, daminolevulinicacid, from glutamate. Plant Physiology, 93 4 , 1273 1279 ref ref Willows ...drugbox Verifiedfields changed verifiedrevid 456688550 IUPAC name 5 amino 4 oxo pentanoic acid image Aminolevulinic acid.svg imagename Aminolevulinicacid Clinical data pregnancy category legal status routes of administration Pharmacokinetic data bioavailability protein bound metabolism elimination half life Identifiers CASNo Ref cascite correct CAS CAS number Ref cascite correct ?? CAS number 106 60 5 ATC prefix L01 ATC suffix XD04 ATC supplemental PubChem 137 DrugBank Ref drugbankcite changed drugbank DrugBank APRD00793 ChemSpiderID Ref chemspidercite correct chemspider ChemSpiderID 134 UNII Ref fdacite correct FDA UNII 88755TAZ87 KEGG Ref keggcite correct kegg KEGG D07567 ChEBI Ref ebicite correct EBI ChEBI 356416 ChEMBL Ref ebicite correct EBI ChEMBL 601 Chemical data C 5 H 9 N 1 O 3 molecular weight 131.13 g mol smiles O C CN CCC O O InChI 1 C5H9NO3 c6 3 4 7 1 2 5 8 9 h1 3,6H2, H,8,9 InChIKey ZGXJTSGNIOSYLO UHFFFAOYAL StdInChI Ref stdinchicite correct chemspider StdInChI 1S C5H9NO3 c6 3 4 7 1 2 5 8 9 h1 3,6H2, H,8,9 StdInChIKey Ref stdinchicite correct chemspider StdInChIKey ZGXJTSGNIOSYLO UHFFFAOYSA N Aminolevulinicacid dALA or ALA or 5ala or 5 aminolevulinicacid is the first compound in the porphyrin synthesis pathway, the pathway that leads to heme in mammals and chlorophyll ..., Zanella F, Reulen HJ title Fluorescence guided surgery with 5 aminolevulinicacid for resection of malignant ... 2 See also Porphyrin Chemotherapeutic agents Heme metabolism intermediates DEFAULTSORT Aminolevulinicacid, D Category Biomolecules Category Amines Category Carboxylic acids Category Antineoplastic ... except for the proteobacteria group and archaea , it is produced from glutamic acid via glutamyl ... 7 issue 5 pages 392 401 year 2006 pmid 16648043 doi 10.1016 S1470 2045 06 70665 9 ref Aminolevulinicacid is also a photosensitizer for photodynamic therapy . Cancer diagnosis Photodynamic detection PDT ... more details
ALA synthase EC number 2.3.1.37 catalyzes the synthesis of DAminolevulinicacid ALA the first common precursor in the biosynthesis of all tetrapyrroles . The enzyme is expressed in all non plant eukaryotes and the class of proteobacteria. Other organisms produce ALA through a three enzyme pathway known as the Shemin pathway. ALA is synthesized through the condensation of glycine and succinyl CoA . In humans, transcription of ALA synthase is tightly controlled by the presence of iron Fe sup 2 sup binding elements, to prevent accumulation of porphyrin intermediates in the absence of iron. There are two forms of ALA synthase in the body. One form is expressed in red blood cell precursor cells ALAS2 , whereas the other ALAS1 is ubiquitously expressed throughout the body. The red blood cell form is coded by a gene on chromosome x, whereas the other form is coded by a gene on chromosome 3. The disease X linked sideroblastic anemia is caused by mutations in the ALA synthase gene on chromosome X, whereas no diseases are known to be caused by mutations in the other gene. Gain of function mutations in the erythroid specific ALA synthase gene have been shown recently to cause a previously unknown form of porphyria known as X linked dominant protoporphyria . ALA synthase removes the carboxyl group from glycine and the coenzyme A CoA from the succinyl CoA by means of its prosthetic group pyridoxal phosphate , forming aminolevulinicacid dALA , so called because the amino group is on the fourth carbon atom in the molecule. Glycine is initially deprotonated by a highly conserved active site lysine, leading to condensation with succinyl CoA and loss of CoA. Protonation of the carbonyl group of the intermediate by an active site histidine leads to loss of the carboxyl group. The last intermediate is finally reprotonated to produce ALA. Dissociation of ALA from the enzyme is the rate ... Shemin, D and Rittenberg, D title The Utilization of Glycine for the Synthesis of a Porphyrin ... more details
Aminolevulinicacid dehydratase deficiency porphyria also known as Doss porphyria, ref name Bolognia and Plumboporphyria ref name Bolognia is a cutaneous condition, disease can present during early childhood as well as in adulthood with acute neurologic symptoms that resemble those encountered in acute intermittent porphyria. ref name Bolognia cite book author Rapini, Ronald P. Bolognia, Jean L. Jorizzo, Joseph L. title Dermatology 2 Volume Set publisher Mosby location St. Louis year 2007 pages isbn 1 4160 2999 0 oclc doi accessdate ref The condition is extremely rare, with less than 10 cases ever reported. ref http rarediseasesnetwork.epi.usf.edu porphyrias patients ADP Overview of the Porphyrias at The Porphyrias Consortium a part of NIH Rare Diseases Clinical Research Network RDCRN Retrieved June 2011 ref ALA dehydratase deficiency is a rare cause of hepatic porphyria . ref name jaffe cite journal author Jaffe EK, Stith L title ALAD porphyria is a conformational disease journal American Journal of Human Genetics volume 80 issue 2 pages 329 37 year 2007 month February pmid 17236137 pmc 1785348 doi 10.1086 511444 url http linkinghub.elsevier.com retrieve pii S0002 9297 07 62690 1 ref ref name pmid513604 cite journal author Doss M, von Tiepermann R, Schneider J, Schmid H title New type of hepatic porphyria with porphobilinogen synthase defect and intermittent acute clinical manifestation journal Klinische Wochenschrift volume 57 issue 20 pages 1123 7 year 1979 month October pmid 513604 doi url ref It is an autosomal recessive disorder that results from inappropriately low levels of the enzyme porphobilinogen synthase ALA dehydratase ALAD, also called porphobilinogen synthase , which is required for normal heme synthesis. ref name jaffe Genetics Image Autorecessive.svg thumb right ALA dehydratase deficiency has an autosomal recessive pattern of heredity inheritance . ALA dehydratase deficiency is inherited in an autosomal recessive manner. ref name jaffe This means a defective ... more details
DISPLAYTITLE small D small Galacturonic acid chembox verifiedrevid 443555791 Name small D small Galacturonic acid ImageFile Galacturonic acid.png ImageSize 180px IUPACName 2S,3R,4S,5R 2,3,4,5 Tetrahydroxy 6 oxo hexanoic acid OtherNames Section1 Chembox Identifiers ChemSpiderID Ref chemspidercite correct chemspider ChemSpiderID 76444 InChI 1 C6H10O7 c7 1 2 8 4 5 10 11 13 6 12 3 1 9 h1 4,6 9,12H, H,10,11 t1 ,2 ,3 ,4 ,6? m0 s1 InChIKey AEMOLEFTQBMNLQ YMDCURPLBW InChI1 1 C6H10O7 c7 1 2 8 3 9 4 10 5 11 6 12 13 h1 5,8 11H, H,12,13 t2 ,3 ,4 ,5 m0 s1 InChIKey1 IAJILQKETJEXLJ RSJOWCBRBL SMILES1 O C C H O C H O C H O C H O C O O StdInChI Ref stdinchicite correct chemspider StdInChI 1S C6H10O7 c7 1 2 8 3 9 4 10 5 11 6 12 13 h1 5,8 11H, H,12,13 t2 ,3 ,4 ,5 m0 s1 StdInChIKey Ref stdinchicite correct chemspider StdInChIKey IAJILQKETJEXLJ RSJOWCBRSA N CASNo Ref cascite correct CAS CASNo 685 73 4 EINECS 211 682 6 PubChem 84740 ChEBI Ref ebicite correct EBI ChEBI 47962 SMILES O C O C H 1OC O C H O C H O C H 1O Section2 Chembox Properties Formula C sub 6 sub H sub 10 sub O sub 7 sub MolarMass 194.139 Appearance Density MeltingPt BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition D Galacturonic acid is a sugar acid, an oxidized form of galactose small D small galactose . It is the main component of pectin , in which it exists as the polymer polygalacturonic acid . It has an aldehyde group at C1 and a carboxylic acid group at C6. Other oxidized forms of small D small galactose are small D small galactonic acid carboxylic group at C1 and meso galactaric acid mucic acid carboxylic groups at C1 and C6 . It is also a uronic acid or hexuronic acid. Naturally occurring uronic acids are small D small glucuronic acid , small D small galacturonic acid, small L small iduronic acid and small D small mannuronic acid . DEFAULTSORT Galacturonic acid, D Category Sugar acids az Qalakturon tur usu bg ca cid galactur nic de Galacturons ure es cido galactur nico ... more details
enzyme Name D amino acid oxidase EC number 1.4.3.3 CAS number 9000 88 8 IUBMB EC number 1 4 3 3 GO code 0003884 image width caption protein Name D amino acid oxidase caption image 1c0p DAAO dimer.jpg width HGNCid 2671 Symbol DAO DAAO AltSymbols EntrezGene 1610 OMIM 124050 RefSeq NM 001917 UniProt P14920 PDB ECnumber 1.4.3.3 Chromosome 12 Arm q Band 24 LocusSupplementaryData D amino acid oxidase DAAO also DAO, OXDA, DAMOX is a peroxisomal enzyme containing FAD as cofactor that is expressed in a wide range of species from yeasts to human. ref name pmid17396222 cite journal author Pollegioni L, Piubelli L, Sacchi S, Pilone MS, Molla G title Physiological functions of D amino acid oxidases from yeast to humans journal Cell. Mol. Life Sci. volume 64 issue 11 pages 1373 94 year 2007 month June pmid 17396222 doi 10.1007 s00018 007 6558 4 url ref It is not present in bacteria or in plants. Its function is to oxidize D amino acids to the corresponding imino acid s, producing ammonia and hydrogen peroxide . This enzyme belongs to the FAD dependent oxidoreductase family , and acts on the CH NH2 group of D amino acid donors with oxygen as acceptor. The enzyme is most active toward neutral D amino acids, and not active toward acidic D amino acids. Recently, mammalian D amino acid oxidase has been connected to the brain D serine metabolism and to the regulation of the glutamatergic neurotransmission . In a postmortem study, the activity of DAAO was found to be two fold higher in schizophrenia ... R title Increased brain d amino acid oxidase DAAO activity in schizophrenia journal Schizophr ... D amino acid solutions and as the biolocical component in several biosensors. See also D amino acid oxidase activator D amino acid dehydrogenase D aspartate oxidase External links MeshName D Amino Acid Oxidase http www.calzyme.com commerce catalog spcategory.jsp?category id 1043 References reflist ... it D amminoacido ossidasi ja D ru D ... more details
D amino acid dehydrogenase EC 1.4.99.1 is a bacteria l enzyme that catalyses the oxidation of amino acidD amino acids into their corresponding ketoacid oxoacids . It contains both Flavin group flavin and nonheme iron as cofactors. ref name Olsiewski cite journal author Olsiewski PJ, Kaczorowski GJ, Walsh C title Purification and properties of D amino acid dehydrogenase, an inducible membrane bound iron sulfur flavoenzyme from Escherichia coli B journal J. Biol. Chem. volume 255 issue 10 pages 4487 94 date 25 May 1980 pmid 6102989 url http www.jbc.org cgi reprint 255 10 4487 ref The enzyme has a very broad specificity and can act on most D amino acids. ref cite journal author Tsukada K title D amino acid dehydrogenases of Pseudomonas fluorescens journal J. Biol. Chem. volume 241 issue 19 pages 4522 8 date 10 October 1966 pmid 5925166 url http www.jbc.org cgi reprint 241 19 4522 ref D amino acid H sub 2 sub O acceptor a 2 oxo acid NH sub 3 sub reduced acceptor This reaction is distinct from the oxidation reaction catalysed by D amino acid oxidase that uses oxygen as a second substrate, as the dehydrogenase can use many different compounds as electron acceptors, with the physiological substrate being coenzyme Q . ref name Olsiewski ref cite journal author Jones H, Venables WA title Effects of solubilisation on some properties of the membrane bound respiratory enzyme D amino acid dehydrogenase of Escherichia coli journal FEBS Lett. volume 151 issue 2 pages 189 92 year 1983 pmid 6131836 doi 10.1016 0014 5793 83 80066 0 ref See also Oxidative phosphorylation Electron transport chain Microbial metabolism References Reflist External links http www.brenda enzymes.org php result flat.php4 ... 1.4.99.1 CH NH2 oxidoreductases Electron transport chain Cellular respiration DEFAULTSORT D Amino Acid Dehydrogenase Category Cellular respiration Category Metabolism Category EC 1.4 Enzyme stub metabolism stub it D amminoacido deidrogenasi ja D ... more details
1955 title D Amino acid transamination in bacillus anthracis journal J. Bacteriol. volume 70 pages ... K date 1973 title Occurrence of D amino acid aminotransferase in pea seedlings journal Biochem ... X issue 3 cite journal author Yonaha K, Misono H, Yamamoto T, Soda K date 1975 title D amino acid aminotransferase ... S, Tanaka H, Soda K date 1989 title Thermostable D amino acid aminotransferase from a thermophilic ..., Bledig SA, Taylor PP date 1998 title Characterization of the genes encoding D amino acid transaminase and glutamate racemase, two D glutamate biosynthetic enzymes of Bacillus sphaericus ATCC 10208 journal ... S, Petsko GA, Manning JM, Soda K, Ringe D date 1995 title Crystal structure of a D amino acid aminotransferase ...enzyme Name D alanine transaminase EC number 2.6.1.21 CAS number 37277 85 3 IUBMB EC number 2 6 1 21 GO code 0047810 image width caption In enzymology , a D amino acid transaminase EC number 2.6.1.21 is an enzyme that catalysis catalyzes the chemical reaction D alanine 2 oxoglutarate math rightleftharpoons math pyruvate D glutamate Thus, the two substrate biochemistry substrates of this enzyme are D alanine and 2 oxoglutarate , whereas its two product chemistry products are pyruvate and D glutamate ... nitrogenous groups. The systematic name of this enzyme class is D alanine 2 oxoglutarate aminotransferase . Other names in common use include D aspartate transaminase , D alanine aminotransferase , D aspartic aminotransferase , D alanine D glutamate transaminase , D alanine transaminase , and D amino acid aminotransferase . This enzyme participates in 6 metabolism metabolic pathways lysine degradation , arginine and proline metabolism , phenylalanine metabolism , d arginine and d ornithine metabolism , d alanine metabolism , and peptidoglycan biosynthesis . It employs one cofactor biochemistry ... RD date 1955 title Transamination of D amino acids by Bacillus subtilis journal J. Bacteriol. volume ... 1965 title D Alanine D glutamate transaminase. I. Purification and characterization journal J. Biol ... more details
DISPLAYTITLE 3 Deoxy small D small manno oct 2 ulosonic acid chembox verifiedrevid 443318227 Name 3 Deoxy small D small manno oct 2 ulosonic acid ImageFile 3 Deoxy D manno oct 2 ulosonic acid linear.png ImageSize 200px IUPACName 4 R ,5 R ,6 R ,7 R 4,5,6,7,8 pentahydroxy 2 oxooctanoic acid OtherNames 2 Oxo 3 deoxy small D small mannooctonic acid 2 Keto 3 Deoxy small D small manno octonate 2 Keto 3 deoxy small D small mannooctanoic acid 3 Deoxy small D small manno 2 octulosonic acid 3 Deoxy small D small manno octulosonic acid Section1 Chembox Identifiers Abbreviations D KDO KDO dOclA ChemSpiderID Ref chemspidercite correct chemspider ChemSpiderID 106511 InChI 1 C8H14O8 c9 2 5 12 7 14 6 13 3 10 1 4 11 8 15 16 h3,5 7,9 10,12 14H,1 2H2, H,15,16 t3 ,5 ,6 ,7 m1 s1 InChIKey KYQCXUMVJGMDNG SHUUEZRQBC SMILES1 O C O C O C C H O C H O C H O C H O CO StdInChI Ref stdinchicite correct chemspider StdInChI 1S C8H14O8 c9 2 5 12 7 14 6 13 3 10 1 4 11 8 15 16 h3,5 7,9 10,12 14H,1 2H2, H,15,16 t3 ,5 ,6 ,7 m1 s1 StdInChIKey Ref stdinchicite correct chemspider StdInChIKey KYQCXUMVJGMDNG SHUUEZRQSA N CASNo 10149 14 1 CASOther linear form PubChem 445569 ChEBI Ref ebicite correct EBI ChEBI 32817 SMILES O C ... coli. III. The isolation and characterization of 3 deoxyoctulosonic acid journal Journal of Biological Chemistry year 1966 volume 241 issue 13 pages 3207 15 pmid 4287911 ref The small D small manno prefix indicates that four chiral centers have the same configuration as small D small mannose . Image 3 Deoxy D manno oct 2 ulosonic acid.svg 400px thumb left The cyclization of 3 deoxy small D small manno oct 2 ulosonic acid to the &beta anomer . The chiral centers are indicated by asterisks. clear left References reflist DEFAULTSORT Deoxy D manno oct 2 ulosonic acid, 3 Category Sugar acids organic ... BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition 3 Deoxy small D small manno oct 2 ulosonic acid or KDO is an ulosonic acid of a octose 2 ketooctose which is used by bacteria ... more details
enzyme Name D amino acid N acetyltransferase EC number 2.3.1.36 CAS number 37257 15 1 IUBMB EC number 2 3 1 36 GO code 0047812 image width caption In enzymology , a D amino acid N acetyltransferase EC number 2.3.1.36 is an enzyme that catalysis catalyzes the chemical reaction acetyl CoA a D amino acid math rightleftharpoons math CoA an N acetyl D amino acid Thus, the two substrate biochemistry substrates of this enzyme are acetyl CoA and D amino acid , whereas its two product chemistry products are coenzyme A CoA and N acetyl D amino acid . This enzyme belongs to the family of transferase s, specifically those acyltransferase s transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl CoA D amino acid N acetyltransferase . Other names in common use include D amino acid acetyltransferase , and D amino acid alpha N acetyltransferase . This enzyme participates in phenylalanine metabolism . References reflist 1 cite journal author Zenk MH and Schmitt J date 1965 title Reinigung und Eigenschaften von Acetyl CoA D Aminosaure alpha N Acetyltransferase aus Hefe journal Biochem. Z. volume 342 pages 54&ndash 65 transferase stub Category EC 2.3.1 Category Enzymes of unknown structure it D amminoacido N acetiltransferasi ... more details
enzyme Name N carbamoyl D amino acid hydrolase EC number 3.5.1.77 CAS number 71768 08 6 IUBMB EC number 3 5 1 77 GO code 0047417 image width caption In enzymology , a N carbamoyl D amino acid hydrolase EC number 3.5.1.77 is an enzyme that catalysis catalyzes the chemical reaction N carbamoyl D amino acid H sub 2 sub O math rightleftharpoons math D amino acid NH sub 3 sub CO sub 2 sub Thus, the two substrate biochemistry substrates of this enzyme are N carbamoyl D amino acid and water H sub 2 sub O , whereas its 3 product chemistry products are D amino acid , ammonia NH sub 3 sub , and carbon dioxide CO sub 2 sub . This enzyme belongs to the family of hydrolase s, those acting on carbon nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is . Structural studies As of late 2007, 7 tertiary structure structures have been solved for this class of enzymes, with Protein Data Bank PDB accession codes PDB link 1ERZ , PDB link 1UF4 , PDB link 1UF5 , PDB link 1UF7 , PDB link 1UF8 , PDB link 2GGK , and PDB link 2GGL . References reflist 1 cite journal author Ogawa J, Shimizu S, Yamada H date 1993 title N carbamoyl D amino acid amidohydrolase from Comamonas sp. E222c purification and characterization journal Eur. J. Biochem. volume 212 pages 685&ndash 91 pmid 8462543 doi 10.1111 j.1432 1033.1993.tb17706.x issue 3 hydrolase stub Category EC 3.5.1 Category Enzymes of known structure ... more details
enzyme Name N acyl D amino acid deacylase EC number 3.5.1.81 CAS number 65979 42 2 IUBMB EC number 3 5 1 81 GO code 0047420 image width caption In enzymology , a N acyl D amino acid deacylase EC number 3.5.1.81 is an enzyme that catalysis catalyzes the chemical reaction N acyl D amino acid H sub 2 sub O math rightleftharpoons math an acidD amino acid Thus, the two substrate biochemistry substrates of this enzyme are N acyl D amino acid and water H sub 2 sub O , whereas its two product chemistry products are acid and D amino acid . This enzyme belongs to the family of hydrolase s, those acting on carbon nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is N acyl D amino acid amidohydrolase . It employs one cofactor biochemistry cofactor , zinc . Structural studies As of late 2007, 8 tertiary structure structures have been solved for this class of enzymes, with Protein Data Bank PDB accession codes PDB link 1M7J , PDB link 1RJP , PDB link 1RJQ , PDB link 1RJR , PDB link 1RK5 , PDB link 1RK6 , PDB link 1V4Y , and PDB link 1V51 . References reflist 1 cite journal author Wakayama M, Katsuno Y, Hayashi S, Miyamoto Y, Sakai K, Moriguchi M year 1995 title Cloning and sequencing of a gene encoding D aminoacylase from Alcaligenes xylosoxydans subsp. xylosoxydans A 6 and expression of the gene in Escherichia coli journal Biosci. Biotechnol. Biochem. volume 59 pages 2115&ndash 9 pmid 8541651 doi 10.1271 bbb.59.2115 issue 11 cite journal author Wakayama M, Hayashi S, Yatsuda Y, Katsuno Y, Sakai K, Moriguchi M year 1996 title Overproduction of D aminoacylase from Alcaligenes xylosoxydans subsp. xylosoxydans A 6 in Escherichia coli and its purification journal Protein. Expr. Purif. volume 7 pages 395&ndash 9 pmid 8776758 doi 10.1006 prep.1996.0059 issue 4 Category EC 3.5.1 Category Zinc enzymes Category Enzymes of known structure hydrolase stub ... more details
DISPLAYTITLE N Methyl small D small aspartic acid chembox Watchedfields changed verifiedrevid 312363528 Name N Methyl small D small aspartic acid ImageFile NMDA.svg ImageFileL2 NMDA spacefill.png ImageFileR2 NMDA2.png IUPACName 2 R 2 Methylamino butanedioic acid OtherNames NMDA Section1 Chembox Identifiers InChI 1 C5H9NO4 c1 6 3 5 9 10 2 4 7 8 h3,6H,2H2,1H3, H,7,8 H,9,1 0 t3 m1 s1 CASNo 6384 92 5 CASNo Ref cascite ChemSpiderID 21436 PubChem 22880 ChEMBL Ref ebicite correct EBI ChEMBL 291278 SMILES C H CC O H O C O H O N H C H H H MeSHName NMDA Section2 Chembox Properties C 5 H 9 N 1 O 4 Appearance Density MeltingPt Solubility soluble Section7 Chembox Hazards EUIndex FlashPt N Methyl small D small aspartic acid or N Methyl small D small aspartate NMDA is an amino acid derivative which acts as a specific agonist at the NMDA receptor mimicking the action of glutamate , the neurotransmitter which normally acts at that receptor. Unlike glutamate, NMDA only binds to and regulates the NMDA receptor and has no effect on other glutamate receptors such as those for AMPA and kainate . NMDA receptors are particularly important when they become overactive during withdrawal from alcohol as this causes symptoms such as Psychomotor agitation agitation and, sometimes, epileptiform seizures . Biological function NMDA is a water soluble synthetic substance that is not normally found in biological tissue. It was first synthesized in 1960s. NMDA is an excitotoxin it kills nerve cells by over exciting ... 004 0196 7 pmid 15597199 . Glutamate receptor ligands DEFAULTSORT Methyl D Aspartic Acid, N Category Neurotransmitters Category Dicarboxylic acids Category Amino acid derivatives ca cid N metil D asp rtic cs NMDA fr NMDA nl N methyl D asparaginezuur ja N D pl Kwas N metylo D asparaginowy pt NMDA fi NMDA tr N metil D aspartik asit ... , memantine , and kynurenic acid the latter is the only known endogenous antagonist. They are commonly ... more details
protein Name D amino acid oxidase activator caption image width HGNCid 21191 Symbol DAOA AltSymbols G72, LG72, SG72 EntrezGene 267012 OMIM 607408 RefSeq NM 172370 UniProt P59103 PDB ECnumber Chromosome 13 Arm q Band 33.2 LocusSupplementaryData D amino acid oxidase activator DAOA , also known as G72 is a protein enriched in various parts of brain, spinal cord, and testis. DAOA is thought to interact with D amino acid oxidase , a peroxisomal enzyme, and its gene was associated with schizophrenia in a number of studies. ref name pmid16581030 cite journal author Detera Wadleigh SD, McMahon FJ title G72 G30 in schizophrenia and bipolar disorder review and meta analysis journal Biol. Psychiatry volume 60 issue 2 pages 106 14 year 2006 pmid 16581030 doi 10.1016 j.biopsych.2006.01.019 ref ref name SZGeneDAOA http www.schizophreniaforum.org res sczgene geneoverview.asp?geneid 289 Gene Overview of All Published Schizophrenia Association Studies for DAOA , schizophreniaforum.org ref In separate studies it has been shown to confer susceptibility to bipolar disorder. Therefore it has been important in researching whether the Kraepelinian dichotomy is genuine. The gene itself was discovered during an investigation of chromosomal 13q22 q34 region, ref name pmid12364586 cite journal author Chumakov I, Blumenfeld M, Guerassimenko O, Cavarec L, Palicio M, Abderrahim H, Bougueleret L, Barry C, Tanaka H, La Rosa P, Puech A, Tahri N, Cohen Akenine A, Delabrosse S, Lissarrague S, Picard FP, Maurice K, Essioux L, Millasseau P, Grel P, Debailleul V, Simon AM, Caterina D, Dufaure I, Malekzadeh K, Belova M, Luan JJ, Bouillot M, Sambucy JL, Primas G, Saumier M, Boubkiri N, Martin Saumier S, Nasroune ... PC, Straub RE, Weinberger DR, Cohen N, Cohen D, Ouelette G, Realson J title Genetic and physiological data implicating the new human gene G72 and the gene for D amino acid oxidase in schizophrenia ... Costa J, Cherif D, Gimalac A, Van Duijn C, Gauvreau D, Ouellette G, Fortier I, Raelson J, Sherbatich ... more details
Infobox Single See Wikipedia WikiProject Songs Name This Is Acid Cover Cover size Caption Artist Maurice Joshua Maurice with Hot Hands Hula from Album A side B side Released 1988 Format Gramophone record 12 Recorded 1987 citation needed date February 2011 Genre Electronic dance music Electronica Acid House Length 4 38 Radio edit version ref It was the Les Adams K&T Remix that was the hit the radio edit of this mix was 4 38 and the 12 version was 6 22. ref Label A&M Records Vendetta A&M Records Writer Hula Mahone , Lidell Townsell Producer Hot Hands Hula, Les Adams Certification Last single This single Next single Misc This Is Acid , also known by its full title, This Is Acid A New Dance Craze , is the name of a 1 Billboard magazine Billboard Hot Dance Club Play chart single by Chicago house music DJ and producer Maurice Joshua , who recorded the track under his first name Maurice. It reached the top spot in April 1989 and stayed there for two weeks. ref Joel Whitburn Whitburn, Joel 2004 . Hot Dance Disco 1974 2003 , Record Research Inc. ref The song contains spoken lyrics performed by male singer Hot Hands Hula Mahone. The lyrics introduce the listener to the acid house sound. Versions ... cite web url http www.discogs.com Maurice This Is Acid master 85253 title This Is Acid master release .... Legacy This Is Acid A New Dance Craze was Joshua s only hit single, but he did go on to be a Grammy Award winning producer and remixer. This Is Acid was cover version covered by Germany German ... Records TX169 A1 I Gotta Big Dick 6 20 A2 I Gotta Big Dick Instrumental 5 23 B1 This Is Acid 4 56 B2 Feel the Mood 4 15 12 Maxi US on Maurice This Is Acid A New Dance Craze Vendetta Records VE 7016 A1 This Is Acid A New Dance Craze S & T Mix 7 22 A2 This Is Acid A New Dance Craze Deep Dub 5 58 B This Is Acid ... Hot Dance Club Songs number one singles Category Acid house songs Category Electronic songs Category House music songs Category Spoken word Category Techno songs it This Is Acid ... more details
Other uses Acid disambiguation Refimprove date March 2008 Expert subject Computer science date August 2009 In computer science , ACID Atomicity database systems atomicity , Consistency database systems consistency , Isolation database systems isolation , Durability database systems durability is a set of properties that guarantee database transaction s are processed reliably. In the context of database s, a single logical operation on the data is called a transaction. For example, a transfer of funds from one bank account to another, even though that might involve multiple changes such as debiting one account and crediting another , is a single transaction. Jim Gray computer scientist Jim Gray defined these properties of a reliable transaction system in the late 1970s and developed technologies to automatically achieve them. ref cite web url http www.microsoft.com presspass features 1998 ... ACID to describe them. ref cite journal first Theo last H rder first2 Andreas last2 Reuter title ... properties, atomicity, consistency, isolation, and durability ACID , describe the major highlights of the transaction ... of ACID is often relaxed i.e. partly respected because of the huge speed decrease this type ... to further explain the ACID properties. In these examples, the database has two fields, A and B ... rely upon locking to provide ACID capabilities. Locking means that the transaction marks the data ... ACID properties in a distributed transaction across a distributed database where no single ... , 1993. ISBN 1 55860 190 2. refend Databases DEFAULTSORT Acid Category Database management systems Category Transaction processing Category Concurrency control ar ACID ca ACID da ACID Transaktion de ACID el ACID es ACID fr Propri t s ACID ko ACID it ACID he ACID hu ACID nl ACID ja ACID pl ACID pt ACID ru ACID simple ACID fi ACID ta , , , uk ACID vi ACID zh ACID ... more details
lowercase title d The sensitivity index or d pronounced dee prime is a statistic used in signal detection theory . It provides the separation between the means of the signal and the noise distributions, in units of the standard deviation of the noise distribution. An estimate of d can be found from measurements of the hit rate and False alarm false alarm rate. It is calculated as d Z hit rate Z false alarm rate , where function Z p , p &isin 0,1 , is the inverse of the Normal distribution Cumulative distribution function cumulative Gaussian distribution . A higher d indicates that the signal can be more readily detected. See also Receiver Operating Characteristic R.O.C. Summary Statistics References http books.google.com books?vid ISBN0195092503&id s3pGN se4v0C&pg PA22&lpg PA22&dq Thomas D. Wickens Elementary Signal Detection Theory by Thomas D. Wickens Ch.2, p.20 . External links Please see Wikipedia External links for guidelines on appropriate external links. http wise.cgu.edu sdtmod index.asp Interactive signal detection theory tutorial including calculation of d . Category Detection theory Category Signal processing Category Summary statistics Signal processing stub stat stub ... more details
D can refer to D band , based in Anacortes, Washington Digital , a Spanish satellite television platform D grade , an academic grade Disambig Short pages monitor This long comment was added to the page to prevent it being listed on Special Shortpages. It and the accompanying monitoring template were generated via Template Longcomment. Please do not remove the monitor template without removing the comment as well. ... more details
about a search algorithm the digital voice and data protocol specification D STAR the physical quantity Specific detectivity Graph search algorithm D is any one of the following three related incremental heuristic search incremental search algorithms The original D ref Citation last Stentz first Anthony ... viewdoc summary?doi 10.1.1.15.3683 ref pronounced D star is an uninformed incremental search algorithm. Focused D ref Citation last Stentz first Anthony title The Focussed D Algorithm for Real ... D . Focused D resulted from a further development of the original D . D Lite ref S. Koenig ... that builds on LPA ref S. Koenig, M. Likhachev and D. Furcy. Lifelong Planning A . Artificial .... D and its variants have been widely used for mobile robot and autonomous vehicle navigation research navigation . Current systems are typically based on D Lite rather than the original D or Focused D . In fact, even Stentz s lab uses D Lite rather than D in some implementations. ref D. Wooden ... Challenge , both developed at Carnegie Mellon University . D The original D was introduced by Anthony Stentz in 1994. The name D comes from the term Dynamic A , because the algorithm behaves like A except that the arc costs can change as the algorithm runs. Operation The basic operation of D is outlined below. Like Dijkstra s algorithm and A , D maintains a list of nodes to be evaluated, known ... is termed expansion . In contrast to A , which follows the path from start to finish, D begins ... the LOWER state to its neighbors. These waves of RAISE and LOWER states are the heart of D .... Focused D As its name suggests, Focused D is an extension of D which uses a heuristic to focus ..., in the same way that A only computes costs for some of the nodes. D Lite D Lite is not based on the original D or Focused D , but implements the same behavior. It is simpler to understand and can be implemented in fewer lines of code, hence the name D Lite . Performance wise, it is as good ... more details
The D or Plus D was a floppy disk and computer printer printer Electrical connector interface for the Sinclair Research Sinclair ZX Spectrum home computer , developed as a successor to Miles Gordon Technology s earlier product, the DISCiPLE . It was designed to be smaller, cheaper, simpler and thus more reliable. It discarded a number of the less important features of the earlier product the computer network network and joystick ports, the inhibit button and the pass through connector and replaced its ancestor s plastic wedge shaped design which fit under the Spectrum with a simple flat metal slab which protruded from the rear of the computer. It provided only floppy disk and Centronics parallel interfaces, plus a non maskable interrupt button. The D s casing was simple folded steel, which was not only stronger than before but acted as a heatsink, improving reliability. Apart from the missing ports, though, it was software compatible with the larger device. The D s disk operating system DOS was named G DOS , and was compatible with the DISCiPLE s DOS, GDOS . SAM DOS for MGT s SAM Coup was backwards compatible with GDOS and G DOS. In later years a complete new system called UNI DOS was developed by SD Software for the DISCiPLE and D interfaces. ref http www.sinclair.hu speccyalista konyvtar kezikonyvek MGT PlusD Disciple UniDos Manual.pdf UNI DOS Manual ref The Complete D Disassembly by Rudy Biesma documents the G DOS system 2a version. ref http www.biehold.nl rudy index.htm Rudy Biesma s homepage ref The popularity of the DISCiPLE led to the formation of a user group and magazine ... Nieuwsbrief in the Netherlands produced enhancements such as extended printer support. The D ... NotThePlusD How to build a D for yourself http www.rwapsoftware.co.uk spectrum spectrum storage.html rwapsoftware.co.uk still offer the D Disk Interface for sale References reflist DEFAULTSORT Plus D Category ZX Spectrum es Plus D it D ... more details
D means Placed before a U.S. state , usually in parentheses, indicates the person it applies to is a Democratic Party United States Democratic Party politician of that state. R is used for the Republican Party United States Republican Party . An academic grade given by certain institutions. Slightly better than an F and slightly worse than a D . See Grade education . A prefix signifying chirality chemistry chirality of a molecule See also Rep. Sen. Disambig ... more details
Image 3 Deoxy D manno oct 2 ulosonic acid linear.png thumb 200px The ulosonic acid ketodeoxyoctulosonic acid . An ulosonic acid is a sugar acid obtained by the oxidation of the 1 hydroxyl group of a ketose to a carboxylic acid , creating an alpha keto acid . An example of an ulosonic acid is ketodeoxyoctulosonic acid . chemistry stub Category Sugar acids ... more details
Infobox musical artist name D A D image D A D 2005 Roskilde.jpg caption D A D at the Roskilde Festival , 2005. image size Only for images narrower than 220 pixels background group or band alias Disneyland After Dark origin Copenhagen , Denmark genre Melodic rock br Hard rock br Cowpunk br Glam metal years active 1982 present label Mermaid Records br EMI br Warner Bros. Records US 1989 1992 associated acts B hse Onkelz , Der W website http www.d a d.dk D A D.dk current members Jesper Binzer br Jacob Binzer br Stig Pedersen br Laust Sonne past members Lene Glumer, Peter Lundholm Jensen. D A D is a Denmark ... as melodic heavy rock. They have also used the names D.A.D., D A D and D A D, each name represents a period in the band s history. History In the early 1980s in Copenhagen , Denmark , D A D started ... their music. The first lineup of D A D consisted of Jesper, Stig, Peter and Stig s girlfriend ... by little he became a member of D A D. The band wanted to make a record, so they began recording ... of the Wild D A D album Call of the Wild in 1986. The group made their international breakthrough in 1989 ... band ADS . He was founder of the band, but was eventually kicked out in 82 , so he founded D A D as a payback ... Call of the Wild D A D album Call of the Wild Released February 4, 1986 Producers Frank Marstokk D.A.D. ... March 1, 1995 Producers Paul Northfield Simpatico D A D album Simpatico Released November 6, 1997 Producers Nick Foss & D A D Everything Glows Released April 13, 2000 Producers Nick Foss Soft Dogs ... Nov 11, 2011 ref http d a d.com discography 54 ref 2 Live albums Osaka After Dark 1990, Japan ... and Finland only Good Clean Family Entertainment You Can Trust 1995 The Early Years D A D album ... 2011 I Want What She s Got center 36 center DIS.NEY.LAN.DAFT.ERD.ARK Quotes D A D s lyrics are often ... groups Category Cowpunk Category Musical groups established in 1982 da D A D de D A D fr D.A.D. it D A D nl D A D no D A D pl D A D fi D A D sv D A D ... more details
selfref For Wikipedia s Article Creation and Improvement Drive, see WP ACID wiktionarypar acid An acid is any chemical compound that, when dissolved in water, gives a solution with a pH less than 7.0. Acid or ACID may also refer to Common parlance corrosive substance Corrosive substances are commonly though imprecisely referred to as acids. Lysergic acid diethylamide Lysergic acid diethylamide LSD , a semisynthetic, psychedelic drug, is commonly referred to as acid. Computer science Acid1 , Acid2 , and Acid3 , webpage rendering test cases. Acid computer virus , a computer virus ACID Pro , professional digital audio workshop software ACID A tomicity, C onsistency, I solation, D urability , an initialism for the transactional properties of database management systems Music Acid band , a Japanese band Acid hip hop , a Burmese hip hop group Acid house , a subgenre of house music Acid jazz , a musical genre Acid rock , a style of psychedelic rock Acid techno , a style of techno Acid trance , a style of trance music The sound produced by the Roland TB 303 electronic music synthesizer is commonly described as acid like. Other ACiD Productions , an underground digital art group Metal Gear Acid , a turn based collectible card video game See also Acid test disambiguation disambig cs Acid de Acid el es Acid fr Acide homonymie ko lv Sk be noz mju atdal ana nl Acid ja no Syre andre betydninger pt Acid ru Acid fi Acid sv Acid vi Acid nh h ng ... more details
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