intracytoplasmic cytoskeleton of epithelial tissue . The term cytokeratin began to be used in the late ... research literature that used the term cytokeratin . Types Image Intermediate trophoblast lmwk high mag.jpg thumb right Micrograph showing low molecular weight cytokeratin LMWCK staining of intermediate ... the acidic type I cytokeratin s and the basic chemistry basic or neutral type II cytokeratin s. Cytokeratins are usually found in pairs comprising a type I cytokeratin and a type II cytokeratin . Basic ... in the course of terminal differentiation and the stage of development. Thus this specific cytokeratin fingerprint allows the classification of all epithelia upon their cytokeratin expression profile. Furthermore this applies also to the malignant counterparts of the epithelia carcinoma s , as the cytokeratin .... The main clinical implication is that the study of the cytokeratin profile by immunohistochemistry ... 19346656 doi 10.4103 0019 509X.49160 ref class wikitable Cytokeratin Sites Cytokeratin 4 Non keratinized ... October 2010 ref Cytokeratin 7 A subgroup of glandular epithelia and their tumors ref name mubio Transitional epithelium and transitional carcinoma ref name mubio Cytokeratin 8 Glandular epithelia of the digestive ... cells Adenocarcinomas originating from those above ref name mubio Cytokeratin 10 Cytokeratin ... areas of highly differentiated squamous cell carcinoma s ref name mubio Cytokeratin 13 Non keratinized squamous epithelia, except cornea ref name mubio Cytokeratin 14 Basal layer of stratified and combined epithelia ref name mubio Cytokeratin 18 Glandular epithelia of the digestive, respiratory ... originating from those above ref name mubio Cytokeratin 19 Glandular type epithelia ref ... them, 20 are epithelial genes and the remaining 10 are specific for trichocytes. All cytokeratin ... domain sequences of type I and II cytokeratin chains contain in both sides of the rod domain the subdomains ... residues enriched by glycines and or serines, the former providing the cytokeratin chain a strong ... more details
Unreferenced stub auto yes date December 2009 Keratin 21 is a type I cytokeratin which expresses immunologically specific fusion protein. It is not found in humans, but only in Rattus norvegicus . Cytoskeletal proteins Category Keratins Protein stub ... more details
PBB geneid 3850 Keratin 3 also known as cytokeratin 3 is a protein that in humans is encoded by the KRT3 gene . ref name pmid7510223 cite journal author Raimondi E, Moralli D, De Carli L, Ceratto N, Balzaretti M, Leube R, Collin C, Romano V title Assignment of the human cytokeratin 3 gene KRT3 to 12q12 q13 by FISH journal Cytogenet. Cell Genet. volume 66 issue 3 pages 162 3 year 1994 pmid 7510223 doi url issn ref ref name pmid16831889 cite journal author Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW title New consensus nomenclature for mammalian keratins journal J. Cell Biol. volume 174 issue 2 pages 169 74 year 2006 month July pmid 16831889 pmc 2064177 doi 10.1083 jcb.200603161 url issn ref Keratin 3 is a type II cytokeratin . It is specifically found in the corneal epithelium together with keratin 12 . Mutations in the KRT3 encoding this protein have been associated with Meesmanns Corneal Dystrophy . ref name pmid9171831 cite journal author Irvine AD, Corden LD, Swensson O, Swensson B, Moore JE, Frazer DG, Smith FJ, Knowlton RG, Christophers E, Rochels R, Uitto J, McLean WH title Mutations in cornea specific keratin K3 or K12 genes cause Meesmann s corneal dystrophy journal Nat. Genet. volume 16 issue 2 pages 184 7 year 1997 month June pmid 9171831 doi 10.1038 ng0697 184 url issn ref References Reflist Cytoskeletal proteins Gene 12 stub Category Keratins ru 3 ... more details
1078 87 year 2004 pmid 15486927 ref ref cite journal author Feldstein AE et al. title Cytokeratin ... host disease ref cite journal author Luft T et al. title Serum cytokeratin 18 fragments as quantitative ... M30 ref cite journal author Leers M et al. title Immunocytochemical detection and mapping of a cytokeratin ... Forms of Extracellular Cytokeratin 18 journal Cancer Research volume 64 pages 1751 1756 year 2004 ... more details
Identification of protein IT of the intestinal cytoskeleton as a novel type I cytokeratin with unusual ... of cytokeratin 20 and mucin 2 mRNA as metastasis markers in regional lymph nodes of colon cancer ... of CD10 and cytokeratin 20. journal Pancreas volume 38 issue 5 pages 558 64 year 2009 pmid 19287335 .... title Mismatch repair protein MSH2, cytokeratin 18 and cytokeratin 20 expression clinicopathological ... author Chan CW, Wong NA, Liu Y, et al. title Gastrointestinal differentiation marker Cytokeratin ... of CD44 and cytokeratin 20 mRNA in voided urine samples as diagnostic tools for bladder cancer ... of cytokeratin 20, and low proliferative activity define those papillary urothelial neoplasms of low ... more details
34 E12 , often written as 34betaE12 and also known as CK34 E12 and keratin 903 CK903 , is an antibody specific for high molecular weight cytokeratin s Keratin 1 1 , Keratin 5 5 , Keratin 10 10 and Keratin 14 14 . ref cite journal author Aishima S, Asayama Y, Taguchi K, et al. title The utility of keratin 903 as a new prognostic marker in mass forming type intrahepatic cholangiocarcinoma journal Mod. Pathol. volume 15 issue 11 pages 1181 90 year 2002 month November pmid 12429797 doi 10.1097 01.MP.0000032537.82380.69 url http www.nature.com modpathol journal v15 n11 full 3880675a.html ref ref name yeh cite journal author Yeh IT, Mies C title Application of immunohistochemistry to breast lesions journal Arch. Pathol. Lab. Med. volume 132 issue 3 pages 349 58 year 2008 month March pmid 18318578 doi url http journals.allenpress.com jrnlserv ?request get abstract&issn 0003 9985&volume 132&page 349 ref It is sometimes, less precisely, referred to as high molecular weight keratin HMWK and high molecular weight cytokeratin HMWCK . Utility It is used to stain basal cell biology cell s in prostate prostatic glands loss of basal cells is seen in prostate adenocarcinoma the most common form of prostate cancer . It can be used to differentiate in situ cancers of the breast lobular carcinoma in situ LCIS exhibits peri nucleus cell nuclear staining with 34 E12. Ductal carcinoma in situ DCIS does not stain for 34 E12. ref name yeh See also Immunohistochemistry References reflist DEFAULTSORT 34 e12 Category Pathology ... more details
PBB geneid 3860 Keratin 13 or cytokeratin 13 is a protein that in humans is encoded by the KRT13 gene . ref name pmid1385306 cite journal author Romano V, Raimondi E, Bosco P, Feo S, Di Pietro C, Leube RE, Troyanovsky SM, Ceratto N title Chromosomal mapping of human cytokeratin 13 gene KRT13 journal Genomics volume 14 issue 2 pages 495 7 year 1992 month October pmid 1385306 doi 10.1016 S0888 7543 05 80250 2 url issn ref ref name pmid16831889 cite journal author Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW title New consensus nomenclature for mammalian keratins journal J. Cell Biol. volume 174 issue 2 pages 169 74 year 2006 month July pmid 16831889 pmc 2064177 doi 10.1083 jcb.200603161 url issn ref Keratin 13 is a type I cytokeratin , it is paired with keratin 4 and found in the suprabasal layers of non cornified stratified epithelia. Mutations in the gene encoding this protein and keratin 4 have been associated with the autosomal dominant disorder White Sponge Nevus . ref name pmid7493031 cite journal author Richard G, De Laurenzi V, Didona B, Bale SJ, Compton JG title Keratin 13 point mutation underlies the hereditary mucosal epithelial disorder white sponge nevus journal Nat. Genet. volume 11 issue 4 pages 453 5 year 1995 month December pmid 7493031 doi 10.1038 ng1295 453 url issn ref K13 is negative in buccal epithelium. Citation needed date February 2010 References reflist Further reading refbegin 2 cite journal author title journal volume issue pages year pmid doi cite journal author Jacques CM, Pereira ... type I cytokeratin genes are a compact cluster. journal Cytogenet. Cell Genet. volume 77 issue ... VP, Blaeuer GL, et al. title Stage specific expression of the intermediate filament protein cytokeratin ... of uterine cervix. Pathological and immunohistochemical analysis with cytokeratin 13. journal ... Burkholderia cepacia binds to cytokeratin 13 of epithelial cells. journal Infect. Immun. volume ... more details
Letter NumberCombination 6A 6C 5B 7B 6B or 6b or VI B may refer to Keratin 6B , a type II cytokeratin Oflag VI B , a World War II German POW camp for officers located 5 km 3 miles SW of the small town D ssel REL 6B Radar , a ground air surveillance and guidance radar Rumpler 6B , a 1916 German single engine floatplane fighter Season 6B , a popular fan theory related to the long running British science fiction television series Doctor Who Stalag VI B , a Nazi World War II camp for prisoners of war TUIfly Nordic IATA airline designator British Rail Class 203 Diesel electric Multiple Units, which were classed as 6B 6 coaches, Buffet pre TOPS 6B Fringe 6B Fringe , an episode of the television series Fringe 6 bits, like in 6b 8b encoding See also B6 Letter NumberCombDisambig de 6B it 6B ... more details
DISPLAYTITLE Technetium sup 99m sup Tc votumumab drugbox type mab drug name Technetium sup 99m sup Tc votumumab image mab type mab source u target tumor antigen CTAA16.88 CAS number 148189 70 2 ATC prefix V09 ATC suffix IA04 ATC supplemental PubChem DrugBank chemical formula molecular weight bioavailability protein bound metabolism elimination half life excretion pregnancy AU pregnancy US pregnancy category legal AU legal CA legal UK legal US legal status not marketed routes of administration Technetium sup 99m sup Tc votumumab trade name HumaSPECT is a human monoclonal antibody labelled with the radionuclide technetium 99m . ref http whqlibdoc.who.int druginfo INN 1999 list41.pdf WHO Drug Information ref It was developed for the detection of colorectal tumor s, but has never been marketed. ref name EMEA http www.emea.europa.eu pdfs human press pus 388504en.pdf EMA Public Statement on HumaSPECT ref The target of votumumab is CTAA16.88, a complex of cytokeratin polypeptides in the molecular weight range of 35 to 43 kDa , which is expressed in colorectal tumors. ref http ec.europa.eu enterprise sectors pharmaceuticals documents community register 1998 199809253252 anx 3252 en.pdf EMA Summary of Product Characteristics for HumaSPECT ref References reflist Radiopharmaceuticals Monoclonals for tumors Category Radiopharmaceuticals monoclonal antibody stub ... more details
Image CutaneousMyxoma.jpg right thumbnail Cutaneous Myxoma A cutaneous myxoma , AKA superficial angiomyxoma , consists of a multilobulated myxoid mass containing stellate and or spindled fibroblasts with pools of mucin forming cleft like spaces. There is often a proliferation of blood vessels and an inflammatory infiltrate. Staining is positive for vimentin , negative for cytokeratin and desmin , and variable for CD34 , Factor VIIIa, SMA dn , MSA dn and S 100 protein S 100 . ref name Review http www3.interscience.wiley.com cgi bin fulltext 121664953 HTMLSTART Solitary superficial angiomyxoma an infrequent but distinct soft tissue tumor. Satter. Journal of Cutaneous Pathology, Vol 36, Issue s1, pages 56 59. ref Clinically, it may present as solitary or multiple flesh colored nodules on the face, trunk, or extremities. It may occur as part of the Carney complex , and is sometimes the first sign. Local recurrence is common. ref name Andrews James, William Berger, Timothy Elston, Dirk 2005 . Andrews Diseases of the Skin Clinical Dermatology . 10th ed. . Saunders. ISBN 0 7216 2921 0. ref rp 614 See also Skin lesion Myxoma References reflist Dermal growth stub Soft tissue tumors and sarcomas Category Dermal and subcutaneous growths ... more details
therefrom, with an analysis of the chromosomal locus containing the cytokeratin 19 gene. journal ... CW, Park HS, Kim YK, et al. title Elastic fiber staining and cytokeratin 15 expression pattern in trichoepithelioma ... M, et al. title Chromosomal assignments of human type I and type II cytokeratin genes to different ... of cytokeratin 15 relationship between CK15 progenitor amplified cells and pre malignant ... more details
PBB geneid 3880 Keratin, type I cytoskeletal 19 also known as cytokeratin 19 CK 19 or keratin 19 K19 is a protein that in humans is encoded by the KRT19 gene . ref name pmid16831889 cite journal author Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW title New consensus nomenclature for mammalian keratins journal J Cell Biol volume 174 issue 2 pages 169 74 year 2006 month Jul pmid 16831889 pmc 2064177 doi 10.1083 jcb.200603161 ref ref name entrez cite web title Entrez Gene KRT19 keratin 19 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 3880 accessdate ref Keratin 19 is a type I keratin . Function Keratin 19 is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Keratin 19 is a type I keratin . The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cell s. It is specifically found in the periderm fish periderm , the transiently superficial layer that envelops the developing epidermis skin epidermis . The type I cytokeratins are clustered in a region of chromosome 17q12 q21. ref name entrez cite web title Entrez Gene KRT19 keratin 19 url http www.ncbi.nlm.nih.gov ... Bader BL, Magin TM, Hatzfeld M, Franke WW title Amino acid sequence and gene organization of cytokeratin ... locus containing the cytokeratin 19 gene journal Eur. J. Cell Biol. volume 47 issue 2 pages 300 ... doi 10.1111 1523 1747.ep12721500 cite journal author Shezen E, Okon E, Ben Hur H, Abramsky O title Cytokeratin ... cite journal author Ceratto N, Dobkin C, Carter M, et al. title Human type I cytokeratin genes are a compact ... and characterization of the 5 flanking region of human cytokeratin 19 gene in human cholangiocarcinoma ... more details
related kinase associates with and phosphorylates cytokeratin 8 and 18 journal J. Cell Biol. volume ..., Elvin P, Jenner D, et al. title Localisation of a cDNA clone for human cytokeratin 18 to chromosome ... author Romano V, Hatzfeld M, Magin TM, et al. title Cytokeratin expression in simple epithelia. I. Identification of mRNA coding for human cytokeratin no. 18 by a cDNA clone journal Differentiation ... Cytokeratin expression in simple epithelia. III. Detection of mRNAs encoding human cytokeratins ... 363314 cite journal author S mat A, Vasseur M, Maillet L, et al. title Sequence analysis of murine cytokeratin ... more details
Letter NumberCombination CJ CL BK DK wiktionarypar CK .ck CK , Ck , or ck may refer to Biochemistry Creatine kinase Cytokinin , a kind of plant hormone Cytokeratin People known by the initials CK Prahalad , a professor at the University of Michigan Ross School of Business Louis C.K. Chaka Khan , American singer and songwriter Other Ck digraph .ck , the Internet country code top level domain for the Cook Islands CK album CK album , 1998 album by Chaka Khan Calvin Klein Candidate key Chaka Khan 1982 album Chaka Khan 1982 album , Chaka Khan s self titled album Chairman King or Circus King , bosses in Okage video games Certified Kinesiologist , Chevrolet C K , car companies Chevrolet and GMC s full size Pickup truck line from 1960 until 1998 China Cargo Airlines s IATA code Citizen Kane Civilinis kodeksas , Code of Lithuania Composite Corridor , a designation of British Rail carriage Con Kolivas , the Linux Kernel developer Conductive keratoplasty Core Knowledge , a textbook series Corner kick Corner Kick , a method of restarting play in a game of association football Cranbrook Kingswood , a Bloomfield Hills school Crusader Kings video game , a grand strategy game made by Paradox Interactive Crip Killer, a member of the Bloods street gang Cyanogen chloride disambig cs CK de CK eo Ck fa CK fr CK ko CK it CK sw CK lv CK lt CK reik m s nl Ck ja CK no CK pl CK sl CK fi Ck sv CK zh CK ... more details
Type 2 or Type II may refer to Type II machine pistol Type II , a Japanese Sub machine Gun Type 2 20 mm AA Machine Cannon , a Japanese weapon Type 2 AT mine Type 2 cannon , a 30 mm Japanese weapon Type 2 encryption Type 2 Gumbel distribution Type 2 Ho I , a Japanese tank Type 2 Ka Mi , a Japanese tank Type II cytokeratin Type II error used in statistics for a false negative error Type II string theory Type II superconductor Type II supernova Activin type 2 receptors Diabetes mellitus type 2 Glutaric acidemia type 2 Hyper IgM Syndrome Type 2 JDBC type 2 driver Kawanishi H8K , Type 2 flying boat code named Emily Multiple endocrine neoplasia type 2 Real Personal Trooper Type 2 Volkswagen Type 2 T3 Volkswagen Type 2 Atelosteogenesis, type II German Type II submarine Glycogen storage disease type II Hyperfinite type II factor Motorola Type II Neurofibromatosis type II R Type II Type I and type II errors Type II civilization , an advanced civilization on the Kardashev scale . Type 2 may also refer to Albinism Charcot Marie Tooth disease Chomsky hierarchy Compact Cassette Compact Font Format CompactFlash Cyclic permutation Dbx noise reduction Gaucher s disease Hypersensitivity PC card Second degree heart block Spinal muscular atrophy Topoisomerase Usher syndrome Von Willebrand disease disambig ru 2 ... more details
Myoepithelial cells sometimes referred to as Myoepithelium are Cell biology cells usually found in glandular epithelium as a thin layer above the basement membrane but generally beneath the lumen anatomy lumenal cells. These may be positive for ACTA2 alpha smooth muscle actin and can contract and expel the secretions of exocrine glands . They are found in the sweat gland , mammary gland , lacrimal gland , and salivary gland . Myoepithelial cells in these cases constitute the basal cell layer of an epithelium that harbors the epithelial Progenitor cell progenitor stem cells . In the case of wound healing , myoepithelial cells reactively cell growth proliferate . Presence of myoepithelial cells in a hyperplasia hyperplastic tissue proves the benign ity of the gland and, when absent, indicates cancer . Only rare cancers like adenoid cystic carcinoma s contains myoepithelial cells as one of the malignant components. It can be found in endoderm or ectoderm . ref name Berman2009 cite book author Jules J. Berman title Neoplasms principles of development and diversity url http books.google.com books?id WWnJ1 IM1yUC&pg PA207 accessdate 16 April 2010 year 2009 publisher Jones & Bartlett Learning isbn 9780763755706 pages 207 ref Markers Myoepithelial cells are true epithelial cell s positive for keratin s, not to be confused with myofibroblasts which are true mesenchymal cell s positive for vimentin . These cells are generally positive for alpha smooth muscle actin SMA , cytokeratin 5 6 and other high molecular weight cytokeratins, TP73L p63 and caldesmon . References reflist External links eMedicineDictionary Myoepithelium AnatomyAtlasesMicroscopic 07 141 Axillary Sweat Gland Myoepithelium OklahomaHistology 43 13 thick skin KansasHistology glands glands09 Simple Tubular Coiled GeorgiaPhysiology 6 6ch4 s6ch4 4 Human cell types derived primarily from endoderm Human cell types derived primarily from ectoderm Category Cell biology anatomy stub cs Myoepitel de Myoepithelzelle ja ... more details
Image Intermediate trophoblast high mag.jpg thumb right Micrograph showing intermediate trophoblasts. H&E stain . Image Intermediate trophoblast lmwk high mag.jpg thumb right Implantation site intermediate trophoblast. Low molecular weight cytokeratin stain. Intermediate trophoblast is a distinct subtype of trophoblast ic tissue that arises from the cytotrophoblast . ref name pmid11192071 cite journal author Shih IM, Kurman RJ title The pathology of intermediate trophoblastic tumors and tumor like lesions journal Int. J. Gynecol. Pathol. volume 20 issue 1 pages 31 47 year 2001 month January pmid 11192071 doi url ref It is sub categorized by location ref name pmid11192071 Implantation site intermediate trophoblast Villous intermediate trophoblast Chorionic type intermediate trophoblast Function The function of the implantation site intermediate trophoblast is to anchor the placenta to the maternal tissue. Histomorphology Large cells Eosinophilic cytoplasm May be multi nucleated Pathology Intermediate trophoblasts are thought to be the cell of origin for ref name pmid11192071 cite journal author Shih IM, Kurman RJ title The pathology of intermediate trophoblastic tumors and tumor like lesions journal Int. J. Gynecol. Pathol. volume 20 issue 1 pages 31 47 year 2001 month January pmid 11192071 doi url ref Exaggerated placental site EPS Placental site nodule PSN Placental site trophoblastic tumour PSTT Epithelioid trophoblastic tumour ETT References reflist Category Embryology ... more details
thumb right keratin intermediate filaments stained red details cytokeratin These proteins are the most diverse among IFs and constitute Type I cytokeratin type I acidic and Type II cytokeratin ... more details
PBB geneid 3855 Keratin, type I cytoskeletal 7 also known as cytokeratin 7 CK 7 or keratin 7 K7 or sarcolectin SCL is a protein that in humans is encoded by the KRT7 gene . ref name pmid1713141 cite journal author Rosenberg M, Fuchs E, Le Beau MM, Eddy RL, Shows TB title Three epidermal and one simple epithelial type II keratin genes map to human chromosome 12 journal Cytogenet Cell Genet volume 57 issue 1 pages 33 8 year 1991 month Aug pmid 1713141 pmc doi 10.1159 000133109 ref ref name pmid16831889 cite journal author Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW title New consensus nomenclature for mammalian keratins journal J Cell Biol volume 174 issue 2 pages 169 74 year 2006 month Jul pmid 16831889 pmc 2064177 doi 10.1083 jcb.200603161 ref ref name entrez cite web title Entrez Gene KRT7 keratin 7 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 3855 accessdate ref Keratin 7 is a type II keratin . It is specifically expressed in the simple epithelium epithelia lining the cavities of the internal Organ anatomy organ s and in the gland ducts and blood vessel s. Function Keratin 7 is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the simple epithelia lining the cavities of the internal organs and in the gland ducts and blood vessels. The genes encoding the type II cytokeratins are clustered in a region of chromosome 12q12 q13. Alternative splicing may result in several transcript variants however, not all variants have been ... pattern of cytokeratin 7 and 20 expression from normal epithelium to intestinal metaplasia of the gastric ... papillomavirus type 16 E7 mRNA by the peptide SEQIKA, shared by rabbit alpha 1 globin and human cytokeratin ... more details
PBB geneid 3851 Keratin, type I cytoskeletal 4 also known as cytokeratin 4 CK 4 or keratin 4 K4 is a protein that in humans is encoded by the KRT4 gene . ref name pmid1702379 cite journal author Barletta C, Batticane N, Ragusa RM, Leube R, Peschle C, Romano V title Subchromosomal localization of two human cytokeratin genes KRT4 and KRT15 by in situ hybridization journal Cytogenet. Cell Genet. volume 54 issue 3 4 pages 148 50 year 1990 pmid 1702379 doi 10.1159 000132979 url issn ref ref name pmid16831889 cite journal author Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW title New consensus nomenclature for mammalian keratins journal J. Cell Biol. volume 174 issue 2 pages 169 74 year 2006 month July pmid 16831889 pmc 2064177 doi 10.1083 jcb.200603161 url issn ref Keratin 4 is a type II cytokeratin s. It is specifically found in differentiated layers of the mucosal and esophageal epithelia together with keratin 13 . Mutations in the genes encoding this protein have been associated with White Sponge Nevus , characterized by Wiktionary oral oral , esophageal , and anus anal leukoplakia . ref name pmid12828738 cite journal author Chao SC, Tsai YM, Yang MH, Lee JY title A novel mutation in the keratin 4 gene causing white sponge naevus journal Br. J. Dermatol. volume 148 issue 6 pages 1125 8 year 2003 month June pmid 12828738 doi 10.1046 j.1365 2133.2003.05337.x url issn ref References reflist Further reading refbegin 2 cite journal author Leube RE, Bader BL, Bosch FX, et al. title Molecular characterization and expression of the stratification related cytokeratins 4 and 15. journal J. Cell Biol. volume 106 issue 4 pages 1249 61 year 1988 pmid 2452170 pmc 2114990 doi 10.1083 jcb.106.4.1249 cite journal author Samen U, Eikmanns BJ, Reinscheid DJ, Borges F title The surface protein Srr 1 of Streptococcus agalactiae ... cytokeratin genes to different chromosomes. journal Cytogenet. Cell Genet. volume 48 issue 3 pages ... more details
PBB geneid 3858 Keratin, type I cytoskeletal 10 also known as cytokeratin 10 CK 10 or keratin 10 K10 is a protein that in humans is encoded by the KRT10 gene . ref name pmid2461420 cite journal author Lessin SR, Huebner K, Isobe M, Croce CM, Steinert PM title Chromosomal mapping of human keratin genes evidence of non linkage journal J Invest Dermatol volume 91 issue 6 pages 572 8 year 1989 month Jan pmid 2461420 pmc doi 10.1111 1523 1747.ep12477087 ref ref name pmid16831889 cite journal author Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW title New consensus nomenclature for mammalian keratins journal J Cell Biol volume 174 issue 2 pages 169 74 year 2006 month Jul pmid 16831889 pmc 2064177 doi 10.1083 jcb.200603161 ref ref name entrez cite web title Entrez Gene KRT10 keratin 10 epidermolytic hyperkeratosis keratosis palmaris et plantaris url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 3858 accessdate ref Keratin 10 is a type I keratin . Function Keratin 10 is a member of the type I acidic cytokeratin family, which belongs to the superfamily of intermediate filament IF proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis . This gene is located within a cluster of keratin family members on chromosome 17q21. ref name entrez Interactions Keratin 10 has been shown to Protein protein interaction interact with AKT1 . ref name pmid11585925 cite journal last Paramio first J M authorlink coauthors Segrelles C, Ruiz S, Jorcano J L year 2001 month Nov ... mammalian cytokeratin gene. High degree of intron sequence conservation during evolution of human cytokeratin 10 journal J. Mol. Biol. volume 204 issue 4 pages 841 56 year 1989 pmid 2464696 ... more details
PBB geneid 3856 Keratin, type I cytoskeletal 8 also known as cytokeratin 8 CK 8 or keratin 8 K8 is a keratin protein that in human is encoded by the KRT8 gene . It is often paired with keratin 18 . Utility as an immunohistochemical stain Antibodies to CK8 e.g. CAM 5.2 can be used to differentiate breast cancer lobular carcinoma of the breast from ductal carcinoma of the breast . ref cite journal author Moriya T, Kasajima A, Ishida K, et al. title New trends of immunohistochemistry for making differential diagnosis of breast lesions journal Med Mol Morphol volume 39 issue 1 pages 8 13 year 2006 month March pmid 16575508 doi 10.1007 s00795 006 0309 8 url ref Keratin 8 is often used together with keratin 18 and keratin 19 to differentiate cells of epithelial origin from hematopoietic cells in tests that enumerate circulating tumor cell s in blood ref cite journal author W. Jeffrey Allard, Jeri Matera, M. Craig Miller, et al. title Tumor Cells Circulate in the Peripheral Blood of All Major Carcinomas but not in Healthy Subjects or Patients With Nonmalignant Diseases journal Clin. Cancer Research volume 10 pages 6897 6904 year 2004 month October doi 10.1158 1078 0432.CCR 04 0378 pmid 15501967 issue 20 ref . Interactions Keratin 8 has been shown to Protein protein interaction interact with MAPK14 , ref name pmid11788583 cite journal last Ku first Nam On authorlink coauthors Azhar Salman, Omary M Bishr year 2002 month Mar. title Keratin 8 phosphorylation by p38 kinase regulates cellular keratin filament reorganization modulation by a keratin 1 like disease causing mutation journal J. Biol. Chem. volume 277 issue 13 pages 10775 82 publisher location United States issn 0021 9258 pmid ... of the human gene encoding cytokeratin 8. journal Gene volume 86 issue 2 pages 241 9 year 1990 pmid ... JF title Cloning and sequence of cDNA for human placental cytokeratin 8. Regulation of the mRNA in trophoblastic ... journal author Leube RE, Bosch FX, Romano V, et al. title Cytokeratin expression in simple epithelia ... more details
Technical date July 2009 PBB geneid 3852 Keratin, type II cytoskeletal 5 also known as KRT5 is a protein that in human is encoded by the KRT5 gene . ref name entrez Cite web title Entrez Gene KRT5 keratin 5 epidermolysis bullosa simplex, Dowling Meara Kobner Weber Cockayne types url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 3852 accessdate ref ref name pmid2447486 Cite journal author Lersch R, Fuchs E title Sequence and expression of a type II keratin, K5, in human epidermal cells journal Mol. Cell. Biol. volume 8 issue 1 pages 486 93 year 1988 month January pmid 2447486 pmc 363157 doi url issn ref ref name pmid2456903 Cite journal author Eckert RL, Rorke EA title The sequence of the human epidermal 58 kD 5 type II keratin reveals an absence of 5 upstream sequence conservation between coexpressed epidermal keratins journal DNA volume 7 issue 5 pages 337 45 year 1988 month June pmid 2456903 doi url issn ref Function The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratin s consist of basic or neutral proteins which are arranged in pairs of heterotypic i.e., different types of keratin chains coexpressed during cellular differentiation differentiation of Epithelium Simple epithelium simple and Epithelium Stratified epithelium stratified epithelial tissues. The type II cytokeratin genes are clustered in a region of chromosome 12q12 q13. This type II cytokeratin is specifically expressed in the stratum germinativum basal layer of the epidermis skin epidermis with family member keratin 14 KRT14 . Clinical significance Mutations in these genes have been associated with a complex of diseases termed epidermolysis bullosa simplex . ref name pmid12655565 Cite journal author Schuilenga Hut PH, Vlies P, Jonkman MF, Waanders E, Buys CH, Scheffer H title Mutation analysis of the entire keratin 5 and 14 genes in patients with epidermolysis bullosa simplex and identification of novel mutations journal Hum. ... more details
that keratins are combined into hard and soft, or cytokeratin s and other keratins Clarify ..., Toh S, Komiyama S, Tsuneyoshi M. Mutation analysis of human cytokeratin 8 gene in malignant rhabdoid ... Y, et al. Subcellular distribution of cytokeratin and vimentin in malignant rhabdoid tumor cells three ... Keratosis pilaris Intermediate filament Desmosome Tinea versicolor Corneous cytokeratin Pachyonychia ... more details
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