Unreferenced date April 2007 protein Name H3histone, family 3A H3.3A caption image width HGNCid 4764 ... Chromosome 1 Arm q Band 41 LocusSupplementaryData protein Name H3histone, family 3B H3.3B caption ... P84243 PDB ECnumber Chromosome 17 Arm q Band 25 LocusSupplementaryData HistoneH3 is one of the five main histone protein s involved in the structure of chromatin in eukaryotic cell s. Citation needed date September 2011 Featuring a main globular domain and a long N terminal end N terminal tail , H3 is involved with the structure of the nucleosome s of the beads on a string structure. Histone proteins are highly post translationally modified however HistoneH3 is the most extensively modified of the five histones. The term HistoneH3 alone is purposely ambiguous in that it does not distinguish between sequence variants or modification state. HistoneH3 is an important protein in the emerging ... Modifications The N terminal tail of histoneH3 protrudes from the globular nucleosome core and can ... author Lachner M, O Carroll D, Rea S, Mechtler K, Jenuwein T title Methylation of histoneH3 lysine ... month March pmid 11242053 doi 10.1038 35065132 url issn ref Acetylation of histoneH3 occurs at several different lysine positions in the histone tail and is performed by a family of enzymes known as histone acetyltransferase s HATs . Acetylation of lysine14 is commonly seen in genes that are being ... of histoneH3. These are denoted as Histone H3.1, Histone H3.2 and Histone H3.3 but are highly ... patterns and post translational modifications associated with mammalian histoneH3 variants journal ... R, Zhang MQ title Determination of enriched histone modifications in non genic portions of the human ... WF, Gongidi P, Woods KR, Jin J, Maltais LJ title The human and mouse replication dependent histone ... jbc.M509266200 url issn ref Genetics Histone H3s are coded by several genes in the human genome ... , HIST1H3I , HIST1H3J H3.2 HIST2H3A , HIST2H3C , HIST2H3D H3.3 H3F3A , H3F3B See also Other histone ... more details
System British NVC community H3 , a heath community of the British National Vegetation Classification system Histamine H3 receptor , a human gene HistoneH3 , a component of DNA higher structure ...NOTOC H3 , H03 or H 3 may refer to Culture Happy Hustle High , a manga series by Rie Takada Halo 3 , a video game by Bungie Studios for the Xbox 360 H3 film H3 film , a 2001 film about the 1981 Irish hunger strike Science H sub 3 sub Triatomic hydrogen Hydrogen 3, H 3, sup 3 sup H a.k.a. Tritium , an unstable ... Diseases of the eye, adnexa ICD 10 code HTML tag Basic text h3 is the HTML tag for a level 3 heading H3 cell phone charger, by Sweden Swedish company myFC, using water fuel cell PIE h , one of the three ... 3 Sea King , a United States Navy helicopter PRR H3 , an American Template PRR locomotives PRR 2 8 0 ... , a 1914 United States Navy H class submarine H3 Monks Way , a road part of the Milton Keynes grid road system HMS Grenville H03 , a 1935 British Royal Navy destroyer HMS H3 , a 1915 British Royal Navy H class submarine Hummer H3 , the smallest of the three Hummer models sold by General Motors Interstate ... Iraq. The main H3 airfield was originally built to support the H 3 oil pumping station. Highway H03 Ukraine , a Template Roads in Ukraine road in Ukraine Other uses H3 pyrotechnics , a pyrotechnic composition H3 Pharmaceutical Chemistry , a higher paper for GCE A level chemistry for Singapore students DSC H3 , a 2008 Sony Cyber shot H series camera Hash House Harriers , an international group of non competitive running, social and drinking clubs H3 or Harrison Number Three, an 18th century marine chronometer H3 lamp , an automotive halogen lamp The Hurricane tie H3 hurricane tie manufactured by Simpson Strong Tie Co. H3 is a successful men handball team from http www.csvhandbal.nl CSV Handball , North Holland, The Netherlands Letter NumberCombDisambig ca H3 de H3 es H3 fr H3 it H3 ja H3 pt H3 zh H3 ... more details
pmid 11893489 doi 10.1016 S0959 437X 02 00282 4 url ref Classes Pfam box Symbol Histone Name Core histone H2A H2B H3 H4 image Protein H2AFJ PDB 1aoi.png width caption Protein Data Bank PDB rendering ... , HIST1H2BL , HIST1H2BM , HIST1H2BN , HIST1H2BO H2B2 HIST2H2BE rowspan 4 align center HistoneH3H3 H3A1 HIST1H3A , HIST1H3B , HIST1H3C , HIST1H3D , HIST1H3E , HIST1H3F , HIST1H3G , HIST1H3H , HIST1H3I , HIST1H3J H3A2 HIST2H3C H3A3 HIST3H3 rowspan 3 align center Histone H4 H4 H41 HIST1H4A , HIST1H4B ... Koji year 2011 title Immunohistochemical Analysis of HistoneH3 Modifications in Germ Cells ... of the H3 protein. Examples of histone modifications in transcription regulation include class wikitable ... metabolism. For example, histoneH3 like CenpA is a histone associated with only the centromere ... journal author Redon C, Pilch D, Rogakou E, Sedelnikova O, Newrock K, Bonner W title Histone H2A variants ... 1s32 , PDB2 1tyz , PDB2 1u35 , PDB2 2aro , PDB2 2cv5 , PDB2 2hio Pfam box Symbol Linker histone Name linker histone H1 and H5 family image PBB Protein HIST1H1B image.jpg width caption Protein Data Bank ... 1ust , PDB2 1yqa Five major families of histones exist H1 H5, H2A, H2B, H3, and H4. ref name Nelson&Cox ... isbn 0 86720 090 1 ref Histones H2A, H2B, H3 and H4 are known as the core histones, while ... 9305837 doi 10.1038 38444 url PDB 1AOI ref The linker histone H1 binds the nucleosome and the entry .... The following is a list of human histone proteins class wikitable border 1 Super family Family Subfamily Members rowspan 4 align center Linker rowspan 3 align center Histone H1 H1 H1F H1F0 , H1FNT ... center Core rowspan 4 align center Histone H2A H2A H2AF H2AFB1 , H2AFB2 , H2AFB3 , H2AFJ , H2AFV , H2AFX ... 4 align center Histone H2B H2B H2BF H2BFM , H2BFO , H2BFS , H2BFWT H2B1 HIST1H2BA , HIST1H2BB , HIST1H2BC ... and a H3 H4 tetramer, forming two nearly symmetry symmetrical halves by tertiary structure Point ... pmid9305837 The H2A H2B dimers and H3 H4 tetramer also show pseudodyad symmetry. The 4 core histones ... more details
H3 is a pyrotechnic composition which is mostly used as burst charge for small diameter shells. It is friction and shock sensitive, as are most compositions containing chlorates. The composition consisting of Potassium chlorate KClO sub 3 sub Oxidizing agent 75 Charcoal 25 Dextrin Binder material binder 2 additional percent Due to the potassium chlorate, H3 should not be mixed with sulfur or compositions containing sulphur. External links http www.pyroguide.com index.php?title H3 A pyroguide article on H3 explosive stub Category Pyrotechnic compositions nl H3 vuurwerk ... more details
Unreferenced stub auto yes date December 2009 Orphan date February 2009 A histone gene is a gene that codes for histone protein s. See also Histone H1 Histone H2A Histone H2B HistoneH3Histone H4 DEFAULTSORT Histone Gene Category Genes Cell biology stub ... more details
Infobox Film name H3 image H3poster.jpg image size caption director Les Blair producer James Flynn writer Brian Campbell br Laurence McKeown starring Brendan Mackey Seamus br Mark O Halloran Bobby Sands music Ray Harmon cinematography Owen McPolin editing Niamh Fagan distributor Metropolitan Films released 2001 in film 2001 runtime 88 minutes country Film Ireland language English language English br Irish language Irish budget gross H3 was a film released in 2001 in film 2001 about the 1981 Irish hunger strike , events leading up to it, and subsequent developments in the prisoners struggle for Prisoner of War status. It was directed by Les Blair and was written by Brian Campbell and Laurence McKeown . Awards The film was nominated for four awards and won one of them, the Golden Rosa Camuna award at the Bergamo Film Meeting . External links imdb title 0290641 H3 amg movie 342527 H3 http www.britfilms.com britishfilms catalogue browse ?id D5FD9B420eeaf2E8F5oTvICEEC3D H3 at the British Film Catalogue Category 2001 films Category Irish films Category English language films Category 2000s drama films Category Films about the Irish Republican Army Ireland film stub 2000s drama film stub ... more details
Infobox automobile image File 2007 Hummer H3 NHTSA.jpg 250px 2007 Hummer H3 caption 2007 Hummer H3 name Hummer H3 manufacturer General Motors production 2005 2010 class Mid size Sport utility vehicle SUV ... transmission manual fuel capacity convert 23 U.S.gal impgal L abbr on The Hummer H3 was a crossover ... Africa the H3 was the smallest among the Hummer models, and the first to be built by GM. It was available ... The H3 was launched with a 3.5 liter straight 5 cylinder GM Atlas engine L52 L52 engine ... H3 204WD&hiddenField Findacar EPA 2009 fuel economy estimates. Retrieved on December 27, 2008. ref Capabilities File Hummer H3 rear.jpg right thumb Hummer H3 showing external spare tire The H3 .... The Hummer H2 , the H3 can ford convert 24 in of water tested in depths up to convert 31 in disp ... are measured at 37.4 , 34.7 , and 22.1 respectively, allowing the H3 to scale a convert 16 in adj ... were standard features on the H3. Side curtain airbags were optional until 2008 when they were made standard across. The H3 was rated Acceptable , the second highest rating, by the Insurance Institute ...?id 629 IIHS HLDI Hummer H3. Retrieved on December 27, 2008. ref The U.S. National Highway Traffic Safety Administration NHTSA gave the 2008 H3 the following scores Frontal Driver rating ... class wikitable Calendar year H3 H3T Total 2005 33,140 0 33,140 2006 ref cite web url http media.gm.com ... H3 s were imported to England because of their right hand drive. The plant manufactured only the Hummer H3 for the South African market, as well as units exported to Asia and Europe. This plant also ... web url http www.automotoportal.com article hummer h3 comes to australia in 2007 title HUMMER H3 comes ... H3, finishing eighth overall. ref cite web title N 302 Team Robby Gordon Motorsports work Dakar ... ref Plug in hybrid In early 2009, Raser Technologies and FEV built a prototype plug in hybrid H3 that could ... www.engadget.com 2009 04 28 raser technologies develops 100mpg hummer h3 just to spite al go title Raser ... more details
HMS Calgarian 1913 6 . She was accompanied by HMS H1 2 , HMS H2 2 and HMS H4 2 . H3 was mined ... Ships sunk by mines UK mil submarine stub ja H3 ... more details
unreferenced date November 2010 Unreferenced stub auto yes date December 2009 A histone octamer is an octamer of the histone s found at the center of a nucleosome core particle . It consists of 2 copies of each of the four core histone proteins Histone H2A H2A , Histone H2B H2B , HistoneH3H3 and Histone H4 H4 . The octamer assembles when a tetramer, containing two copies of both H3 and H4, complexes with two H2A H2B dimers. These histones of the histone octamer all contain N terminal tail s that emanate from their central histone fold s, and core domains with the C terminals. The core domains are hydrophobic. See also Nucleosome Histone Chromatin DEFAULTSORT Histone Octamer Category Proteins Category Molecular biology Biochem stub pl Oktamer histonowy ... more details
Unreferenced stub auto yes date December 2009 Protein Name H4 histone, family 3 caption image width HGNCid 4780 Symbol H4F3 AltSymbols EntrezGene 3023 OMIM RefSeq UniProt P62805 PDB ECnumber Chromosome 3 Arm q Band 13.13 LocusSupplementaryData Histone H4 is one of the 5 main histone protein s involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N terminal tail, H4 is a structural component of the nucleosome , and is subject to covalent modification, including acetylation and methylation , which may alter expression of genes located on DNA associated with its parent histone octamer. Genetics Histone H4 is encoded in multiple genes at different loci including HIST1H4A , HIST1H4B , HIST1H4C , HIST1H4D , HIST1H4E , HIST1H4F , HIST1H4H , HIST1H4I , HIST1H4J , HIST1H4K , HIST1H4L , HIST2H4A , HIST2H4B , HIST4H4 , Hip See also nucleosome histone chromatin Other histone proteins involved in chromatin Histone H1 H1 Histone H2A H2A Histone H2B H2B HistoneH3H3 Chromo Cell biology stub de Histon H4 hu H4 hiszton pl Histon H4 zh H4 ... more details
Unreferenced stub auto yes date December 2009 Protein Name H2B histone family, member M caption image width HGNCid 27867 Symbol H2BFM AltSymbols EntrezGene 286436 OMIM RefSeq XM 210048 UniProt Q99879 PDB ECnumber Chromosome X Arm q Band 22.2 LocusSupplementaryData Histone H2B is one of the 5 main histone protein s involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N terminal tail H2B is involved with the structure of the nucleosome s of the beads on a string structure. See nucleosome , histone and chromatin . Other histone proteins involved Histone H1 H1 Histone H2A H2A HistoneH3H3Histone H4 H4 Chromo In popular culture H2B is mentioned in the Rap music rap song pistol pistol in Obie Trice s remix, saying a H2B to light your kidneys DEFAULTSORT Histone H2b Cell biology stub hu H2B zh H2B ... more details
Histone H2A is one of the 5 main histone protein s involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N terminal tail, H2A is involved with the structure of the nucleosome s of the beads on a string structure. Other histone proteins involved Histone H1 H1 Histone H2B H2B HistoneH3H3Histone H4 H4 Sequence Variants The term Histone H2A is intentionally non specific and refers to a variety of closely related proteins that vary often by only a few amino acids. Notable variants include H2A.1, H2A.2, H2A.X, and H2A.Z. Genetics H2A is coded by many genes in the human genome, including H2AFB1 , H2AFB2 , H2AFB3 , H2AFJ , H2AFV , H2AFX , H2AFY , H2AFY2 , and H2AFZ See also Chromatin Nucleosome Chromo External links http www.nextbio.com b home home.nb?q h2a Nextbio Cell biology stub Category Proteins de Histon H2B it Istone H2a hu H2A zh H2A ... more details
Histone methylation is the modification of certain amino acids in a histone protein by the addition of one, two, or three methyl groups. In the cell nucleus, DNA is wound around histones. Methylation and demethylation of histones turns the genes in DNA off and on , respectively, either by loosening their tails, thereby allowing transcription factors and other proteins to access the DNA, or by encompassing their tails around the DNA, thereby restricting access to the DNA. This is true in most cases. Function This modification alters the properties of the nucleosome and affects its interactions with other proteins. Histone methylation is in general associated with transcriptional Repressor repression . However, methylation of some lysine and arginine residues of histones results in transcriptional activation. Examples include methylation of lysine 4 of histone 3 H3K4 , and arginine R residues on H3 and Histone H4 H4 . See also methylation Histone methyltransferase Histone acetylation and deacetylation Transcription DEFAULTSORT Histone Methylation Category Molecular genetics Category Cellular processes Cell biology stub genetics stub ar ... more details
of histone modifications. While it is accepted that modifications such as methylation , acetylation , ADP ribosylation, ubiquitination and phosphorylation to histone tails alter chromatin structure, a complete understanding of the precise mechanisms by which these alterations to histone tails influence DNA histone interactions remains elusive. However, some specific examples have been worked out in detail. For example, phosphorylation of serine residues 10 and 28 on histoneH3 is a marker ... of a lysine residue 14 on histoneH3 is a tell tale sign of active Transcription genetics ...The histone code is a hypothesis that the transcription of genetic information encoded in DNA is in part regulated by chemical modifications to histone proteins, primarily on their unstructured ends. Together ... Jenuwein cite journal author Jenuwein T, Allis C title Translating the histone code journal Science ... with a flexible N terminus taken to be the tail that protrudes from the nucleosome. Many of the histone tail modifications correlate very well to chromatin structure and both histone modification state and chromatin structure correlate well to gene expression levels. The critical concept of the histone code hypothesis is that the histone modifications serve to recruit other proteins by specific recognition of the modified histone via protein domain s specialized for such purposes, rather than through simply stabilizing or destabilizing the interaction between histone and the underlying DNA .... For details of gene expression regulation by histone modifications see Histone code Modifications ... author Strahl B, Allis C title The language of covalent histone modifications journal Nature volume 403 issue 6765 pages 41 5 year 2000 pmid 10638745 doi 10.1038 47412 ref Acetylation by Histone acetyltransferase HAT histone acetyl transferase deacetylation by HDAC histone deacetylase Deacetylation ... last6 Zhang first6 Michael Q author5 link Michael Q. Zhang title Determination of enriched histone ... more details
Unreferenced stub auto yes date December 2009 Orphan date December 2009 A histone fold is a fold found near the C terminus of each type histone in a histone octamer . The core histones share a structurally conserved Structural motif motif , the histone fold, averaging about 70 amino acid s. The histone fold consists of three alpha helix alpha helices connected by short loops. DEFAULTSORT Histone Fold Category Protein folding Category Molecular biology Biochem stub ar ... more details
H3H3Histone H4 H4 References Reflist 2 Chromo Cell biology stub Category Proteins de Histon H1 ...Pfam box Symbol Linker histone Name linker histone H1 and H5 family image PBB Protein HIST1H1B image.jpg ... 1hst , PDB2 1uhm , PDB2 1uss , PDB2 1ust , PDB2 1yqa Histone H1 is one of the five main histone protein ... sequence conserved , it is nevertheless the most variable histone in sequence across species. Structure ... V, Finch JT, Graziano V, Lee PL, Sweet RM title Crystal structure of globular domain of histone ... quote isbn 0 12 364565 4 oclc doi url accessdate ref Much has been learned about histone H1 from studies ... pmid561660 cite journal author Thoma F, Koller T title Influence of histone H1 on chromatin structure ... of histone H1 in the organization of the nucleosome and of the salt dependent superstructures ... suggest that the globular domain of histone H1 localizes near the nucleosome dyad, where it protects ... of histone H1 journal Nucleic Acids Res. volume 3 issue 2 pages 477 92 year 1976 month February pmid ... JP, Simpson RT title Removal of histone H1 exposes a fifty base pair DNA segment between nucleosomes ... C, Aviles FX title The structure of histone H1 and its location in chromatin journal Nature volume ..., linker DNA, and linker histone form a unique structural motif that directs the higher order folding ..., Kandolf H, Smith RC title The maternal histone H1 variant, H1M B4 protein , is the predominant H1 histone ... cite journal author Gunjan A, Alexander BT, Sittman DB, Brown DT title Effects of H1 histone variant ... histone depletion causes 2 fold lengthwise extension of mitotic chromosomes, while overexpression ... Maresca TJ, Freedman BS, Heald R title Histone H1 is essential for mitotic chromosome architecture ... of multiple isoforms that may be present in several gene clusters, but various linker histone isoforms ... histone H1 isoform H1.1 is essential for chromatin silencing and germline development in Caenorhabditis ... P, Konev AY, Fyodorov DV, Skoultchi AI title Linker histone H1 is essential for Drosophila development ... more details
protein Name euchromatic histone lysine N methyltransferase 1 caption image width HGNCid 24650 Symbol EHMT1 AltSymbols EntrezGene 79813 OMIM 607001 RefSeq NM 024757 UniProt Q9H9B1 PDB ECnumber 2.1.1.43 Chromosome 9 Arm Band LocusSupplementaryData Histone methyltransferases HMT are enzyme s, EZH2 histone lysine N methyltransferase and histone arginine N methyltransferase, that catalyze the transfer of one to three methyl groups from the cofactor biochemistry cofactor S Adenosyl methionine to lysine and arginine residues of histone protein s. These proteins clarify date October 2010 often contain a SET S u var 3 9, E nhancer of Zeste, T rithorax Protein domain domain , however the recently discovered HMT Dot1 lacks the characteristic SET domain. fact date October 2010 Role in gene regulation Histone methylation serves in epigenetic gene regulation . Methylated histones bind DNA more tightly, which inhibits transcription genetics transcription . fact date October 2010 Methylated histones can either repress or activate transcription as different experimental findings suggest. See Histone Chromatin regulation . See also Histone Modifying Enzymes Histone acetyltransferase Histone deacetylase RNA polymerase control by chromatin structure Histone methylation References reflist External links http www.ncbi.nlm.nih.gov bookshelf br.fcgi?book gene&part kleefstra GeneReviews NCBI NIH UW entry on Kleefstra Syndrome MeshName Histone Lysine N Methyltransferase MeshName Protein Arginine N Methyltransferase http www.begellhouse.com journals 6dbf508d3b17c437,277d588e5dacdac4,25a707f32f2d19e3.html Structure and Function of Histone Methyltransferases. Trievel. 2004 http www.genetics.org cgi content short 182 2 437 The Dot1 Histone Methyltransferase and the Rad9 Checkpoint Adaptor Contribute to Cohesin Dependent Double Strand Break Repair by Sister Chromatid Recombination in Saccharomyces cerevisiae. Methyltransferases Transcription DEFAULTSORT Histone Methyltransferase Category EC 2.1.1 ... more details
Other uses Hat disambiguation enzyme Name Histone acetyltransferase EC number 2.3.1.48 CAS number 9054 51 7 IUBMB EC number 2 3 1 48 GO code 0004402 image width caption Histone acetyltransferases HAT are enzyme s that acetylation acetylate conserved lysine amino acid s on histone proteins by transferring an acetyl group from Coenzyme A acetyl CoA to form N acetyl lysine. In general, histone acetylation is linked to DNA transcription transcriptional activation and associated with euchromatin . When it was first discovered, it was thought that acetylation of lysine neutralizes the positive electric charge charge normally present, thus reducing affinity between histone and negatively charged DNA, which renders DNA more accessible to transcription factors . Research has emerged, since, to show that lysine acetylation and other posttranslational modification s of histones generate binding sites for specific protein protein interaction domains, such as the acetyl lysine binding bromodomain . Citation needed date July 2008 Histone acetyltransferases can also acetylate non histone proteins, such as transcription factors and nuclear receptors to facilitate gene expression. Examples Human proteins that possess histone acetyltransferase catalytic activity include CREB binding protein CREBBP , CDY1 , CDY2 , CDYL1 , CLOCK ELP3 , EP300 HAT1 KAT2A , PCAF KAT2B , KAT5 MYST1 , MYST2 , MYST3 , MYST4 ... coactivator 3 NCOA3 , MGEA5 NCOAT GTF3C4 TF3C4 Interaction with HDACs Histone acetyltransferases HATs and histone deacetylase s HDACs are recruited to their target promoters through a physical interaction ... also Histone Modifying Enzymes Histone deacetylase Histone methyltransferase RNA polymerase control by chromatin structure Acetyltransferase External links MeshName Histone Acetyltransferases Acyltransferases Transcription DEFAULTSORT Histone Acetyltransferase Category Transferases Category EC 2.3.1 Category Epigenetics transferase stub es Histona acetiltransferasa fr Histone ac tyl transf rase ... more details
Lead missing date March 2011 For many years histone methylation was thought to be a permanent modification. Very recently two families of histone demethylating enzyme s were discovered. The first was Lysine Specific Demethylase 1 LSD1 which is an Flavin group flavin dependent monoamine oxidase which can demethylate mono and di methylated lysines, specifically histone 3, lysines 4 and 9 H3K4 and H3K9 . This enzyme cannot demethylate tri methylated lysines and for a short while it was thought that tri methylated lysines may indeed be permanent modifications. In late 2005 the Jumonji domain containing JmjC histone demethylases were discovered which are able to demethylate mono , di , or tri methylated lysines thereby disproving the theory that histone methylation is permanent once and for all. Although this conclusion has since come into question. ref Webby CJ et al. Jmjd6 catalyses lysyl hydroxylation of U2AF65, a protein associated with RNA splicing. 2009 Science 325 5936 90 3. ref Two specific JmjC histone demethylase s are PHF8 and KIAA1718 . References reflist External links MeshName Histone demethylase CH NH2 oxidoreductases Transcription Category Molecular genetics biochem stub ... more details
enzyme Name histone deacetylase EC number 3.5.1.98 CAS number 9076 57 7 IUBMB EC number 3 5 1 98 GO code 0046970 image width caption Pfam box Symbol Hist deacetyl Name Histone deacetylase superfamily image ... Histone deacetylases HDAC Enzyme Commission number EC number 3.5.1 are a class of enzyme s that remove acetyl group s O C CH sub 3 sub from an N acetyl lysine amino acid on a histone . This is important ... acetylation. Its action is opposite to that of histone acetyltransferase . HDAC proteins are now also ... includes non histone proteins. ref name pmid19608861 cite journal author Choudhary C title Lysine ... with the acetylpolyamine amidohydrolase s and the acetoin utilization protein s, the histone deacetylases form an ancient protein superfamily known as the histone deacetylase superfamily. ref name pmid9278492 cite journal author Leipe DD, Landsman D title Histone deacetylases, acetoin utilization ... M, Clarke C, Marks PA title Histone deacetylase inhibitors overview and perspectives journal Mol. Cancer ... histone acetylation, increase in p21 and p27 HDAC2 1 Nucleus Ubiquitous Glucocorticoid receptor ... except class III contain zinc and are known as Zn dependent histone deacetylases. ref name pmid19459166 cite journal author Marks PA, Xu WS title Histone Deacetylase Inhibitors Potential in Cancer ... potassium dependency 3 Rpd3 , which corresponds to Class I histone deacetylase 1 hda1 , corresponding ... cite journal author Sengupta N, Seto E title Regulation of histone deacetylase activities ... author de Ruijter AJ, van Gennip AH, Caron HN, Kemp S, van Kuilenburg AB title Histone deacetylases ... pmid16532030 cite journal author Longworth MS, Laimins LA title Histone deacetylase 3 localizes ... j.tcb.2008.04.003 url issn ref Function Histone modification Histone tails are normally positively ... help the histone tails to interact with and bind to the negatively charged phosphate group s on the DNA backbone. Acetylation , which occurs normally in a cell, neutralizes the positive charges on the histone ... more details
Infobox Aircraft Begin name H3 image File VFW H 3E Sprinter.jpg caption VFW Fokker H3 on display Infobox Aircraft Type type Experimental rotorcraft manufacturer VFW Fokker designer first flight Spring Avyear 1970 introduced retired status primary user more users produced 2 number built unit cost developed from variants with their own articles The VFW Fokker H3 was a single engined experimental rotorcraft designed and built in West Germany . Two aircraft were produced by VFW Fokker in the early 1970s, registered D 9543 and D 9544 . Intended as the first of a family of tip jet driven helicopter s the two H3 prototypes flew briefly but the method of rotor propulsion was found to be unsuccessful for this size of aircraft. An improved H4 variant was designed but not built. Aircraft on display Both aircraft have survived, D 9543 is currently on display at the Hubschrauber Museum , B ckeburg with the other H3 thought to be in a private collection in Germany. ref http www.hubschraubermuseum.de exhibition v f w h 3 e sprinter?set language en&cl en Hubschrauber Museum VFW H3 www.hubschraubermuseum.de Retrieved 18 March 2010 ref Specifications H3 Aircraft specifications plane or copter? copter jet or prop? options jet prop both neither jet ref Jane s Pocket Book of Research and Experimental Aircraft, 1976. ref Taylor 1976, p. 243. ref crew One capacity 2 passengers payload main kg 270 kg payload alt lb 595 lb length main 7.37 m length alt 24 ft 2.25 in span main span alt height main height alt area main area alt airfoil empty weight main empty weight alt loaded weight main kg loaded weight alt lb useful load main kg useful load alt lb max takeoff weight main 968 kg max takeoff weight alt 2,134 lb more general engine jet Allison Model 250 Allison 250 C18 type of jet turboshaft number of jets 1 thrust main thrust alt max speed main max speed alt cruise speed main 250 km h km h cruise ... Cancelled aircraft projects Category Gyrodynes Category VFW aircraft H3 Category V tail aircraft de ... more details
H3 Pharmaceutical Chemistry Syllabus 9812 is an additional subject being offered to the GCE A level students in Singapore. It replaces the decades old Special paper otherwise known as paper 0 in syllabus 9251 , a paper that is often taken by students aiming for local overseas scholarship or simply wants to challenge themselves. The first batch of students will be sitting for their examination in November 2007. As given under the Introduction in the syllabus provided by University of Cambridge , H3 is meant for students with exceptional ability and interest in chemistry. The depth of the knowledge is pitched at college freshmen level, with approximately 140 hours of teaching and self directed independent learning. Syllabus The syllabus is divided into 6 sections as follow Effects and development of drugs Properties of functional groups and intermolecular interactions Molecular Stereochemistry Understanding Reaction Mechanisms Separation and Analytical Techniques Some classes of drugs Additional information The above syllabus is somewhat similar to the optional topics offered by International Baccalaureate chemistry. It overlaps considerably with option B, G and H, which are titled Medicines and Drugs , Modern Analytical Chemistry and Further Organic Chemistry respectively. The move from Special paper to H3 is primarily to place more emphasis on independent thinking, learning and creativity. Unlike Special paper, H3 takes the students beyond what is covered in the basic H2 syllabus it therefore allows students to be exposed to more in depth knowledge at a younger age. Teaching materials notes are mainly obtained from a guide written by the University of Cambridge . External links 1. http www.seab.gov.sg SEAB aLevel syllabus 2008 GCE A Level Syllabuses 9812 2008.pdf 2. http www.seab.gov.sg SEAB aLevel syllabus 2007 GCE A Level Syllabuses 9251 Chem 2007.pdf 3. http ibchem.com IB ibfiles options opt B opb.htm 4. http ibchem.com IB ibfiles options opt G opg.htm 5. http ibchem.com ... more details
Infobox automobile image File Great wall hover.jpg 250px name Great Wall Haval H3 aka Great Wall Hover br Great Wall Hover CUV br Great Wall Hover H3 br Great Wall Hafu br Great Wall X240 Australia manufacturer Great Wall Motor Great Wall Motor Company production 2005 present class Sports Utility Vehicle body style SUV engine 2.4 L Mitsubishi Mitsubishi Sirius engine 4G64 engine Petrol br 2.8 L Great Wall Motor GW2.8TC Diesel length convert 4620 mm in 1 abbr on wheelbase convert 2700 mm in 1 abbr on width convert 1800 mm in 1 abbr on height convert 1710 mm in 1 abbr on weight convert 1720 kg lb 1 abbr on predecessor related File Great Wall Hover with Sportkit.jpg thumb Rear view. The Great Wall Haval H3 zh c p Ch ngch ng H f , also known as the Great Wall Hover , is a Sports Utility Vehicle Sports Utility Vehicle SUV sold by the Great Wall Motor Great Wall Motor Company in several countries. It was the first Chinese car to be exported in large quantities to Western Europe in 2006, with 30,000 units shipped to Italy . Its main advantage over established European, North ... 2009 09 30 ref In Australia, the Haval H3 was badged as the Great Wall X240 ref cite web last Pettendy ... H3 is that it is based heavily on older models by other manufacturers. The entry level engine is the 4G64 ... ref the exterior resembles the Isuzu Axiom and the chassis is from a Toyota 4Runner . The Haval H3 ... H3 is a Sports Utility Vehicle , with selectable rear wheel drive or 4WD 4 wheel drive 4WD ... Haval H3 uses the Mitsubishi Mitsubishi Sirius engine 4G69 ref cite web url http www.auto chinese.com ... H3 and H5. For the Chinese market Great Wall Motors also offer 2.5 and 2.8 TCI diesel engines with Convert ... H3 complies with the European emission standards Euro III emissions standard . ref cite web url http ... ref The Great Wall Haval H3 has not yet been tested by EURO NCAP. With new engines which Great Wall Motor installed in the Haval H3, all models now comply with Euro 4 regulations. In Italy, a version ... more details
and behavioral properties of A 349821, a selective and potent human histamine H3 receptor antagonist ..., agents used for ADHD and nootropics Nootropics Antidepressants Category H3 receptor antagonists ... more details
on histamine containing neurons. ref name urlInterPro IPR003980 Histamine H3 receptor cite web url http www.ebi.ac.uk interpro IEntry?ac IPR003980 title InterPro IPR003980 Histamine H3 receptor ... I, Esbenshade TA, Hancock AA. G protein dependent pharmacology of histamine H3 receptor ligands ... human histamine H3 receptor antagonist. Biochemical Pharmacology . 2004 Sep 1 68 5 933 45. PMID ... S, Dalziel RG, Brass A, Roberts JC, Medhurst AD, Chessell IP title Novel histamine H3 receptor ... cloning to H3 receptor drugs journal Nature reviews. Drug discovery volume 4 issue 2 pages 107 20 ... H3 receptor antagonists References Reflist 2 Further reading refbegin 2 PBB Further reading citations ... H3 receptors general characterization and their function in the cardiovascular system journal ... Leurs R, Hoffmann M, Wieland K, Timmerman H title H3 receptor gene is cloned at last journal Trends ... 01411 X cite journal author Leurs R, Bakker RA, Timmerman H, de Esch IJ title The histamine H3 receptor from gene cloning to H3 receptor drugs journal Nature reviews. Drug discovery volume 4 issue 2 pages ... MD title Histamine H3 receptor antagonists preclinical promise for treating obesity and cognitive ... expression of the human histamine H3 receptor journal Mol. Pharmacol. volume 55 issue 6 pages 1101 ... of splice variants of the human histamine H3 receptor journal Biochem. J. volume 355 issue Pt ... H3 receptor induced attenuation of norepinephrine exocytosis from cardiac sympathetic nerve endings ... H, Oerters F, Br ss M title Structure of the human histamine H3 receptor gene HRH3 and identification ..., tele methylhistamine and down regulation of histamine H3 receptor sites in autopsied brain tissue ... M, Gr tzkau A, et al. title Human skin mast cells express H2 and H4, but not H3 receptors journal J ... pages language archiveurl archivedate quote MeshName H3 receptors G protein coupled receptors Histaminergics ... inspection no update protein box yes update summary no update citations yes de Histamin H3 Rezeptor ... more details
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