otheruses lowercase PBB geneid 7157 p53 also known as protein 53 or tumor protein 53 , is a tumor suppressor ... of a human p53 cDNA clone expression of the human p53 gene journal EMBO J. volume 3 issue 13 pages ... author Isobe M, Emanuel BS, Givol D, Oren M, Croce CM title Localization of gene for human p53 ... A, Jarosz D, Friedman P, Prives C, Vogelstein B title Identification of p53 as a sequence specific DNA ... D, Givol D title The gene for human p53 cellular tumor antigen is located on chromosome 17 short arm ... pmc 322805 doi 10.1073 pnas.83.1.130 url ref p53 is crucial in multicellular organism s, where it regulates ... . As such, p53 has been described as the guardian of the genome because of its role in conserving ... 0 471 33061 2 oclc doi chapter Chapter 18 Cancer Genetics ref The name p53 is in reference to its apparent ... from its amino acid residues, p53 s mass is actually only 43.7 kDa. This difference is due to the high ... 257 18 11176.abstract ref This effect is observed with p53 from a variety of species, including humans, rodents, frogs, and fish. Nomenclature p53 is also known as UniProt name Cellular tumor antigen p53 Antigen NY CO 13 Phosphoprotein p53 Transformation related protein 53 TRP53 Tumor suppressor p53 Gene In humans, p53 is encoded by the TP53 gene located on the short arm of chromosome 17 human chromosome ... of p53 as a sequence specific DNA binding protein journal Science volume 252 issue 5013 pages 1708 ... TP53. ref May, P. and May, E. 1999 . Twenty years of p53 research structural and functional aspects of the p53 protein. Oncogene, 18 , 7621 36. ref TP53 orthologs ref name OrthoMaM cite web title OrthoMaM ... the protein it encodes. Structure Human p53 is 393 amino acid s long and has seven domain protein ... for the p53 proline rich functional domain for mediation of apoptosis is correlated with specific ... domain important for the apoptotic activity of p53 residues 64 92. central DNA binding core domain .... This region is responsible for binding the p53 co repressor LMO3 . ref name Larsen S, Yokochi T, Isogai ... more details
P53 may refer to P53 , a tumor suppressor protein P53 band , an experimental music group P53 album , a 1996 live album by experimental music group P53 disambig ... more details
Infobox musical artist See Wikipedia WikiProject Musicians name P53 image caption background group or band ... Rose br Zeena Parkins P53 , sometimes written p53 , was an experimental music group commissioned by English ... entitled P53 album P53 . ref name CD liner notes The group reassembled in May 1997 to play at the Angelica ... 2006 a new and reduced lineup of P53 performed with the BBC Scottish Symphony Orchestra in Glasgow , Scotland, which was recorded and broadcast by the BBC in March 2007. ref name BBC P53 was an musical ... sampling processing of the pianists. ref name amg ref name Tokoyo Cutler interview ref name Cutler P53 ... before there was time to give it its name, P53 consisted of Cutler percussion, electronics , German ... . ref name CD liner notes P53 s performance at the Frankfurt Jazz Festival was filmed and later broadcast several times on German television. ref name CD liner notes An album of the concert called P53 album P53 was also released by Recommended Records in 1996. ref name japanimprov p53 In May 1997 P53, with the same lineup, performed for the second time at the Angelica International Festival of contemporary ... of P53 comprising Cutler, Australian violinist Jon Rose and American harpist Zeena Parkins , to perform ... by the BBC on 24 March 2007. ref name BBC Music main P53 album The instrumentation of the P53 ..., electronics and real time processing. ref name amg ref name Cutler P53 The pianists were instructed ... s name was taken from the p53 tumor tumour suppressing gene ref group nb name nb1 that was discovered ... harp Discography Albums P53 album P53 1996, CD, Recommended Records , United Kingdom U.K. Appears on Various artists Angelica 1997 1998, CD, Dischi di Angelica, Italy includes one P53 track Footnotes reflist group nb refs ref group nb name nb1 P53 is actually a protein encoded by the TP53 gene, but the P53 album P53 CD liner notes refer to it as a gene . ref References reflist refs ref name CD liner notes P53 album P53 CD liner notes. ref ref name PSF Cutler interview cite web url http www.furious.com ... more details
Infobox Album Name P53 Type Live album Artist P53 band P53 Cover P53 AlbumCover P53.jpg Background orange Released 1996 Recorded 1994 Genre Experimental music Experimental , free improvisation Length 44 08 Label Recommended Records Recommended United Kingdom U.K. Producer Chris Cutler , Lutz Glandien Last album This album P53 br 1996 Next album P53 , sometimes written p53 , is a 1996 live album by experimental music group P53 band P53 . It was their debut album and was recorded at the 25th Frankfurt Jazz Festival in Germany on nowrap 16 September 1994. It was released in 1996 in the United Kingdom by Recommended Records . ref name CD liner notes P53 was an musical improvisation al project that involved ... name Cutler P53 Music The instrumentation of the P53 project consisted of two grand pianos, amplified ... amg ref name Cutler P53 Cutler s interest in sampling music sampling and turntablism began when it became ... This led to the idea of real time Sound collage montaging , which formed the basis of P53. ref name PSF Cutler interview Cutler established P53 as a free improvisation project within a predetermined .... Herb of Wired magazine Wired magazine described P53 as a surrealist adventure that must have been ... musical orthodoxy. ref name Wired Rick Anderson of Allmusic said while P53 is not the stuff for everyone ... scene in years. ref name amg Track listing P53 Chris Cutler Cutler , Marie Goyette Goyette , Zygmunt ... Liner notes by Chris Cutler References reflist refs ref name CD liner notes P53 CD liner notes ... title P53 work AllMusic first Rick last Anderson accessdate 2009 10 08 ref ref name Tokoyo Cutler ... 2009 10 08 ref ref name Cutler P53 cite web url http www.ccutler.com ccutler bands group09.shtml p53 title P53 work Chris Cutler homepage accessdate 2009 10 12 ref ref name Wired cite web url http www.wired.com wired archive 5.04 music reviews.html?pg 3 title P53 work Wired magazine Wired first ... P53 . discogs release id 1182399 name P53 . Category 1996 live albums Category Debut albums Category ... more details
Summary Cover of P53 band P53 album, P53 album P53 1996, Recommended Records Source http www.discogs.com viewimages?release 1182399 discogs.com Licensing Non free album cover Non free use rationale album cover Article P53 album Use Infobox ADDITIONAL INFORMATION Name P53 album P53 Artist P53 band P53 Label Recommended Records Graphic Artist Item Type CD Website Owner Commentary OVERRIDE FIELDS Description Source http www.discogs.com viewimages?release 1182399 Portion Low resolution Purpose Replaceability other information ... more details
P53 family The p53 p63 p73 family is a family of tumor suppressor gene s. ref name pmid10769197 cite journal author Levrero M, De Laurenzi V, Costanzo A, Gong J, Wang JY, Melino G title The p53 p63 p73 family of transcription factors overlapping and distinct functions journal J. Cell. Sci. volume 113 Pt 10 issue pages 1661 70 year 2000 month May pmid 10769197 doi url http jcs.biologists.org cgi pmidlookup?view long&pmid 10769197 ref ref name Finch2007 cite book author Caleb Ellicott Finch title The biology of human longevity inflammation, nutrition, and aging in the evolution of lifespans url http books.google.com books?id 4rGOLEOC4mEC&pg PA350 accessdate 23 December 2010 year 2007 publisher Academic Press isbn 9780123736574 pages 350 ref It consists of p53 TP73L also known as p63 p73 They are sometimes considered part of a p53 family . ref name pmid18627398 cite journal author Chen S, Moroi Y, Urabe K, et al. title Differential expression of two new members of the p53 family, p63 and p73, in extramammary Paget s disease journal Clin. Exp. Dermatol. volume 33 issue 5 pages 634 40 year 2008 month July pmid 18627398 doi 10.1111 j.1365 2230.2008.02851.x ref Evolution of the p53 family P53, p63, and p73 have similar features in their gene structures and functions but have also diverged evolutionarily. The p53 family evolved from a p63 p73 ancestor gene in invertebrates. ref name Levine et al. 2010 cite journal author Levine, A. J., V. A. Belyi, P. Ak, E. Markert, H. J. Wang, W. W. Hu, and A. Puzio Kuter. title The origins and evolution of the p53 family of genes journal Cold Spring Harbor Perspectives in Biology volume 2 year 2010 ref P53 diverged from p63 p73 with a gene duplication in the cartilaginous fish. ref name Levine et al. 2010 ref P63 and p73 differentiated from each other in bony fish. ref name Levine et al. 2010 ref . These genes developed different functions and structures throughout their evolutionary divergence TP73L , p73 , p53 . References reflist Tumor ... more details
Summary Stereo pair for cross eyed viewing of three subunits of the DNA binding domain of the p53 tumor suppression protein. File was produced from PDB entry 1TUP and rendered in PyMOL. Licensing PD self date November 2006 Copy to Wikimedia Commons bot Fbot ... more details
Lowercase title PBB geneid 27113 The p53 upregulated modulator of apoptosis PUMA also known as Bcl 2 ..., is induced by p53 journal Mol. Cell volume 7 issue 3 pages 683 94 year 2001 month March pmid 11463392 ... suppressor p53 . PUMA is involved in p53 dependent and independent apoptosis induced by a variety ... p53 journal Oncogene volume 27 Suppl 1 issue pages S71 83 year 2008 month December pmid 19641508 pmc ... domains from the p53 inducible BH3 only proteins Noxa and Puma in complex with Mcl 1 journal J. Mol ... L title PUMA mediates the apoptotic response to p53 in colorectal cancer cells journal Proc. Natl. Acad ... KH title PUMA, a novel proapoptotic gene, is induced by p53 journal Mol. Cell volume 7 issue 3 pages ... Wu B, Qiu W, Wang P, Yu H, Cheng T, Zambetti GP, Zhang L, Yu J title p53 independent induction of PUMA ... activation of the tumor suppressor protein p53 . p53 is activated by survival signals such as glucose ... SR, Cui K, Rathmell JC title Glucose metabolism attenuates p53 and Puma dependent cell death upon ... dysfunction . p53, and with it PUMA, is activated due to DNA damage caused by a variety of genotoxicity genotoxic agents . Other agents that induce p53 dependent apoptosis are neurotoxins , ref ..., Jord n J title Activation of p53 and the pro apoptotic p53 target gene PUMA during depolarization induced ... Mutually exclusive subsets of BH3 only proteins are activated by the p53 and c Jun N terminal kinase ... UF, Fojo T title Enhanced microtubule dependent trafficking and p53 nuclear accumulation by suppression ... also be induced independently of p53 activation by other stimuli, such as oncogenic stress ref name ... JL, Piacentini M, Kroemer G title p53 A pro apoptotic signal transducer involved in AIDS journal Biochem .... Additionally, many human tumors contain p53 mutations , ref name pmid15286780 cite journal author ... name pmid15865941 cite journal author Yu J, Zhang L title The transcriptional targets of p53 in apoptosis ... doi 10.1016 j.dld.2006.11.006 ref Many cancers do exhibit p53 gene mutations, making gene therapies ... more details
Infobox Ship Begin Infobox Ship Image Ship image Ship caption Infobox Ship Career Hide header Ship country Ship flag Navy IND Ship name INS Savitri Ship namesake Ship ordered Ship builder Hindustan Shipyard Limited Ship laid down Ship launched 23 May 1989 Ship acquired Ship commissioned 27 November 1990 Ship decommissioned Ship in service Ship out of service Ship struck Ship reinstated Ship honours Ship fate Ship status Active Ship notes Infobox Ship Characteristics Hide header Header caption Ship class Sukanya class patrol vessel ref name in sukanya http www.indiannavy.nic.in opv sukanya.htm ref Ship type Ship tonnage Ship displacement 1,890 tons full load ref name in sukanya http indiannavy.nic.in opv sukanya.htm ref Ship tons burthen Ship length 101 metres Ship beam 11.5 metres Ship height Ship draught Ship draft Ship depth Ship hold depth Ship decks Ship deck clearance Ship ramps Ship ice class Ship power Ship propulsion 2 diesel engine s, convert 12800 bhp kW 1 abbr on , 2 shafts Ship sail plan Ship speed convert 21 kn km h 0 Ship range convert 7000 nmi km 3 at convert 15 kn km h 0 Ship endurance Ship test depth Ship boats Ship capacity Ship troops Ship complement 70 Ship crew Ship time to activate Ship sensors 1 x Racal Decca 2459 search radar br 1 BEL 1245 navigation radar Ship EW Ship armament 1 x 40 mm, 60 cal Bofors anti aircraft gun br 2 x 12.7 mm machine guns br P51 added 1 Dhanush missile Dhanush ballistic missile br P55 added 2 x 25 mm, 80 cal anti aircraft guns Ship armour Ship armor Ship aircraft 1 HAL Chetak Ship aircraft facilities Ship notes INS Savitri P53 is a Sukanya class patrol vessel of the Indian Navy . ref name in sukanya References references Ship classes of the Indian Navy DEFAULTSORT Savitri P53 Category Sukanya class patrol vessels Category Patrol vessels of the Indian Navy Category Active naval ships of India india mil stub mil ship stub ... more details
Non free logo logo fur Article Matamata College Use Infobox ADDITIONAL INFORMATION Used for Owner Website http www.matamatacollege.school.nz History Commentary OVERRIDE FIELDS Description Source Portion Low resolution Purpose Replaceability other information History of Image Matamata College logo.gif 2008 01 21T21 51 10Z User Onco p53 Onco p53 User talk Onco p53 Talk Special Contributions Onco p53 contribs 469 bytes nowiki add Non free logo nowiki 2008 01 21T11 03 29Z User STBotI STBotI User talk STBotI Talk Special Contributions STBotI contribs 490 bytes nowiki This image has no licensing information nowiki 2008 01 21T10 54 16Z User Onco p53 Onco p53 User talk Onco p53 Talk Special Contributions Onco p53 contribs 450 bytes nowiki revised fur nowiki 2008 01 21T10 52 54Z User Onco p53 Onco p53 User talk Onco p53 Talk Special Contributions Onco p53 contribs 443 bytes nowiki logo fur Article Roncalli College Use Infobox ADDITIONAL INFORMATION Used for Owner Website http www.roncalli.school.nz History Commentary nowiki 2008 01 21T10 52 54Z User Onco p53 Onco p53 User talk Onco p53 Talk Special Contributions Onco p53 contribs 56x77 3523 bytes ... more details
Non free logo logo fur Article Sancta Maria College, New Zealand Use Infobox ADDITIONAL INFORMATION Used for Owner Website http www.sanctamaria.school.nz History Commentary OVERRIDE FIELDS Description Source Portion Low resolution Purpose Replaceability other information History of File Sancta maria college logo.gif 2008 01 24T23 06 46Z User Onco p53 Onco p53 User talk Onco p53 Talk Special Contributions Onco p53 contribs 482 bytes nowiki fixed article to Sancta Maria College, New Zealand nowiki 2008 01 24T23 04 31Z User Onco p53 Onco p53 User talk Onco p53 Talk Special Contributions Onco p53 contribs 469 bytes nowiki added rationale nowiki 2008 01 24T04 56 25Z User BetacommandBot BetacommandBot User talk BetacommandBot Talk Special Contributions BetacommandBot contribs 432 bytes nowiki tagging as invalid rationale per WP NONFREE nowiki 2007 04 24T11 03 03Z User Cydebot Cydebot User talk Cydebot Talk Special Contributions Cydebot contribs 56 bytes nowiki Robot Renaming non free template logo per Wikipedia Non free content templates . nowiki 2006 12 02T01 00 08Z User Onco p53 Onco p53 User talk Onco p53 Talk Special Contributions Onco p53 contribs nowiki from http www.sanctamaria.school.nz Logo nowiki 2006 12 02T01 00 08Z User Onco p53 Onco p53 User talk Onco p53 Talk Special Contributions Onco p53 contribs 300x55 1421 bytes ... more details
AmpliChip is a family of clinical tests from Hoffmann La Roche Roche aiming to find out the patients genotype using micro array technology. The tests include CYP450 Test and P53 Test. The CYP450 Test was approved by FDA. AmpliChip CYP450 Test AmpliChip P53 Test disambig Category Microarrays ... more details
Summary logo fur Article Carey College, New Zealand Use Public facility ADDITIONAL INFORMATION Used for Owner Website http www.careycollege.com History Commentary OVERRIDE FIELDS Description Source Portion Low resolution Purpose Must be specified if Use is not Infobox Org Brand Product Replaceability other information Licensing Non free logo taken from http www.careycollege.com History of Image Carey college logo.gif 2008 02 18T06 10 45Z User MBisanz MBisanz User talk MBisanz Talk Special Contributions MBisanz contribs 618 bytes nowiki adding fair use rationale FUR using User AWeenieMan furme FURME nowiki 2008 02 12T04 59 56Z User BetacommandBot BetacommandBot User talk BetacommandBot Talk Special Contributions BetacommandBot contribs 434 bytes nowiki tagging as invalid rationale per WP NONFREE nowiki 2007 04 24T10 57 53Z User Cydebot Cydebot User talk Cydebot Talk Special Contributions Cydebot contribs 57 bytes nowiki Robot Renaming non free template logo per Wikipedia Non free content templates . nowiki 2006 12 04T10 06 00Z User Onco p53 Onco p53 User talk Onco p53 Talk Special Contributions Onco p53 contribs nowiki logo taken from http www.careycollege.com nowiki 2006 12 04T10 06 00Z User Onco p53 Onco p53 User talk Onco p53 Talk Special Contributions Onco p53 contribs 360x81 12966 bytes ... more details
GFDL with disclaimers migration relicense Source A lipid micelle I have taken this from Image Lipid bilayer and micelle.png and cleaned up the right hand image. This might be used for a biochem stub pic. User Onco p53 Onco p53 ... more details
GFDL self with disclaimers migration relicense Source I created this small LaTeX file using WinEDT and MiKTeX , compiled to a PDF with pdfLaTeX , took screenshots, then pasted together in Photoshop User Onco p53 Onco p53 Copy to Wikimedia Commons bot Fbot ... more details
17P or 17.P may refer to 17P Holmes , a comet SpaceShipOne flight 17P , a commercial spaceflight 17 Hydroxyprogesterone , a medication to prevent pre term labor 17p, the short arm of the Chromosome 17 human 17th human chromosome that has the p53 tumour suppressor gene See also P17 disambiguation Letter NumberCombDisambig de 17P ... more details
Non free use rationale Description Ship s badge of the submarine HMS Ultor P53 Source http www.submariners.co.uk Dits Badges Official show.htm?ULTOR Article HMS Ultor P53 Portion No Low resolution Yes Purpose image is used solely for the purposes of identifying the related vessel, or illustrating that vessel s badge directly. Replaceability A free replacement would be difficult to obtain given the related vessels status. Other information The badge is not defaced, misrepresented or used in a misleading manner Non free symbol Category Royal Navy submarine badges ... more details
orphan date December 2008 Adenovirus E1B protein usually refers to one of two proteins Transcription genetics transcribed from the E1B gene of the adenovirus a 55kDa protein and a 19kDa protein. Primarily, the two work to delay cell lysis during viral replication. Afterwards, they help induce cell death and control the export of viral transcripts. Specifically, the E1B 55kDa protein inhibits p53 acetylation, and therefor activation, by PCAF 1 . References 1. Yue Liu, April L. Colosimo, Xiang Jiao Yang, and Daiqing Liao 2000 . Adenovirus E1B 55 Kilodalton Oncoprotein Inhibits p53 Acetylation by PCAF . Molecular and Cellular Biology Vol 20 p5540 5553. See also Adenoviridae Category Proteins genetics stub ... more details
Orphan date February 2009 Siva protein is a novel zinc containing intracellular ligand of the CD4 sensory receptor receptor that promotes HIV 1 envelope induced apoptosis in T lymphoid cells. Recent research has demonstrated that Siva is a direct transcriptional target for the tumor suppressors p53 and E2F1. ref cite journal author Fortin A, MacLaurin JG, Arbour N, et al. title The proapoptotic gene SIVA is a direct transcriptional target for the tumor suppressors p53 and E2F1 journal J. Biol. Chem. volume 279 issue 27 pages 28706 14 year 2004 month July pmid 15105421 doi 10.1074 jbc.M400376200 url http www.jbc.org cgi pmidlookup?view long&pmid 15105421 ref References reflist Category Proteins biochem stub ... more details
annurev.pharmtox.48.113006.094723 pmc 2676449 ref . Inhibiting the interaction between mdm2 and p53 stabilizes p53 and is thought to selectively induce a growth inhibiting state called senescence ... or wild type p53. Citation needed date April 2011 Nutlin 3 has been shown to affect the production of p53 within minutes. ref name Leeuwen et al. Cite journal work Cell Cycle publisher Landes Bioscience title Mechanism specific signatures for small molecule p53 activators volume 10 issue 10 date 15 ... more details
Gendicine is a recombinant adenovirus engineered to express wildtype p53 rAd p53 . This virus is designed to treat patients with tumors which have mutated p53 genes. Gendicine is the first gene therapy product approved for clinical use in humans. Gendicine is manufactured by Shenzhen SiBiono GeneTech . Gendicine was approved by the Chinese SFDA State Food and Drug Administration to treat head and neck squamous cell carcinoma and various forms of cancer. ref name nature Cite web url http www.nature.com nbt journal v22 n1 full nbt0104 3.html title China approves first gene therapy Article Nature Biotechnology work nature.com accessdate February 24, 2010 ref References Reflist Category Gene delivery Category Viruses Genetics stub de Gendicine ... more details
lowercase title p53 PBB geneid 7161 p73 is a protein related to the p53 tumor protein. Because of its structural resemblance to p53, it has also been considered a tumor suppressor gene tumor suppressor . It is involved in cell cycle regulation, and induction of apoptosis . Like p53, p73 is characterized by the presence of different isoforms of the protein. This is explained by splice variant s, and an alternative promoter biology promoter in the DNA sequence. p73, also known as tumor protein 73 TP73 , protein was the first identified homologue of the tumor suppressor gene, p53. Like p53, p73 has ... suppressor p53. The over expression of p73 in cultured cells promotes a growth arrest and or apoptosis similarly to p53. The p73 gene has been mapped to a chromosome region 1p36. 2 3 a locus commonly deleted in various tumor entities and human cancers. Similar to p53 the protein product of p73 induces ... deficient mice do not show a tumorigenic phenotype. A deficiency of p53 almost certainly leads ... a role in tumorigenesis. Genes of the p53 family are known to be complex. The viral oncoproteins e.g. Adenovirus E1B that efficiently inhibit p53 function are unable to inactivate p73, and those that seem to inhibit p73 have no effect on p53. Debate persists about the exact function of p73. Recently ... function of p53. This strongly implicates p73 as playing a large role in cellular differentiation ... occurring p73 mutation in a p73 p53 double mutant lung cancer cell line encodes p73 protein with a dominant ... gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers ... A, Gong J, Wang JY, Melino G title The p53 p63 p73 family of transcription factors overlapping ... FD title An anti apoptotic role for the p53 family member, p73, during developmental neuron death journal ... p53 gene family. journal J. Natl. Cancer Inst. volume 91 issue 7 pages 594 8 year 1999 pmid 10203277 ... Jacobs WB, Walsh GS, Miller FD title Neuronal survival and p73 p63 p53 a family affair. journal The Neuroscientist ... more details
PBB geneid 4193 Mdm2 is an important negative regulator of the p53 tumor suppressor. It is the name of a gene ... E3 ubiquitin ligase that recognizes the N terminal trans activation domain TAD of the p53 tumor suppressor and an inhibitor of p53 transcriptional activation. Discovery and expression in tumor cells ... also called MdmX , has been discovered and is also an important negative regulator of p53 . Ubiquitination target p53 The key target of Mdm2 is the p53 tumor suppressor. Mdm2 has been identified as a p53 interacting protein that represses p53 transcriptional activity. Mdm2 achieves this repression by binding to and blocking the N terminal trans activation domain of p53. Mdm2 is a p53 responsive gene that is, its transcription can be activated by p53. Thus when p53 is stabilized, the transcription ... as an Ubiquitin ligase E3 ubiquitin ligase , targeting both itself and p53 for degradation by the proteasome see also Ubiquitin . Several lysine residues in p53 C terminus have been identified as the sites of ubiquitination, and it has been shown that p53 protein levels are downregulated by Mdm2 in a proteasome ..., a cooperating Ubiquitin ligase E3 ubiquitin ligase , is capable of polyubiquitinating p53. In this manner, Mdm2 and p53 are the members of a negative feedback control loop that keeps the level of p53 low in the absence of p53 stabilizing signals. This loop can be interfered with by kinases and genes like p14arf when p53 activation signals, including DNA damage, are high. Structure and function ... terminal p53 interaction domain, the structure of which has been solved using x ray crystallography ... in protein function and stabilization of p53 . Additionally, phosphorylation at certain residues within the central acidic domain of Mdm2 may stimulate its ability to target p53 for degradation. The induction ... a mechanism of negatively regulating the p53 Mdm2 interaction. p14arf directly interacts with Mdm2 and leads to up regulation of p53 transcriptional response. ARF sequesters Mdm2 in the nucleolus ... more details
MedalTableTop MedalSport Track and field P53 MedalCountry NZL MedalCompetition Paralympic Games MedalGold 2000 Summer Paralympics 2000 Sydney Athletics at the 2000 Summer Paralympics Men s Pentathlon P53 Pentathlon P53 MedalGold 1992 Summer Paralympics 1992 Barcelona Athletics at the 1992 Summer Paralympics Men s Javelin throw F52 JT F52 MedalSilver 1996 Summer Paralympics 1996 Atlanta Athletics at the 1996 Summer Paralympics Men s Javelin throw F51 JT F51 MedalBottom David McCalman is a Paralympian Track and field athlete from New Zealand competing mainly in category P53 pentathlon events. He competed in the 1992 Summer Paralympics in Barcelona , Spain . There he finished fourth in the men s Shot putt THW2 event, finished fifth in the men s Javelin throw THW2 event, finished twelve in the men s Discus throw THW2 3 event, finished seventh in the men s 200 metres TW2 event and went out in the first round of the men s 800 metres TW2 event. He also competed at the 1996 Summer Paralympics in Atlanta , United States . There he won a silver medal in the men s Javelin throw F51 event and finished sixth in the men s Shot putt F51 event. He also competed at the 2000 Summer Paralympics in Sydney , Australia . There he won a gold medal in the men s Pentathlon P53 event, a gold medal in the men s Javelin throw F52 event and finished fourth in the men s Shot putt F52 event. He also competed at the 2004 Summer Paralympics in Atlanta , United States . There he finished twelve in the men s Javelin throw F52 53 event and finished ninth in the men s Shot putt F52 event External links IPC profile surname MacCalman givenname David Persondata Metadata see Wikipedia Persondata . NAME Maccalman, David ALTERNATIVE NAMES SHORT DESCRIPTION New Zealand paralympic athlete DATE OF BIRTH PLACE OF BIRTH DATE OF DEATH PLACE OF DEATH DEFAULTSORT Maccalman, David Category Paralympic athletes of New Zealand Category Athletes track and field at the 1992 Summer Paralympics Category Athletes track and field ... more details
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