transcription as part of a dynamic interactome within the cell. Lipidomics may be defined as the large ... cite journal author Wenk MR title The emerging field of lipidomics journal Nat Rev Drug Discov ... to metabolic and cardiovascular disorders. Lipidomics a global approach to lipid analysis in biological ... molecules proteins amino acids, sugars and nucleic acids. Lipidomics is a relatively recent research ... the family of systems biology . Lipidomics research involves the identification and quantification ..., and other metabolites. Investigators in lipidomics examine the structures, functions, interactions ... to lipidomics journal J. Lipid Res. volume 44 issue 6 pages 1071 9 year 2003 month June pmid 12671038 ... defined the field of lipidomics through integrating the specific chemical properties inherent in lipid molecular species with a comprehensive mass spectrometric approach. Although lipidomics is under the umbrella of the more general field of metabolomics , lipidomics is itself a distinct discipline ... ref and The European Lipidomics Initiative ELIfe . ref http www.lipidomics.net European Lipidomics ... The progress of modern lipidomics has been greatly accelerated by the development of spectrometric .... Han and coworkers have developed a method known as shotgun lipidomics which involves direct infusion ... title Lipidomics in diabetes and the metabolic syndrome journal Meth. Enzymol. volume 433 issue pages .... MALDI Time of flight MALDI TOF MS has become a very promising approach for lipidomics studies ... Schiller J, Suss R, Fuchs B, Muller M, Zschornig O, Arnold K title MALDI TOF MS in lipidomics ... of a gene product coupled with lipidomics, can give valuable insights into the role ... challenge for lipidomics, in particular for MS based approaches, lies in the computational and bioinformatic ... Puig A, Oresic M title Bioinformatics strategies for lipidomics analysis characterization of obesity ... side of lipidomics involves the construction of metabolic maps from data on lipid structures and lipid ... more details
Orphan date November 2006 In lipidomics , the process of shotgun lipidomics named by analogy with shotgun sequencing uses analytical chemistry to investigate the biological function, significance, and sequelae ... function in cells. Lipidomics has been greatly facilitated by recent advances in, and novel applications of, electrospray ionization mass spectrometry ESI MS . Lipidomics is a research field .... Investigators in lipidomics examine the structures, functions, interactions, and dynamics of cellular ... platforms currently used for lipidomic analyses are HPLC MS and shotgun lipidomics. History Shotgun lipidomics was developed by http outlook.wustl.edu spring2005 images feature fatlab.jpg Richard W ... Shotgun lipidomics is fast, highly sensitive, and it can identify hundreds of lipids missed by other ... can be examined. Further reading cite journal author Han X, Gross RW title Shotgun lipidomics electrospray ... cite journal author Han X, Gross RW title Shotgun lipidomics multidimensional MS analysis of cellular ... to lipidomics journal J. Lipid Res. volume 44 issue 6 pages 1071 9 year 2003 month June pmid 12671038 ... title Shotgun lipidomics of phosphoethanolamine containing lipids in biological samples after one ... of an automated high throughput platform for shotgun lipidomics cite journal author Cheng H, Mancuso DJ, Jiang X, et al. title Shotgun lipidomics reveals the temporally dependent, highly diversified ... Yang K, Zhao Z, Gross RW, Han X editor1 last Fox editor1 first Debbie title Shotgun lipidomics identifies ... cite journal author Gross RW, Han X title Lipidomics in diabetes and the metabolic syndrome journal ... extracts extends shotgun lipidomics analyses to the low abundance regime of cellular sphingolipids ... earliest stages of diabetes a shotgun lipidomics study journal Biochemistry volume 46 issue 21 ... lipidomics of cardiolipin molecular species in lipid extracts of biological samples journal J. Lipid ... DR, Gross RW title Shotgun lipidomics identifies cardiolipin depletion in diabetic myocardium linking ... more details
Garc a M, Henry SA title The emergence of yeast lipidomics journal Biochim. Biophys. Acta volume 1771 ... 2011 05 07 refend External links http www.lipidmaps.org Lipidomics gateway Category Lipids ... more details
Extrapolation based Molecular Systems Biology is the utilization of molecular data from one or many sub cellular levels to indirectly infer the remaining components of a sub cellular system via statistical algorithms and priori biological knowledge. The motivation to rebuild remaining components of a system is driven primarily by adopting a systems biologist s view of a biological phenomenon where a pan omic view is a consistent requirement ... Denis Noble The Music of Life . The term extrapolation is chosen to provide caution due to a high potential of false positives with high levels of extrapolation. On average, fewer levels and smaller leaps of inference and greater levels of observational data is recommended for a statistically significant extrapolated system. Sub cellular levels may include one or more of the following but not limited to see Systems Biology Genomics , Epigenomics Epigenetics , Transcriptomics , Interferomics , Translatomics Proteomics , Metabolomics , Glycomics , Lipidomics , Interactomics , and Fluxomics . File Example of Extrapolation121009 1.jpg thumb Example see image on right Molecular level of quantitative data is illustrated in green, inferred levels are illustrated in yellow, and non active missing molecular levels are illustrated in grey. Data source s & Algorithm s are listed on the right. Acknowledgements Irizarry et al. 2004, Su et al. 2004, Subramanium et al. 2005, Warren et al. 2008, Theocharidis et al. 2009. Category Systems biology ... more details
chembox verifiedrevid 361336915 ImageFile Hexatriacontanoic acid.svg ImageSize 300px IUPACName hexatriacontanoic acid OtherNames Section1 Chembox Identifiers CASNo PubChem 5282596 SMILES CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC O O Section2 Chembox Properties Formula C sub 36 sub H sub 72 sub O sub 2 sub MolarMass 537.0 g mol Appearance Density MeltingPt BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition Hexatriacontanoic acid or hexatriacontylic acid is a saturated fatty acid . ref name Ries cite journal title Monolayer Structure as Revealed by Electron Microscopy journal Journal of Physical Chemistry date January 1955 first Herman E. Jr. last Ries coauthors Wayne A. Kimball volume 59 issue 1 pages 94 doi 10.1021 j150523a028 url http pubs.acs.org doi abs 10.1021 j150523a028 format accessdate 2010 05 09 ref ref name patent395 cite patent US 3954975 ref See also List of saturated fatty acids References reflist External links http www.lipidmaps.org data get lm lipids dbgif.php?LM ID LMFA01010036 Hexatriacontanoic acid at the Nature Lipidomics Gateway organic compound stub Fatty acids Category Fatty acids ... more details
chembox verifiedrevid 361312018 ImageFile Ceroplastic acid.svg ImageSize 300px IUPACName Ceroplastic acid OtherNames Section1 Chembox Identifiers CASNo PubChem 5282595 SMILES CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC O O Section2 Chembox Properties Formula C sub 35 sub H sub 70 sub O sub 2 sub MolarMass 522.93 g mol Appearance Density MeltingPt BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition Ceroplastic acid or pentatriacontanoic acid is a saturated fat saturated aliphatic compound aliphatic carboxylic acid . ref name US patent 6077908 patent US 6077908 ref Applications Like many other carboxylic acids, ceroplastic acid can react with UV curable moiety alcohols to form reactive esters, such as 2 allyloxyethanol . ref name US patent 7578587 patent US 7578587 ref See also List of saturated fatty acids References reflist External links http www.lipidmaps.org data LMSDRecord.php?LMID LMFA01010035 Ceroplastic acid at the Nature Lipidomics Gateway organic compound stub Fatty acids Category Fatty acids ... more details
chembox Watchedfields changed verifiedrevid 428816863 ImageFile Hentriacontylic acid.svg ImageSize 300px IUPACName Hentriacontanoic acid OtherNames Henatriacontylic acid Henatriacontanoic acid Section1 Chembox Identifiers CASNo Ref cascite correct ?? CASNo 38232 01 8 PubChem 37982 SMILES OC CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC O Section2 Chembox Properties C 31 H 62 O 2 Appearance Density MeltingPt 109.3 109.6 C ref Cite journal author Bowman, R. E. journal Journal of the Chemical Society year 1951 pages P2748 51 ref BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition Hentriacontylic acid also hentriacontanoic acid , henatriacontylic acid , or henatriacontanoic acid is a carboxylic acid carboxylic saturated fat saturated fatty acid . Sources Hentriacontylic acid can be derived from peat wax and montan wax . The olefin triacontene 1 can be reacted to yield linear n henatriacontanoic acid. ref patent US 3718676 ref See also List of saturated fatty acids References reflist External links http www.lipidmaps.org data LMSDRecord.php?LMID LMFA01010031 Hentriacontylic acid at the Nature Lipidomics Gateway organic compound stub Fatty acids Category Fatty acids ... more details
Cytomes are the cellular systems, subsystems, and functional components of the Human anatomy body . The cytome is the collection of the complex and dynamic cellular processes structure and function underlying Physiology physiological processes. It describes the structural and functional heterogeneity of the cellular diversity of an organism . The study of cytomes is called Cytomics . The Human Cytome Project is about the study of the biological system structure and function of an organism at the cytome level. It relates to Cytomics , which is the study of Cell biology cell systems cytomes at a single cell level. At the http www.focusonmicroscopy.org Focus on Microscopy FOM meeting in Philadelphia, on Wednesday afternoon, 7 April 2004, the idea of a Human Cytome Project was for the first time discussed at a scientific meeting. See also Cytomics Cell biology Human Genome Project EuroPhysiome Lipidomics References Davies E, Stankovic B, Azama K, Shibata K, Abe S., Novel components of the plant cytoskeleton A beginning to plant cytomics , Plant Science, Invited Review, Plant Science 2001 160 2 185 196. Fenech M., Cytokinesis block micronucleus assay evolves into a cytome assay of chromosomal instability, mitotic dysfunction and cell death., Mutat Res. 2006 Aug 30 600 1 2 58 66. Galle J, Aust G, Schaller G, Beyer T, Drasdo D., Individual cell based models of the spatial temporal organization of multicellular systems achievements and limitations, Cytometry A. 2006 Jul 69 7 704 10. Valet G, Tarnok A, Potential and challenges of a human cytome project, J Biol Regul Homeost Agents, 2004, Apr Jun 18 2 87 91. Valet G., Cytomics an entry to biomedical cell systems biology, Cytometry A. 2005 Feb 63 2 67 8. Perez OD, Nolan GP., Phospho proteomic immune analysis by flow cytometry from mechanism to translational medicine at the single cell level, Immunol Rev. 2006 Apr 210 208 28. cell biology stub Category Cell biology ... more details
chembox verifiedrevid 403877042 ImageFile Dotriacontanoic acid.svg ImageSize 300px IUPACName dotriacontanoic acid OtherNames Section1 Chembox Identifiers CASNo PubChem 19255 SMILES CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC O O Section2 Chembox Properties Formula C sub 32 sub H sub 64 sub O sub 2 sub MolarMass 480.85 g mol Appearance Density MeltingPt BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition Lacceroic acid or dotriacontanoic acid is a saturated fat saturated fatty acid . Sources Lacceroic acid can be derived by sapon. of lacceryl lacceroate , or oxidation of laccerol and purification of the product by certain methods. ref name ACS1922 cite journal title Chemical Abstracts journal American Chemical Society date 1922 01 10 first last coauthors volume 16 issue 1 pages 50 id url http books.google.com books?id 1K 2AAAAIAAJ&printsec frontcover format accessdate 2010 05 10 ref Derivatives Ethyl lacceroate can be obtained by the action of Hydrogen chloride HCl gas on lacceroic acid in boiling abs. alc., rhombic plates, m. 76 . ref name ACS1922 See also List of saturated fatty acids References reflist External links http www.lipidmaps.org data LMSDRecord.php?LMID LMFA01010032 Lacceroic acid at the Nature Lipidomics Gateway Fatty acids DEFAULTSORT Lacceroic Acid Category Fatty acids organic compound stub ... more details
chembox verifiedrevid 434945288 ImageFile Melissic acid.svg ImageSize 300 IUPACName triacontanoic acid OtherNames Section1 Chembox Identifiers CASNo Ref cascite correct ?? CASNo 506 50 3 PubChem 10471 SMILES CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC O O Section2 Chembox Properties Formula C sub 30 sub H sub 60 sub O sub 2 sub MolarMass 452.46 g mol Appearance Density MeltingPt BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition Melissic acid or triacontanoic acid is a saturated fat saturated fatty acid . History Melissic acid was named as such because Melissa is derived from a Greek language Greek word meaning bee, owing to the abundance of nectar in the flowers which attracts bees. Synthesis n Triacontanoic acid was synthesized by Bleyberg and Ulrich 1931 and by Mrs. Robinson. ref name Chibnall cite journal title The isolation of n triacontanol from lucerne wax journal Biochemical Journal year 1933 first Albert Charles last Chibnall coauthors Ernest Frank Williams, Alfred Louis Latner, Stephen Harvey Piper volume 27 issue 6 pages 1885 1888 pmid 16745314 pmc 1253114 ref Self assembly Triacontanoic acid and triacontanamide CH sub 3 sub CH2 sub 28 sub CONHI can be self assembled. ref name Weinbach 1993 cite journal title Self assembled Langmuir monolayers and trilayers at the air formamide interface journal Journal of Physical Chemistry date May 1993 first Susan P. last Weinbach coauthors Kristian Kjaer, Jens Als Nielsen, Meir Lahav, Leslie Leiserowitz volume 97 issue 20 pages 5200 5203 doi 10.1021 j100122a003 ref See also List of saturated fatty acids References reflist External links http www.lipidmaps.org data LMSDRecord.php?LMID LMFA01010030 Melissic acid at the Nature Lipidomics Gateway Fatty acids Category Fatty acids organic compound stub de Melissins ure lv Melis nsk be pl Kwas melisowy pt cido mel ssico ... more details
A virosome is a drug carrier drug or vaccine delivery mechanism consisting of unilamellar phospholipid lipid bilayer bilayer vesicle lipidomics vesicle incorporating virus derived proteins to allow the virosomes to fuse with target cells. Virosomes are not able to replicate but are pure fusion active vesicles. Influenza virosomes In contrast to liposome s, virosomes contain functional viral envelope glycoprotein s influenza virus hemagglutinin HA and neuraminidase NA intercalated in the phospholipid bilayer membrane. They have a typical mean diameter of 150 nm. Essentially, virosomes represent reconstituted empty influenza virus envelopes, devoid of the nucleocapsid including the genetic material of the source virus . ref http www.ncbi.nlm.nih.gov pubmed 16026906 The virosome concept for influenza vaccines. 2005 ref The unique properties of virosomes partially relate to the presence of biologically active influenza HA in their membrane. This viral protein not only confers structural stability and homogeneity to virosome based formulations, but it significantly contributes to the immunological properties of virosomes, which are clearly distinct from other liposomal and proteoliposomal carrier systems. It has been shown that a physical association between the virosome and the antigen of interest is necessary for the full immunologic adjuvant adjuvant effect of virosomes. Fact date July 2007 Such physical association can be achieved by a variety of methods, depending on the properties of the antigen. Antigens can be incorporated into virosomes, adsorption adsorbed to the virosome surface, or integrated into the lipid membrane, either via hydrophobic domains or lipid moieties cross linked to the antigen. Virosomes therefore represent an innovative, broadly applicable adjuvant and carrier system with prospective applications in areas beyond conventional vaccines. They are one of only three adjuvant systems widely approved by regulatory authorities Fact date July 2007 and ... more details
Cytomics is the study of Cell biology cell systems cytomes at a single cell level. It combines all the bioinformatic knowledge to attempt to understand the molecular architecture and functionality of the cell system Cytome . Much of this is achieved by using molecular and microscopic techniques that allow the various components of a cell to be visualised as they interact in vivo . See also Cytome EuroPhysiome Flow cytometry Genomics Human Genome Project Lipidomics List of omics topics in biology Metabolomics Microscopy Omics Proteomics Tissue microarray References Reflist Bernas T., Gregori G., Asem E. K., Robinson J. P., Integrating cytomics and proteomics, Mol Cell Proteomics. 2006 Jan 5 1 2 13. Chen X., Velliste M., Murphy R. F., Automated interpretation of subcellular patterns in fluorescence microscope images for location proteomics, Cytometry A. 2006 Jul 69 7 631 40. Davies E., Stankovic B., Azama K., Shibata K., Abe S., Novel components of the plant cytoskeleton A beginning to plant cytomics , Plant Science, Invited Review, Plant Science 2001 160 2 185 196. Herrera G., Diaz L., Martinez Romero A., Gomes A., Villamon E., Callaghan R. C., O connor J. E., Cytomics A multiparametric, dynamic approach to cell research, Toxicol In Vitro. 2006 Jul 22. Kriete A., Cytomics in the realm of systems biology, Cytometry A. 2005 Nov 68 1 19 20. Murphy R. F., Cytomics and location proteomics automated interpretation of subcellular patterns in fluorescence microscope images, Cytometry A. 2005 Sep 67 1 1 3. Schubert W., Cytomics in characterizing toponomes towards the biological code of the cell, Cytometry A. 2006 Apr 69 4 209 11. Valet G., Tarnok A, Cytomics in predictive medicine, Cytometry, 2003, 53B 1 3. Valet G., Predictive medicine by cytomics and the challenges of a human cytome project, Business Briefing Future Drug Discovery 2004, Ed E Cooper, World Markets Research Center Ltd, London, 2004 46 51. Valet G., Cytomics an entry to biomedical cell systems biology, Cytomet ... more details
Shotgun proteomics is a method of identifying protein s in complex mixtures using a combination of high performance liquid chromatography combined with mass spectrometry . ref cite journal author Washburn MP, Wolters D, Yates JR title Large scale analysis of the yeast proteome by multidimensional protein identification technology journal Nat. Biotechnol. volume 19 issue 3 pages 242 247 year 2001 pmid 11231557 doi 10.1038 85686 ref ref cite journal author Wolters DA, Washburn MP, Yates JR title An automated multidimensional protein identification technology for shotgun proteomics journal Anal. Chem. volume 73 issue 23 pages 5683 5690 year 2001 pmid 11774908 doi 10.1021 ac010617e ref ref cite journal author Hu L, Ye M, Jiang X, Feng S, Zou H title Advances in hyphenated analytical techniques for shotgun proteome and peptidome analysis a review journal Anal. Chim. Acta volume 598 issue 2 pages 193 204 year 2007 pmid 17719892 doi 10.1016 j.aca.2007.07.046 ref ref name pmid17649983 cite journal author Fournier ML, Gilmore JM, Martin Brown SA, Washburn MP title Multidimensional separations based shotgun proteomics journal Chem. Rev. volume 107 issue 8 pages 3654 86 year 2007 pmid 17649983 doi 10.1021 cr068279a ref ref name pmid17185772 cite journal author Nesvizhskii AI title Protein identification by tandem mass spectrometry and sequence database searching journal Methods Mol. Biol. volume 367 issue pages 87 119 year 2007 pmid 17185772 doi 10.1385 1 59745 275 0 87 ref The name is derived from shotgun sequencing of DNA which is itself named by analogy with the rapidly expanding, quasi random firing pattern of a shotgun . In shotgun proteomics, the proteins in the mixture are protease digested and the resulting peptide s are separated by liquid chromatography. Tandem mass spectrometry is then used to identify the peptides. See also Shotgun lipidomics Protein mass spectrometry Bottom up proteomics Top down proteomics Mass spectrometry software References Reflist Bibliograph ... more details
Infobox Company company name Premier Biosoft company logo Image Pbi.png company type Private company Private foundation 1994 location Palo Alto , California key people Kay Brown CEO homepage http www.premierbiosoft.com www.premierbiosoft.com PREMIER Biosoft International PBI for short is a California , United States based bioinformatics company. The company specializes in developing software for use in life science research. In addition to developing software products, the company offers assay design services and consultancy for bioinformatics projects. ref http lifesciencedirectory.com link.php?n 1394 Link Details Bioinformatics Companies premier Biosoft Bot generated title ref Company Background PREMIER Biosoft, established in 1994, is one of the earliest bioinformatics company, founded by Ms. Kay Brown with a mission to serve the life science research labs all over the world. The mission statement for PBI reads as follows Accelerating Research in Life Sciences The company serves research labs, pharmaceuticals, core facilities and biotechnology companies with its products. The company s first product, Primer Premier, was authored over 12 years ago, for designing PCR assays. Products & Services After the launch of Primer Premier the company released SimVector, a plasmid drawing and cloning simulation tool, and Array Designer, for designing microarray probes. The trend in the PCR market was soon shifting towards a new and powerful technique called real time PCR. PREMIER Biosoft caught up early and authored Beacon Designer , supporting the most popular real time PCR chemistries The company later came out with a pathogen detection system called AlleleID with support for real time PCR and microarray probe design for designing cross species, species specific, intron exon spanning assays and splice variant microarrays. The company has ventured into proteomics, glycomics and lipidomics research with the launch of Xpression Primer tagged primer design tool , SimGlycan MS M ... more details
Image Maldi ms imaging msi rat mz616.gif thumb right 300 px MALDI MS image shows distribution of m z 616 in a whole body tissue section of a rat. m z 616 corresponds to the mass of heme b . MALDI imaging is the use of matrix assisted laser desorption ionization as a mass spectrometry imaging ref name pmid17471576 cite journal author McDonnell LA, Heeren RM title Imaging mass spectrometry journal Mass spectrometry reviews volume 26 issue 4 pages 606 43 year 2007 pmid 17471576 doi 10.1002 mas.20124 ref technique in which the sample, often a thin Tissue biology tissue section, is moved in two dimensions while the mass spectrum is recorded. ref name pmid17081040 cite journal author Chaurand P, Norris JL, Cornett DS, Mobley JA, Caprioli RM title New developments in profiling and imaging of proteins from tissue sections by MALDI mass spectrometry journal J. Proteome Res. volume 5 issue 11 pages 2889 900 year 2006 pmid 17081040 doi 10.1021 pr060346u ref Applications File MALDI imaging target.jpg thumb right 200 px Target for MALDI imaging with two conductive surface microscope slides. MALDI imaging mass spectrometry involves the visualization of the spatial distribution of proteins, peptides, drug candidate compounds and their metabolites, biomarkers or other chemicals within thin slices of sample such as animal tissue or plant. ref name pmid15677390 cite journal author Caldwell RL, Caprioli RM title Tissue profiling by mass spectrometry a review of methodology and applications journal Mol. Cell Proteomics volume 4 issue 4 pages 394 401 year 2005 pmid 15677390 doi 10.1074 mcp.R500006 MCP200 ref ref name pmid17185024 cite journal author Reyzer ML, Caprioli RM title MALDI MS based imaging of small molecules and proteins in tissues journal Current opinion in chemical biology volume 11 issue 1 pages 29 35 year 2007 pmid 17185024 doi 10.1016 j.cbpa.2006.11.035 ref ref name pmid16796390 cite journal author Woods AS, Jackson SN title Brain tissue lipidomics direct probing using m ... more details
Infobox Non profit Non profit name American Society for Biochemistry and Molecular Biology Non profit logo Non profit type founded date December 26th, 1906 founder John Jacob Abel location Bethesda, Maryland origins key people Suzanne Pfeffer President br Merle S. Olson Treasurer br Mark Lemmon Secretary area served product focus method revenue endowment num volunteers num employees num members 12,000 subsid owner Non profit slogan homepage http www.asbmb.org www.asbmb.org dissolved footnotes The American Society for Biochemistry and Molecular Biology ASBMB is a learned society that was founded on December 26, 1906 at a meeting organized by John Jacob Abel Johns Hopkins University . ref Bradshaw, R. A., Hancock, C. C., Kresge, N. 2009 The ASBMB Centennial History 100 Years of the Chemistry of Life ref The roots of the society were in the American Physiological Society , which had been formed some 20 years earlier. The ASBMB was originally called the American Society of Biological Chemists , before obtaining its current name in 1987. The society is based in Rockville, Maryland . ASBMB s mission is to advance the science of biochemistry and molecular biology through publication of scientific journal scientific and educational journals, the organization of scientific meetings, advocacy for funding of basic research and education, support of science education at all levels, and by promoting the diversity of individuals entering the scientific workforce. The organization currently has over 12,000 members. Publications The American Society for Biochemistry and Molecular Biology publishes three research journals and a monthly magazine covering society news and activity updates. ASBMB journals are Peer review peer reviewed and cover research in the fields of microbiology , molecular genetics, RNA related research, proteomics , genomics , transcription, peptides, cell signaling , lipidomics, and systems biology . All articles are published online as Papers in Press upon acce ... more details
platforms biomarker assay techniques, metabolomics, lipidomics, glycomics, and secretomics are the most ... . Lipidomics Approach Lipidomics refers to the analysis of lipids. Since lipids have unique ... more details
Confusing date December 2006 Transfersome is a term registered as a trademark by the Germany German company IDEA AG, and used by it to refer to its wikt proprietary proprietary drug delivery technology. The name means carrying body , and is derived from the Latin word transferre , meaning to carry across , and the Greek word soma , for a body . A Transfersome carrier is an vesicle lipidomics artificial vesicle designed to be like a vesicle biology cell vesicle or a cell engaged in exocytosis , and thus suitable for controlled and, potentially targeted, drug delivery. Discovery The term Transfersome and the underlying concept were introduced in 1991 by Gregor Cevc. Numerous groups have since been working with similar carriers, frequently under different names elastic vesicle, flexible vesicle, Ethosome, etc. to describe them. In broadest sense, a Transfersome is a highly adaptable and stress responsive, complex aggregate. Its preferred form is an ultradeformable vesicle possessing an aqueous core surrounded by the complex lipid bilayer . Interdependency of local composition and shape of the bilayer makes the vesicle both self regulating and self optimising. This enables the Transfersome to cross various transport barriers efficiently, and then act as a Drug carrier for non invasive targeted drug delivery and sustained release of therapy therapeutic agents. Composition and mechanism of action The carrier aggregate is composed of at least one amphiphat such as phosphatidylcholine , which in aqueous solvents self assembly self assembles into lipid bilayer that closes into a simple lipid vesicle biology vesicle . By addition of at least one bilayer softening component such as a biocompatible surfactant or an amphiphile drug lipid bilayer flexibility and Semipermeable membrane permeability are greatly increased. The resulting, flexibility and permeability optimised, Transfersome vesicle can therefore adapt its shape to ambient easily and rapidly, by adjusting local concen ... more details
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