- Efalizumab
Category Withdrawn drugs monoclonal antibody stub antineoplastic drug stub de Efalizumab es Efalizumab it Efalizumab pl Efalizumab zh ... more details
|
- ATC code L04
ATC codes lead L 04 Immunosuppressants anchor L04A L04A Immunosuppressants anchor L04AA L04AA Selective immunosuppressants L04AA02 Muromonab CD3 L04AA03 Antilymphocyte immunoglobulin horse L04AA04 Antithymocyte immunoglobulin rabbit L04AA06 Mycophenolic acid L04AA10 Sirolimus L04AA13 Leflunomide L04AA15 Alefacept L04AA18 Everolimus L04AA19 Gusperimus L04AA21 Efalizumab L04AA22 Abetimus L04AA23 Natalizumab L04AA24 Abatacept L04AA25 Eculizumab L04AA26 Belimumab L04AA27 Fingolimod L04AA28 Belatacept anchor L04AB L04AB Tumor necrosis factor alpha TNF inhibitors L04AB01 Etanercept L04AB02 Infliximab L04AB03 Afelimomab L04AB04 Adalimumab L04AB05 Certolizumab pegol L04AB06 Golimumab anchor L04AC L04AC Interleukin inhibitors L04AC01 Daclizumab L04AC02 Basiliximab L04AC03 Anakinra L04AC04 Rilonacept L04AC05 Ustekinumab L04AC06 Mepolizumab L04AC07 Tocilizumab L04AC08 Canakinumab L04AC09 Briakinumab L04AC10 Secukinumab anchor L04AD L04AD Calcineurin inhibitors L04AD01 Ciclosporin L04AD02 Tacrolimus L04AD03 Voclosporin anchor L04AX L04AX Other immunosuppressants L04AX01 Azathioprine L04AX02 Thalidomide L04AX03 Methotrexate L04AX04 Lenalidomide L04AX05 Pirfenidone References Reflist Immunosuppressants Category ATC codes L04 Category Immunosuppressants ca Codi ATC L04 cs ATC k d L04 es Anexo C digo ATC L04 ko ATC L04 hu ATC L04 Immunszuppressz v szerek pl ATC L04 ro Cod ATC L04 sv ATC kod L04 Immunsuppressiva medel th ATC L04 ... more details
|
- Immunomodulation therapy
An immunomodulator , also known as an immunotherapy is a substance e. g. a medication drug which has an effect on the immune system . Immunomodulators Immune system can be modulated by the different ways with the use of Immunosuppressants Inhibits immune response in organ transplantation and autoimmune diseases. Immunostimulants Increase the immune response, useful in infections, immunodeficiency for example, AIDS and cancers. Tolerogens Induces tolerance and makes the tissue non responsive to antigen. Immunosuppressant drugs These drugs have major role in organ transplantation and auto immune diseases. The drugs are 1. Calcineurin inhibitors Specific T cell inhibitors . Cyclosporine Ciclosporin , Tacrolimus 2. Antiproliferative drugs Cytotoxic drugs . Azathioprine , Cyclophosphamide , Methotrexate , Chlorambucil , Mycophenolate mofetil MMF 3. Glucocorticoids . Prednisolone and others 4. Antibodies . Muromonab CD3, Antithymocyte globin ATG , Rho D immuneglobin, Efalizumab Immunostimulant drugs They stimulate the immune system to fight against immunodeficiencies like AIDS , infections and cancers. 1. Levamisole . An antihelmintic drug that also restores functions of B lymphocytes, T lymphocytes, monocytes and macrophages. Hence it has been used in colon cancer along with 5 FU. 2. Thalidomide . Different effects of this old drug have been utilized in conditions such as Erythema nodosum leprosum Anti inflammatory effect Multiple myleoma Anti angiogenesis Rheumatoid arthritis Anti TNF effect. 3. BCG . Used in carcinoma bladder. 4. Recombinant cytokines. Interferons In tumors and chronic hepatitis B and C Interleukin 2 aldeslukin has been used in renal cell carcinoma and melanoma Main Immunostimulant Tolerogens Induces tolerance and makes the tissue non responsive to antigen. Tolerance is the state of non responsiveness to antigen. The agents used as tolerogens are 1. Costimulatory blockade. For activation, T lymphocytes need agonist specific signal from interaction of m ... more details
|
- Psoriatic nails
ointment. ref cite pmid 19212110 ref Efalizumab ref cite pmid 18856162 ref Infliximab ref cite ... more details
|
- Progressive multifocal leukoencephalopathy
immune response or drug combination therapies rather than individual drugs. These include efalizumab ... more details
|
- JC virus
trials. The boxed warning was added on Feb. 19, 2009, for the drug efalizumab Raptiva, marketed ... patients who received efalizumab in clinical trials. The drug was pulled off the U.S. market because ... more details
|
- CD11a
PBB geneid 3683 Integrin, alpha L antigen CD11A p180 , lymphocyte function associated antigen 1 alpha polypeptide , also known as ITGAL , is a human gene which functions in the immune system. It is involved in cellular adhesion and costimulatory signaling. It is the target of the drug efalizumab . The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I domain containing alpha integrin combines with the beta 2 chain ITGB2 to form the integrin lymphocyte function associated antigen 1 LFA 1 , which is expressed on all leukocytes. LFA 1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1 3 intercellular adhesion molecules 1 through 3 , and also functions in lymphocyte costimulatory signaling. ref cite web title Entrez Gene ITGAL integrin, alpha L antigen CD11A p180 , lymphocyte function associated antigen 1 alpha polypeptide url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 3683 accessdate ref CD11a is one of the two components, along with CD18 , which form lymphocyte function associated antigen 1 . Efalizumab acts as an immunosuppressant by binding to CD11a. See also CD11c integrin leukocyte adhesion deficiency Cluster of differentiation Interactions CD11a has been shown to Protein protein interaction interact with ICAM 1 . ref name pmid11279101 cite journal last Lu first C authorlink coauthors Takagi J, Springer T A year 2001 month May. title Association of the membrane proximal regions of the alpha and beta subunit cytoplasmic domains constrains an integrin in the inactive state journal J. Biol. Chem. volume 276 issue 18 pages 14642 8 publisher location United States issn 0021 9258 pmid 11279101 doi 10.1074 jbc.M100600200 bibcode oclc id ur ... more details
|
- Genentech
asthma . 2003 Efalizumab Raptiva efalizumab Antibody designed to block the activation and reactivation ... more details
|
- List of drugs: E-El
Name INN Edrophonium ef eg efalizumab United States Adopted Name USAN efaproxiral United ... more details
|
- List of withdrawn drugs
depression and suicide Efalizumab Raptiva 2009 Withdrawn because of increased risk of progressive ... more details
|
- Annual pharmaceutical drug sales
319.5 dornase alfa Pulmozyme Cystic fibrosis CF Genentech 257 223 199 186.5 157.1 143.7 138.1 123 efalizumab ... more details
|
- Influenza-like illness
The Greek experience with efalizumab in psoriasis from a university dermatologic hospital journal Br ... more details
|
- Psoriasis
drugs that target T cells are efalizumab and alefacept . Efalizumab is a monoclonal antibody which ... infections. Efalizumab was voluntarily withdrawn from the US market in April, 2009 by the manufacturer ... more details
|
- Monoclonal antibody therapy
nocturnal hemoglobinuria Efalizumab Raptiva 2002 humanized CD11a Psoriasis Gemtuzumab Mylotarg 2000 ... more details
|
- List of monoclonal antibodies
Efalizumab ref name WHOList85 Raptiva mab humanized LFA 1 CD11a psoriasis blocks T cell migration ... more details
|
Encyclopedia
top
