Infobox Disease Name Demyelinatingdisease Image MS Demyelinisation CD68 10xv2.jpg Caption Photomicrograph of a demyelinating MS Lesion. Immunohistochemical staining for CD68 highlights numerous macrophages brown . Original magnification 10 . DiseasesDB ICD10 ICD10 G 35 g 35 ICD10 G 37 g 35 , ICD10 G 61 0 g 60 ICD9 ICD9 340 ICD9 341 , ICD9 357.0 ICDO OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID D003711 A demyelinatingdisease is any disease of the nervous system in which the myelin sheath of neuron s is damaged. ref DorlandsDict three 000030717 demyelinatingdisease ref This impairs the conduction of signals in the affected nerves, causing impairment in sensation, movement, cognition, or other functions depending on which nerves are involved. The term describes the effect of the disease, rather than its cause some demyelinating diseases are caused by genetics , some by infection infectious agents, some by autoimmune disorder autoimmune reactions, and some by unknown factors. Organophosphate s, a class of chemicals which are the active ingredients in commercial insecticides such as sheep dip , herbicide weed killers , and flea treatment preparations for pets, etc., will also demyelinate nerves. Neuroleptics can cause demyelination. ref cite journal author Konopaske GT, Dorph ... retrieve pii S0006 3223 07 00847 5 ref Demyelinating diseases Demyelinating diseases of the central ... inflammatory demyelinating diseases Vitamin B12 deficiency Central pontine myelinolysis Tabes Dorsalis transverse myelitis Devic s disease progressive multifocal leukoencephalopathy Optic neuritis Leukodystrophy Leukodystrophies Demyelinating diseases of the peripheral nervous system include Guillain Barr syndrome and its chronic counterpart, chronic inflammatory demyelinating polyneuropathy anti MAG peripheral neuropathy Charcot Marie Tooth Disease Copper deficiency See also Multiple sclerosis ... References reflist CNS diseases of the nervous system Demyelinating diseases of CNS PNS diseases of the nervous ... more details
Infobox Disease Name PAGENAME Image Caption DiseasesDB ICD10 ICD9 ICD9 330.0 ICDO OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID D020279 A Hereditary CNS demyelinatingdisease is a demyelinatingdiseasedemyelinating central nervous system disease that is primarily due to an inherited genetic condition. This is in contrast to autoimmune demyelinating conditions, such as multiple sclerosis , or conditions such as central pontine myelinolysis that are associated with acute acquired insult. Examples include ref name urlHereditary Central Nervous System Demyelinating Diseases Genetics Home Reference cite web url http ghr.nlm.nih.gov conditionGroup hereditarycentralnervoussystemdemyelinatingdiseases title Hereditary Central Nervous System Demyelinating Diseases Genetics Home Reference format work accessdate 2009 03 11 Dead link date October 2010 bot H3llBot ref Alexander disease Canavan disease Krabbe disease leukoencephalopathy with vanishing white matter megalencephalic leukoencephalopathy with subcortical cysts metachromatic leukodystrophy X linked adrenoleukodystrophy References Reflist disease stub CNS diseases of the nervous system Category Demyelinating diseases of CNS ... more details
Infobox Disease Name CNS demyelinating autoimmune diseases Image Caption DiseasesDB ICD10 ICD9 ICDO OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID D020278 CNS demyelinating autoimmune diseases are autoimmune disease s which primarily affect the central nervous system . Examples include Diffuse cerebral sclerosis of Schilder Acute disseminated encephalomyelitis Acute hemorrhagic leukoencephalitis Multiple sclerosis though ethiology is unknown, it is sure that immune system is involved Transverse myelitis Neuromyelitis optica See also Idiopathic inflammatory demyelinating diseases A wider group of diseases which includes also the non autoimmune demyelinating diseases. Demyelinatingdisease s Group including them all, regardless of their autoimmunity or idiopathic and inflammatory status. CNS diseases of the nervous system disease stub Category Autoimmune diseases Category Demyelinating diseases of CNS ... more details
for the acute version of this disease Guillain Barr syndrome Infobox Disease Name Chronic inflammatory demyelinating polyneuropathy Image Caption DiseasesDB 30084 ICD10 ICD9 ICD9 357.81 ICDO OMIM 139393 MedlinePlus eMedicineSubj neuro eMedicineTopic 467 MeshID D020277 Chronic inflammatory demyelinating polyneuropathy CIDP is an acquired autoimmune disorder immune mediated inflammatory disorder of the peripheral nervous system . The disorder is sometimes called chronic relapsing polyneuropathy or chronic inflammatory demyelinating poly radiculo neuropathy because it involves the nerve roots ref name radiculo . CIDP is closely related to Guillain Barr syndrome and it is considered the Chronic medical chronic counterpart of that acute medicine acute disease. Its symptoms are also similar to progressive ... of the disease is loss of the myelin sheath the fatty covering that insulates and protects nerve fibers of the peripheral nerves. Chronic inflammatory demyelinating polyneuropathy is believed to be due ... of the disease is high. CIDP is under recognized and under treated due to its heterogeneous presentation ... author Toothaker TB, Brannagan TH title Chronic inflammatory demyelinating polyneuropathies current ... left untreated despite progression of their disease. ref cite journal author Latov N title ... of treatment for inflammatory demyelinating neuropathy journal Journal of Anatomy volume 200 issue ... demyelinating polyneuropathy treated successfully with ciclosporin journal J. Neurol. Neurosurg. Psychiatr ... is lacking, mostly due to the heterogeneous nature of the disease in the patient population in addition ... As in multiple sclerosis , another demyelinating condition, it is not possible to predict with certainty ... name radiculo cite journal author Kissel JT title The treatment of chronic inflammatory demyelinating .... Because of the variability in severity and progression of the disease, doctors will not be able ... PNS diseases of the nervous system DEFAULTSORT Chronic Inflammatory Demyelinating Polyneuropathy Category ... more details
?glngUserChoice 8412 . The Medline medical dictionary defines it as a demyelinatingdisease marked ... demyelinating diseases IIDDs , sometimes known as borderline forms of multiple sclerosis , ref cite ... one disease or many? edition 2nd ref ref cite journal author Hartung HP, Grossman RI title ADEM distinct disease or part of the MS spectrum? journal Neurology volume 56 issue 10 pages 1257 60 ... outside the scope of Multiple Sclerosis and inside the scope of Devic s disease , ref cite ... 2009 pmid 19465451 doi 10.1177 1352458509104595 ref Devic s disease , currently considered a separate disease Acute disseminated encephalomyelitis or ADEM, a closely related disorder in which a known ... myelinoclastic sclerosis Schilder disease or diffuse myelinoclastic sclerosis is a rare disease that presents clinically as a pseudotumoural demyelinating lesion and is more common in children. ref cite journal author Garrido C, Levy Gomes A, Teixeira J, Temudo T title Schilder s disease two new ... SA title Myelinoclastic diffuse sclerosis Schilder s disease report of a case and review of the literature ... appearance of tumefactive demyelinating lesions journal AJR Am J Roentgenol volume 182 issue 1 ... W, Jimenez JJ, Alexander JS title Multiple sclerosis as a vascular disease journal Neurol. Res. volume ... aka Chronic fatigue syndrome ref http health.nytimes.com health guides disease chronic fatigue ... has been established, nobody can tell whether the disease dealing with is MS. Cases of MS before ... are rare before puberty, but they can happen. Whether they constitute a separate disease is still an open subject. Anyway, even this pubertal MS could be more than one disease, because early onset ... . In ICD 9 it used to say chronic disease characterized by presence of numerous areas of demyelination ... have to be considered non affected until the definition conditions are satisfied. See also Demyelinatingdisease Pathophysiology of multiple sclerosis The Myelin Project References Reflist 2 Multiple ... more details
Infobox television episode Title The Disease Image Image ST VOY The Disease.jpg 270px Caption Harry Kim becomes intimate with Varro scientist Tal Series Star Trek Voyager Season 5 Episode 17 Production 210 Airdate February 24, 1999 Writer Kenneth Biller br Michael Taylor screenwriter Michael Taylor Director David Livingston director David Livingston Guests Musetta Vander as Tal br Charles Rocket as Jippeq Prev Dark Frontier Next Course Oblivion Star Trek Voyager Course Oblivion Episode list List of Star Trek Voyager episodes List of Star Trek Voyager episodes NOTOC for an abnormal condition affecting the body of an organism Disease The Disease is an episode of Star Trek Voyager , the 17th episode of the fifth season. The episode had an average rating of 4.2 5 on the official Star Trek website as of August 23, 2007 . http www.startrek.com startrek view series VOY episode 104851.html Plot Voyager stops to assist a xenophobic species known as the Varro. This species lives on a Generation ship generational ship which has housed them for 400 years. While the crew works on the Varro ship, Voyager is infested with synthetic ship eating parasites that had been released on the Varro ship by dissident Varro. Meanwhile, Harry Kim Star Trek Harry Kim becomes intimate with Varro scientist Tal, and develops a physiological bond with her, one that is standard in the Varro. The physiological connection alters his behavior and sways him from his duties aboard Voyager . It is later revealed that Tal is one of the separatists. There has been a rumour of a minority of Varro that want off the ship. The parasites that Tal helped create were made to separate the individual pods of the Varro ship without destroying the ship itself. Fractures along the hull created by the parasites begin to grow as the Varro ship begins to fall apart. Voyager s docking port is seized, trapping it with the Varro ... Trek VOY Star Trek DEFAULTSORT Disease, The Category Star Trek Voyager episodes Category 1999 television ... more details
charitable trust DEFAULTSORT Alpers Disease Category Demyelinating diseases of CNS ca S ndrome d Alpers ...Infobox Disease Name Alpers& 39 disease Image Caption DiseasesDB 29298 ICD10 ICD10 G 31 8 g 30 ICD9 ICD9 330.8 ICDO OMIM 203700 MedlinePlus eMedicineSubj eMedicineTopic MeshID D002549 Alpers disease , also called Alpers syndrome , ref name naude2004 Naud , J te Water, C M Verity, R G Will, G Devereux, and L Stellitano. 2004. http jnnp.bmj.com cgi content abstract 75 6 910 Is variant Creutzfeldt Jakob disease in young children misdiagnosed as Alpers syndrome? An analysis of a national surveillance study Journal of Neurology Neurosurgery and Psychiatry , 2004 75 910 913. Fee for full text. Retrieved on 2007 09 27. ref progressive sclerosing poliodystrophy , and progressive infantile poliodystrophy , is a progressive degenerative disease of the central nervous system that occurs mostly in infants and children. It is an autosomal recessive disorder that is sometimes seen in siblings. Alpers disease is caused by certain genetic mutations in the POLG gene. Presentation Alpers formal name is Alpers Huttenlocher syndrome AHS . First signs of the disease, which include intractable seizure s and failure to meet meaningful developmental milestones, usually occur in infancy, after the first year of life, but sometimes as late as the fifth year. Primary symptoms of the disease are developmental delay, progressive mental retardation , hypotonia low muscle tone , spasticity stiffness of the limbs ... to liver failure. While some researchers believe that Alpers disease is caused by an underlying ... for Alpers disease and, currently, no way to slow its progression. Treatment is symptomatic and supportive ... with Alpers disease is poor. Those with the disease usually die within their first decade of life ... WhoNamedIt synd 1459 Alpers disease ref References Reflist 2 Diseases of the nervous system External links http www.ninds.nih.gov disorders alpersdisease alpersdisease.htm Alpers Disease Information ... more details
Infobox Disease Name Alexander disease Image Caption DiseasesDB ICD10 ICD9 ICD9 331.89 ICDO OMIM 203450 MedlinePlus eMedicineSubj eMedicineTopic MeshID D038261 Alexander disease is a slowly progressing and fatal neurodegenerative disease . It is a very rare disorder which results from a genetic mutation .... ref http www.highbeam.com doc 1P1 38896449.html MUTATION KEY TO ALEXANDER DISEASE United ... alexander Alexander Disease Gene Reviews ref ref name NINDS Clinical features Delays in development ... Alexander disease is a genetic disorder affecting the central nervous system midbrain and cerebellum ... into a child with Alexander disease. ref name Gene Alexander disease belongs to leukodystrophies ... fiber s. ref name Gene ref name NINDS http www.ninds.nih.gov disorders alexander disease alexander disease.htm ref ref name BBC http news.bbc.co.uk 2 hi health 1097277.stm Cause of brain disease ... Alexander The Rosenthal fibers found in Alexander disease are not distributed in the same areas or as concentrated ... importance neurology articlesNeurology task force articles The cause of Alexander disease is a mutation ... Onset Alexander Disease? AJNR ref Diagnosis It is possible to detect the signs of Alexander disease ... signs for the disease. ref name Alexander ref http www.ajnr.org cgi content abstract 22 3 541?maxtoshow &HITS 10&hits 10&RESULTFORMAT &searchid 1&FIRSTINDEX 3470&resourcetype HWCIT Alexander Disease Diagnosis with MR Imaging AJNR ref It is even possible to detect adult onset Alexander disease with MR imaging. ref name Adult Alexander disease may also be revealed by genetic testing for the known cause of Alexander disease. ref name Alexander http www.ulf.org types Alexander.html ref A rough diagnosis ... bone marrow transplantation for Alexander s disease Nature ref Prognosis The prognosis is generally ..., the later the disease occurs, the slower its course is. ref name Gene ref name NINDS See also ... books NBK1172 GeneReviews NCBI NIH UW entry on Alexander disease http www.ncbi.nlm.nih.gov ... more details
Infobox Disease Name Canavan disease Image Caption DiseasesDB 29780 ICD10 ICD10 E 75 2 e 70 ICD9 ICD9 330.0 ICDO OMIM 271900 MedlinePlus 001586 eMedicineSubj eMedicineTopic MeshID D017825 Canavan disease , also called Canavan Van Bogaert Bertrand disease , aspartoacylase deficiency or aminoacylase 2 ..., J Moffett, Jr Madhavarao, Cn title Canavan disease and the role of N acetylaspartate in myelin ... brain brain . Canavan disease is also one of the most common degenerative cerebreal diseases of infancy. This disease is one of a group of genetic disorders called leukodystrophies . Leukodystrophies ... disease was first described in 1931 by Myrtelle Canavan . ref cite journal author Canavan MM title ... Institute The discovery of the gene for Canavan disease, and subsequent events, generated considerable controversy. In 1987 the Greenbergs, a family with two children affected by Canavan disease, donated ... of couples at risk of having a child with Canavan disease. ref name pmid10464621 cite pmid 10464621 ... in arguments about the appropriateness of patenting genes. Prevalence Although Canavan disease may ... Image autorecessive.svg thumb right Canavan disease has an autosomal recessive pattern of inheritance . Canavan disease is inherited in an autosomal recessive fashion. When both parents are carriers, there is a 25 ... for families with two parental carriers. Canavan disease is caused by a defective ASPA gene ASPA ... for efficient transmission of nerve impulses. Symptoms Symptoms of Canavan disease, which appear in early ... also occur. Treatment There is no cure for Canavan disease, nor is there a standard course of treatment ... citrate . When a person has Canavan Disease, his or her levels of N acetyl aspartate are chronically elevated. The lithium citrate has proven that, in a rat genetic model of Canavan Disease, the lithium ... therapy for children with Canavan disease by significantly decreasing the elevated amounts of N acetyl ... disease. ref name pmid12162821 Cite journal author Janson C et al. title Clinical protocol. Gene therapy ... more details
Refimprove date December 2007 Infobox Disease Name Krabbe disease Image Caption DiseasesDB 29468 ICD10 ... MeshID D007965 Krabbe disease also known as globoid cell leukodystrophy ref name pmid17403939 cite ... system . This condition is inherited in an autosomal recessive pattern. The disease is named for the Danish neurologist Knud Haraldsen Krabbe . ref WhoNamedIt synd 1457 ref Incidence Krabbe disease ... condition krabbedisease title Krabbe disease accessdate 2008 05 07 date 2008 05 02 work Genetics Home ... high rates of the disease, reported to be 1 in 50,000 births. ref http books.google.com books?id I3Kh1cNJxyUC ... 20disease 20sweden 2050,000&f false Books.Google.com ref Krabbe disease may also be found in cats ... D, Cornaglia E, Schiffer D title Krabbe s disease in two West Highland White terriers journal ... Krabbe disease is caused by mutation s in the GALC gene located on chromosome chromosome 14 human 14 .... As part of a group of disorders known as leukodystrophy leukodystrophies , Krabbe disease results ... in both the CNS and PNS by disrupting lipid rafts and may play a role in Krabbe disease. ref cite journal ... 08.2009 pmid 19439584 ref Symptoms Infants with Krabbe disease are normal at birth. Symptoms begin ..., vomit ing, and slowing of mental and motor development. In the first stages of the disease ... juvenile and adult onset cases of Krabbe disease, which have similar symptoms but slower progression. Diagnosis The disease may be diagnosed by its characteristic grouping of certain cells multinucleated ... stains for myelin e.g. luxol fast blue may be used to aid diagnosis. Prognosis In infants, the disease is generally fatal before age 2. Patients with late onset Krabbe disease tend to have a slower progression of the disease and live significantly longer. Treatment Although there is no cure for Krabbe disease, bone marrow Organ transplant transplantation has been shown to benefit cases early in the course of the disease. Generally, treatment for the disorder is symptomatic and supportive. Physical ... more details
A polycystic disease is a disease that involves multiple cysts scattered throughout an organ, including Polycystic kidney disease Polycystic liver disease Polycystic ovary syndrome disambig ... more details
Artery disease may refer to the following coronary artery disease Peripheral artery disease, more commonly called peripheral vascular disease Carotid artery disease, more commonly called carotid artery stenosis disambig ... more details
wiktionary disease A disease is an abnormal condition of an organism that impairs bodily functions and can be deadly. Disease may also refer to Disease album Disease album , a 1993 album by G.G.F.H. Disease song Disease song , a 2002 song by Matchbox Twenty disambiguation ... more details
expert subject 1 Medicine date November 2011 Infobox disease Name Autoimmune diseases Image Caption DiseasesDB ... places e.g. Goodpasture s disease which may affect the basement membrane in both the lung and the kidney ... which decreases the immune response. Criteria For a disease to be regarded as an autoimmune disease ... T cells Indirect evidence based on reproduction of the autoimmune disease in experimental animals ... type III , or Type IV hypersensitivity type IV . No type of autoimmune disease mimics ... accessdate ref There is an on going discussion about when a disease should be considered autoimmune ... ADEM Accepted ref name Mesh MeshName Autoimmune Diseases ref Addison s Disease interferon ... liver antigen Autoimmune inner ear disease Accepted ref name urlAutoimmune Inner Ear Disease cite web url http www.bcm.edu oto grand 4893.html title Autoimmune Inner Ear Disease, Baylor College ... polyendocrine syndrome Accepted Unknown or multiple APS 1 see Addison s Disease Autoimmune progesterone ... unused data Immunology ref Autoimmune uveitis Accepted HLAB 27 ? Balo disease Balo concentric sclerosis Beh et s disease immune mediated systemic vasculitis linkage to HLA B51 HLA B27 very different manifestations with ulcers as common symptom also called Morbus Adamandiades Beh et Berger s disease ... Handbook work accessdate ref Cancer Castleman s disease Over expression of Interleukin 6 IL 6 Celiac disease Accepted ref name urlCeliac Disease cite web url http digestive.niddk.nih.gov ddiseases pubs celiac 1 title Celiac Disease format work accessdate ref ref name pmid16234635 cite journal author Meize Grochowski R title Celiac disease a multisystem autoimmune disorder journal Gastroenterol ... B title Is celiac disease an autoimmune disorder? journal Curr. Opin. Immunol. volume 17 issue ... HLA DQ8 and DQ2.5 Chagas disease Suspected ref cite journal author Hyland KV, Engman DM title Further thoughts on where we stand on the autoimmunity hypothesis of Chagas disease journal Trends Parasitol ... more details
Disease management may refer to Disease management agriculture Disease management health disambig Long comment to avoid being listed on short pages ... more details
Sir James Paget , a surgeon and pathologist, described several diseases, including Paget s disease of bone most common use of Paget s disease Paget s disease of the breast Paget Schroetter disease Extramammary Paget s disease EMPD disambig ar sl Pagetova bolezen ... more details
Still s disease can refer to Juvenile idiopathic arthritis Adult onset Still s disease disambig DEFAULTSORT Still S diSeaSe Category Connective tissue diseases pt Doen a de Still fr Maladie de Still ... more details
Duroziez s disease is a congenital variant of mitral stenosis . It was described in 1877 by Paul Louis Duroziez . External links WhoNamedIt synd 2735 Duroziez disease Congenital heart defects Category Heart diseases disease stub ... more details
Unreferenced stub auto yes date December 2009 Macrovascular disease is a disease of any large macro blood vessel s in the body. It is a disease of the large blood vessels, including the coronary arteries, the aorta, and the sizable arteries in the brain and in the limbs. This sometimes occurs when a person has had diabetes for a long time. Fat and blood clot s build up in the large blood vessels and stick to the vessel walls. Three common macrovascular diseases are coronary disease in the heart , cerebrovascular disease in the brain , and peripheral vascular disease in the limbs DEFAULTSORT Macrovascular Disease Category Vascular diseases Disease stub ... more details
Disseminated disease refers to a diffuse disease process, generally either infectious disease infectious or neoplastic . The term may sometimes also characterize connective tissue disease . A disseminated infection, for example, has extended beyond its origin or Locus of infection nidus and involved the bloodstream to seed other areas of the body. Similarly, one can view metastatic cancer as a disseminated infection in that it has extended into the bloodstream or into the lymphatic system and thus seeded distant sites a process known as metastasis . Disseminated disease often contrasts localized disease . Disease stub Category Diseases and disorders Category Medical terms ... more details
Infobox disease Name Tooth disease Image Caption DiseasesDB ICD10 K00 K05 ICD9 ICD9 520 ICD9 525 ICDO OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID D014076 A tooth disease is a disorder of the tooth that can be congenital or acquired. Examples Expand section date August 2011 Congenital anodontia Acquired dental caries Medical conditions Tooth disease Category Dental disorders disease stub ... more details
Bronze disease may refer to The irreversible and nearly inexorable corrosion process occurring when copper Chloride chlorides come into contact with Bronze Properties bronze Addison s disease , which acquired the nickname bronze disease from the Medical sign clinical sign of skin hyperpigmentation that its sufferers exhibit disambiguation ... more details
Infobox Disease Name PAGENAME Image Caption DiseasesDB ICD10 ICD9 ICDO OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID D005882 A gingival disease is a disorder primarily affecting the gingiva . An example is gingivitis . disease stub Oral pathology Periodontology Category Periodontal disorders ... more details
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