effecting their activity. Phospholipids DEFAULTSORT Phosphatidylinositol 3,4 Bisphosphate Category Phospholipids Cell biology stub de Phosphatidylinositol 4,5 bisphosphate es Fosfatidilinositol 3,4 bifosfato ... more details
Phosphatidylinositol 4 phosphate PtdIns4 P or PI4P is a precursor of Phosphatidylinositol 4,5 bisphosphate . PtdIns4 P is prevalent in the membrane of the Golgi apparatus . In the Golgi apparatus , PtdIns4 P binds to the GTP binding protein ARF and to effector protein s, including four phosphate adaptor protein 1 and 2 FAPP1 and FAPP2 . ref Godi A et al., FAPPs control Golgi to cell surface membrane traffic by binding to ARF and PtdIns 4 P. Nat Cell Biol. 2004 May 6 5 393 404. ref This three molecule complex recruits proteins that need to be carried to the cell membrane . ref Choudhury RR, Hyvola N, Lowe M. Phosphoinositides and membrane traffic at the trans Golgi network. Biochem Soc Symp. 2005 72 31 8. ref References references Phospholipids Biochemistry stub Category Phospholipids Category Signal transduction ... more details
enzyme Name phosphatidylinositol deacylase EC number 3.1.1.52 CAS number 81604 94 6 IUBMB EC number 3 1 1 52 GO code 0050185 image width caption In enzymology , a phosphatidylinositol deacylase EC number 3.1.1.52 is an enzyme that catalysis catalyzes the chemical reaction 1 phosphatidyl D myo inositol H sub 2 sub O math rightleftharpoons math 1 acylglycerophosphoinositol a carboxylate Thus, the two substrate biochemistry substrates of this enzyme are 1 phosphatidyl D myo inositol and water H sub 2 sub O , whereas its two product chemistry products are 1 acylglycerophosphoinositol and carboxylate . This enzyme belongs to the family of hydrolase s, specifically those acting on carboxylic ester bonds. The systematic name of this enzyme class is 1 phosphatidyl D myo inositol 2 acylhydrolase . Other names in common use include phosphatidylinositol phospholipase A2 , and phospholipase A2 . References reflist 1 cite journal author Gray NC, Strickland KP date 1982 title The purification and characterization of a phospholipase A2 activity from the 106,000 X g pellet microsomal fraction of bovine brain acting on phosphatidylinositol journal Can. J. Biochem. volume 60 pages 108&ndash 17 pmid 7083039 issue 2 cite journal author Gray NC, Strickland KP date 1982 title On the specificity of a phospholipase A2 purified from the 106,000 X g pellet of bovine brain journal Lipids. volume 17 pages 91&ndash 6 pmid 7087686 doi 10.1007 BF02535181 issue 2 hydrolase stub Category EC 3.1.1 Category Enzymes of unknown structure ... more details
enzyme Name phosphatidylinositol alpha mannosyltransferase EC number 2.4.1.57 CAS number 37277 65 9 IUBMB EC number 2 4 1 57 GO code 0043750 image width caption In enzymology , a phosphatidylinositol alpha mannosyltransferase EC number 2.4.1.57 is an enzyme that catalysis catalyzes the chemical reaction in which at least one alpha D mannose residues are transferred from GDP mannose to positions 6, 2 and others in 1 phosphatidyl myo inositol . This enzyme belongs to the family of glycosyltransferase s, specifically the hexosyltransferases. The systematic name of this enzyme class is GDP mannose 1 phosphatidyl 1D myo inositol alpha D mannosyltransferase . Other names in common use include GDP mannose phosphatidyl myo inositol alpha mannosyltransferase , GDPmannose 1 phosphatidyl myo inositol alpha D mannosyltransferase , guanosine diphosphomannose phosphatidyl inositol , alpha mannosyltransferase , and phosphatidyl myo inositol alpha mannosyltransferase . References reflist 1 cite journal author Brennan P, Ballou CE date 1968 title Phosphatidylmyoinositol monomannoside in Propionibacterium shermanii journal Biochem. Biophys. Res. Commun. volume 30 pages 69&ndash 75 pmid 4295288 doi 10.1016 0006 291X 68 90714 6 issue 1 enzyme stub Category EC 2.4.1 Category Enzymes of unknown structure it Fosfatidilinositolo alfa mannosiltransferasi ... more details
Phosphatidylinositol 5 phosphate PtdIns5P or PI5P is one of the seven Phosphatidylinositol phosphoinositides , and is the last to have been discovered to be naturally occurring. In 1997 Lucia Rameh, while working as a postdoctoral fellow with Lewis C. Cantley observed that the enzymes referred to as type II PIP kinases did not utilize PtdIns4P as a substrate as had been proposed . In fact, they required PtdIns5P as a substrate to produce PtdIns 4,5 P2. The observation immediately suggested that cells must contain a natural pool of PtdIns 5 P, a prediction that was verified by Rameh, Cantley, and colleagues. ref name Rameh cite journal author Rameh LE, Tolias KF, Duckworth BC, Cantley LC title A new pathway for synthesis of phosphatidylinositol 4,5 bisphosphate journal Nature volume 390 issue 6656 pages 192 6 year 1997 month November pmid 9367159 doi 10.1038 36621 url ref The function of PtdIns5P remains uncertain, especially since no specific PtdIns5P binding proteins have been unambiguously identified. There is some thought that it may function in membrane trafficking from late endosomes to the plasma membrane . ref name pmid18774718 cite journal author Lecompte O, Poch O, Laporte J title PtdIns5P regulation through evolution roles in membrane trafficking? journal Trends Biochem. Sci. volume 33 issue 10 pages 453 460 year 2008 month October pmid 18774718 pmc doi 10.1016 j.tibs.2008.07.002 url issn ref References reflist Phospholipids Biochemistry stub Category Phospholipids ... more details
Use mdy dates date February 2011 Year nav 345 BC year in topic 345 NOTOC Year 345 BC was a year of the Roman calendar pre Julian Roman calendar . At the time it was known as the Year of the Consulship of Dorsuo and Camerinus or, less frequently, year 409 Ab urbe condita . The denomination 345 BC for this year has been used since the early medieval period, when the Anno Domini calendar era became the prevalent method in Europe for naming years. Events onlyinclude By place Greece Supported by Thebes, Greece Thebes and Thessaly , Macedon ia takes over Phocis votes in the Amphictyonic League , a Greek religious organisation formed to support the greater temples of Apollo and Demeter . Despite some reluctance on the part of the Athenian leaders, Athens finally accepts Philip II of Macedon Philip II s entry into the Council of the League. The Athenian statesman, Demosthenes , is among those who recommend this stance in his oration On the Peace . onlyinclude Births Deaths Nicochares , Athens Athenian poet of the Old Comedy References Reflist DEFAULTSORT 345 Bc Category 345 BC ast 345 edC be 345 . . be x old 345 . . bs 345 p.n.e. ca 345 aC cs 345 p . n. l. cy 345 CC da 345 f.Kr. de 345 v. Chr. el 345 . . es 345 a. C. eo 345 eu K. a. 345 fa fr 345 gl 345 ko 345 hy . . . 345 hr 345. pr. Kr. io 345 aK id 345 SM it 345 a.C. ka . . 345 kk . . . 345 sw 345 KK la 345 a.C.n. lb 345 lt 345 m. pr. m. e. hu I. e. 345 mk 345 . . . mr . . . ms 345 SM nl 345 v.Chr. ne . . new nap 345 AC no 345 f.Kr. oc 345 uz Mil. av. 345 pl 345 p.n.e. pt 345 a.C. ro 345 .Hr. ru 345 . . sq 345 p.e.s. sk 345 pred Kr. sl 345 pr. n. t. sr 345. . . . sh 345. pne. su 345 SM fi 345 eaa. sv 345 f.Kr. tl 345 BC th . . 199 uk 345 . . vec 345 a.C. war 345 UC yo 345 SK zh 345 ... more details
Infobox planet width 25em background FFFFC0 name 345 Tercidina discoverer Auguste Charlois discovered November 23, 1892 alt names 1892 O mp category Asteroid belt Main belt epoch 30 January 2005 Julian day JD 2453400.5 semimajor 347.812 Giga G m 2.325 Astronomical unit AU perihelion 326.411 Gm 2.182 AU aphelion 369.214 Gm 2.468 AU eccentricity 0.062 period 1294.85 day d 3.55 Julian year astronomy a inclination 9.751 degree angle asc node 212.797 arg peri 229.931 mean anomaly 201.557 avg speed 19.53 km second s dimensions 126x94x90km ref name Richard ref name euroster ref name jpldata br 94 km ref name jpldata cite web date 2008 08 26 last obs title JPL Small Body Database Browser 345 Tercidina 1892 O url http ssd.jpl.nasa.gov sbdb.cgi?sstr 345 accessdate 2008 12 03 ref mass 1.1 e 18 ? kg ref Using the Volume Volume formulas volume of an ellipsoid of 126x94x90km an assumed density of 2 g cm yields a mass m d v of 1.116E 18 kg ref density unknown surface grav unknown escape velocity unknown ... 8.71 ref name jpldata albedo 0.065 ref name jpldata single temperature unknown 345 Tercidina is a large ... url http www.euraster.net results 2002 index.html 0917 345 accessdate 2008 12 03 http www.euraster.net ... 111 km. ref name Richard cite web date 2005 11 15 title 345 Tercidina 2005 Nov 15 publisher Richard ... 345 20Tercidina accessdate 2008 12 03 ref This larger result may be caused by a different orientation ... sbdb.cgi?sstr 345 orb 1 Orbital simulation from JPL Java http ssd.jpl.nasa.gov horizons.cgi?find body 1&body group sb&sstr 345 Ephemeris Minor planets navigator 344 Desiderata 346 Hermentaria ... stub de 345 Tercidina el 345 es 345 Tercidina eo 345 Tercidino eu 345 Tercidina fa fr 345 Tercidina it 345 Tercidina la 345 Tercidina hu 345 Tercidina ja no 345 Tercidina nn 345 Tercidina pl 345 Tercidina pt 345 Tercidina sk 345 Tercidina sl 345 Tercidina sr 345 Tercidina tl 345 Tercidina uk 345 vi 345 Tercidina yo 345 Tercidina zh 345 ... more details
Prisoner 345 is a 2006 in film 2006 documentary film about detained Al Jazeera cameraman Sami Al Hajj , who was detained at the United States detainee camp at Guantanamo Bay detention camp in 2002. The film retells the arrest of Al Hajj at the Afghan Pakistani border. The film has been shown at international film festivals in Australia, Canada, Lebanon, New Zealand and the United States. The film runs 50 minutes and is a production of the Al Jazeera television network. The film is produced by Ahmad Ibrahim & Abdallah El Binni and directed by Abdallah El Binni. The film has been distributed to Amnesty International , Human Rights Watch , Reporters Without Borders , and Reprieve organisation Reprieve . ref Prisoner 345 takes the Story of Al Hajj to the Screen, MEB Journal, http www.mebjournal.com index.php?option content&task view&id 151 ref References references External links http www.youtube.com watch?v wB ijz2I9VI Film in full length at YouTube imdb title id 0860511 title Prisoner 345 http www.onthemedia.org episodes 2007 07 27 segments 82946 Link to article on National Public Radio s On the Media Category 2006 films Category Documentary films about law poli documentary film stub ... more details
New Testament manuscript infobox form Minuscule number 345 image isize caption name sign text Gospel s script Greek language Greek date 11th century found now at Biblioteca Ambrosiana cite Scholz, Biblisch kritische Reise 1823 size 14.8 11.4 cm type mixed cat hand note full marginalia Minuscule 345 in the Biblical manuscript Gregory Aland Gregory Aland numbering , 119 Biblical manuscript Von Soden Soden , ref name Gregory1908 cite book last Gregory first Caspar Ren authorlink Caspar Ren Gregory title Die griechischen Handschriften des Neuen Testament url http www.archive.org stream diegriechischen00greggoog page n71 mode 2up year 1908 publisher J. C. Hinrichs sche Buchhandlung location Leipzig page 60 ref is a Greek language Greek Lower case minuscule manuscript of the New Testament , on parchment. Palaeography Paleographically it has been assigned to the 11th century. The manuscript was prepared for Church reading. It has full marginalia . Description The codex contains a complete text of the four Gospel s on 375 parchment leaves 14.8 11.4 cm with only some Lacuna manuscripts lacunae e.g. in Matthew 1 1 10 the ornamented heading . The text is written in two columns per page, in 15 lines per page. ref name Aland Cite book last Aland first Kurt authorlink Kurt Aland coauthors M. Welte, B. K ster, K. Junack title Kurzgefasste Liste der griechischen Handschriften des Neues Testaments publisher Walter de Gruyter year 1994 location Berlin, New York page 67 url doi id isbn 3110119862 ref The text is divided according to the lang grc chapters , whose numbers are given at the margin, and their titles of chapters at the top of the pages. There is also a division according to the smaller Ammonian Sections in Mark 237 Sections, the last in 16 16 , with references to the Eusebian Canons written below Ammonian Section numbers . ref name Gregory It contains lectionary markings at the margin for Church reading , subscriptions at the end of each Gospel, with numbers ... more details
enzyme Name inositol trisphosphate 3 kinase EC number 2.7.1.127 CAS number 106283 10 7 IUBMB EC number 2 7 1 127 GO code 0008440 image width caption In enzymology , an inositol trisphosphate 3 kinase EC number 2.7.1.127 is an enzyme that catalysis catalyzes the chemical reaction ATP 1D myo inositol 1,4,5 trisphosphate math rightleftharpoons math ADP 1D myo inositol 1,3,4,5 tetrakisphosphate Thus, the two substrate biochemistry substrates of this enzyme are adenosine triphosphate ATP and 1D myo inositol 1,4,5 trisphosphate , whereas its two product chemistry products are adenosine diphosphate ADP and 1D myo inositol 1,3,4,5 tetrakisphosphate . This enzyme belongs to the family of transferase s, specifically those transferring phosphorus containing groups phosphotransferase s with an alcohol group as acceptor. The systematic name of this enzyme class is ATP 1D myo inositol 1,4,5 trisphosphate 3 phosphotransferase . Other names in common use include 1D myo inositol trisphosphate 3 kinase , and Ins 1,4,5 P3 3 kinase . This enzyme participates in 3 metabolism metabolic pathways inositol phosphate metabolism , calcium signaling pathway , and phosphatidylinositol signaling system . This enzyme has at least one effector biology effector , Calcium . Structural studies As of late 2007, 3 tertiary structure structures have been solved for this class of enzymes, with Protein Data Bank PDB accession codes PDB link 1TZD , PDB link 2A98 , and PDB link 2AQX . References reflist 1 cite journal author Hansen CA, Mah S, Williamson JR date 1986 title Formation and metabolism of inositol 1,3,4,5 tetrakisphosphate in liver journal J. Biol. Chem. volume 261 pages 8100&ndash 3 pmid 3487541 issue 18 cite journal author Irvine RF, Letcher AJ, Heslop JP, Berridge MJ date 1986 title The inositol tris tetrakisphosphate pathway &mdash demonstration of Ins 1,4,5 P3 3 kinase activity in animal tissues journal Nature. volume 320 pages 631&ndash 4 pmid 3010126 doi 10.1038 320631a0 issue 6063 cite journal ... more details
protein Name ITPR1 inositol 1,4,5 trisphosphate receptor, type 1 ref name pmid15664189 cite journal author Bosanac I, Yamazaki H, Matsu Ura T, Michikawa T, Mikoshiba K, Ikura M title Crystal structure of the ligand binding suppressor domain of type 1 inositol 1,4,5 trisphosphate receptor journal Mol. Cell volume 17 issue 2 pages 193 203 year 2005 month January pmid 15664189 doi 10.1016 j.molcel.2004.11.047 url ref caption Crystal structure of the ligand binding suppressor domain of type 1 inositol 1,4,5 trisphosphate receptor image 1XZZ.pdb.jpg width HGNCid 6180 Symbol ITPR1 AltSymbols EntrezGene 3708 OMIM 147265 RefSeq NM 002222 UniProt Q14643 PDB ECnumber Chromosome 3 Arm p Band 26.1 LocusSupplementaryData protein Name ITPR2 inositol 1,4,5 trisphosphate receptor, type 2 caption image width HGNCid Crystal structure of the ligand binding suppressor domain of type 1 inositol 1,4,5 trisphosphate receptor 6181 Symbol ITPR2 AltSymbols EntrezGene 3709 OMIM 600144 RefSeq NM 002223 UniProt Q14571 ... trisphosphate receptor, type 3 caption image width HGNCid 6182 Symbol ITPR3 AltSymbols EntrezGene ... Inositol trisphosphate receptor InsP3R is a membrane glycoprotein complex acting as calcium channel Ca sup 2 sup channel activated by inositol trisphosphate InsP3 . InsP3R is very diverse ... of the inositol 1,4,5 trisphosphate receptor binding core in complex with its ligand journal ... trisphosphate receptor journal Jpn. J. Pharmacol. volume 74 issue 2 pages 125 37 year 1997 month ... pubmed 17429043?dopt Citation Inositol trisphosphate receptor Ca2 release chann... Physiol ... Bosanac I, Alattia JR, Mal TK, et al. title Structure of the inositol 1,4,5 trisphosphate receptor ... pharmacological activity. See also inositol inositol phosphate inositol monophosphate inositol trisphosphate .... References reflist External links MeshName Inositol Trisphosphate Receptor Lipid signaling Ion channels g1 DEFAULTSORT Inositol Trisphosphate Receptor Category Signal transduction Category Transmembrane ... more details
Orphan date February 2009 Pfam box Symbol IP trans Name image 2a1l.gif width 220 caption Phosphatidylinositol transfer protein, beta isoform Pfam PF02121 InterPro IPR001666 SMART Prosite SCOP 1fvz TCDB OPM family 147 OPM protein 2a1l PDB PDB3 2a1l A 2 254 PDB3 1t27 A 2 255 PDB3 1kcm A 2 255 PDB3 1uw5 C 2 254 Phosphatidylinositol transfer protein PITP or priming in exocytosis protein 3 PEP3 is a ubiquitous cytosolic domain involved in transport of phospholipid s from their site of synthesis in the endoplasmic reticulum and Golgi to other cell membrane s. ref name PUB00000922 cite journal author Liscovitch M, Cantley LC title Signal transduction and membrane traffic the PITP phosphoinositide connection journal Cell volume 81 issue 5 pages 659 662 year 1995 pmid 7774006 doi 10.1016 0092 8674 95 90525 1 ref ref name pmid8255295 cite journal author Hay JC, Martin TF title Phosphatidylinositol transfer protein required for ATP dependent priming of Ca 2 activated secretion journal Nature volume 366 issue 6455 pages 572 5 year 1993 month December pmid 8255295 doi 10.1038 366572a0 ref Biological function PITP has been also shown to be an essential component of the polyphosphoinositide synthesis machinery and is hence required for proper signalling by epidermal growth factor and f Met Leu Phe, as well as for exocytosis . The role of PITP in polyphosphoinositide synthesis may also explain ... one molecule of phosphatidylinositol PI or phosphatidylcholine PC and thus aids their transfer between ... of phosphatidylinositol transfer proteins journal Genome Biol. volume 2 issue 9 pages REVIEWS3011 year ... of human phosphatidylinositol transfer proteins has several members Phosphatidylinositol transfer protein, alpha PITPNA Phosphatidylinositol transfer protein, beta PITPNB Phosphatidylinositol transfer protein, cytoplasmic 1 PITPNC Phosphatidylinositol transfer protein, membrane associated 1 PITPNM1 Phosphatidylinositol transfer protein, membrane associated 2 PITPNM2 PITPNM family member 3 PITPNM3 ... more details
enzyme Name phosphatidylinositol diacylglycerol lyase EC number 4.6.1.13 CAS number 37288 19 0 IUBMB EC number 4 6 1 13 GO code 0004436 image width caption Image 1t6m.gif thumb right 500 Phosphatidylinositol specific phospholipase C , image from OPM database In enzymology , a phosphatidylinositol diacylglycerol lyase EC number 4.6.1.13 is an enzyme that catalysis catalyzes the chemical reaction 1 phosphatidyl 1D myo inositol math rightleftharpoons math 1D myo inositol 1,2 cyclic phosphate 1,2 diacyl sn glycerol Hence, this enzyme has one substrate biochemistry substrate , 1 phosphatidyl 1D myo inositol , and two product chemistry products , 1D myo inositol 1,2 cyclic phosphate and 1,2 diacyl sn glycerol . This enzyme belongs to the family of lyase s, specifically the class of phosphorus oxygen lyases. The systematic name of this enzyme class is 1 phosphatidyl 1D myo inositol 1,2 diacyl sn glycerol lyase 1D myo inositol 1,2 cyclic phosphate forming . Other names in common use include monophosphatidylinositol phosphodiesterase , phosphatidylinositol phospholipase C , 1 phosphatidylinositol phosphodiesterase , 1 phosphatidyl D myo inositol inositolphosphohydrolase , cyclic phosphate forming , 1 phosphatidyl 1D myo inositol diacylglycerol lyase , and 1,2 cyclic phosphate forming . This enzyme participates in inositol phosphate metabolism . Structural studies As of late 2007, two tertiary structure structures have been solved for this class of enzymes, with Protein Data Bank PDB accession codes PDB link 1T6M and PDB link 2OR2 . References reflist 1 cite journal author Allan D, Michell RH date 1974 title Phosphatidylinositol cleavage catalysed by the soluble fraction from lymphocytes ... cyclis phosphate as a product of phosphatidylinositol breakdown by phospholipase C Bacillus cereus ... by a phosphatidylinositol specific phospholipase C journal Biochem. J. volume 167 pages 281 ... H, Low MG date 1988 title Sequence of the Bacillus thuringiensis phosphatidylinositol specific ... more details
PBB geneid 5306 Phosphatidylinositol transfer protein alpha isoform is a protein that in humans is encoded by the PITPNA gene . ref name pmid8255295 cite journal author Hay JC, Martin TF title Phosphatidylinositol transfer protein required for ATP dependent priming of Ca 2 activated secretion journal Nature volume 366 issue 6455 pages 572 5 year 1994 month Jan pmid 8255295 pmc doi 10.1038 366572a0 ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text Phosphatidylinositol transfer proteins are a diverse set of cytosolic phospholipid transfer proteins that are distinguished by their ability to transfer phospholipid s between membranes in vitro Wirtz, 1991 . ref cite web title Entrez Gene PITPNA phosphatidylinositol transfer protein, alpha url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 5306 accessdate ref References reflist Further reading refbegin PBB Further reading citations cite journal author Wirtz KW title Phospholipid transfer proteins journal Annu. Rev. Biochem. volume 60 issue pages 73 99 year 1991 pmid 1883207 doi 10.1146 annurev.bi.60.070191.000445 refend PDB Gallery geneid 5306 External links UMichOPM families superfamily 147 Category Water soluble transporters Category Peripheral membrane proteins membrane protein stub The PBB Controls template provides controls for Protein Box Bot, please see Template PBB Controls for details. PBB Controls update page yes require manual inspection no update protein box yes update summary no update citations yes ... more details
orphan date November 2007 Phosphatidylinositol phosphate kinases PIPK are kinase s that phosphorylate the phosphoinositide s PtdIns P and PtdIns P sub 2 sub that are derivatives of phosphatidylinositol PtdIns . It has been found that PtdIns is only phosphorylated on three 3,4,5 of its five hydroxyl groups, possibly because D 2 and D 6 hydroxyl groups cannot be phosphorylated because of steric hindrance ref Pettitt TR, Dove SK, Lubben A, Calaminus SDJ, Wakelam MJO. Analysis of intact phosphoinositides in biological samples. American Soc f Biochem and Mol Biol 2006 47 1588 1596 ref . All 7 combinations of phosphorylated PtdIns have been found in animal s, all except PtdIns 3,4,5 P sub 3 sub have been found in plant s ref Muller Roeber B, Pical C. Inositol Phospholipid Metabolism in Arabidopsis. Characterized and Putative Isoforms of Inositol Phospholipid Kinase and Phosphoinositide Specific Phospholipase C. Plant Physiol 2002 130 22 46 ref . PIPKs are today divided into three groups, type I, II and III that share significant sequence homology but differ in the substrate specificities, subcellular localisations and functions. ref Anderson RA, Boronenkov IV, Doughman SD, Kunz J, Loijens JC . Phosphatidylinositol phosphate kinases, a multifaceted family of signalling enzymes. J Biol Chem 1999 274 9907 9910 ref Type 1 are PIPKs that phosphorylate PtdIns4 P to PtdIns 4,5 P sub 2 sub and are called PtdIns4 P 5 kinases because they phosphorylate on the D 5 hydroxyl group. Type II PIPKs phosphorylate PtdIns5 P at the D 4 site and are called PtdIns5 P 4 kinases. And finally PIPKs of type III are PtdIns3 P 5 kinases that phosphorylate PtdIns to PtdIns 3,5 P sub 2 sub , which prototype is Fab1 in yeast see http jcs.biologists.org content vol114 issue12 images large JCS8533F1.jpeg for destriptic picture . The substrate specificity of type I and II depends on the so called activation .... The activation loop of phosphatidylinositol phosphate kinases determines signaling specificity. Mol ... more details
Orphan date July 2011 enzyme Name phosphatidylinositol N acetylglucosaminyltransferase EC number 2.4.1.198 CAS number 144388 35 2 IUBMB EC number 2 4 1 198 GO code 0017176 image width caption In enzymology , a phosphatidylinositol N acetylglucosaminyltransferase EC number 2.4.1.198 is an enzyme that catalysis catalyzes the chemical reaction UDP N acetyl D glucosamine 1 phosphatidyl 1D myo inositol math rightleftharpoons math UDP 6 N acetyl alpha D glucosaminyl 1 phosphatidyl 1D myo inositol Thus, the two substrate biochemistry substrates of this enzyme are UDP N acetyl D glucosamine and 1 phosphatidyl 1D myo inositol , whereas its two product chemistry products are uridine diphosphate UDP and 6 N acetyl alpha D glucosaminyl 1 phosphatidyl 1D myo inositol . This enzyme belongs to the family of glycosyltransferase s, to be specific the hexosyltransferases. The systematic name of this enzyme class is UDP N acetyl D glucosamine 1 phosphatidyl 1D myo inositol 6 N acetyl alpha D glucosaminyl transferase . Other names in common use include UDP N acetyl D glucosamine phosphatidylinositol , N acetyl D glucosaminyltransferase , uridine diphosphoacetylglucosamine , and alpha1,6 acetyl D glucosaminyltransferase . This enzyme participates in 3 metabolism metabolic pathways glycosylphosphatidylinositol gpi anchor , ???, and glycan structures biosynthesis 2 . References reflist 1 cite journal author Doering TL, Masterson WJ, Englund PT, Hart GW year 1989 title Biosynthesis of the glycosyl phosphatidylinositol membrane anchor of the trypanosome variant surface glycoprotein. Origin of the non acetylated glucosamine journal J. Biol. Chem. volume 264 pages 11168&ndash 73 pmid 2525555 issue 19 cite journal author Kinoshita T year 1998 title The first step of glycosylphosphatidylinositol biosynthesis is mediated by a complex of PIG A, PIG H, PIG C and GPI1 journal EMBO J. volume 17 pages 877&ndash 85 pmid 9463366 doi 10.1093 emboj 17.4.877 last2 Inoue first2 N last3 Westfall first3 B last4 ... more details
Phosphatidylinositol 3 kinase related kinases PIKKs are a family of serine threonine specific protein kinase Ser Thr protein kinase s with sequence similarity to phosphatidylinositol 3 kinases phosphoinositide 3 kinase PI3Ks . ref name pmid19779456 cite journal author Lempi inen H, Halazonetis TD title Emerging common themes in regulation of PIKKs and PI3Ks journal EMBO J. volume 28 issue 20 pages 3067 73 year 2009 month October pmid 19779456 pmc 2752028 doi 10.1038 emboj.2009.281 url issn ref Members The human PIKK family includes six members class wikitable style text align center Gene Protein Function ataxia telangiectasia mutated ATM ataxia telangiectasia mutated response to DNA damage Ataxia telangiectasia and Rad3 related ATR ataxia and Rad3 related DNA PKcs PRKDC DNA dependent protein kinase catalytic subunit DNA PKcs Mammalian target of rapamycin FRAP1 mammalian target of rapamycin mTOR nutrient regulated kinase that controls metabolism and cell growth SMG1 gene SMG1 suppressor of morphogenesis in genitalia regulates nonsense mediated messenger RNA mRNA decay transformation transcription domain associated protein TRRAP transformation transcription domain associated protein transcription factor coactivator genetics co activator Structure PIKKs proteins contain the following four protein domain domains N terminus FRAP ATM TRRAP FAT domain, Pfam PF02259 kinase domain KD phosphoinositide 3 kinase PI3 PI4 kinase , PIKK regulatory domain PRD , and C terminus FAT C terminal FATC domain Pfam PF02260 References Reflist protein stub Serine threonine specific protein kinases Intracellular signaling peptides and proteins Category EC 2.7.11 ... more details
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