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Insulin like growth factor 1 receptor
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Encyclopedia results for Insulin like growth factor 1 receptor

Insulin like growth factor 1 receptor





Encyclopedia results for Insulin like growth factor 1 receptor

  1. Insulin-like growth factor 1 receptor

    PBB geneid 3480 The Insulin like Growth Factor 1 IGF 1 Receptor is a transmembrane receptor transmembrane ... R, Brewster SF, Macaulay VM title Expression of the type 1 insulin like growth factor receptor is up ... AM, Voelker MA, Sternberg H, Timiras PS title Insulin like growth factor 1 receptor immunoreactive ... . Interactions Insulin like growth factor 1 receptor has been shown to Protein protein interaction interact ... interaction of the insulin like growth factor I receptor with IRS 1, Shc, and Grb10 journal ... 2001 month Aug. title Association of insulin like growth factor 1 receptor with EHD1 and SNAP29 journal ... of SHC and the insulin receptor substrate 1 IRS 1 with the insulin like growth factor I IGF I receptor ... K year 2001 month Nov. title Direct interaction of insulin like growth factor 1 receptor with leukemia ... like growth factor 2 receptor IGF 2R and their respective ligands IGF 1 and IGF 2 , along with several ... C, Hofmann F, Krystal GW title The insulin like growth factor I receptor kinase inhibitor, NVP ADW742 ... D, Knowlden JM, Williams S, Wakeling AE, Nicholson RI title Insulin like growth factor I receptor ..., Bell RH, Hurtado Coll A, Fazli L, Gleave ME, Cox ME title Increased insulin like growth factor I receptor ... with the insulin like growth factor I receptor journal Biochem. Biophys. Res. Commun. volume ... Aug. title Localization of the insulin like growth factor I receptor binding sites for the SH2 ... ligand induced ubiquitination and stability of the insulin like growth factor I receptor journal ... of phosphatidylinositol 3 kinase with insulin like growth factor 1 signaling proteins journal ... kinase associates with ligand stimulated insulin like growth factor I receptor journal J. Biol. Chem ... of c Cbl as a new ligase for insulin like growth factor I receptor with distinct roles from ... T A year 1997 month Apr. title 14 3 3 epsilon interacts with the insulin like growth factor I receptor ... like growth factor 1 receptor in tongue squamous cell carcinoma cells journal Biochemical Journal ...   more details



  1. Insulin-like growth factor 2 receptor

    A, Francke U title Chromosomal mapping of the gene for the type II insulin like growth factor receptor ... is a multifunctional protein receptor biochemistry receptor that binds insulin like growth factor 2 ... Insulin like growth factor 2 receptor has been shown to Protein protein interaction interact with M6PRBP1 ... author Hawkes C, Kar S title The insulin like growth factor II mannose 6 phosphate receptor structure ... Insulin like growth factor II receptor as a multifunctional binding protein journal Nature volume 329 ... 6 phosphate insulin like growth factor II receptor locus in human hepatocellular tumors journal ... Siemsen C, Waheed A, et al. title Localization of the insulin like growth factor II binding site to amino acids 1508 1566 in repeat 11 of the mannose 6 phosphate insulin like growth factor II receptor ... 6 Phosphate Insulin like Growth Factor II Receptor Targets the Urokinase Receptor to Lysosomes ... cation dependent mannose 6 phosphate receptor In the fields of biochemistry and cell biology , the insulin like growth factor 2 receptor IGF2R , also called the cation independent mannose 6 phosphate ... O Dell SD, Day IN title Insulin like growth factor II IGF II journal Int. J. Biochem. Cell Biol ... M title Expression of insulin like growth factors I and II and their receptor mRNAs in primary ... cite journal author Zhou J, Bondy C title Insulin like growth factor II and its binding proteins ... Ishiwata T, Bergmann U, Kornmann M, et al. title Altered expression of insulin like growth factor II ... Like Growth Factor II Receptor PDB Gallery geneid 3482 Clusters of differentiation Growth factor receptors ... Identification and cloning of a connective tissue growth factor like cDNA from human osteoblasts encoding ... pnas.160251397 url ref See also Cluster of differentiation IGF 1 Receptor Mannose 6 phosphate receptor ... doi 10.1038 ng1295 447 cite journal author Ilvesm ki V, Blum WF, Voutilainen R title Insulin like growth factor binding proteins in the human adrenal gland journal Mol. Cell. Endocrinol. volume 97 ...   more details



  1. Insulin-like growth factor 1

    is mediated by binding to its specific receptor, the Insulin like growth factor 1 receptor , abbreviated ... IGF 1 has for its receptor, Insulin like growth factor 1 receptor IGFR , its binding does not interfere ...PBB geneid 3479 Insulin like growth factor 1 IGF 1 also known as somatomedin C is a protein that in humans ... factors IGF 1 is closely related to a second protein called Insulin like growth factor 2 IGF 2 ... available for binding with IGF 1R. As the name insulin like growth factor 1 implies, IGF 1 is structurally ... al, 2008 cite journal title Functionally significant insulin like growth factor I receptor mutations ... ref Interactions Insulin like growth factor 1 has been shown to bind and interact with all the IGF ... II to insulin like growth factor binding proteins 1 6 journal J. Biol. Chem. volume 268 issue 13 ... al. title Insulin like growth factor 1 as a vascular protective factor journal Circulation volume ... Insulin and insulin like growth factor 1 abnormalities in antipsychotic naive schizophrenia journal ... The human gene encoding insulin like growth factor I is located on chromosome 12 journal Hum. Genet ... JC, Tong PC., Glucose lowering effect of transgenic human insulin like growth factor I from rice in vitro ... to the insulin like effects, IGF 1 can also regulate cell growth and development, especially ... serum insulin like growth factor I concentration journal J Anim Sci volume 77 issue 4 pages 835 9 .... Like the insulin receptor, the IGF 1 receptor is a receptor tyrosine kinase meaning it signals by causing ... also called the mannose 6 phosphate receptor . The insulin growth factor II receptor IGF2R lacks ... 00 81751 1 url ref daf 2 encodes the worm s unified insulin IGF 1 like receptor biochemistry receptor ... hormone insulin like growth factor GH IGF axis by pharmaceutical, nutraceutical and environmental ... D, Holly J title Cancer and insulin like growth factor I A potential mechanism linking the environment ... of recombinant insulin like growth factor I in the treatment of the short child journal Curr ...   more details



  1. Insulin-like growth factor

    ligand s IGF 1 and IGF 2 , a family of six high affinity Insulin like growth factor binding protein IGF binding proteins IGFBP 1 6 , as well as associated Insulin like growth factor binding protein IGFBP ... referred to as the Growth Hormone IGF1 Axis. Insulin like growth factor 1 IGF 1 is mainly secreted by the liver as a result of stimulation by growth hormone GH . IGF 1 is important for both the regulation ... PDR.0b013e3181425869 ref IGF Receptors The IGF s are known to bind the IGF 1 receptor , the insulin receptor , the insulin like growth factor 2 receptor IGF 2 receptor , the insulin related receptor ... 4522 97 00539 3 ref See also Insulin like growth factor 1 Insulin like growth factor 2 Growth hormone ...Image 3GF1 Insulin Like Growth Factor Nmr 10 01.png thumb ILGF The insulin like growth factors IGFs are protein ... death apoptosis . Insulin like growth factor 2 IGF 2 is thought to be a primary growth factor required for early development while IGF 1 expression is required for achieving maximal growth. Gene ... like Growth Factor I and Insulin like Growth Factor Binding Protein 3 with Intelligence Quotient ... higher affinity than it binds the insulin receptor. Like the insulin receptor, the IGF 1 ... R, Goldfine ID, Pezzino V year 1993 title Insulin like growth factor I receptors are overexpressed ... hormone insulin like growth factor GH IGF axis by pharmaceutical, nutraceutical and environmental ... like growth factor 1 messenger RNA expression are severely attenuated in middle aged and aged rats ... tissue types express the IGF 1 receptor , IGF 1 s effects are diverse. It acts as a neurotrophic factor ... like growth factor binding protein IGF Binding Proteins . These proteins help to modulate IGF ... 2001 title Regulation of DAF 2 receptor signaling by human insulin and ins 1, a member of the unusually ... 6 pages 672 86 pmid 11274053 pmc 312654 doi 10.1101 gad.867301 ref that are insulin like or IGF 1 like ... RG year 1991 title Insulin like growth factors IGFs , IGF receptors, and IGF binding proteins ...   more details



  1. Insulin-like growth factor 2

    by binding to the Insulin like growth factor 1 receptor IGF 1 receptor . IGF2 may also bind to the Insulin like growth factor 2 receptor IGF 2 receptor also called the cation independent mannose 6 phosphate receptor , which acts as a signalling antagonist that is, to prevent IGF2 responses. Function ... by binding to the Insulin like growth factor 1 receptor IGF 1 receptor . IGF2 may also bind to the Insulin like growth factor 2 receptor IGF 2 receptor also called the cation independent mannose ... and Transferrin . ref name pmid11749962 See also Insulin like growth factor 2 receptor Insulin like growth factor II IRES References reflist External links MeshName Insulin Like Growth Factor II Further ... IH, et al. title Insulin like growth factor I receptor signal transduction at the interface between ...PBB geneid 3481 Infobox protein family Symbol IGF2 C Name Insulin like growth factor II E peptide image ... OPM protein CAZy CDD Insulin like growth factor 2 IGF 2 is one of three protein hormone s that share structural similarity to insulin . Gene structure In humans, the IGF2 gene is located on chromosome ... mallitus Interactions Insulin like growth factor 2 has been shown to Protein protein interaction ... insulin like growth factors and affects binding properties of insulin like growth factor binding protein ... surface binding of insulin like growth factor binding protein 3 journal J. Biol. Chem. volume ... KR, Conover CA title The insulin like growth factor insulin system in epithelial ovarian cancer ... journal author Wood AW, Duan C, Bern HA title Insulin like growth factor signaling in fish. journal ... citations yes DEFAULTSORT Insulin Like Growth Factor 2 Category Peptide hormones Category Growth ... last Twigg first S M authorlink coauthors Baxter R C year 1998 month Mar. title Insulin like growth ... like growth factor II IGF II . journal Int. J. Biochem. Cell Biol. volume 30 issue 7 pages 767 ... along with Differentially methylated Region 1 DMR1 and Matrix Attachment Region 3 MAR3 . These three ...   more details



  1. Insulin-like growth factor-binding protein

    Pfam box Symbol IGFBP Name Insulin like growth factor br binding protein image PDB 1boe EBI.jpg width caption Structure of the IGF binding domain of the insulin like growth factor binding protein 5 IGFBP 5 . ref name pmid9822601 cite journal author Kalus W, Zweckstetter M, Renner C, et al. title Structure of the IGF binding domain of the insulin like growth factor binding protein 5 IGFBP 5 implications for IGF and IGF I receptor interactions journal EMBO J. volume 17 issue 22 pages 6558 72 year 1998 month November pmid 9822601 pmc 1171003 doi 10.1093 emboj 17.22.6558 url ref Pfam PF00219 InterPro IPR000867 SMART SM00121 PROSITE PDOC00194 SCOP 1boe TCDB OPM family OPM protein PDB PDB2 1boe , PDB2 1h59 The Insulin like growth factor binding protein also known as IGFBP serves as a carrier protein for Insulin like growth factor 1 IGF 1 . ref name pmid10605625 cite journal author Hwa V, Oh Y, Rosenfeld RG title The insulin like growth factor binding protein IGFBP superfamily journal Endocr. Rev. volume 20 issue 6 pages 761 87 year 1999 month December pmid 10605625 doi 10.1210 er.20.6.761 url issn ref Function Approximately 98 of IGF 1 is always bound to one of 6 binding proteins IGF BP . IGFBP 3, the most abundant protein, accounts for 80 of all IGF binding. IGF 1 binds to IGFBP 3 in a 1 1 molar ratio. IGF BP also binds to IGF 1 inside the liver, allowing growth hormone to continuously act upon the liver to produce more IGF 1. This is important because proliferating IGF 1 IGF BP complex allow growth of the femur and the muscle. fact date May 2011 IGF binding proteins IGFBPs are proteins ... title Role of insulin like growth factor binding proteins in the control of IGF actions journal Prog. Growth Factor Res. volume 6 issue 2 4 pages 357 66 year 1995 pmid 8817679 doi 10.1016 0955 2235 ... SM, Pell JM title Potentiation of insulin like growth factor I IGF I activity by an antibody ... Reflist External links MeshName Insulin like growth factor binding proteins biochemistry stub Carrier ...   more details



  1. Insulin-like growth factor II IRES

    Infobox rfam Name Insulin like growth factor II IRES image RF00483.jpg width caption Predicted secondary structure and sequence conservation of IRES IGF2 Symbol IRES IGF2 AltSymbols Rfam RF00483 miRBase miRBase family RNA type Cis regulatory element Cis reg Internal ribosome entry site IRES Tax domain Eukaryota GO GO 0043022 SO SO 0000243 CAS number EntrezGene HGNCid OMIM PDB RefSeq Chromosome Arm Band LocusSupplementaryData The insulin like growth factor II IGF II internal ribosome entry site IRES is found in the 5 UTR of Insulin like growth factor 2 IGF II leader 2 mRNA . This cis regulatory element RNA element allows cap independent translation of the mRNA and it is thought that this family may facilitate a continuous IGF II production in rapidly dividing cells during development. ref cite journal last Pedersen first SK coauthors Christiansen J, Hansen TO, Larsen MR, Nielsen FC year 2002 title Human insulin like growth factor II leader 2 mediates internal initiation of translation journal Biochem J volume 363 pages 37&ndash 44 pmid 11903044 doi 10.1042 0264 6021 3630037 issue Pt 1 pmc 1222448 ref References reflist 1 External links Rfam id RF00483 name Insulin like growth factor II IRES http iresite.org IRESite web.php?page view&entry id 337 IRESite page for IGF2 leader2 Category Cis regulatory RNA elements molecular cell biology stub ...   more details



  1. Fibroblast growth factor receptor 1

    PBB geneid 2260 Fibroblast growth factor receptor 1 FGFR1 , also known as basic fibroblast growth factor receptor 1 , fms related tyrosine kinase 2 Pfeiffer syndrome , and cluster of differentiation CD 331, is a receptor tyrosine kinase whose ligands are specific members of the fibroblast growth factor ... growth factor receptor 1 fms related tyrosine kinase 2, Pfeiffer syndrome url http www.ncbi.nlm.nih.gov ... Fibroblast growth factor receptor 1 has been shown to Protein protein interaction interact with GRB14 ... growth factor receptor 1 with the adaptor protein Grb14. Characterization of a new receptor ... and function of vertebrate fibroblast growth factor receptor 1 journal Int. J. Dev. Biol. volume ... form of human basic fibroblast growth factor receptor deduced from its cDNA journal Biochem. Biophys ... motif on fibroblast growth factor receptor mediates direct association and activation of SNT ... factor receptor 1 on the Atlas of Genetics and Cytogenetics in Oncology and Haematology Atlas of Genetics ... 291X 90 90384 Y url ref Function The protein encoded by this gene is a member of the fibroblast growth factor receptor FGFR family, where amino acid sequence is highly conserved between members and throughout ... Targets on Fibroblast Growth Factor and Nerve Growth Factor Receptors journal Mol. Cell. Biol. volume ... title Expression and biological activity of mouse fibroblast growth factor 9 journal J. Biol. Chem ... Cytokine Growth Factor Rev. volume 16 issue 2 pages 187 203 year 2005 pmid 15863034 doi 10.1016 j.cytogfr.2005.03.001 ... immunoglobulin like domains, a single hydrophobic membrane spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factor s, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors ... in olfactory bulb and palate morphogenesis journal Hum. Mutat. volume 28 issue 1 pages 97 8 year 2007 ...   more details



  1. Relaxin/insulin-like family peptide receptor 1

    PBB geneid 59350 Relaxin insulin like family peptide receptor 1 , also known as RXFP1 , is a human G protein coupled receptor . ref name entrez cite web title Entrez Gene RXFP1 relaxin insulin like family peptide receptor 1 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch ..., Kuei C, et al. title Relaxin 3 insulin like peptide 5 chimeric peptide, a selective ligand for G protein coupled receptor GPCR 135 and GPCR142 over leucine rich repeat containing G protein coupled receptor 7 journal Mol. Pharmacol. volume 67 issue 1 pages 231 40 year 2005 pmid 15465925 doi 10.1124 ... relaxin receptor increases the transcription of IGFBP 1 and prolactin in human decidual and endometrial ... Template PBB Controls to Stop updates. PBB Summary section title summary text See also Relaxin receptor ... for relaxin family peptides journal Pharmacol. Rev. volume 58 issue 1 pages 7 31 year 2006 .... title H3 relaxin is a specific ligand for LGR7 and activates the receptor by interacting with both ... Immunoexpression of the relaxin receptor LGR7 in breast and uterine tissues of humans and primates journal Reprod. Biol. Endocrinol. volume 1 issue pages 114 year 2004 pmid 14633277 doi 10.1186 1477 7827 1 114 pmc 293425 cite journal author Ota T, Suzuki Y, Nishikawa T, et al. title Complete sequencing and characterization of 21,243 full length human cDNAs journal Nat. Genet. volume 36 issue 1 ... JA, et al. title Gene expression pattern and immunoreactive protein localization of LGR7 receptor ..., Samuel CS, et al. title Increased expression of the relaxin receptor LGR7 in human endometrium during ... rich repeat containing G protein coupled receptor 7 journal Clin. Exp. Pharmacol. Physiol. volume 31 ... B llesbach EE, Schwabe C title The trap like relaxin binding site of the leucine rich G protein coupled receptor 7 journal J. Biol. Chem. volume 280 issue 14 pages 14051 6 year 2005 pmid 15695505 ... author Bond CP, Parry LJ, Samuel CS, et al. title Increased expression of the relaxin receptor LGR7 ...   more details



  1. Fibroblast growth factor receptor

    L, Tissot B. et al. title N glycosylation of fibroblast growth factor receptor 1 regulates ligand and heparan sulfate co receptor binding journal J. Biol. Chem. year 2006 volume 281 issue 37 pages 27178 ... belong to the tyrosine kinase superfamily FGFR1 to FGFR4 . Gene FGFR1 see also Fibroblast growth factor receptor 1 CD331 Gene FGFR2 see also Fibroblast growth factor receptor 2 CD332 Gene FGFR3 see also Fibroblast growth factor receptor 3 CD333 Gene FGFR4 see also Fibroblast growth factor receptor ...The fibroblast growth factor receptors are, as their name implies, Receptor biochemistry receptors that bind to members of the fibroblast growth factor family of proteins. Some of these receptors are involved ... gene splicing alternate splicing of four fibroblast growth factor receptor FGFR genes results in the production ... receptor i.e., FGF 1, which binds all seven principal FGFRs ref name ornitz2 cite journal author Ornitz DM, et al. title Receptor Specificity of the Fibroblast Growth Factor Family journal JBC volume ... Sleeman M, Fraser J. et al. title Identification of a new fibroblast growth factor receptor, FGFR5 ... http www.sabiosciences.com pathway.php?sn FGF Signaling FGF signaling with refs Growth factor receptors Tyrosine kinases DEFAULTSORT Fibroblast Growth Factor Receptor Category Tyrosine kinase receptors ... . Structure The fibroblast growth factor receptors consist of an extracellular ligand domain composed of three immunoglobulin like domains, a single transmembrane helix domain, and an intracellular domain with tyrosine kinase activity. These receptors bind fibroblast growth factor s, members of the largest family of growth factor ligands, comprising 22 members. ref name ornitz cite journal author Ornitz DM. and Itoh, N. title Fibroblast growth factors journal Genome Biol. year 2001 volume 2 issue ... to the FGFR. Immunoglobulin like domains D2 and D3 are sufficient for FGF binding. Each receptor ... Ig like domains D1 D3 , and thus belong to the immunoglobulin superfamily . ref name coutts ...   more details



  1. Epidermal growth factor receptor

    by the type 1 insulin like growth factor receptor interplay with the epidermal growth factor ... geneid 1956 The epidermal growth factor receptor EGFR ErbB 1 HER1 in humans is the Cell membrane cell surface receptor biochemistry receptor for members of the epidermal growth factor family EGF family ... tyrosine phosphatase SHP 1 to the epidermal growth factor receptor and attenuation of receptor signaling ... like growth factor I receptor with distinct roles from Mdm2 in receptor ubiquitination and endocytosis ... the epidermal growth factor receptor journal IUBMB Life volume 53 issue 1 pages 3 14 year 2002 ... Herbst RS title Review of epidermal growth factor receptor biology journal Int. J. Radiat. Oncol. Biol ... url ref The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily ... or Medicine in 1986. Function EGFR epidermal growth factor receptor exists on the cell surface ... growth factor receptor journal Nature volume 311 issue 5985 pages 483 5 year 1984 pmid 6090945 doi ..., Funahashi A, Kitano H title A comprehensive pathway map of epidermal growth factor receptor signaling ... growth factor receptor journal J Clin Invest. volume 116 issue 7 pages 1878 1885 year 2006 pmid 16778986 ... DA title Activating mutations in the epidermal growth factor receptor underlying responsiveness of non ... LV, Johnson BE title Impact of epidermal growth factor receptor and KRAS mutations on clinical ... cell line HaCaT were incubated with anti epithelial growth factor receptor EGFR antibody conjugated ... status removed Image Egfr inhibitor diagram.jpg Interactions Epidermal growth factor receptor has been ... GTPase mediates epidermal growth factor receptor dependent phospholipase D2 activation journal J. Biol ... authorlink coauthors Norton L year 1998 month Apr. title The epidermal growth factor receptor modulates ... Mar. title cbl b inhibits epidermal growth factor receptor signaling journal Oncogene volume 18 issue ... 2002 month May. title Identification of epidermal growth factor receptor as a target of Cdc25A protein ...   more details



  1. Growth factor receptor

    A growth factor receptor is a Receptor biochemistry receptor which binds to growth factor . ref MeshName Growth Factor Receptors ref These receptors may use the JAK STAT signaling pathway JAK STAT , MAP kinase , and Phosphoinositide 3 kinase PI3 kinase pathways. ref name HoffbrandMoss2006 cite book author1 A. V. Hoffbrand author2 P. A. H. Moss author3 J. E. Pettit title Essential haematology url http books.google.com books?id IFFL 1YNy oC&pg PA6 accessdate 28 November 2010 year 2006 publisher Wiley Blackwell isbn 9781405136495 pages 6 ref References reflist Growth factor receptors Category Receptors biochem stub ...   more details



  1. Nerve growth factor receptor

    Nerve growth factor receptors are a group of growth factor receptor s which specifically bind to neurotrophin s. There are two classes of receptors, p75 and the Trk family of Tyrosine kinase s receptors. p75 is a low affinity neurotrophin receptor , to which all neurotrophins bind. It is a member of the tumour necrosis super family. In some contexts, the phrase x only applies to this receptor. ref MeshName Nerve Growth Factor Receptor p75 ref The Trk receptor Trk family include TrkA , TrkB , and TrkC , and will only bind with specific neurotrophins, but with a much higher affinity. The Trks mediate the functional signals of the neurotrophins. NGF binds to TrkA, BDNF and NT 4 bind to TrkB and NT 3 binds to TrkC . In addition NT 3 also binds to and activates TrkA and TrkB but it does so less efficiently. Whilst the Trk receptors have a clearly defined trophic role, p75 receptors activate signalling pathways which can also result in apoptosis . TrkA, B, and C receptors TrkA is a receptor tyrosine kinase meaning it mediates its actions by causing the addition of phosphate molecules on certain tyrosines in the cell, activating cellular signaling . There are other related Trk receptors TrkB and TrkC , and there are other neurotrophic factors structurally related to NGF BDNF , NT 3 , and NT 4 TrkA mediates the effects of NGF TrkB binds and is activated by BDNF , NT 4 , and NT 3 TrkC binds and is activated only by NT 3 LNGFR receptor The other NGF receptor, the LNGFR , for Low affinity nerve growth factor receptor , commonly known as p75 , plays a less clear role. LNGFR binds and serves as a sink for neurotrophins. Cells which express both the LNGFR and the Trk receptors might therefore have a greater activity since they have a higher microconcentration of the neurotrophin. However ... basalis of postmortem Alzheimer s brains. References reflist External links MeshName Nerve Growth Factor Receptors Growth factor receptors Category Receptors biochem stub ...   more details



  1. Growth factor-like domain

    Pfam box Symbol APP CU bd Name Amyloid precursor N terminal image 1mwp gfld.png width 200 caption The GFLD region of amyloid precursor protein Pfam PF02177 InterPro IPR008154 SMART SM00006 PROSITE SCOP 1mwp TCDB PDB PDB2 1mwp , PDB2 1owt , PDB2 2fjz , PDB2 2fk1 , PDB2 2fk2 , PDB2 2fk3 , PDB2 2fkl , PDB2 2fma A growth factor like domain GFLD is a protein domain structurally related to epidermal growth factor , which has a high binding affinity for the epidermal growth factor receptor . As structural domains within larger proteins, GFLD regions commonly bind calcium ion s. A subtype present in the N terminus N terminal region of the amyloid precursor protein is a member of the heparin binding class of GFLDs and may itself have growth factor function, particularly in promoting neuron al development. References Rossjohn J, Cappai R, Feil SC, Henry A, McKinstry WJ, Galatis D, Hesse L, Multhaup G, Beyreuther K, Masters CL, Parker MW. 1999 . Crystal structure of the N terminal, growth factor like domain of Alzheimer amyloid precursor protein. Nat Struct Biol 6 4 327 31. protein stub Category Protein domains ...   more details



  1. Fibroblast growth factor receptor 4

    Signal transduction by fibroblast growth factor receptor 4 FGFR 4 . Comparison with FGFR 1 journal ...PBB geneid 2264 Fibroblast growth factor receptor 4 is a protein that in humans is encoded by the FGFR4 ... growth factor receptor family, where amino acid sequence is highly conserved between members and throughout ... fibroblast growth factor receptor 4 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 2264 accessdate ref Interactions Fibroblast growth factor receptor 4 has been shown ... domain of recombinant human fibroblast growth factor receptor 4 journal Int. J. Biochem ... al. title A radiation hybrid map of 18 growth factor, growth factor receptor, hormone receptor, or neurotransmitter ... J, Bellosta P, et al. title Fibroblast growth factor receptor 4 shows novel features in genomic ... FGFR 4, a novel acidic fibroblast growth factor receptor with a distinct expression pattern journal ... kinases expressed in human lung fourth member of the fibroblast growth factor receptor family and an intracellular ... protein tyrosine kinases and the epidermal growth factor receptor journal J. Biol. Chem. volume 270 ... D, Reich R, Chedid M, et al. title Fibroblast growth factor receptor 4 is a high affinity receptor for both acidic and basic fibroblast growth factor but not for keratinocyte growth factor journal J. Biol ... P, Alitalo K title Association of a 85 kDa serine kinase with activated fibroblast growth factor receptor ... DM, Xu J, Colvin JS, et al. title Receptor specificity of the fibroblast growth factor family journal ... for members 1 3. This particular family member preferentially binds acidic fibroblast growth ... factor receptor 4 gene to chromosome region 5q33 qter journal Genes Chromosomes Cancer volume 4 issue ... molecules between keratinocyte growth factor and basic fibroblast growth factor define domains ... kinases with immunoglobulin like domains journal J. Mol. Evol. volume 45 issue 1 pages 43 9 year ... of three immunoglobulin like domains, a single hydrophobic membrane spanning segment and a cytoplasmic ...   more details



  1. Fibroblast growth factor receptor 2

    PBB geneid 2263 Fibroblast growth factor receptor 2 FGFR2 also known as CD332 cluster of differentiation ... A, Courtois Y, Breathnach R title Related fibroblast growth factor receptor genes exist in the human ... and basic fibroblast growth factors journal EMBO J. volume 9 issue 9 pages 2685 92 year 1990 month September pmid 1697263 pmc 551973 doi url issn ref FGFR2 is a receptor for fibroblast growth factor . The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where ... Entrez Gene FGFR2 fibroblast growth factor receptor 2 bacteria expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1, Crouzon syndrome, Pfeiffer syndrome, Jackson Weiss syndrome ... alternatives of fibroblast growth factor receptor 2 FGFR2 journal Dev. Biol. volume 158 ... growth factor receptor with its ligands journal Proc. Natl. Acad. Sci. U.S.A. volume 97 issue ... TL title Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin ... Receptor specificity of the fibroblast growth factor family journal J. Biol. Chem. volume 271 issue ... growth factor receptor family, these receptors signal by binding to their ligand and dimerisation ... localized derivative of the fibroblast growth factor receptor 3 kinase domain journal Mol ... 2 cite journal author McKeehan WL, Kan M title Heparan sulfate fibroblast growth factor receptor ... Fibroblast Growth Factor Receptor 2 PDB Gallery geneid 2263 Tyrosine kinases Clusters of differentiation ... and or keratinocyte growth factor, depending on the isoform. Isoforms FGFR2 has two naturally occurring ... of this gene and isoform are associated with craniosynostosis . Interactions Fibroblast growth factor ... A, Ornitz DM title Expression and biological activity of mouse fibroblast growth factor 9 journal ... fibroblast growth factor 2 , FGF4 4 , FGF6 6 , FGF8 8 , FGF9 9 , FGF17 17 and FGF18 18 These differences ... domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting ...   more details



  1. Fibroblast growth factor receptor 3

    PBB geneid 2261 Fibroblast growth factor receptor 3 is a protein that in humans is encoded by the FGFR3 gene . ref name pmid1847508 cite journal author Keegan K, Johnson DE, Williams LT, Hayman MJ title Isolation of an additional member of the fibroblast growth factor receptor family, FGFR 3 journal ... by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence ... FGFR3 fibroblast growth factor receptor 3 achondroplasia, thanatophoric dwarfism url http www.ncbi.nlm.nih.gov ... of FGFR3 and TP53 mutations journal J. Urol. volume 176 issue 6 Pt 1 pages 2686 9 year 2006 pmid 17085196 doi 10.1016 j.juro.2006.07.132 ref Interactions Fibroblast growth factor receptor 3 has been ... Fibroblast growth factor receptor References Reflist Further reading refbegin 2 PBB Further ... to an Ala391Glu substitution in FGFR3. journal Am. J. Med. Genet. volume 98 issue 1 pages 75 91 year 2001 pmid 11426459 doi 10.1002 1096 8628 20010101 98 1 75 AID AJMG1010 3.0.CO 2 6 cite journal author Horton WA, Lunstrum GP title Fibroblast growth factor receptor 3 mutations in achondroplasia and related ... Fibroblast growth factor receptor 3 mutations in epidermal nevi and associated low grade bladder ... growth factor receptor autoinhibition and ligand binding promiscuity. journal Pnas USA ... Expression and biological activity of mouse fibroblast growth factor 9 journal J. Biol. Chem. volume ... M, Ornitz D M year 1999 month Dec. title Mapping ligand binding domains in chimeric fibroblast growth factor receptor molecules. Multiple regions determine ligand binding specificity journal J. Biol ... NLM content Tyrosine kinases Growth factor receptors Clusters of differentiation The PBB Controls ... consist of an extracellular region, composed of three immunoglobulin like domains, a single hydrophobic ... of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals ... acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations ...   more details



  1. Platelet-derived growth factor receptor

    Refimprove date September 2010 protein Name PDGFRA platelet derived growth factor receptor, alpha polypeptide ... PDGFRB platelet derived growth factor receptor, beta polypeptide caption Ribbon image of two molecules of human PDGF receptor beta yellow and magenta in complex with dimeric PDGFB PDGF B cyan and green ... Platelet derived growth factor receptors PDGF R are cell surface receptor tyrosine kinase tyrosine kinase receptor s for members of the platelet derived growth factor PDGF family. PDGF subunits PDGFA ... growth , Morphogenesis development and many diseases including cancer . ref name pmid2538922 Cite journal author Williams LT title Signal transduction by the platelet derived growth factor receptor ... derived growth factor three isoforms and two receptor types journal Trends Genet. volume 5 issue 4 pages 108 11 year 1989 month April pmid 2543106 doi 10.1016 0168 9525 89 90040 1 url issn ref Depending on which growth factor is bound, PDGF R homo or heterodimerizes. ref name pmid1315403 Cite ... derived growth factor isoform specific signalling via heterodimeric or homodimeric receptor complexes ... Reflist External links MeshName Platelet Derived Growth Factor Receptors Tyrosine kinases Growth factor receptors http angiogenesis.amgen.com DEFAULTSORT Platelet Derived Growth Factor Receptor Category ... X. title Structures of a platelet derived growth factor propeptide complex and a platelet derived growth factor receptor complex journal PNAS volume 107 issue 25 no 25 pages 11307 12 year 2010 pmid 20534510 ... in their monomer ic forms. The PDGFs bind to the protein Receptor tyrosine kinase tyrosine kinase receptor s PDGF receptor and . These two receptor isoform s protein dimer dimer ize upon binding the PDGF dimer, leading to three possible receptor combinations, namely , and . The extracellular region of the Receptor biochemistry receptor consists of five immunoglobulin like domains ... with signal transduction molecules Tyrosine phosphorylation sites in growth factor receptors serve ...   more details



  1. Insulin receptor

    interacts differentially with the insulin receptor, insulin like growth factor I receptor, and epidermal growth factor receptor via the Grb10 Src homology 2 SH2 domain and a second novel domain located ... of an insulin and growth factor receptor binding protein with PH and SH2 domains journal J. Biol ... O Dell SD, Day IN title Insulin like growth factor II IGF II journal Int. J. Biochem. Cell Biol. volume ... uptake and metabolism. Insulin binds to its receptor 1 , which, in turn, starts many protein activation ... by the Insulin Receptor include a protein called IRS 1 for insulin receptor substrate ... Jan. title Membrane glycoprotein PC 1 inhibition of insulin receptor function occurs via direct ... substrate 1 blocks interactions with the insulin receptor and inhibits insulin action journal J. Biol ... loop of the insulin receptor kinase journal Biochem. J. volume 335 issue 1 pages 103 9 publisher location ... growth factor I journal Acta Biochim. Pol. volume 46 issue 1 pages 51 60 year 1999 pmid 10453981 doi ...Use dmy dates date July 2011 PBB geneid 3643 In molecular biology , the insulin receptor is a transmembrane receptor transmembrane receptor proteomics receptor that is activated by insulin . ref name pmid19274663 ... and two beta subunits make up the insulin receptor . The beta subunits pass through the cellular membrane ... INSR . The insulin receptor has also recently been designated CD220 cluster of differentiation 220 ... receptors , including the insulin receptor , mediate their activity by causing the addition of a phosphate ... activity of activation of the insulin receptor is inducing glucose uptake. For this reason insulin insensitivity , or a decrease in insulin receptor signaling, leads to diabetes mellitus type 2 the cells ... non functional insulin receptor. These patients have low set, often protuberant, ears, flared nostrils ... . Stimulation of glycogen synthesis Glycogen synthesis is also stimulated by the insulin receptor ... Once an insulin molecule has docked onto the receptor and effected its action, it may be released ...   more details



  1. Heparin-binding EGF-like growth factor

    binding EGF like growth factor journal Cytokine Growth Factor Rev. year 2004 volume 15 issue 1 ... heparin binding epidermal growth factor like growth factor diphtheria toxin receptor journal Biochemistry ...PBB geneid 1839 Heparin binding EGF like growth factor HB EGF is a member of the epidermal growth factor ... EGF like growth factor that mediates cell migration journal EMBO J. volume 20 issue 13 pages 3342 50 ... form of heparin binding EGF like growth factor a unique role for proHB EGF in cell survival ... of heparin binding EGF like growth factor. Multiple forms, primary structure, and glycosylation ... increases transcription of the heparin binding epidermal growth factor like growth factor gene in vascular ... toxin binds to the epidermal growth factor EGF like domain of human heparin binding EGF like growth factor diphtheria toxin receptor and inhibits specifically its mitogenic activity journal J. Biol ... author Hashimoto K, Higashiyama S, Asada H, et al. title Heparin binding epidermal growth factor like growth factor is an autocrine growth factor for human keratinocytes journal J. Biol. Chem. volume ... H, Friess H, et al. title Induction and expression of heparin binding EGF like growth factor in human ... heparin binding EGF like growth factor that mediate interaction with heparin journal J. Biol. Chem ... domain of CD9 and the epidermal growth factor EGF like domain of heparin binding EGF like growth ... JS, et al. title Heparin binding epidermal growth factor like growth factor is an autocrine mediator ... binding EGF like growth factor a unique role for proHB EGF in cell survival regulation journal ... refend PDB Gallery geneid 1839 External links MeshName heparin binding EGF like growth factor Category ... growth factor has been shown to Protein protein interaction interact with NRD1 , ref name pmid11432822 ... factor secreted by macrophage like cells that is related to EGF journal Science volume 251 issue ... growth factor journal J. Cell Biol. volume 128 issue 4 pages 687 98 year 1995 pmid 7532176 doi 10.1083 ...   more details



  1. Relaxin/insulin-like family peptide receptor 2

    PBB geneid 122042 Relaxin insulin like family peptide receptor 2 , also known as RXFP2 , is a human G protein coupled receptor . ref name entrez cite web title Entrez Gene RXFP2 relaxin insulin like family peptide receptor 2 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 122042 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text The receptors for glycoprotein hormones such as follicle stimulating hormone FSH see MIM 136530 and thyroid stimulating hormone TSH see MIM 188540 are G protein coupled, 7 transmembrane receptors GPCRs with large N terminal extracellular domains. Leucine rich repeat LRR containing GPCRs LGRs form a subgroup of the GPCR superfamily. supplied by OMIM ref name entrez See also Relaxin receptor References reflist External ... insulin like peptide activates the LGR8 receptor important in testis descent journal J. Biol. Chem ... receptor binding surface of insulin like peptide 3 journal J. Biol. Chem. volume 281 issue 38 pages ... A, Feng S, et al. title T222P mutation of the insulin like 3 hormone receptor LGR8 is associated with testicular maldescent and hinders receptor expression on the cell surface membrane journal Am. J. Physiol. Endocrinol. Metab. volume 292 issue 1 pages E138 44 year 2007 pmid 16926383 doi 10.1152 ... like factor journal J. Biol. Chem. volume 280 issue 15 pages 14586 90 year 2005 pmid 15708846 ... insulin like peptide 3 journal Mol. Endocrinol. volume 21 issue 7 pages 1699 712 year 2007 pmid ... journal Pharmacol. Rev. volume 58 issue 1 pages 7 31 year 2006 pmid 16507880 doi 10.1124 pr.58.1.9 ... ligand for LGR7 and activates the receptor by interacting with both the ectodomain and the exoloop 2 ... receptor pair in human cryptorchidism journal J. Clin. Endocrinol. Metab. volume 88 issue 9 pages ... of novel splice variants of LGR7 and LGR8 reveals that receptor signaling is mediated by their unique ...   more details



  1. Relaxin/insulin-like family peptide receptor 3

    PBB geneid 51289 Relaxin insulin like family peptide receptor 3 , also known as RXFP3 , is a human G protein coupled receptor . ref name entrez cite web title Entrez Gene RXFP3 relaxin insulin like family peptide receptor 3 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 51289 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text See also Relaxin receptor References reflist External links cite web url http www.iuphar db.org GPCR ReceptorDisplayForward?receptorID 3024 title Relaxin Family Peptide Receptors RXFP3 accessdate author authorlink coauthors date format work IUPHAR Database of Receptors and Ion Channels publisher International Union of Basic and Clinical Pharmacology pages language archiveurl archivedate quote Further reading refbegin 2 PBB Further reading citations cite journal author Bathgate RA, Ivell R, Sanborn BM, et al. title Receptors for relaxin family peptides. journal Ann. N. Y. Acad. Sci. volume 1041 issue pages 61 76 year 2005 pmid 15956688 doi 10.1196 annals.1282.010 cite journal author Bathgate RA, Ivell R, Sanborn BM, et al. title International Union of Pharmacology LVII recommendations for the nomenclature of receptors for relaxin family peptides. journal Pharmacol. Rev. volume 58 issue 1 pages 7 31 year 2006 ... cite journal author Liu C, Chen J, Kuei C, et al. title Relaxin 3 insulin like peptide 5 chimeric peptide, a selective ligand for G protein coupled receptor GPCR 135 and GPCR142 over leucine rich repeat containing G protein coupled receptor 7 journal Mol. Pharmacol. volume 67 issue 1 pages 231 .... title The novel G protein coupled receptor SALPR shares sequence similarity with somatostatin and angiotensin receptors. journal Gene volume 248 issue 1 2 pages 183 9 year 2000 pmid 10806363 doi 10.1016 ... of relaxin 3 INSL7 as an endogenous ligand for the orphan G protein coupled receptor GPCR135 journal ...   more details



  1. Relaxin/insulin-like family peptide receptor 4

    PBB geneid 339403 Relaxin insulin like family peptide receptor 4 , also known as RXFP4 , is a human G protein coupled receptor . ref name entrez cite web title Entrez Gene RXFP4 relaxin insulin like family peptide receptor 4 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 339403 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text GPR100 is a member of the rhodopsin family of G protein coupled receptors GPRs Fredriksson et al., 2003 . supplied by OMIM ref name entrez See also Relaxin receptor References reflist External links cite web url http www.iuphar db.org GPCR ReceptorDisplayForward?receptorID 3037 title Relaxin Family Peptide Receptors RXFP4 accessdate author authorlink coauthors date format work IUPHAR Database of Receptors and Ion Channels publisher International Union of Basic and Clinical Pharmacology pages language archiveurl archivedate quote Further reading refbegin 2 PBB Further reading citations cite journal author Bathgate ... Schi th first5 Helgi B cite journal author Liu C title Relaxin 3 insulin like peptide 5 chimeric peptide, a selective ligand for G protein coupled receptor GPCR 135 and GPCR142 over leucine rich repeat containing G protein coupled receptor 7 journal Mol. Pharmacol. volume 67 issue 1 pages 231 40 year ... of receptors for relaxin family peptides journal Pharmacol. Rev. volume 58 issue 1 pages 7 31 year ... of G protein coupled receptor genes from the human genome sequence journal FEBS Lett. volume 520 issue 1 3 pages 97 101 year 2002 pmid 12044878 doi 10.1016 S0014 5793 02 02775 8 author separator ... bradykinin receptor journal Br. J. Pharmacol. volume 140 issue 5 pages 932 8 year 2004 pmid 14530218 ... 280 issue 1 pages 292 300 year 2005 pmid 15525639 doi 10.1074 jbc.M409916200 author separator , author2 ... Gregory SG title The DNA sequence and biological annotation of human chromosome 1 journal Nature volume ...   more details



  1. Teratocarcinoma-derived growth factor 1

    Orphan date February 2009 PBB geneid 6997 Teratocarcinoma derived growth factor 1 is a protein that in humans ... cite web title Entrez Gene TDGF1 teratocarcinoma derived growth factor 1 url http www.ncbi.nlm.nih.gov ... Saccone S, Rapisarda A, Motta S, et al. title Regional localization of the human EGF like growth factor CRIPTO gene TDGF 1 to chromosome 3p21. journal Hum. Genet. volume 95 issue 2 pages 229 30 year ..., Viglietto G, Rocchi M, Persico MG title Assignment of human teratocarcinoma derived growth factor ... cite journal author Salomon DS, Bianco C, De Santis M title Cripto a novel epidermal growth factor ... 1 pages 61 70 year 1999 pmid 10070255 doi 10.1002 SICI 1521 1878 199901 21 1 61 AID BIES8 3.0.CO 2 H cite journal author Adamson ED, Minchiotti G, Salomon DS title Cripto a tumor growth factor and more .... title Identification and biological characterization of an epidermal growth factor related protein cripto 1. journal J. Biol. Chem. volume 269 issue 25 pages 17320 8 year 1994 pmid 8006041 doi cite journal author Friess H, Yamanaka Y, B chler M, et al. title Cripto, a member of the epidermal growth factor family, is over expressed in human pancreatic cancer and chronic pancreatitis. journal Int ... of transforming growth factor alpha, amphiregulin and CRIPTO in human normal and malignant breast tissues. journal Int. J. Cancer volume 65 issue 1 pages 51 6 year 1996 pmid 8543395 doi 10.1002 SICI 1097 0215 19960103 65 1 51 AID IJC9 3.0.CO 2 0 cite journal author Kannan S, De Santis M, Lohmeyer ... 1. journal Dev. Biol. volume 196 issue 2 pages 237 47 year 1998 pmid 9576836 doi 10.1006 dbio.1998.8862 ... author Ebert AD, Wechselberger C, Frank S, et al. title Cripto 1 induces phosphatidylinositol 3 kinase ... author Reissmann E, J rnvall H, Blokzijl A, et al. title The orphan receptor ALK7 and the Activin receptor ALK4 mediate signaling by Nodal proteins during vertebrate development. journal Genes Dev. volume ... author Bianco C, Adkins HB, Wechselberger C, et al. title Cripto 1 activates nodal and ALK4 dependent ...   more details



  1. Colony stimulating factor 1 receptor

    PBB geneid 1436 Colony stimulating factor 1 receptor CSF1R , also known as macrophage colony stimulating factor receptor M CSFR , and CD115 C luster of D ifferentiation 115 , is a cell surface protein ... Colony stimulating factor 1 receptor has been shown to Protein protein interaction interact ... stimulating factor 1 receptor journal Mol. Cell. Biol. volume 10 issue 11 pages 5601 8 year ... for the mononuclear phagocyte growth factor, CSF 1 journal Cell volume 41 issue 3 pages 665 76 year ... Mechanism of kinase activation in the receptor for colony stimulating factor 1 journal Proc. Natl. Acad ... called Macrophage colony stimulating factor colony stimulating factor 1 . Genomics The gene is located ... for macrophage colony stimulating factor colony stimulating factor 1 , a cytokine which controls ... C, Murphy GM title Microglia overexpressing the macrophage colony stimulating factor receptor ... ref Both CSF1R, and its ligand macrophage colony stimulating factor colony stimulating factor 1 play ... ML, Miron A, Iglehart JD, Colditz GA, Hankinson SE title Circulating colony stimulating factor 1 ... Pollard JW, Hennighausen L title Colony stimulating factor 1 is required for mammary gland development ... factor, c Fms, and down modulates this receptor but not the viral oncogene v Fms journal J. Biol ... 1, and their association with its receptor journal EMBO J. volume 12 issue 3 pages 943 50 year 1993 ... stimulating factor receptor and negatively regulates its proliferation signal journal J. Biol. Chem ... 1 CSF 1 receptor c fms proto oncogene product and its ligand journal J. Cell Sci. Suppl. volume ..., Lee PS, Pixley FJ, Wang Y, Yeung YG title Biology and action of colony stimulating factor 1 journal ... Roussel MF, Cleveland JL, Shurtleff SA, Sherr CJ title Myc rescue of a mutant CSF 1 receptor impaired ... MF, Sherr CJ title Tandem linkage of human CSF 1 receptor c fms and PDGF receptor genes journal Cell ... CJ, Rettenmier CW title The fms gene and the CSF 1 receptor journal Cancer Surv. volume 5 issue ...   more details




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