PBB geneid 9261 MAP kinase activated protein kinase 2 is an enzyme that in humans is encoded by the MAPKAPK2 gene . ref name pmid8179591 cite journal author Zu YL, Wu F, Gilchrist A, Ai Y, Labadia ME, Huang CK title The primary structure of a human MAP kinase activated protein kinase 2 journal Biochem Biophys Res Commun volume 200 issue 2 pages 1118 24 year 1994 month Jun pmid 8179591 pmc doi 10.1006 bbrc.1994.1566 ref ref name pmid8280084 cite journal author Stokoe D, Caudwell B, Cohen PT, Cohen P title The substrate specificity and structure of mitogen activated protein MAP kinase activated protein kinase 2 journal Biochem J volume 296 Pt 3 issue Pt 3 pages 843 9 year 1994 month Feb pmid 8280084 pmc 1137771 doi ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text This gene encodes a member of the Ser Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene. ref name entrez cite web title Entrez Gene MAPKAPK2 mitogen activated protein kinase activated protein kinase 2 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 9261 accessdate ref See also SB 203580 , suppresses the activation of MAPKAPK2 Interactions MAPKAPK2 has been shown to Protein protein interaction interact with MAPK14 , ref name pmid11042204 cite journal last Rane first M J authorlink coauthors Coxon P Y, Powell D W, Webster R, Klein J B, Pierce W ... yes update citations yes es MAPKAPK2 ... more details
PBB geneid 7514 Exportin 1 is a protein that in humans is encoded by the XPO1 gene . ref name pmid9205132 cite journal author Fornerod M, van Baal S, Valentine V, Shapiro DN, Grosveld G title Chromosomal localization of genes encoding CAN Nup214 interacting proteins human CRM1 localizes to 2p16, whereas Nup88 localizes to 17p13 and is physically linked to SF2p32 journal Genomics volume 42 issue 3 pages 538 40 year 1997 month Sep pmid 9205132 pmc doi 10.1006 geno.1997.4767 ref ref name pmid9368044 cite journal author Kudo N, Khochbin S, Nishi K, Kitano K, Yanagida M, Yoshida M, Horinouchi S title Molecular cloning and cell cycle dependent expression of mammalian CRM1, a protein involved in nuclear export of proteins journal J Biol Chem volume 272 issue 47 pages 29742 51 year 1997 month Dec pmid 9368044 pmc doi 10.1074 jbc.272.47.29742 ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text The protein encoded by this gene mediates leucine rich nuclear export signal NES dependent protein transport. Exportin 1 specifically inhibits the nuclear export of Structure and genome of HIV Genome organization Rev and U snRNA s. It is involved in the control of several cellular processes by controlling the localization of cyclin B , MPAK , and MAPKAPK2 MAPKAP kinase 2 . This protein also regulates NFAT and AP 1 . ref cite web title Entrez Gene XPO1 exportin 1 CRM1 homolog, yeast url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 7514 accessdate ref Interactions XPO1 has been shown to Protein protein interaction interact with NMD3 , ref name pmid12724356 cite journal last Thomas first Franziska authorlink coauthors Kutay Ulrike year 2003 month Jun. title Biogenesis and nuclear export of ribosomal subunits in higher eukaryotes depend on the CRM1 export pathway journal J. Cell. Sci. volume 116 issue Pt 12 pages 2409 19 publisher location England iss ... more details
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