Image IgM.png thumb IgM ImmunoglobulinM antibody molecule consisting of 5 base units. br 1 Base unit. br 2 Heavy chain s. br 3 Immunoglobulin light chain Light chain s. br 4 J chain . br 5 Intermolecular disulfide bonds. Image IgM scheme.svg thumb IgM scheme. Heavy chains are blue light chains are yellow. ImmunoglobulinM , or IgM for short, is a basic antibody that is produced by B cell s. IgM is by far the physically largest antibody in the human circulatory system. It is the first antibody to appear in response to initial exposure to antigen. ref Houghton Mifflin Company, 2004. ImmunoglobulinM. The American Heritage Dictionary of the English Language, Fourth Edition. Accessed on 12 Oct. 2007 ref Structure and function IgM forms polymers where multiple immunoglobulins are covalently linked together with disulfide bond s, mostly as a pentamer but also as a hexamer. IgM has a molecular mass of approximately 900 Dalton unit kDa in its pentamer form . Because each monomer has two antigen binding sites, a pentameric IgM has 10 binding sites. Typically ... also Immunodeficiency with hyper immunoglobulinMImmunoglobulinM deficiency Antibody IgA , IgD , IgE , IgG References Reflist External links MeshName ImmunoglobulinM immune system Immune proteins ... ca Immunoglobulina M cs Imunoglobulin M da ImmunoglobulinM de Immunglobulin M es Inmunoglobulina M fr Immunoglobuline M id Antibodi M it IgM ja M pl Immunoglobuliny M pt Imunoglobulina M fi IgM sv ImmunoglobulinM ... important as a secretory immunoglobulin. Due to its polymeric nature, IgM possesses high .... For this reason, IgM is the first immunoglobulin expressed by mature B cells. It is also the first immunoglobulin expressed in the fetus around 20 weeks and also phylogenetically the earliest ... Immunoglobulin G IgG . This technique was historically used to distinguish between these isotypes before ... more details
infobox disease Name X linked hyper immunoglobulinM syndrome Image Alt Caption DiseasesDB ICD10 ICD10 Group Major minor LinkGroup LinkMajor ICD9 ICD9 xxx ICDO OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID GeneReviewsID xlhi GeneReviewsName X Linked Hyper IgM Syndrome X linked hyper immunoglobulinM syndrome is an inherited condition characterized by recurrent sinopulmonary and GI infections with pyogenic bacteria and opportunistic organisms, a disease which may have cutaneous manifestations including pyodermas extensive warts. ref name Bolognia cite book author Rapini, Ronald P. Bolognia, Jean L. Jorizzo, Joseph L. title Dermatology 2 Volume Set publisher Mosby location St. Louis year 2007 pages 817 isbn 1 4160 2999 0 oclc doi accessdate ref See also Immunodeficiency with hyper immunoglobulinM List of cutaneous conditions References reflist Cutaneous condition stub Category Noninfectious immunodeficiency related cutaneous conditions ... more details
Infobox Disease Name PAGENAME Image IgM scheme.svg Caption ImmunoglobulinM DiseasesDB ICD10 ICD10 D 80 4 d 80 ICD9 ICD9 279.02 ICDO OMIM MedlinePlus eMedicineSubj med eMedicineTopic 3436 MeshID Isolated primary immunoglobulinM deficiency ref name Bolognia cite book author Rapini, Ronald P. Bolognia, Jean L. Jorizzo, Joseph L. title Dermatology 2 Volume Set publisher Mosby location St. Louis year 2007 pages isbn 1 4160 2999 0 oclc doi accessdate ref or selective IgM immunodeficiency SIgMD is a poorly defined dysgammaglobulinemia characterized by decreased levels of IgM while levels of other immunoglobulin immunoglobulins are normal. The immunodeficiency has been associated with some clinical disorders including recurrent infections, atopy, Bloom s syndrome, celiac disease, systemic lupus erythematosus and malignancy, but, surprisingly, SIgMD seems to also occur in asymptomatic individuals ref name Yel2009 cite journal author Yel L, Ramanuja S, Gupta S title Clinical and Immunological Features in IgM Deficiency journal Int Arch Allergy Immunol year 2009 volume 150 issue 3 pages 291 8 doi 10.1159 000222682 pmid 19494527 ref . High incidences of recurrent upper respiratory tract infections 77 , asthma 47 and allergic rhinitis 36 have also been reported ref name Goldstein2006 cite journal author Goldstein MF, Goldstein AL, Dunsky EH, Dvorin DJ, Belecanech GA, Shamir K title Selective IgM immunodeficiency retrospective analysis of 36 adult patients with review of the literature journal Ann Allergy Asthma Immunol year 2006 volume 97 issue 6 pages 717 30 doi 10.1016 S1081 1206 10 60962 3 pmid 17201230 ref . SIgMD seems to be a particularly rare antibody deficiency with a reported prevalence between 0.03 general population and 0.1 hospitalized patients ref name Yel2009 . The etiology ... index.html ref . See also Immunodeficiency with hyper immunoglobulinMImmunoglobulinM List of cutaneous ... among others ref name Yel2009 . It is however puzzling that Immunoglobulin class switching class ... more details
form, IgA is the main immunoglobulin found in mucous membrane mucous secretions , including tears ... of sIgA protects the immunoglobulin from being degraded by proteolytic enzymes, thus sIgA can survive ... mass 15kD, rich with cysteine and structurally completely different from other immunoglobulin chains ... s that produce polymeric IgA pIgA , and mucosal epithelial cells that express an immunoglobulin ... adjacent to mucosal surfaces. It binds to the polymeric immunoglobulin receptor on the basolateral ..., JP Vaerman, and ME Lamm title The polymeric immunoglobulin receptor secretory component mediates ... IgM , IgD , IgE , IgG TGF beta References references External links MeshName Immunoglobulin A immune ... ca Immunoglobulina A cs Imunoglobulin A da Immunoglobulin A de Immunglobulin A es Inmunoglobulina ... A pl Immunoglobuliny A pt Imunoglobulina A fi IgA sv Immunoglobulin A ... more details
Infobox protein family Symbol IgSF Name Immunoglobulin Superfamily image PDB 1a2y EBI.jpg width caption ... PROSITE PS50835 SCOP 1tlk TCDB OPM family OPM protein CDD cd00096 PDB The immunoglobulin superfamily ... immunoglobulins also known as antibodies they all possess a domain known as an immunoglobulin ..., a member of the immunoglobulin superfamily, has also been identified as the only sperm membrane protein essential for sperm egg fusion. Immunoglobulin domains Proteins of the IgSF possess a structural domain known as an immunoglobulin domain immunoglobulin Ig domain . Ig domains are named after the antibody immunoglobulin molecules. They contain about 70 110 amino acid s and are categorised according to their size and function. ref cite journal author Barclay A title Membrane proteins with immunoglobulin ... a characteristic immunoglobulin fold Ig fold , which has a sandwich like structure formed by two ... cite book author1 B. D. Gomperts author2 Ijsbrand M. Kramer author3 Peter E. R. Tatham ... Many of the immunoglobulin superfamily domains in cell adhesion molecules and surface receptors belong ... Members of the immunoglobulin superfamily The Ig domain was reported to be the most populous family ... Bateman A, Eddy SR, Chothia C title Members of the immunoglobulin superfamily in bacteria journal ... wikitable Members of the immunoglobulin superfamily Molecule function category Examples Description ... found on the surface of T and B lymphocyte s in all jawed vertebrates belong to the IgSF. Immunoglobulin ... distinct types of antibody immunoglobulin molecule all containing a heavy chain with four ... with cell activation by the B Cell Receptor BCR immunoglobulin. Two chains are used or signaling, CD79 ... Co stimulatory pathways in lymphocyte regulation the immunoglobulin superfamily journal Br J Haematol ... immunoglobulin like receptor s KIR Receptors on Leukocytes Leukocyte immunoglobulin like receptors ... , PTPRF Ig binding receptors polymeric immunoglobulin receptor PIGR Some Fc receptor s Others CD147 ... more details
eggs. Thus, in preparations from chicken eggs, there is no contamination with Immunoglobulin A IgA or ImmunoglobulinM IgM . The yield of IgY from a chicken egg is comparable to that of IgG from ...Immunoglobulin Y abbreviated as IgY is a type of immunoglobulin which is the major antibody in bird , reptile , and lungfish blood . It is also found in high concentrations in chicken egg yolk . As with the other immunoglobulins, IgY is a class of protein s which are formed by the immune system in reaction to certain foreign substances, and specifically recognize them. IgY is often mislabelled as Immunoglobulin G IgG in older literature, and sometimes even in commercial product catalogues, due to its functional similarity to mammalian IgG and Immunoglobulin E IgE . However, this older nomenclature is obsolete, since IgY differs both structurally and functionally from mammalian IgG, ref Larsson A, B l w RM, Lindahl TL, Forsberg PO. Poult Sci. 1993 Oct 72 10 1807 12.Chicken antibodies taking advantage of evolution a review. ref and does not cross react with antibodies raised against mammalian IgG. ref http www.gallusimmunotech.com Structure of IgY Structure, Function and Physicochemical Properties of IgY , Gallus Immunotech. Accessed 28 October 2010. ref Since chickens can lay eggs almost ..., immunoglobulin Y is the functional equivalent to Immunoglobulin G IgG . Like IgG, it is composed of two light and two heavy chains. Structurally, these two types of immunoglobulin differ primarily ... comparable to Immunoglobulin E IgE , as well as to IgG. However, in contrast to IgG, IgY does ..., and immunoglobulin G. Other synonymous names are Chicken IgG , Egg Yolk IgG , and 7S IgG . Bioanalytic ... pylori urease immunoglobulin Y on Helicobacter pylori infection journal Aliment. Pharmacol. Ther ... of functional drinking yogurt containing specific egg yolk immunoglobulin on Helicobacter pylori in humans ... 2001, ISBN 3 54 066679 6 G.A. Leslie, L.W. Clem Phylogeny of immunoglobulin structure and function ... more details
J, Pabst M, Kolarich D, Kunert R, Altmann F. year 2008 title Analysis of immunoglobulin glycosylation ...for the internet gaming site IGG Internet Gaming Gate Immunoglobulin G IgG are antibody molecules . Each IgG is composed of four peptide chains two Antibody Heavy chain heavy chains and two Antibody Light chain light chains . Each IgG has two antigen binding sites. Other immunoglobulins may be described in terms of polymers with the IgG structure considered the monomer . IgG constitutes 75 of blood plasma serum immunoglobulins in humans. ref name Junqueira cite book last Junqueira first Luiz C. coauthors Jose Carneiro title Basic Histology year 2003 publisher McGraw Hill isbn 0838505902 ref IgG molecules are synthesized and secreted by plasma B cells . Functions IgG antibodies are involved in predominantly the Memory B cell secondary immune response . The presence of specific IgG, in general, corresponds to maturation of the antibody response. ref Meulenbroek, A.J. Zeijlemaker, W.P. 1996 . ref Human IgG Subclasses IgG is the only Antibody Isotypes isotype that can pass through the human placenta , thereby providing protection to the fetus in utero . Along with IgA secreted in the breast milk , residual IgG absorbed through the placenta provides the neonate with humoral immunity before its own immune system develops. Colostrum contains a high percentage of IgG, especially in bovine colostrum . IgG can bind to many kinds of pathogen s, for example virus es, bacteria , and fungi , and protects the body against them by Agglutination biology agglutination and immobilization, complement ... . Structure Image Immunoglobulin basic unit.svg right thumb 200px Immunoglobulin IgG antibodies ... 2858 2871 pmid 18655055 doi 10.1002 pmic.200700968 ref Low frequency internal motion Immunoglobulin ... G da Immunoglobulin G de Immunglobulin G es Inmunoglobulina G fr Immunoglobuline G id Antibodi G it IgG ja G pl Immunoglobuliny G pt Imunoglobulina G sr Imunoglobulin G fi IgG sv Immunoglobulin ... more details
Intravenous immunoglobulin IVIG is a Blood donation blood product administered intravenous ly. It contains the pooled IgG immunoglobulin antibody G extracted from the Blood plasma plasma of over one thousand blood donors. IVIG s effects last between 2 weeks and 3 months. It is mainly used as treatment in three major categories Immune deficiency Immune deficiencies such as X linked agammaglobulinemia , hypogammaglobulinemia primary immune deficiencies , and acquired compromised immunity conditions secondary immune deficiencies featuring low antibody levels. Autoimmune diseases e.g. Immune thrombocytopenia ITP and Inflammatory diseases e.g. Kawasaki disease . Acute infections. IVIG use IVIG is given as a plasma protein replacement therapy IgG for immune deficient patients who have decreased or abolished antibody production capabilities. In these immune deficient patients, IVIG is administered to maintain adequate antibody levels to prevent infection s and confers a passive immunity. Treatment ... journal author Siragam V, Crow AR, Brinc D, Song S, Freedman J, Lazarus AH title Intravenous immunoglobulin ... and induction of tolerance to self. ref cite journal author Bayry J, Thirion M, Misra N, et al. title Mechanisms of action of intravenous immunoglobulin in autoimmune and inflammatory diseases ... url ref IVIG notes IVIG is an infusion of Immunoglobulin G IgG antibody antibodies only. Therefore .... Anaphylactic shock has a higher chance to occur in Immunoglobulin A IgA deficient patients which ... KB, Kirkpatrick AW, Delaney A title Polyclonal intravenous immunoglobulin for the treatment of severe ... myeloma , as well as various rare deficiencies of immunoglobulin synthesis e.g. X linked agammaglobulinemia , hypogammaglobulinemia , IVIG is administered to maintain adequate immunoglobulin levels ... Failure After Administering Intravenous Immunoglobulin journal Postgraduate Medicine. month March ... 2 Major drug groups Immune sera and immunoglobulins Intravenous therapy DEFAULTSORT Intravenous Immunoglobulin ... more details
ref ref cite journal author Watanabe N, Bruschi F, Korenaga M title IgE a question of protective immunity ... P, Mishra G, Kombila M, Pied S title Total and functional parasite specific IgE responses in Plasmodium ... first3 S title Immunoglobulin E importance in parasitic infections and hypersensitivity responses ... Physico chemical properties of human reaginic antibody. IV. Presence of a unique immunoglobulin ... Rebecca L. last3 Fabiane first3 Stella M. last4 Beavil first4 Andrew J. last5 Sohi first5 Maninder ... ar ca Immunoglobulina E cs Imunoglobulin E da Immunoglobulin E de Immunglobulin ... E pt Imunoglobulina E fi Immunoglobuliini E sv Immunoglobulin E ... more details
Image AntibodyChains.svg thumb The allotype affects the constant region labeled CL and CH1 3 in the diagram. In immunology , an immunoglobulin allotype is the allele of the antibody chains found in the individual. To reduce risk of transplant rejection , tissue typing is used to try to match donors and recipients with the same or similar allotypes. The most important types are Gm heavy chain and km light chain . It can be used in resolving paternity disputes. ref name urlTHE STRUCTURE AND FUNCTION OF IMMUNOGLOBULINS ANTIBODIES cite web url http pathmicro.med.sc.edu mayer IgTypes2000.htm title THE STRUCTURE AND FUNCTION OF IMMUNOGLOBULINS ANTIBODIES work accessdate 2009 05 19 ref See also Isotype immunology isotype idiotype allotype References reflist External links MeshName Immunoglobulin allotypes eMedicineDictionary allotype http pathmicro.med.sc.edu mayer IgTypes2000.htm Overview at University of South Carolina School of Medicine http www.cehs.siu.edu fix medmicro igs.htm Overview at Southern Illinois University Carbondale Immune system Category Genetics Category Transplantation medicine immunology stub fr Allotype it Allotipo pl Allotyp ... more details
Riesbeck, Charlotte Cunningham Rundles, Alessandro Plebani, Andrea Cerutti title Immunoglobulin .... See also Antibody IgM , IgA , IgE , IgG External links MeshName Immunoglobulin D References references ... ar ca Immunoglobulina D da Immunoglobulin D de Immunglobulin D es Inmunoglobulina ... sv Immunoglobulin D ... more details
Pfam box Symbol ig Name Immunoglobulin domain image PDB 8fab EBI.jpg width caption Structure of an antigen binding fragment of an antibody. Pfam PF00047 Pfam clan CL0011 InterPro IPR013151 SMART PROSITE PDOC00262 SCOP 8fab TCDB OPM family OPM protein PDB PDB3 1ev2 H 271 344 PDB3 1e0o B 271 344 PDB3 1ii4 E 271 344 PDB3 1iil E 271 344 PDB3 1djs A 271 344 PDB3 1nun B 271 344 PDB3 1ry7 B 268 341 PDB3 1qct E 264 335 PDB3 2cpc A 731 790 PDB3 1pwi A 252 303 PDB3 2bjp A 252 303 PDB3 1rhf A 57 119 PDB3 2cr3 A 48 103 PDB3 1olz A 569 626 PDB3 1wf5 A 228 284 PDB3 1cs6 A 249 303 PDB3 1nbq B 146 214 PDB3 1f97 A 145 214 PDB3 1epf B 132 191 PDB3 1qz1 A 132 191 PDB3 3ncm A 132 191 PDB3 1wfn A 516 569 PDB3 1bih B 245 307 PDB3 1l6z A 159 216 PDB3 2c5d D 42 112 PDB3 1xau A 57 126 PDB3 2aw2 X 51 117 PDB3 1n26 A 40 98 PDB3 1n2q C 40 98 PDB3 1bqh G 46 131 PDB3 1nez G 46 131 PDB3 1g0y R 43 98 PDB3 1itb B 43 98 PDB3 1ira Y 43 98 PDB3 1j89 D 44 95 PDB3 1j87 A 44 95 PDB3 1f6a A 44 95 PDB3 1j88 A 44 95 PDB3 1rpq D ... 2c9a A 199 262 PDB3 1o0v A 128 195 PDB3 1g84 A 128 195 The immunoglobulin domain is a type of protein ... pmid7932691 cite journal author Bork P, Holm L, Sander C title The immunoglobulin fold. Structural classification ... cite journal author Br mmendorf T, Rathjen FG title Cell adhesion molecules 1 immunoglobulin superfamily ... of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibody antibodies , the giant muscle kinase titin and receptor tyrosine kinase s. Immunoglobulin ... AN title The immunoglobulin superfamily domains for cell surface recognition journal Annu. Rev ... url issn ref Examples Human genes encoding proteins containing the immunoglobulin domain include ... ICAM3 ICAM5 Immunoglobulin heavy constant alpha 1 IGHA1 IGHD IGHE IGSF10 IGSF11 IGSF2 IGSF21 IGSF3 ... VSIG1 VSIG2 VSIG4 hEMMPRIN kir3d Div col end See also Immunoglobulin superfamily References reflist External links http scop.mrc lmb.cam.ac.uk scop data scop.b.c.b.html SCOP listing of immunoglobulin ... more details
protein Name V set and immunoglobulin domain containing 4 caption image width HGNCid 17032 Symbol VSIG4 AltSymbols EntrezGene 11326 OMIM 300353 RefSeq NM 007268 UniProt Q9Y279 PDB ECnumber Chromosome X Arm q Band 12 LocusSupplementaryData q13.3 Complement receptor of the immunoglobulin family is a protein expressed in Kupffer cell s. ref cite journal author Helmy K, Katschke K, Gorgani N, Kljavin N, Elliott J, Diehl L, Scales S, Ghilardi N, van Lookeren Campagne M title CRIg a macrophage complement receptor required for phagocytosis of circulating pathogens. journal Cell volume 124 issue 5 pages 915 27 year 2006 pmid 16530040 doi 10.1016 j.cell.2005.12.039 ref See also complement system immunoglobulin References references gene X stub ... more details
N, Klein J, Nei M title Evolutionary redefinition of immunoglobulin light chain isotypes in tetrapods ... disease. In other animals The immunoglobulin light chain genes in tetrapod s can be classified ... immunoglobulin domain s one constant C sub L sub domain one variable domain V sub L sub that is important ... S Y author2 Cooper, Kumarason author3 Leong, F Joel W M year 2003 title Manual of Diagnostic ... protein s. See also Monoclonal antibodies References Reflist 2 External links MeshName Immunoglobulin Light Chains http www.wikilite.com wiki index.php Biology of immunoglobulin light chains Educational Resource for Immunoglobulin Light Chains Immune proteins Category Immune system protein stub ca ... more details
M, Peitsch MC, Casanova JE title Mutational analysis of polymeric immunoglobulin receptor ligand ...PBB geneid 5284 Polymeric immunoglobulin receptor is a protein that in humans is encoded by the PIGR gene . ref name entrez It is a Fc receptor which facilitates the secretion of immunoglobulin A and immunoglobulinM . The PBB Summary template is automatically maintained by Protein Box Bot. See Template ... transport of polymeric immunoglobulin molecules. It is a member of the immunoglobulin superfamily Hood ... and a transmembrane region, which also has some homology to certain immunoglobulin variable regions. supplied by OMIM ref name entrez cite web title Entrez Gene PIGR polymeric immunoglobulin receptor ... Kaetzel CS title The polymeric immunoglobulin receptor bridging innate and adaptive immune responses ... E, Wiederhold M, et al. title Determination of the molecular structure of the human free secretory ... R, Sandberg M, et al. title Molecular cloning of the human transmembrane secretory component poly Ig ... MK, Le Beau MM, Eddy RL, et al. title Genetic mapping of the human polymeric immunoglobulin receptor ... 11 year 1989 pmid 3197448 doi 10.1159 000132601 cite journal author Hood L, Kronenberg M, Hunkapiller T title T cell antigen receptors and the immunoglobulin supergene family journal Cell volume 40 issue ... JF, France JA, Tamer CM, et al. title Interferon gamma induces polymeric immunoglobulin receptor mRNA ... polymeric immunoglobulin receptor gene by interferon gamma journal Mol. Immunol. volume 34 issue ... acid residues of the polymeric immunoglobulin receptor journal FEBS Lett. volume 410 issue 2 3 pages ... 10227981 doi cite journal author R e M, Norderhaug IN, Brandtzaeg P, Johansen FE title Fine specificity ... Mostov KE, Friedlander M, Blobel G. title The receptor for transepithelial transport of IgA and IgM contains multiple immunoglobulin like domains journal Nature volume 308 issue 5954 pages 37 43 year ... 5284 External links MeshName Polymeric Immunoglobulin Receptor NLM content immunology stub The PBB ... more details
Orphan date December 2010 Pfam box Symbol C2 set Name Immunoglobulin C2 set domain image width caption Pfam PF05790 InterPro IPR008424 SMART Prosite SCOP TCDB OPM family OPM protein PDB PDB3 1wip A 317 388 PDB3 1wiq B 317 388 PDB3 1wio B 317 388 PDB3 1cid 316 386 PDB3 1hng B 128 198 PDB3 1hnf 135 205 PDB3 1rzk C 125 203 PDB3 1gc1 C 125 203 PDB3 1cdi 125 203 PDB3 2b4c C 125 203 PDB3 1g9n C 125 203 PDB3 1cdu 125 203 PDB3 1rzj C 125 203 PDB3 1jl4 D 125 203 PDB3 1opw C 125 203 PDB3 1cdy 125 203 PDB3 1cdj 125 203 PDB3 3cd4 125 203 PDB3 1opt C 125 203 PDB3 1cdh 125 203 PDB3 1g9m C 125 203 PDB3 1opn C 125 203 PDB3 1vca A 133 221 PDB3 1ij9 A 133 220 PDB3 1vsc A 133 219 The basic structure of immunoglobulin Ig molecules is a tetramer of two light chains and two heavy chains linked by disulphide bonds. There are two types of light chains kappa and lambda, each composed of a constant domain CL and a variable domain VL . There are five types of heavy chains alpha, delta, epsilon, gamma and mu, all consisting of a variable domain VH and three in alpha, delta and gamma or four in epsilon and mu constant domains CH1 to CH4 . Ig molecules are highly modular proteins, in which the variable and constant ... journal author Smith DK, Xue H title Sequence profiles of immunoglobulin and immunoglobulin like ... M, Kister A, Gelfand I title Protein Protein Recognition Juxtaposition of Domain and Interface Cores ... author Clarke J, Fowler SB title Mapping the folding pathway of an immunoglobulin domain structural ... 5 pages 355 366 year 2001 pmid 11377196 doi 10.1016 S0969 2126 01 00596 2 ref Immunoglobulin like domains ... C, Teichmann SA title Immunoglobulin superfamily proteins in Caenorhabditis elegans journal J ... P, Carrillo C, Brun A, Sussman M title An African swine fever virus gene with similarity to the T lymphocyte ... has four immunoglobulin like domains in its extracellular region that share the same structure, but can ... Immunoglobulin C2 Set Domain Category Protein domains Category Single pass transmembrane proteins ... more details
Infobox disease Name Selective immunoglobulin A deficiency Image Immunglobulin A as Dimer.png Caption The dimeric IgA molecule. 1 H chain, 2 L chain, 3 J chain, 4 secretory component DiseasesDB 29569 ICD10 ICD10 D 80 2 d 80 ICD9 ICD9 279.01 ICDO OMIM 137100 MedlinePlus 001476 eMedicineSubj med eMedicineTopic 1159 MeshID D017098 Selective immunoglobulin A IgA deficiency is a relatively mild genetic immunodeficiency . People with this deficiency lack immunoglobulin A IgA , a type of antibody that protects against infections of the mucous membranes lining the mouth, airways, and digestive tract. It is defined as an undetectable serum IgA level in the presence of normal serum levels of IgG and IgM. It is the most common of the primary antibody deficiencies. Epidemiology Prevalence varies by population, but is on the order of up to 1 in 333 people, ref name titleIgA Deficiency Immunodeficiency Disorders Merck Manual Professional cite web url http www.merck.com mmpe sec13 ch164 ch164k.html title IgA Deficiency Immunodeficiency Disorders Merck Manual Professional accessdate 2008 03 01 format work ref making it relatively common for a genetic disease. It is more common in males than in females. ref name pmid15025682 cite journal author Weber Mzell D, Kotanko P, Hauer AC, et al. title Gender, age and seasonal effects on IgA deficiency a study of 7293 Caucasians journal Eur. J. Clin. Invest ... immunoglobulin IgA immunoglobulin A IgA , a part of the body s defenses against infection at the body ... 8 cite book author Tierney, Lawrence M. McPhee, Stephen J. Papadakis, Maxine A. title Current medical ... or intravenous immunoglobulin due to the presence of IgA in these blood products. When suspected ... subpopulation abnormalities. ref name pmid17223965 cite journal author Litzman J, Vlkov M, Pikulov ... 2007&volume 147&issue 2&spage 249 ref Those patients with selective immunoglobulin A deficiency ... do not forget selective immunoglobulin A deficiency journal Nephrol. Dial. Transplant. volume ... more details
, which are the first two heavy chain segments in the immunoglobulin Locus genetics locus . After ... region of the immunoglobulin heavy chain changes but the variable regions, and therefore antigenic ... S, Hickernell TR, Murphy M, Gumaste S, Geyer M, Zarrin AA, Manis JP, Rajewsky K, Alt FW title IgH ... M, Shlomchik MJ title Immunobiology. edition 5th publisher Garland Publishing year 2001 id http ... wikitable Table 1. Class switching in mouse rowspan 2 T cells rowspan 2 Cytokines colspan 6 Immunoglobulin ... rowspan 2 Cytokines colspan 6 Immunoglobulin classes IgG1 IgG2 IgG3 IgG4 IgA IgE rowspan 2 Th2 ... References reflist 2 External links MeshName Immunoglobulin class switching http pathmicro.med.sc.edu ... more details
Pfam box Symbol C1 set Name Immunoglobulin C1 set domain image PDB 1z5l EBI.jpg width caption Structure of T cell surface glycoprotein CD1d antigen. ref name pmid cite journal author Zajonc DM, Cantu C, Mattner J, et al. title Structure and function of a potent agonist for the semi invariant natural killer T cell receptor journal Nat. Immunol. volume 6 issue 8 pages 810 8 year 2005 month August pmid 16007091 pmc 2045075 doi 10.1038 ni1224 url ref Pfam PF07654 InterPro IPR003597 SMART Prosite SCOP TCDB OPM family OPM protein 1z5l PDB PDB3 1w72 D 208 295 PDB3 1q94 D 208 295 PDB3 1qvo A 208 295 PDB3 1x7q A 208 295 PDB3 2bck A 208 295 PDB3 1sys A 208 295 PDB3 1syv A 208 295 PDB3 1n2r A 208 295 PDB3 1m6o A 208 295 PDB3 1m05 A 208 295 PDB3 1agf A 208 295 PDB3 1agc A 208 295 C1 set domains are classical Ig like domains resembling the antibody constant domain. C1 set domains are found almost exclusively in molecules involved in the immune system, such as in immunoglobulin light and heavy chains, in the major histocompatibility complex MHC class I and II complex molecules, ref name PUB00015111 cite journal author Cresswell P, Pamer E title Mechanisms of MHC class I restricted antigen processing journal Annu. Rev. Immunol. volume 16 issue 1 pages 323 358 year 1998 pmid 9597133 doi 10.1146 annurev.immunol.16.1.323 ref ref name PUB00015113 cite journal author Ono SJ, Radosevich M title Novel mechanisms of class II major histocompatibility complex gene regulation journal Immunol Res volume 27 issue 1 pages 85 106 year 2003 pmid 12637770 doi 10.1385 IR 27 1 85 ref and in various T cell receptors. Human proteins containing this domain AZGP1 B2M CD1A CD1B CD1C CD1D CD1E DMA DQB2 DRB1 ELK2P1 FCGRT HFE gene HFE HHLA2 HLA A HLA B HLA B35 HLA B57 HLA C HLA CW HLA Cw HLA D HLA DMA HLA DMB HLA DOA HLA DOB HLA DP HLA DPA1 HLA DPB1 HLA DQA1 HLA DQA2 HLA DQB1 HLA DQB2 HLA DRA HLA DRB1 HLA DRB2 HLA DRB3 HLA DRB4 HLA DRw12 HLA Dw12 HLA E HLA F HLA G HLA G2.2 HLA H HLAC IGHA1 IGHA2 IGHD IGHE IGHG1 ... more details
The leukocyte immunoglobulin like receptors LILR are a protein family family of Receptor biochemistry receptors possessing extracellular immunoglobulin domains . ref name pmid15242876 cite journal author David E. Sloane, Nicodemus Tedla, Muyiwa Awoniyi, Donald W. MacGlashan Jr., Luis Borges, K. Frank Austen & Jonathan P. Arm title Leukocyte immunoglobulin like receptors novel innate receptors for human basophil activation and inhibition journal Blood journal Blood volume 104 issue 9 pages 2832 2839 year 2004 month November pmid 15242876 doi 10.1182 blood 2004 01 0268 url http bloodjournal.hematologylibrary.org cgi reprint 104 9 2832.pdf format Portable Document Format PDF ref They are also known as CD85 , ILTs and LIR, and can exert immunomodulatory effects on a wide range of immune cells. ref name pmid15304001 Damian Brown, Rachel L Allen, & John Trowsdale. The LILR family modulators of innate and adaptive immune pathways in health and disease. Tissue Antigens 2004 64 215 http onlinelibrary.wiley.com doi 10.1111 j.0001 2815.2004.00290.x pdf ref The human genes encoding these receptors are found in a gene cluster at chromosomal region 19q13.4. They include LILRA1 LILRA2 LILRA3 LILRA4 LILRA5 LILRA6 LILRB1 LILRB2 LILRB3 LILRB4 LILRB5 LILRB6 or LILRA6 LILRB7 or LILRA5 A subset of LILR recognise MHC class I also known as Human leukocyte antigen HLA class I in humans . Of these, the inhibitory receptors LILRB1 and LILRB2 show a broad specificity for classical and non classical MHC alleles with preferential binding to Beta 2 microglobulin b2m associated complexes. In contrast, the activating receptors LILRA1 and LILRA3 prefer b2m independent free heavy chains of MHC class I, and in particular HLA C alleles. ref name pmid21270408 cite journal author Jones DC, Kosmoliaptsis V, Apps ... ref See also LAIR1 Killer cell immunoglobulin like receptor References reflist biochem stub receptor stub Immunoglobulin superfamily immune receptors Category Immunoglobulin like receptors ... more details
PBB geneid 3309 Binding immunoglobulin protein BiP also known as 78 kDa glucose regulated protein GRP 78 or heat shock 70 kDa protein 5 HSPA5 is a Hsp70 HSP70 molecular chaperone protein chaperone located in the lumen of the endoplasmic reticulum endoplasmic reticulum ER that binds newly synthesized proteins as they are protein targeting translocated into the ER, and maintains them in a state competent for subsequent protein folding folding and oligomer oligomerization . BiP is also an essential component of the translocation machinery, as well as playing a role in retrograde transport across the ER membrane of aberrant proteins destined for degradation by the proteasome . BiP is an abundant protein under all growth conditions, but its synthesis is markedly induced under conditions that lead to the accumulation of unfolded polypeptides in the ER. In humans, BiP is encoded by the HSPA5 gene . ref name pmid2840249 cite journal author Ting J, Lee AS title Human gene encoding the 78,000 dalton glucose regulated protein and its pseudogene structure, conservation, and regulation journal DNA volume 7 issue 4 pages 275 86 year 1988 month May pmid 2840249 doi 10.1089 dna.1988.7.275 url ref ref name pmid8020977 cite journal author Hendershot LM, Valentine VA, Lee AS, Morris SW, Shapiro DN title Localization of the gene encoding human BiP GRP78, the endoplasmic reticulum cognate of the HSP70 ... referred to as immunoglobulin heavy chain binding protein BiP , is a member of the heat shock protein ... and thus PDI s work is halted as well. ref name pmid10893409 cite journal author Mayer M, Kies U, Kammermeier ... for GRP78 binding. Interactions Binding immunoglobulin protein has been shown to Protein protein ... proteins. Refolding of colloidal thyroglobulin by protein disulfide isomerase and immunoglobulin ... Smith MD, Brunst M, Cornell H, Panayi GS.. title Inhibition of antigen presenting cell function ... O, Panayi GS. title Binding immunoglobulin protein treated peripheral blood monocyte derived ... more details
Infobox protein family Symbol Adhes Ig like Name Adhes Ig like image PDB 1gsm EBI.jpg width caption a reassessment of the madcam 1 structure and its role in integrin recognition. Pfam PF09085 Pfam clan CL0011 InterPro IPR015169 SMART PROSITE MEROPS SCOP 1gsm TCDB OPM family OPM protein CAZy CDD In molecular biology, the adhesin molecule immunoglobulin like is a protein domain . This domain is found in mucosal vascular addressin cell adhesion molecule 1 protein s MAdCAM 1 . These are cell adhesion molecule s gene expression expressed on the endothelium in mucosa that guide the specific homing of lymphocytes into mucosal tissue biology tissue s. MAdCAM 1 belongs to a subclass of the antibody immunoglobulin superfamily IgSF , the members of which are ligands for integrins . ref name pmid9655832 cite journal author Tan K, Casasnovas JM, Liu JH, Briskin MJ, Springer TA, Wang JH title The structure of immunoglobulin superfamily domains 1 and 2 of MAdCAM 1 reveals novel features important for integrin recognition journal Structure volume 6 issue 6 pages 793 801 year 1998 month June pmid 9655832 doi 10.1016 S0969 2126 98 00080 X url ref The crystal structure of this domain has been reported it adopts an immunoglobulin like beta sandwich structure, with seven strands arranged in two beta sheet s in a Greek key topology. ref name pmid11807247 cite journal author Dando J, Wilkinson KW, Ortlepp S, King DJ, Brady RL title A reassessment of the MAdCAM 1 structure and its role in integrin recognition journal Acta Crystallogr. D Biol. Crystallogr. volume 58 issue Pt 2 pages 233 41 year 2002 month February pmid 11807247 doi 10.1107 S0907444901020522 url ref ref name pmid9655832 cite journal author Tan K, Casasnovas JM, Liu JH, Briskin MJ, Springer TA, Wang JH title The structure of immunoglobulin superfamily domains 1 and 2 of MAdCAM 1 reveals novel features important for integrin recognition journal Structure volume 6 issue 6 pages 793 801 year 1998 month June pmid 9655832 doi 10.1 ... more details
immunoglobulin domains but also have a hinge region for added flexibility. ref name woof cite journal ... is composed of a single immunoglobulin domain. These domains are about 110 amino acids long. In fish ... in all jawed fish and is the heavy chain for what is thought to be the primordial immunoglobulin. The resulting ..., 2005, pages 6919 24. ref and zebrafish , ref N. Danilova, J. Bussmann, K. Jekosch, L.A Steiner. The immunoglobulin ... isotype, immunoglobulin Z. Nature Immunology, Volume 6, Issue 3, 2005, pages 295 302. ref could potentially ... IgX or IgNARC and IgNAR immunoglobulin new antigen receptor . ref H. Dooley and M.F. Flajnik. Antibody ... Immunoglobulin Heavy Chains http www.wikilite.com wiki index.php Biology of immunoglobulin light chains ... more details
Pfam box Symbol I set Name Immunoglobulin I set domain image PDB 1evt EBI.jpg width caption Structures of fibroblast growth factor 1. ref name pmid10830168 cite journal author Plotnikov AN, Hubbard SR, Schlessinger J, Mohammadi M title Crystal structures of two FGF FGFR complexes reveal the determinants of ligand receptor specificity journal Cell volume 101 issue 4 pages 413 24 year 2000 month May pmid 10830168 doi 10.1016 S0092 8674 00 80851 X url ref Pfam PF07679 InterPro IPR013098 SMART Prosite SCOP TCDB OPM family OPM protein PDB PDB3 1bih B 327 412 PDB3 1cs6 A 322 407 PDB3 1cvs C 159 247 PDB3 1epf B 20 114 PDB3 1evt D 159 247 PDB3 1fhg A 42 132 PDB3 1fq9 C 159 247 PDB3 1gxe A 652 767 PDB3 1ie5 A 214 304 PDB3 1ij9 A 25 112 PDB3 1koa 6585 6674 PDB3 1pd6 A 363 448 PDB3 1qct E 153 241 PDB3 1qz1 A 214 305 PDB3 1ry7 B 157 245 PDB3 1tlk 42 132 PDB3 1tnm 33489 3357 PDB3 1tnn 33489 3357 PDB3 1u2h A 43 113 PDB3 1vca A 25 112 PDB3 1vsc A 25 112 PDB3 1wf5 A 306 320 PDB3 1wit 4150 4239 PDB3 1wiu 4150 4239 PDB3 1wwc A 325 352 PDB3 1x44 A 342 430 PDB3 2cqv A 1238 1327 PDB3 2cry A 419 516 PDB3 2ncm 20 114 I set domains are found in several cell adhesion molecule s, including vascular VCAM 1 VCAM , intercellular Intercellular adhesion molecule ICAM , neural Neural cell adhesion molecule NCAM and mucosal addressin Addressin MADCAM cell adhesion molecules, as well as junction adhesion molecules JAM2 JAM . I set domains are also present in several other diverse protein families, including several tyrosine protein kinase receptors, the hemolymph protein hemolin, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin 1, ref name PUB00024043 cite journal author Sonderegger P, Welte W, Diederichs K, Freigang J, Proba K, Leder L title The crystal structure of the ligand binding module of axonin 1 TAG 1 suggests a zipper mechanism for neural cell adhesion journal Cell volume 101 issue 4 pages 425 33 year 2000 pmid 10830169 doi 10.1016 S0092 8674 00 80852 ... more details
Pfam box Symbol V set Name Immunoglobulin V set domain image PDB 1mcp EBI.jpg width caption Structure of phosphocholine binding immunoglobulin Fab McPC603. ref name pmid3097327 cite journal author Satow Y, Cohen GH, Padlan EA, Davies DR title Phosphocholine binding immunoglobulin Fab McPC603. An X ray diffraction study at 2.7 A journal J. Mol. Biol. volume 190 issue 4 pages 593 604 year 1986 month August pmid 3097327 doi 10.1016 0022 2836 86 90245 7 url ref Pfam PF07686 InterPro IPR013106 SMART Prosite SCOP TCDB OPM family OPM protein PDB PDB3 2mcp H 1 121 PDB3 1mcp H 1 121 PDB3 1ohq B 20 116 PDB3 1hou H 20 116 PDB3 1hez B 20 138 PDB3 2fb4 H 2 125 PDB3 2ig2 H 2 125 PDB3 1mqk H 20 116 PDB3 1ub6 A 4 96 PDB3 1ub5 A 1 96 PDB3 1i8k B 26 116 PDB3 1i8i B 26 116 PDB3 1igc H 17 135 PDB3 1l7i H 20 139 PDB3 2dlf H 1 114 PDB3 1sm3 H 2 114 PDB3 2fbj H 1 117 PDB3 7fab H 2 116 PDB3 1ezv X 20 115 PDB3 1kcs H 25 115 PDB3 1kcv H 25 115 PDB3 1j1p H 2 112 PDB3 1ic5 H 2 112 PDB3 1j1x H 2 112 PDB3 1c08 B 2 112 PDB3 1ic4 H 2 112 PDB3 1ic7 H 2 112 PDB3 1j1o H 2 112 PDB3 1g7m B 20 115 PDB3 1dvf B 20 115 PDB3 1g7l B 20 115 PDB3 1g7h B 20 115 PDB3 1g7j B 20 115 V set domains are Ig like domains resembling the antibody variable domain. V set domains are found in diverse protein families, including immunoglobulin light and heavy chains in several T cell receptors such as CD2 Cluster of Differentiation 2 , CD4, CD80, and CD86 in myelin membrane adhesion molecules in junction adhesion molecules JAM in tyrosine protein kinase receptors and in the programmed cell death protein 1 PD1 . Subfamilies Immunoglobulin V set, subgroup InterPro IPR003596 T cell surface antigen CD2 InterPro IPR013285 Human proteins containing this domain ACAM protein ACAM Aggrecan ACAN ADAMTSL1 AGC1 AMICA1 BCAM BCAN CEACAM1 BGP BGPc BT3.3 BTN1A1 BTN2A1 BTN2A2 BTN2A3 BTN3A1 BTN3A2 BTN3A3 BTNL2 BTNL3 BTNL8 BTNL9 C10orf54 C1orf32 C9orf94 CADM1 CADM2 CADM3 CADM4 CD2 CD226 CD274 CD276 CD300A CD300C CD300D CD300E CD300LB CD300LF CD300LG ... more details
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