Infobox Disease Name Osteosarcoma Image Osteosarcoma intermed mag.jpg Caption Intermediate magnification micrograph of an osteosarcoma center and right of image adjacent to non malignant bone left bottom ... radio 504 eMedicine2 radio 505 MeshID D012516 Osteosarcoma is an aggressive cancerous neoplasm ... of osteosarcoma. In Jaffe N. et al. Pediatric and Adolescent Osteosarcoma publisher Springer location ... Osteosarcoma is the eighth most common form of childhood cancer, comprising 2.4 of all malignancies ... Incidence rates for osteosarcoma in U.S. patients under 20 years of age are estimated at 5.0 per ... surgical en bloc resection is the treatment of choice in osteosarcoma. ref name OttavianiJaffe Although ... to osteosarcoma have recently been declining at approximately 1.3 per year. ref name OttavianiJaffe Current long term survival probabilities for osteosarcoma have improved dramatically in recent decades ... thumb 120px left Predilections of osteosarcoma The tumor may be localized at the end of the long bone. Most often it affects the upper end of tibia or humerus , or lower end of femur . Osteosarcoma ... angles form what is known as Codman s triangle . Surrounding tissues are infiltrated. Image Osteosarcoma very high mag.jpg thumb right High magnification micrograph showing osteoid formation in an osteosarcoma, H&E stain Microscopically The characteristic feature of osteosarcoma is presence of osteoid ... of osteosarcoma are not known. Several research groups are investigating cancer stem cells and their potential ... 10.2174 157488709787047585 ref The connection between osteosarcoma and fluoride has been investigated there is no clear association between water fluoridation and deaths due to osteosarcoma. ref cite .... Radiation induced periosteal osteosarcoma. Grand Rounds 10 13 18 http www.grandrounds e med.com articles ... are sent straight to physical therapy without an x ray . The route to osteosarcoma diagnosis usually ... or benign . The biopsy of suspected osteosarcoma should be performed by a qualified orthopedic ... more details
The most common bone tumor is called osteosarcoma , which usually affects older dogs or giant breed dogs. Osteosarcoma seems to be rare in cats. Osteosarcoma is an aggressive cancer that can develop in any bone of the body but the majority is seen in the limbs eg elbow or the knee . Signs and symptoms Dogs with limb osteosarcoma typically show lameness and swelling at the affected site. For other sites, dogs may show difficulty to open their mouth if jaw bone cancer , nasal discharge if nasal cavity bone cancer or neurological signs if spine bone cancer . Diagnosis The initial evaluation involves X rays of the affected site, but the only way to confirm the diagnosis is by tissue biopsy . ref name MacEwan 2001 cite book author Withrow SJ, MacEwen EG, eds title Small Animal Clinical Oncology edition 3rd ed. publisher W.B. Saunders Company year 2001 ref Treatment Depending on the pet s unique condition, there are several treatment options, including surgery, chemotherapy and radiation therapy . References Reflist External links http www.petcancercenter.org Cancer Types Bone.html Bone Cancer in Cats and Dogs from Pet Cancer Center http www.vet.uga.edu vpp clerk Kramer index.php Canine osteosarcoma from UGA Veterinary School of Medicine http veterinarycancer.com osteosarcoma.html Osteosarcoma from Animal Cancer & Imaging Center http www.vetspecialists.co.uk 06 Animal Welfare Oncology Facts Canine Osteosarcoma.html Canine Osteosarcoma from Davies Veterinary Specialists http www.dogcancerblog.com bone cancer pain new ideas Bone Cancer Pain in Dogs New Ideas from Dr. Demian Drsssler, DVM of Dog Cancer Blog Category Dog diseases Category Cat diseases ... more details
Ottaviani first1 G. last2 Jaffe first2 N. year 2009 chapter The epidemiology of osteosarcoma title Pediatric and Adolescent Osteosarcoma location New York publisher Springer doi 10.1007 978 1 4419 0284 ... more details
Codman triangle is a term used to describe the triangular area of new subperiosteal bone that is created when a lesion, often a tumour, raises the periosteum away from the bone. ref name gpnotebook http www.gpnotebook.co.uk cache 288358364.htm General Practioner s notebook ref The main causes for this sign are osteosarcoma , Ewing s sarcoma , and a subperiosteal abscess . ref name gpnotebook References references med stub Category Skeletal system Eponymous medical signs for integumentary and musculoskeletal systems ja pl Ostroga Codmana pt Tri ngulo de Codman ... more details
names, based on the type of tissue from which they arise. For example, osteosarcoma arises from ... before chemotherapy, long term survival for patients with localized osteosarcoma was only approximately ... M, Bacci G title Primary bone osteosarcoma in the pediatric age state of the art journal Cancer Treat ... 9130 3 Malignant Schwannoma 9560 3 9561 3 Osteosarcoma 9180 3 9190 3 Soft tissue sarcoma ... tumor 8806 3 Epithelioid Sarcoma 8804 3 Extraskeletal chondrosarcoma 9220 3 Extraskeletal osteosarcoma .... ref http www.acor.org ped onc diseases rhabdo.html ref Osteosarcoma is treated with surgical resection ... common in adults than in children. Most high grade bone sarcomas, including Ewing s sarcoma and osteosarcoma ... more details
Orphan date July 2008 Saos 2 Osteosarcoma Sarcoma osteogenic is a non Transformation genetics transformed cell line derived from the primary osteosarcoma of an 11 year old Caucasian girl since identified as Alice Abernathy in 1973 by Fogh et al . ref cite journal author Fogh J, Fogh JM, Orfeo T year 1977 title One hundred and twenty seven cultured human tumor cell lines producing tumors in nude mice journal J Natl Cancer Inst volume 59 issue 1 pages 221 226 PMID 327080 ref In 1987 Rodan et al . determined that Saos 2 cells possess several osteoblast ic features and could be useful as a permanent line of human osteoblast like cells and as a source of bone related molecules. ref cite journal author Rodan SB, Imai Y, Thiede MA, Wesolowski G, Thompson D, Bar Shavit Z, Shull S, Mann K, Rodan GA year 1987 title Characterization of a human osteosarcoma cell line Saos 2 with osteoblastic properties journal Cancer Res. volume 47 issue 18 pages 4961 6 PMID 3040234 ref Besides their worldwide availability, some of the advantages for using Saos 2 cell line are that they have well documented characterization data, the possibility to obtain large amounts of cells in short time, and the fact that Saos 2 cells can be fully differentiated in a manner that the osteoblastic cells naturally do. ref cite journal author Hausser H J, Brenner RE title Phenotypic instability of Saos 2 cells in long term culture journal Biochem. Biophys. Res. Commun. year 2005 volume 333 issue 1 pages 216 22 PMID 15939397 ref The latter point is described particularly as the ability of Saos 2 cells to deposit a mineralization competent extracellular matrix , ref cite journal author McQuillan DJ, Richardson MD, Bateman JF title Matrix deposition by a calcifying human osteogenic sarcoma cell line SAOS 2 journal Bone year 1995 volume 16 issue 4 pages 415 26 PMID 7605701 ref which makes these cells a valuable model for studying events associated with the late osteoblastic differentiation stage in human cells. ref ... more details
Image EpiMetaDiaphyse.jpg thumb Long bone. Captions in German, but region visible labeled as metaphyse . The metaphysis is the wider portion of a long bone adjacent to the epiphyseal plate . ref Dorland s Pocket Medical Dictionary, 27th edition ref It is this part of the bone that grows during childhood as it grows, it ossifies near the diaphysis and the epiphyses. At roughly 18 to 25 years of age, the metaphysis stops growing altogether and completely ossifies into solid bone. Epiphyseal plates growth plates are located in the metaphysis and are responsible for growth in the length of the bone. Clinical significance Because of their rich blood supply, metaphysis of long bones are prone to hematogenous spread of osteomyelitis in children. Metaphyseal tumors or lesions include osteosarcoma , chondrosarcoma , fibrosarcoma , osteoblastoma , enchondroma , fibrous dysplasia , simple bone cyst , aneurysmal bone cyst , non ossifying fibroma , and osteoid osteoma . ref name urlInroductory Course cite web url http www.umdnj.edu tutorweb introductory.htm title New Jersey Medical School, Pathology Department Introductory Course on Bone Tumours format work accessdate 2009 03 12 ref References reflist External links UCDavisOrganology Musculoskeletal bone structure0 structure2 Bone, structure Gross, Low developmental biology stub Bone and cartilage Category Skeletal system da Metafyse de Metaphyse es Met fisis fr M taphyse pt Met fise ru fi Metafyseaalinen ... more details
orphan date May 2009 Thaddeus P. Dryja , MD is a physician and noted biomedical researcher. A 1976 graduate of Yale Medical School , he specializes in ophthalmology and is recognized for his 1986 discovery of the Rb tumor suppressor gene, mutations in which lead to a cancer of the eye known as retinoblastoma . He was elected to the United States National Academy of Sciences National Academy of Sciences in 1996, and currently is Professor of Ophthalmology at Harvard Medical School . He leads a research group at the Massachusetts Eye and Ear Infirmary in Boston, Massachusetts, USA. References Friend SH, Bernards R, Rogelj S, Weinberg RA, Rapaport JM, Albert DM, Dryja TP. A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma. Nature 1986 323 643 6. PMID 2877398. External links http www.meei.harvard.edu shared staff ophthodocs tdryja.htm DEFAULTSORT Dryja, Thad Category Yale School of Medicine alumni Category Harvard Medical School faculty Category Living people Category American medical researchers Category Members of the United States National Academy of Sciences Category Year of birth missing living people US med bio stub ... more details
Italic title Multiple issues unreferenced December 2010 notability December 2010 Into the Wind is a 2010 documentary film which chronicles the story of Terry Fox , a man who inspired millions and gave hope to many cancer patients. At the age of 18 Terry Fox was diagnosed with osteosarcoma . The cancer had taken over his right leg, which was then amputated six inches above the knee. However, three years later Fox set out to raise funds for cancer research and raise awareness by running 30 miles a day from the eastern shore of Canada , to British Columbia and the Pacific Ocean totaling over 4000 miles. The film was directed by the NBA star Steve Nash who grew up in Canada and followed Fox s run across the country as a kid in 1980. Two thirds across Canada Fox was once again diagnosed with cancer which had spread to his lungs. He died at the age of 22, inspiring the Terry Fox Foundation which has raised over 10 million dollars. External links IMDb title 1735870 Into the Wind DEFAULTSORT Into The Wind Category 2010 films Category American films Category English language films Category Terry Fox documentary film stub ... more details
Now Available for Patients With Osteosarcoma Bone Cancer publisher Takeda date November 2009 accessdate ... Approval in Europe for Treatment of Patients with Non Metastatic, Resectable Osteosarcoma date 2009 ... of osteosarcoma date 2007 08 28 publisher The Medical News accessdate 2009 11 12 ref Indications ... resection resectable osteosarcoma following complete surgical removal in children, adolescents and young ... format PDF accessdate 2009 11 12 ref Osteosarcoma is a type of bone cancer diagnosed in about 1,000 ... in about 800 newly diagnosed osteosarcoma patients, mifamurtide was combined with the chemotherapeutic ... more details
Cleanup date January 2010 Wikify date January 2010 Expert subject Medicine date June 2008 Infobox Disease Name Bone tumor Image Osteosarcoma high mag.jpg Caption Micrograph of an osteosarcoma , a malignant primary bone tumor. DiseasesDB ICD10 ICD10 C 40 c 40 ICD10 C 41 c 40 ICD9 ICD9 170.9 ICDO OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID D001859 Image Giant cell tumor of bone08.JPG thumb 250px X ray of a giant cell bone tumor in the head of the 4th metacarpal of the left hand. Image Bonetumor.jpg thumb right 250px An arm bone tumor A bone tumor refers to a neoplastic growth of tissue in bone . Abnormal growths found in the bone can be either benign noncancerous or malignant cancerous . Classification Bone tumors may be classified as primary tumors which originate in the bone, and Secondary tumor s which originate elsewhere. Primary tumors are more uncommon compared to secondary or metastatic tumors. Primary tumors Primary tumors of bone can be divided into benign benign tumors and cancer s. Common benign bone tumors may be neoplasia neoplastic , developmental, Physical trauma traumatic , infection infectious , or inflammation inflammatory in etiology. Examples of benign bone tumors include osteoma , osteoid osteoma , osteochondroma , osteoblastoma , enchondroma , giant cell tumor of bone , aneurysmal bone cyst , and fibrous dysplasia of bone . Malignant primary bone tumors include osteosarcoma , chondrosarcoma , Ewing s sarcoma , malignant fibrous histiocytoma, fibrosarcoma , and other sarcoma types. Multiple myeloma is a hematology hematologic cancer which also frequently presents as one or more bone tumors. The tailbone is a common location for a teratoma , known as a sacrococcygeal teratoma , and related germ cell tumor s. Secondary tumors Secondary bone tumors include metastasis metastatic tumors which have spread from other organs, such as the breast cancer breast , lung cancer lung , and prostate cancer prostate . Symptoms The most common symptom of b ... more details
generated title ref Teriparatide should not be prescribed for patients who are at increased risks for osteosarcoma ... is an increased risk of osteosarcoma , at least as seen in rat studies. Cases of bone tumor and osteosarcoma have been reported rarely in the postmarketing period. ref name Ref a http www.drugs.com ... more details
Infobox disease Name Rothmund Thomson syndrome Image Caption DiseasesDB 29891 ICD10 Q82.8 ILDS Q82.852 ICD9 ICD9 757.33 ICDO OMIM 268400 MedlinePlus eMedicineSubj derm eMedicineTopic 379 MeshID D011038 Rothmund Thomson syndrome RTS , also known as poikiloderma atrophicans with cataract or poikiloderma congenitale , ref name omim ref name Andrews cite book author James, William Berger, Timothy Elston, Dirk year 2005 title Andrews Diseases of the Skin Clinical Dermatology 10th ed. publisher Saunders isbn 0 7216 2921 0 page 576 ref is a rare autosome autosomal dominance genetics recessive ref name rtsar cite pmid 20113479 ref ref cite journal author Raza N, Malik QU, Hussain Z title Rothmund Thomson syndrome more than just a cosmetic concern journal J Coll Physicians Surg Pak. volume 17 issue 7 pages 423&ndash 424 year 2007 pmid 17686357 doi 07.2007 JCPSP.423424 ref skin condition originally described by August von Rothmund 1830 1906 in 1868. Matthew Sydney Thomson 1894 1969 published further descriptions in 1936. There have been several reported cases associated with osteosarcoma . A hereditary Genetics genetic basis, mutations in the DNA Helicase RECQL4 gene, has been implicated in the syndrome. ref name omim OMIM 268400 ref ref name req ref cite journal author Hicks MJ, Roth JR, Kozinetz CA, Wang LL title Clinicopathologic features of osteosarcoma in patients with Rothmund Thomson syndrome journal J. Clin. Oncol. volume 25 issue 4 pages 370 5 year 2007 pmid 17264332 doi 10.1200 JCO.2006.08.4558 url ref Characteristics Sun sensitive rash with prominent poikiloderma and telangiectasias Juvenile cataracts Saddle nose Congenital bone defects, including short stature and radial ray anomalies such as absent thumbs Hair growth problems absent eyelashes, eyebrows and or hair Hypogonadism has not been well documented Hypodontia Calcium problems not documented in journals Ear problems not documented in journals but identified by patients in support groups Osteosarcoma ref cit ... more details
Image Hemipelvectomy gas gangrene.jpg thumb right Hemipelvectomy being performed on a patient suffering from gas gangrene . A hemipelvectomy is a high level pelvic amputation . Along with hip disarticulations, hemipelvectomies are the rarest of lower extremity amputations. In some cases, an internal hemipelvectomy can be performed, which is a limb sparing procedure. A complete hemipelvectomy, however, is the amputation of half of the pelvis and the leg on that side. This type of procedure is also called transpelvic amputation . Hemipelvectomies may be required for several reasons, such as a car accident or cancer. Examples of cancers that can require hemipelvectomies are sarcoma s like Ewing s Sarcoma , osteosarcoma or chondrosarcoma . People who have experienced a hemipelvectomy may or may not be able to use a prosthesis . They may use adaptive devices such as a wheelchair , underarm crutches , forearm crutches, or, in the case of internal hemipelvectomies, a Cane medical device cane . Physical therapy can be useful to those with hemipelvectomies to build strength and prevent problems like back pain and scoliosis . Because a hemipelvectomy is a rare type of amputation, it is important that the physical therapist is trained in the special needs of a post hemipelvectomy patient. There are two types of hemipelvectomy External Amputation of the whole leg plus the pelvis on that side. The other name for external hemipelvectomy is called a hindquarter amputation. Internal Removal of the pelvis on the one side, but the leg is saved. External links http www.hphdhelp.org Hemipelvectomy and Hip Disarticulation Help http www.amputee coalition.org Amputee Coalition of America http www.beenamputatie.nl Dutch hemipelvectomy site Muscle soft tissue procedures Surgery stub Category Surgical oncology Category Surgical removal procedures de Hemipelvektomie ... more details
orphan date November 2007 Ivy S. Gunter born June 22, 1950 in Bellevue, Ohio ref name Royster cite book last Royster first Jacqueline Jones title Profiles of Ohio women, 1803 2003 year 2003 publisher Ohio University Press isbn 9780821415085 pages 203 url http books.google.com books?id tV3CKGuGoRkC&pg PT219&lpg PT219&dq v onepage&q&f false ref is an amputee , fashion model , osteosarcoma survivor, inspirational speaker , and Physical fitness fitness enthusiast. She is the author of the book On the Ragged Edge of Drop Dead Gorgeous . ref name Coping cite web last Phiffer first Cindy title Ivy Gunter Supermodel url http copingmag.com cwc index.php celebrities celebrity article ivy gunter publisher Coping with Cancer accessdate 29 December 2010 date September October 1999 ref ref name ODJFS cite web title Ohio Women s Hall of Fame Bio url http www.odjfs.state.oh.us women halloffame bio.asp?ID 116 publisher ODJFS accessdate 29 December 2010 ref In early 1980 she was diagnosed with bone cancer in her right leg, leading to its amputation . ref name King cite book last King first Dean title Cancer Combat year 1998 publisher Bantam Books isbn 9780553378450 pages 18 coauthors Jessica King, Jonathan Pearlroth ref Five months after surgery, she returned to filming, with wigs and a prosthesis prosthetic leg . She returned to modeling shortly thereafter. Gunter was inducted into the Ohio Women s Hall of Fame in 1993. ref name ODJFS References Reflist Persondata Metadata see Wikipedia Persondata . NAME Gunter, Ivy ALTERNATIVE NAMES SHORT DESCRIPTION DATE OF BIRTH 22 June 1950 PLACE OF BIRTH Bellevue, Ohio DATE OF DEATH PLACE OF DEATH DEFAULTSORT Gunter, Ivy Category American memoirists Category American female models Category American amputees Category 1950 births Category Living people ... more details
Dz13 is an experimental treatment developed by Australia n scientists which aims to combat a range of illnesses from diabetes to Heart Disease heart disease and cancer . How it works Dz13 is a Deoxyribozyme DNAzyme that targets c Jun , a transcription factor found in diseased blood vessels, eyes, lungs and joints. The treatment works by destroying RNA , essentially inhibiting c Jun expression in cells. ref name Dass2008 The potential of Dz13 as a therapeutic derives from the fact that deactivation of c Jun can have an effect on Upstream and downstream transduction downstream gene genes such as MMP 2 , MMP 9 , VEGF and FGF 2 . ref name Fahmy2006 Dz13 in cancer Dz13 has been shown to inhibit tumour growth and angiogenesis in Squamous cell carcinoma . ref name Fahmy2006 Anti cancer effects have also been demonstrated in models of prostate cancer , breast cancer and osteosarcoma . ref name Tan2010 Clinical trials of Dz13 in patients with skin cancer basal cell carcinoma commenced in 2010. ref name ACT2010 References Reflist refs ref name Dass2008 Dass, C.R. et al 2008 . DNAzyme technology and cancer therapy cleave and let die. Mol Cancer Ther. 7 2 243 51. ref ref name Fahmy2006 Fahmy, R. et al 2006 . Suppression of vascular permeability and inflammation by targeting of the transcription factor c Jun. Nat Biotechnol. 24 7 856 863. ref ref name Tan2010 Tan, M.L. et al 2010 . Direct anti metastatic efficacy by the DNA enzyme Dz13 and downregulated MMP 2, MMP 9 and MT1 MMP in tumours. Cancer Cell Int. 10 9. ref ref name ACT2010 Australian Cancer Trials 2010 . A phase I study of the Dz13 drug targeting the c Jun gene in subjects with skin cance nodular Basal Cell Carcinoma . http www.australiancancertrials.gov.au search clinical trials search results clinical trials details.aspx?TrialID 335133&ds 1 . ref External links http www.smh.com.au news National New super drug may combat cancer 2006 07 03 1151778858991.html New super drug may combat cancer Category Experimental medica ... more details
Infobox Disease Name PAGENAME Image Caption DiseasesDB ICD10 ICD10 M 80 m 80 ICD10 M 90 m 86 ICD9 ICD9 730 ICD9 733 ICDO OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID D001847 Bone disease refers to the medical conditions which affect the bone . Terminology See Osteopathy A bone disease is also called an osteopathy , but because the term osteopathy is often used to a health care approach, use of the term can cause some confusion. Bone and cartilage disorders Main Osteochondrodysplasia Osteochondrodysplasia is a general term for a disorder of the development dysplasia of bone osteo and cartilage chondro . List B Bone cyst Bone spur Osteophytes Bone tumor C Craniosynostosis F Fibrodysplasia ossificans progressiva Fibrous dysplasia G Giant cell tumor of bone H Hypophosphatasia K Klippel Feil syndrome M Metabolic Bone Disease O Osteoarthritis Osteitis deformans or Paget s disease of bone Osteitis fibrosa cystica or Osteitis fibrosa , or Von Recklinghausen s disease of bone Osteitis pubis Condensing osteitis or Osteitis condensans Osteitis condensans ilii Osteochondritis dissecans Osteochondroma Bone Tumor Osteogenesis Imperfecta Osteomalacia Osteomyelitis Osteopenia Osteopetrosis Osteoporosis Osteosarcoma Bone Tumor P Porotic hyperostosis Primary hyperparathyroidism R Renal Osteodystrophy W Water on the knee See also Osteoimmunoology External links http www.nlm.nih.gov medlineplus bonediseases.html disease stub Medical conditions Osteochondropathy Category Musculoskeletal disorders ... more details
No footnotes date March 2009 yvind S. Bruland born 1952 is a professor of Clinical Oncology and faculty of Medicine at the University of Oslo . Bruland holds a B.Sc. , Doctor of Medicine M.D and Ph.D. from the University of Oslo , Norway . His research includes primary bone and soft tissue cancer s sarcoma s and skeletal metastases from prostate cancer and breast cancer targeted radionuclide therapy , for instance the clinical development of Alpharadin , based on Radium 223 the tumor biology and prognostic impact of micro metastases in bone marrow aspirates on patients with primary bone cancer osteosarcoma external beam radiotherapy and the radiotherapy of skeletal metastases and soft tissue sarcomas. He has served as supervisor to twelve Ph.D students, nine so far having completed their Ph.D. theses. In 2008 he was elected as a member of the Norwegian Academy of Science and Letters . References http www.algeta.com default.asp?menuID 4308&smenuID 4310 Alpharadin trial treatment of cancer with skeletal metastasis http www.thelancet.com journals lanonc article PIIS1470 2045 07 70147 X abstract Lancet publication of Alpaharadin phase II results http www.algeta.com xml press underside.asp?xml http cws.huginonline.com A 134655 PR 200902 1286756.xml&menuID 4447 US Approval for phase III testing of Alpharadin http search2.google.cit.nih.gov search?site NIH Master&client NIHNEW frontend&proxystylesheet NIHNEW frontend&output xml no dtd&filter 0&getfields &q Alpharadin&btnG.x 22&btnG.y 10&btnG search US National Institute of Health information on Alpharadin http bruland.info index.php?mid 2&k bruland Pubmed Publications according to PubMed http www.bruland.info yvind S. Bruland, further information DEFAULTSORT Bruland, Oyvind S. Category 1952 births Category Living people Category University of Oslo alumni Category Norwegian Academy of Science and Letters ... more details
Italic title Taxobox name Spirocerca lupi regnum Animal ia phylum Nematoda classis Secernentea ordo Spirurida familia Spirocercidae genus Spirocerca species S. lupi binomial Spirocerca lupi binomial authority Spirocerca lupi is a species of nematode . ref name pmid17512766 cite journal author van der Merwe LL, Kirberger RM, Clift S, Williams M, Keller N, Naidoo V title Spirocerca lupi infection in the dog a review journal Vet. J. volume 176 issue 3 pages 294 309 year 2008 month June pmid 17512766 doi 10.1016 j.tvjl.2007.02.032 url http linkinghub.elsevier.com retrieve pii S1090 0233 07 00098 6 ref In dogs, infestation can cause osteosarcoma of the esophagus . ref name Ranen cite journal author Ranen E, Lavy E et al. year 2004 title Spirocercosis associated esophageal sarcomas in dogs. A retrospective study of 17 cases 1997 2003 journal Vet Parasitol 119 2 3 209 21 volume 119 pages 209 doi 10.1016 j.vetpar.2003.10.023 ref Doramectin has been used against it. ref name pmid13129670 cite journal author Lavy E, Harrus S, Mazaki Tovi M, et al. title Spirocerca lupi in dogs prophylactic effect of doramectin journal Res. Vet. Sci. volume 75 issue 3 pages 217 22 year 2003 month December pmid 13129670 doi url http linkinghub.elsevier.com retrieve pii S0034528803001152 ref References reflist Category Nematodes nematode stub he ... more details
File Chiarabadano.jpg thumb right Chiara Luce Badano Chiara Badano , called Chiara Luce which means Light , Sassello , October 29 , 1971 Sassello , October 7 , 1990 was an Italian teenager who has been declared Blessed within the Catholic Church . She belonged to the Focolare Movement and died prematurely at eighteen after succumbing to osteosarcoma , an aggressive and painful form of bone cancer. ref http www.catholicnewsagency.com news italian teen one step closer to sainthood ref She was beatified on September 25, 2010 in the Sanctuary of Our Lady of Divine Love in Rome . See also Pier Giorgio Frassati Ivan Merz Alberto Marvelli Bartolome Blanco Marquez References Reflist External links http www.chiaralucebadano.it Official Site Persondata Metadata see Wikipedia Persondata . NAME Badano, Chiara Luce ALTERNATIVE NAMES SHORT DESCRIPTION DATE OF BIRTH 1971 PLACE OF BIRTH DATE OF DEATH 1990 PLACE OF DEATH DEFAULTSORT Badano, Chiara Luce Category 1971 births Category 1990 deaths Category Deaths from bone cancer Category People from the Province of Benevento Category Child saints Category Italian children Category Italian Roman Catholics Category Beatified people Category Roman Catholic activists Italy bio stub Reli bio stub cs Chiara Badano de Chiara Badano fr Chiara Badano it Chiara Badano pl Klara Badano pt Chiara Badano ro Chiara Badano ... more details
Refimprove date March 2009 Apart from the true Monogenic genetics monogenic genetic disorder s, environmental factors may determine the development of disease in those genetically predisposed to a particular condition. Stress biology Stress , human body physical and mind mental abuse , Diet nutrition diet , exposure to toxin s, pathogen s, radiation and chemicals found in almost all personal care products and household cleaners are common environmental factors that determine a large segment of non hereditary disease. Environmental factors such as the weather affect business interests. If a disease process is concluded to be the result of a combination of genetics genetic and environmental factor influences, its etiological origin can be referred to as having a multifactorial pattern. An example of an environmental trigger would be a component of a human s drinking water which holds the possibility of activating triggering a change in a person s body. These changes are mainly negative ones. Citation needed date February 2007 Using this example, what is in the drinking water may affect one person entirely different than another someone may be affected greatly, whereas someone may not be at all. Many cancer s osteosarcoma , etc , along with a plethora of other disease s, are thought to be a result of environmental triggers. Citation needed date February 2007 Nitrates may be an environmental trigger for Alzheimer s , diabetes , and Parkinson s disease . ref Lifespan , http www.sciencedaily.com releases 2009 07 090705215239.htm Nitrates May Be Environmental Trigger For Alzheimer s, Diabetes And Parkinson s Disease , ScienceDaily 6 July 2009, retrieved 5 March 2010 ref Environmental triggers for asthma ref http www.niehs.nih.gov health topics conditions asthma docs FactsheetAsthmaandItsEnvironmentalTriggers.pdf Asthma and Its Environmental Triggers , National Institute of Environmental Health Sciences , May 2006, retrieved 5 March 2010 ref and autism ref http www.physorg. ... more details
Chembox verifiedrevid 400317479 ImageFile Muramyl dipeptide.png ImageSize 200px IUPACName small 4R 4 2S 2 2R 2 2R,5S 3 acetamido 2,5 dihydroxy 6 hydroxymethyl oxan 4 yl oxypropanoyl amino propanoyl amino 5 amino 5 oxopentanoic acid small OtherNames Acetylmuramyl Alanyl Isoglutamine Section1 Chembox Identifiers ChemSpiderID Ref chemspidercite correct chemspider ChemSpiderID 9794910 InChI 1 C19H32N4O11 c1 7 17 30 23 10 16 20 29 4 5 12 26 27 21 18 31 8 2 33 15 13 22 9 3 25 19 32 34 11 6 24 14 15 28 h7 8,10 11,13 15,19,24,28,32H,4 6H2,1 3H3, H2,20,29 H,21,31 H,22,25 H,23,30 H,26,27 t7 ,8 ,10 ,11 ,13 ,14 ,15 ,19? m0 s1 InChIKey BSOQXXWZTUDTEL QAQREVAFBN StdInChI Ref stdinchicite correct chemspider StdInChI 1S C19H32N4O11 c1 7 17 30 23 10 16 20 29 4 5 12 26 27 21 18 31 8 2 33 15 13 22 9 3 25 19 32 34 11 6 24 14 15 28 h7 8,10 11,13 15,19,24,28,32H,4 6H2,1 3H3, H2,20,29 H,21,31 H,22,25 H,23,30 H,26,27 t7 ,8 ,10 ,11 ,13 ,14 ,15 ,19? m0 s1 StdInChIKey Ref stdinchicite correct chemspider StdInChIKey BSOQXXWZTUDTEL QAQREVAFSA N CASNo 53678 77 6 PubChem 11620162 SMILES O C N C H NC O C H NC O C H O C H 1 C H O C H OC O C H 1NC O C CO C C CCC O O MeSHName Muramyl dipeptide Section2 Chembox Properties Formula C sub 19 sub H sub 32 sub N sub 4 sub O sub 11 sub MolarMass 492.47758 Appearance Density MeltingPt BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition Muramyl dipeptide is a peptidoglycan constituent of both Gram positive and Gram negative bacteria . It is composed of N acetylmuramic acid linked by its lactic acid moiety to the N terminus of an small L small alanine small D small isoglutamine dipeptide. ref pmid 12514169 ref See also Dipeptide Mifamurtide , a synthetic analogue for the treatment of osteosarcoma References reflist DEFAULTSORT Muramyl Dipeptide Category Peptides Category Amino sugars Organic compound stub es Muramil dip ptido ja ... more details
Infobox Football biography 2 playername Taishi Tsukamoto image fullname Taishi Tsukamoto dateofbirth Birth date and age 1985 7 4 cityofbirth Saitama prefecture countryofbirth Japan height height m 1.77 currentclub Omiya Ardija clubnumber 2 position Defender association football Right fullback youthyears1 1998 2000 youthclubs1 Kashiwa Reysol Junior Youth youthyears2 2001 2003 youthclubs2 Urawa Higasgi High School youthyears3 2004 2007 youthclubs3 Komazawa University years1 2008 clubs1 Omiya Ardija caps1 27 goals1 2 nationalyears1 nationalteam1 nationalcaps1 nationalgoals1 pcupdate 12 December 2010 ntupdate nihongo Taishi Tsukamoto Tsukamoto Taishi born July 4, 1985 is a Japanese people Japanese football soccer football player currently playing for Omiya Ardija . ref cite web publisher Guardian.co.uk title Stats Centre Taishi Tsukamoto Facts url http guardian.touch line.com StatsCentre.asp?Lang 0&CTID 63&CPID 147&pStr Player&PLID 207382&TEID 3704 accessdate 2009 08 05 ref Club career stats As of 12 December 2010 Football player statistics 1 YN Football player statistics 2 JPN YN 2008 J. League Division 1 2008 rowspan 3 Omiya Ardija rowspan 3 J. League Division 1 6 0 2 0 1 0 9 0 2009 J. League Division 1 2009 21 2 0 0 1 0 22 2 2010 J. League Division 1 2010 0 0 0 0 0 0 0 0 Football player statistics 5 27 2 2 0 2 0 31 2 Football player statistics end Personal life On 28 February 2010 was announced that the 24 year old Japanese is injured with the Osteosarcoma at the knee. Whether the defender can continue his career is still uncertain. ref http www.japantoday.com category sports view omiya defender tsukamoto says he has cancer Omiya defender Tsukamoto says he has cancer Japan Today ref References reflist Omiya Ardija Squad Persondata Metadata see Wikipedia Persondata . NAME Tsukamoto, Taishi ALTERNATIVE NAMES SHORT DESCRIPTION DATE OF BIRTH 1985 07 04 PLACE OF BIRTH Saitama prefecture , Japan DATE OF DEATH PLACE OF DEATH DEFAULTSORT Tsukamoto, Taishi Category 1985 ... more details
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