cytidine and uridine , which are absorbed intact. ref name Jonas In humans, dietary cytidine is converted ... 2952 00 00436 6 doi 10.1016 S0006 2952 00 00436 6 ref which is probably the compound behind cytidine ... Category Pyrimidones Category Ribosides ca Citidina cs Cytidin de Cytidin es Citidina fr Cytidine it Citidina lt Citidinas hu Citidin nl Cytidine ja oc Citidina pt Citidina ru sl Citidin ... more details
PBB geneid 978 Cytidine deaminase is an enzyme that in humans is encoded by the CDA gene . ref name pmid8422236 ... cytidine deaminase CDD and its use as a marker of monocyte macrophage differentiation journal ... S, Bruschi M, Garattini E title Isolation and characterization of the gene coding for human cytidine ... 9878810 pmc doi ref ref name entrez cite web title Entrez Gene CDA cytidine deaminase url http www.ncbi.nlm.nih.gov ... of cytidine and deoxycytidine to uridine and deoxyuridine, respectively. It is one of several deaminases ... of certain childhood leukemias. ref name entrez cite web title Entrez Gene CDA cytidine deaminase ... R title On the interaction of 3,4,5,6 tetrahydrouridine with human liver cytidine deaminase. journal ... journal author Lalibert J, Momparler RL title Human cytidine deaminase purification of enzyme, cloning ... of the human cytidine deaminase CDA gene to chromosome 1 band p35 p36.2. journal Genomics volume ... by human cytidine deaminase requires the catalytic function of the protein. journal Blood volume ... A, et al. title Intracellular localization of human cytidine deaminase. Identification of a functional ... adenosine deaminase and cytidine deaminase activities in patients with systemic lupus erythematosus ... induced cytidine deaminase deaminates deoxycytidine on single stranded DNA but requires the action of RNase ... Expression of cytidine deaminase mRNA in bone marrow cells from patients with acute leukemia journal ... cytidine deaminase. journal Nucleosides Nucleotides Nucleic Acids volume 22 issue 5 8 pages 1535 ... A, et al. title Human cytidine deaminase understanding the catalytic mechanism. journal Nucleosides ... NCN 120023029 cite journal author Ge Y, Jensen TL, Stout ML, et al. title The role of cytidine deaminase ... al. title Functional properties of subunit interactions in human cytidine deaminase. journal Protein ... SJ, Fromme JC, Verdine GL title Structure of human cytidine deaminase bound to a potent inhibitor ... cytidine deaminase. journal Protein Eng. Des. Sel. volume 17 issue 12 pages 871 7 year 2005 pmid ... more details
cytidylyl . Metabolism CMP can be phosphorylated to Cytidine diphosphate by the enzyme CMP kinase ... group. Since Cytidine triphosphate is generated by amination of UTP uridine triphosphate , the main ... References reflist 2 Nucleobases, nucleosides, and nucleotides DEFAULTSORT Cytidine Monophosphate ... da Cytidinmonofosfat fr Cytidine monophosphate it Citosina monofosfato nl Cytidinemonofosfaat ja ... more details
chembox verifiedrevid 414402383 ImageFile Cytidindiphosphat protoniert.svg ImageSize IUPACName OtherNames Section1 Chembox Identifiers ChemSpiderID Ref chemspidercite correct chemspider ChemSpiderID 5902 InChI 1 C9H15N3O11P2 c10 5 1 2 12 9 15 11 5 8 7 14 6 13 4 22 8 3 21 25 19,20 23 24 16,17 18 h1 2,4,6 8,13 14H,3H2, H,19,20 H2,10,11,15 H2,16,17,18 t4 ,6 ,7 ,8 m1 s1 InChIKey ZWIADYZPOWUWEW XVFCMESIBF ChEMBL Ref ebicite correct EBI ChEMBL 425252 StdInChI Ref stdinchicite correct chemspider StdInChI 1S C9H15N3O11P2 c10 5 1 2 12 9 15 11 5 8 7 14 6 13 4 22 8 3 21 25 19,20 23 24 16,17 18 h1 2,4,6 8,13 14H,3H2, H,19,20 H2,10,11,15 H2,16,17,18 t4 ,6 ,7 ,8 m1 s1 StdInChIKey Ref stdinchicite correct chemspider StdInChIKey ZWIADYZPOWUWEW XVFCMESISA N CASNo 63 38 7 CASNo Ref cascite correct CAS CASOther br 34393 59 4 disodium salt NOT CAS verified PubChem 290 SMILES O P O O OP O O OC C H 2O C H N 1C O N C N C C 1 C H O C H 2O Section2 Chembox Properties Formula C sub 9 sub H sub 15 sub N sub 3 sub O sub 11 sub P sub 2 sub MolarMass 403.176422 Appearance Density MeltingPt BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition Cytidine diphosphate , abbreviated CDP , is a nucleotide . It is an ester of pyrophosphoric acid with the nucleoside cytidine . CDP consists of the pyrophosphate Functional group group , the pentose sugar ribose , and the nucleobase cytosine . See also Nucleoside Nucleotide DNA RNA Oligonucleotide External links Nucleobases, nucleosides, and nucleotides Category Nucleotides Category Pyrimidones biochem stub ca Difosfat de citidina da Cytidindifosfat de Cytidindiphosphat it Citosindifosfato nl Cytidinedifosfaat ja sr Citidin difosfat zh ... more details
Chembox ImageFile Cytidine diphosphate glucose.png ImageSize 200px IUPACName nowiki nowiki 2 R ,3 S ,4 R ,5 R 5 4 amino 2 oxopyrimidin 1 yl 3,4 dihydroxyoxolan 2 yl methoxy hydroxyphosphoryl 2 R ,3 R ,4 S ,5 S ,6 R 3,4,5 trihydroxy 6 hydroxymethyl oxan 2 yl hydrogen phosphate OtherNames CDP glucose Section1 Chembox Identifiers CASNo 2906 23 2 PubChem 439244 SMILES C1 CN C O N C1N C H 2 C H C H C H O2 COP O O OP O O O C H 3 C H C H C H C H O3 CO O O O O O Section2 Chembox Properties C 15 H 25 N 3 O 16 P 2 Appearance Density MeltingPt BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition Cytidine diphosphate glucose , often abbreviated CDP glucose , is a nucleotide linked sugar consisting of cytidine diphospahte and glucose. ref name Reeves cite journal author Samuel G, Reeves P title Biosynthesis of O antigens genes and pathways involved in nucleotide sugar precursor synthesis and O antigen assembly journal Carbohydr. Res. volume 338 issue 23 pages 2503 19 year 2003 pmid 14670712 doi 10.1016 j.carres.2003.07.009 ref ref name Liu cite journal doi 10.1146 annurev.biochem.71.110601.135339 author Xue M. He and Hung wen Liu title Formation of unusual sugars Mechanistic studies and biosynthetic applications journal Annu Rev Biochem volume 71 issue pages 701 754 year 2002 pmid 12045109 ref Biosynthesis CDP glucose is produced from cytidine triphosphate CTP and glucose 1 phosphate by the enzyme glucose 1 phosphate cytidylyltransferase . References reflist Nucleotide sugars Category biochemistry Category nucleotides ... more details
Activation Induced Cytidine Deaminase AID is a 24 kDa enzyme that creates deliberate mutations in DNA . AID removes the amino group from a cytidine base, turning it into a uridine which is recognized as a thymidine . In other words, it changes a CG base pair into a UG base pair, which the cell s DNA repair machinery recognizes as a TG base pair, and finally ends up as a TA base pair. In B cells in the lymph nodes, AID causes mutations that produce antibody diversity, but that same mutation process leads to B cell lymphoma. ref cite journal author Georg Lenz and Louis M. Staudt title Aggressive Lymphomas journal N Engl J Med volume 362 issue pages 1417 year 2010 pmid 20393178 doi url http content.nejm.org cgi content short 362 15 1417 ref AID is currently thought to be the master regulator of secondary antibody diversification. It is involved in the initiation of three separate immunoglobulin Ig diversification processes somatic hypermutation SHM , in which the antibody genes are shuffled to provide enough diversity to deal with millions of antigens class switch recombination CSR , in which B cells change their expression from IgM to IgG or other immune types and gene conversion GC . AID has been shown in vitro to be active on single stranded DNA ref Bransteitter et al. PNAS 100 7 4102 4107 ref , and has been shown to require active Transcription genetics transcription in order to exert its deaminating activity. The involvement of Cis regulatory factors is suspected as AID activity is several orders of magnitude higher in the immunoglobulin variable region than other regions of the genome that are known to be subject to AID activity. This is also true of artificial reporter constructs and transgene s that have been integrated into the genome . Mechanism AID is believed to initiate SHM in a multi step mechanism. AID deaminates cytidine in the target DNA. Cytidines located ..., C cytidine, Y pyrimidine, or the inverse RGYW G guanidine . The resultant U G U uridine mismatch is then subject ... more details
enzyme Name 4 cytidine 5 diphospho 2 C methyl D erythritol kinase EC number 2.7.1.148 CAS number IUBMB EC number 2 7 1 148 GO code 0050515 image width caption In enzymology , a 4 cytidine 5 diphospho 2 C methyl D erythritol kinase EC number 2.7.1.148 is an enzyme that catalysis catalyzes the chemical reaction ATP 4 cytidine 5 diphospho 2 C methyl D erythritol math rightleftharpoons math ADP 2 phospho 4 cytidine 5 diphospho 2 C methyl D erythritol Thus, the two substrate biochemistry substrates of this enzyme are adenosine triphosphate ATP and 4 cytidine 5 diphospho 2 C methyl D erythritol , whereas its two product chemistry products are adenosine diphosphate ADP and 2 phospho 4 cytidine 5 diphospho 2 C methyl D erythritol . This enzyme belongs to the family of transferase s, specifically those transferring phosphorus containing groups phosphotransferase s with an alcohol group as acceptor. The systematic name of this enzyme class is ATP 4 cytidine 5 diphospho 2 C methyl D erythritol 2 phosphotransferase . This enzyme is also called CDP ME kinase . This enzyme participates in biosynthesis of steroids . Structural studies As of late 2007, 7 tertiary structure structures have been solved for this class of enzymes, with Protein Data Bank PDB accession codes PDB link 1OJ4 , PDB link 1UEK , PDB link 2V2Q , PDB link 2V2V , PDB link 2V2Z , PDB link 2V34 , and PDB link 2V8P . References reflist 1 cite journal author Fellermeier M, Sagner S, Zenk MH, Bacher A, Eisenreich W date 2000 title Biosynthesis of terpenoids YchB protein of Escherichia coli phosphorylates the 2 hydroxy group of 4 diphosphocytidyl 2C methyl D erythritol journal Proc. Natl. Acad. Sci. U. S. A. volume 97 pages 1062&ndash 7 pmid 10655484 doi 10.1073 pnas.97.3.1062 issue 3 pmc 15522 cite journal author Seto H date 2000 title Studies on the nonmevalonate pathway conversion of 4 cytidine 5 diphospho 2 C methyl D erythritol to its 2 phospho derivative by 4 cytidine 5 diphospho 2 C methyl D erythritol kinase journal ... more details
enzyme Name N acylneuraminate cytidylyltransferase EC number 2.7.7.43 CAS number 9067 82 7 IUBMB EC number 2 7 7 43 GO code 0008781 image width caption In enzymology , a N acylneuraminate cytidylyltransferase EC number 2.7.7.43 is an enzyme that catalysis catalyzes the chemical reaction CTP N acylneuraminate math rightleftharpoons math diphosphate CMP N acylneuraminate Thus, the two substrate biochemistry substrates of this enzyme are cytidine triphosphate CTP and N acylneuraminate , whereas its two product chemistry products are diphosphate and CMP N acylneuraminate . This enzyme belongs to the family of transferase s, specifically those transferring phosphorus containing nucleotide groups nucleotidyltransferase s . The systematic name of this enzyme class is CTP N acylneuraminate cytidylyltransferase . Other names in common use include CMP sialate pyrophosphorylase , CMP sialate synthase , cytidine 5 monophosphosialic acid synthetase , CMP Neu5Ac synthetase , CMP NeuAc synthetase , acylneuraminate cytidyltransferase , CMP N acetylneuraminate synthetase , CMP N acetylneuraminate synthase , CMP N acetylneuraminic acid synthase , CMP NANA synthetase , CMP sialate synthetase , CMP sialic synthetase , cytidine 5 monophospho N acetylneuraminic acid synthetase , cytidine 5 monophosphate N acetylneuraminic acid synthetase , cytidine monophosphosialic acid synthetase , cytidine monophosphoacetylneuraminic synthetase , cytidine monophosphosialate pyrophosphorylase , cytidine monophosphosialate synthetase , and acetylneuraminate cytidylyltransferase . This enzyme participates in aminosugars metabolism . Structural studies As of late 2007, three tertiary structure structures have been solved for this class of enzymes, with Protein Data Bank PDB accession codes PDB link 1EYR , PDB link 1EZI , and PDB link 1QWJ . References reflist 1 cite journal author Kean EL, Roseman S date 1966 title The sialic acids. X. Purification and properties of cytidine 5 monophosphosialic acid synth ... more details
enzyme Name D ribitol 5 phosphate cytidylyltransferase EC number 2.7.7.40 CAS number 9027 07 0 IUBMB EC number 2 7 7 40 GO code 0047349 image width caption In enzymology , a D ribitol 5 phosphate cytidylyltransferase EC number 2.7.7.40 is an enzyme that catalysis catalyzes the chemical reaction CTP D ribitol 5 phosphate math rightleftharpoons math diphosphate CDP ribitol Thus, the two substrate biochemistry substrates of this enzyme are cytidine triphosphate CTP and D ribitol 5 phosphate , whereas its two product chemistry products are diphosphate and CDP ribitol . This enzyme belongs to the family of transferase s, specifically those transferring phosphorus containing nucleotide groups nucleotidyltransferase s . The systematic name of this enzyme class is CTP D ribitol 5 phosphate cytidylyltransferase . Other names in common use include CDP ribitol pyrophosphorylase , cytidine diphosphate ribitol pyrophosphorylase , ribitol 5 phosphate cytidylyltransferase , and cytidine diphosphoribitol pyrophosphorylase . This enzyme participates in pentose and glucuronate interconversions . References reflist 1 cite journal author Shaw DRD year 1962 title Pyrophosphorolysis and enzymic synthesis of cytidine diphosphate glycerol and cytidine diphosphate ribitol journal Biochem. J. volume 82 pages 297&ndash 312 pmid 13911452 pmc 1243453 Category EC 2.7.7 Category Enzymes of unknown structure enzyme stub ... more details
A ribonucleoside is a type of nucleoside including ribose as a component. ref MeshName Ribonucleosides ref An example is cytidine . References Reflist Nucleobases, nucleosides, and nucleotides Chem stub Category Nucleosides Category Ribosides fr Ribonucl oside nl Ribonucleoside sr Ribonukleozid ... more details
enzyme Name CDP abequose epimerase EC number 5.1.3.10 CAS number 37318 36 8 IUBMB EC number 5 1 3 10 GO code 0047732 image width caption In enzymology , a CDP paratose 2 epimerase EC number 5.1.3.10 is an enzyme that catalysis catalyzes the chemical reaction CDP 3,6 dideoxy D glucose math rightleftharpoons math CDP 3,6 dideoxy D mannose Hence, this enzyme has one substrate biochemistry substrate , CDP 3,6 dideoxy D glucose , and one product chemistry product , CDP 3,6 dideoxy D mannose . This enzyme belongs to the family of isomerase s, specifically those racemase s and epimerase s acting on carbohydrate s and derivatives. The systematic name of this enzyme class is CDP 3,6 dideoxy D glucose 2 epimerase . Other names in common use include CDP paratose epimerase , cytidine diphosphoabequose epimerase , cytidine diphosphodideoxyglucose epimerase , cytidine diphosphoparatose epimerase , and cytidine diphosphate paratose 2 epimerase . It is also incorrectly known as CDP abequose epimerase , and CDP D abequose 2 epimerase . This enzyme participates in starch and sucrose metabolism. It employs one cofactor biochemistry cofactor , NAD . References reflist 1 cite journal author Matsuhashi S date 1966 title Enzymatic synthesis of cytidine diphosphate 3,6 dideoxyhexoses. II Reversible 2 epimerization of cytidine diphosphate paratose journal J. Biol. Chem. volume 241 pages 4275&ndash 82 pmid 5924649 issue 18 cite journal author Liu HW, Thorson JS date 1994 title Pathways and mechanisms in the biogenesis of novel deoxysugars by bacteria journal Annu. Rev. Microbiol. volume 48 pages 223&ndash 56 pmid 7826006 doi 10.1146 annurev.mi.48.100194.001255 isomerase stub Category EC 5.1.3 Category NADH dependent enzymes Category Enzymes of unknown structure ... more details
enzyme Name CMP N acylneuraminate phosphodiesterase EC number 3.1.4.40 CAS number 55326 41 5 IUBMB EC number 3 1 4 40 GO code 0047392 image width caption In enzymology , a CMP N acylneuraminate phosphodiesterase EC number 3.1.4.40 is an enzyme that catalysis catalyzes the chemical reaction CMP N acylneuraminate H sub 2 sub O math rightleftharpoons math CMP N acylneuraminate Thus, the two substrate biochemistry substrates of this enzyme are CMP N acylneuraminate and water H sub 2 sub O , whereas its two product chemistry products are cytidine monophosphate CMP and N acylneuraminate . This enzyme belongs to the family of hydrolase s, specifically those acting on phosphoric ester diester bonds. The systematic name of this enzyme class is CMP N acylneuraminate N acylneuraminohydrolase . Other names in common use include CMP sialate hydrolase , CMP sialic acid hydrolase , CMP N acylneuraminic acid hydrolase , cytidine monophosphosialic hydrolase , cytidine monophosphosialate hydrolase , cytidine monophosphate N acetylneuraminic acid hydrolase , and CMP N acetylneuraminate hydrolase . References reflist 1 cite journal author Kean EL, Bighouse KJ date 1974 title Cytidine 5 monophosphosialic acid hydrolase. Subcellular location and properties journal J. Biol. Chem. volume 249 pages 7813&ndash 23 pmid 4372219 issue 24 hydrolase stub Category EC 3.1.4 Category Enzymes of unknown structure ... more details
enzyme Name CDP diacylglycerol serine O phosphatidyltransferase EC number 2.7.8.8 CAS number 9068 48 8 IUBMB EC number 2 7 8 8 GO code 0003882 image width caption In enzymology , a CDP diacylglycerol serine O phosphatidyltransferase EC number 2.7.8.8 is an enzyme that catalysis catalyzes the chemical reaction CDP diacylglycerol L serine math rightleftharpoons math CMP 3 sn phosphatidyl L serine Thus, the two substrate biochemistry substrates of this enzyme are CDP diacylglycerol and L serine , whereas its two product chemistry products are cytidine monophosphate CMP and 3 sn phosphatidyl L serine . This enzyme belongs to the family of transferase s, specifically those transferring non standard substituted phosphate groups. The systematic name of this enzyme class is CDP diacylglycerol L serine 3 sn phosphatidyltransferase . Other names in common use include phosphatidylserine synthase , CDPdiglyceride serine O phosphatidyltransferase , PS synthase , cytidine 5 diphospho 1,2 diacyl sn glycerol , CDPdiglyceride L serine O phosphatidyltransferase , phosphatidylserine synthetase , CDP diacylglycerol L serine O phosphatidyltransferase , cytidine diphosphoglyceride serine O phosphatidyltransferase , CDP diglyceride L serine phosphatidyltransferase , CDP diglyceride serine phosphatidyltransferase , cytidine 5 diphospho 1,2 diacyl sn glycerol L serine , O phosphatidyltransferase , and CDP diacylglycerol L serine 3 O phosphatidyltransferase . This enzyme participates in glycine, serine and threonine metabolism and glycerophospholipid metabolism . References reflist 1 cite journal author Larson TJ, Dowhan W date 1976 title Ribosomal associated phosphatidylserine synthetase from Escherichia coli purification by substrate specific elution from phosphocellulose using cytidine 5 diphospho 1,2 diacyl sn glycerol journal Biochemistry. volume 15 pages 5212&ndash 8 pmid 187212 doi 10.1021 bi00669a003 issue 24 cite journal author Raetz CR, Kennedy EP date 1974 title Partial purificati ... more details
enzyme Name glycerol 3 phosphate cytidylyltransferase EC number 2.7.7.39 CAS number 9027 11 6 IUBMB EC number 2 7 7 39 GO code 0047348 image width caption In enzymology , a glycerol 3 phosphate cytidylyltransferase EC number 2.7.7.39 is an enzyme that catalysis catalyzes the chemical reaction CTP sn glycerol 3 phosphate math rightleftharpoons math diphosphate CDP glycerol Thus, the two substrate biochemistry substrates of this enzyme are cytidine triphosphate CTP and sn glycerol 3 phosphate , whereas its two product chemistry products are diphosphate and CDP glycerol . This enzyme belongs to the family of transferase s, specifically those transferring phosphorus containing nucleotide groups nucleotidyltransferase s . The systematic name of this enzyme class is CTP sn glycerol 3 phosphate cytidylyltransferase . Other names in common use include CDP glycerol pyrophosphorylase , cytidine diphosphoglycerol pyrophosphorylase , cytidine diphosphate glycerol pyrophosphorylase , CTP glycerol 3 phosphate cytidylyltransferase , and Gro PCT . This enzyme participates in glycerophospholipid metabolism . Structural studies As of late 2007, 3 tertiary structure structures have been solved for this class of enzymes, with Protein Data Bank PDB accession codes PDB link 1COZ , PDB link 1N1D , and PDB link 2B7L . References reflist 1 cite journal author Shaw DRD year 1962 title Pyrophosphorolysis and enzymic synthesis of cytidine diphosphate glycerol and cytidine diphosphate ribitol journal Biochem. J. volume 82 pages 297&ndash 312 pmid 13911452 pmc 1243453 Category EC 2.7.7 Category Enzymes of known structure enzyme stub ... more details
enzyme Name CDP glycerol diphosphatase EC number 3.6.1.16 CAS number 37289 28 4 IUBMB EC number 3 6 1 16 GO code 0047734 image width caption In enzymology , a CDP glycerol diphosphatase EC number 3.6.1.16 is an enzyme that catalysis catalyzes the chemical reaction CDP glycerol H sub 2 sub O math rightleftharpoons math CMP sn glycerol 3 phosphate Thus, the two substrate biochemistry substrates of this enzyme are CDP glycerol and water H sub 2 sub O , whereas its two product chemistry products are cytidine monophosphate CMP and sn glycerol 3 phosphate . This enzyme belongs to the family of hydrolase s, specifically those acting on acid anhydrides in phosphorus containing anhydrides. The systematic name of this enzyme class is CDP glycerol phosphoglycerohydrolase . Other names in common use include CDP glycerol pyrophosphatase , and cytidine diphosphoglycerol pyrophosphatase . This enzyme participates in glycerophospholipid metabolism . References reflist 1 cite journal author GLASER L date 1965 title THE SYNTHESIS OF TEICHOIC ACID. IV. ON THE REGULATION OF CYTIDINE 5 DIPHOSPHATEGLYCEROL CONCENTRATION journal Biochim. Biophys. Acta. volume 101 pages 6&ndash 15 pmid 14329291 hydrolase stub Category EC 3.6.1 Category Enzymes of unknown structure ... more details
enzyme Name CDP glucose 4,6 dehydratase EC number 4.2.1.45 CAS number 37259 55 5 IUBMB EC number 4 2 1 45 GO code 0047733 image width caption In the field of enzymology , a CDP glucose 4,6 dehydratase is an enzyme that catalysis catalyzes the chemical reaction Cytidine diphosphate glucose CDP glucose math rightleftharpoons math CDP 4 dehydro 6 deoxy D glucose H sub 2 sub O Hence, this enzyme has one substrate biochemistry substrate , cytidine diphosphate glucose CDP glucose , and two product chemistry products , CDP 4 dehydro 6 deoxy D glucose and water H sub 2 sub O . This enzyme belongs to the family of lyase s, specifically the hydro lyases, which cleave carbon oxygen bonds. This enzyme participates in starch and sucrose metabolism . It employs one cofactor biochemistry cofactor , Nicotinamide adenine dinucleotide NAD . Nomenclature The systematic name of this enzyme class is CDP glucose 4,6 hydro lyase CDP 4 dehydro 6 deoxy D glucose forming . Other names in common use include cytidine diphosphoglucose oxidoreductase, and CDP glucose 4,6 hydro lyase. Structural studies As of late 2007, two tertiary structure structures have been solved for this class of enzymes, with Protein Data Bank PDB accession codes PDB link 1RKX and PDB link 1WVG . References reflist 1 cite journal author Hey AE, Elbein AD date 1966 title Biosynthesis of tyvelose. The purification and properties of cytidine diphosphate D glucose oxidoreductase journal J. Biol. Chem. volume 241 pages 5473&ndash 8 pmid 4380946 issue 22 cite journal author Matsuhashi S, Matsuhashi M, Brown JG, Strominger JL date 1966 title Enzymatic synthesis of cytidine diphosphate 3,6 dideoxyhexoses. 3 Cytidine diphosphate D glucose oxidoreductase journal J. Biol. Chem. volume 241 pages 4283&ndash 7 pmid 4288651 issue 18 cite journal author Melo A, Elliott WH, Glaser L date 1968 title The mechanism of 6 deoxyhexose synthesis. I. Intramolecular hydrogen transfer catalyzed by deoxythymidine diphosphate D glucose oxidoreductas ... more details
enzyme Name CDP diacylglycerol inositol 3 phosphatidyltransferase EC number 2.7.8.11 CAS number 9027 01 4 IUBMB EC number 2 7 8 11 GO code 0003881 image width caption In enzymology , a CDP diacylglycerol inositol 3 phosphatidyltransferase EC number 2.7.8.11 is an enzyme that catalysis catalyzes the chemical reaction CDP diacylglycerol myo inositol math rightleftharpoons math CMP phosphatidyl 1D myo inositol Thus, the two substrate biochemistry substrates of this enzyme are CDP diacylglycerol and myo inositol , whereas its two product chemistry products are cytidine monophosphate CMP and phosphatidyl 1D myo inositol . This enzyme belongs to the family of transferase s, specifically those transferring non standard substituted phosphate groups. The systematic name of this enzyme class is CDP diacylglycerol myo inositol 3 phosphatidyltransferase . Other names in common use include CDP diglyceride inositol phosphatidyltransferase , phosphatidylinositol synthase , CDP diacylglycerol inositol phosphatidyltransferase , CDP diglyceride inositol transferase , cytidine 5 diphospho 1,2 diacyl sn glycerol myo inositol , 3 phosphatidyltransferase , CDP DG inositol transferase , cytidine diphosphodiglyceride inositol phosphatidyltransferase , CDP diacylglycerol myo inositol 3 phosphatidyltransferase , CDP diglyceride inositol transferase , cytidine diphosphoglyceride inositol phosphatidyltransferase , and cytidine diphosphoglyceride inositol transferase . This enzyme participates in glycerophospholipid metabolism and phosphatidylinositol signaling system . References reflist 1 cite journal author Bleasdale JE, Wallis P, MacDonald PC, Johnston JM date 1979 title Characterization of the forward and reverse reactions catalyzed by CDP diacylglycerol inositol transferase in rabbit lung tissue journal Biochim. Biophys. Acta. volume 575 pages 135&ndash 47 pmid 41587 issue 1 cite journal author Prottey C, Hawthorne JN date 1967 title The biosynthesis of phosphatidic acid and phosphatidyli ... more details
enzyme Name glucose 1 phosphate cytidylyltransferase EC number 2.7.7.33 CAS number 9027 10 5 IUBMB EC number 2 7 7 33 GO code 0047343 image width caption In enzymology , a glucose 1 phosphate cytidylyltransferase EC number 2.7.7.33 is an enzyme that catalysis catalyzes the chemical reaction CTP alpha D glucose 1 phosphate math rightleftharpoons math diphosphate CDP glucose Thus, the two substrate biochemistry substrates of this enzyme are cytidine triphosphate CTP and alpha D glucose 1 phosphate , whereas its two product chemistry products are diphosphate and CDP glucose . ref name Reeves cite journal author Samuel G, Reeves P title Biosynthesis of O antigens genes and pathways involved in nucleotide sugar precursor synthesis and O antigen assembly journal Carbohydr. Res. volume 338 issue 23 pages 2503 19 year 2003 pmid 14670712 doi 10.1016 j.carres.2003.07.009 ref ref name Liu cite journal author Xue M. He and Hung wen Liu title Formation of unusual sugars Mechanistic studies and biosynthetic applications journal Annu Rev Biochem volume 71 issue pages 701 754 year 2002 doi 10.1146 annurev.biochem.71.110601.135339 pmid 12045109 ref This enzyme belongs to the family of transferase s, specifically those transferring phosphorus containing nucleotide groups nucleotidyltransferase s . The systematic name of this enzyme class is CTP alpha D glucose 1 phosphate cytidylyltransferase . Other names in common use include CDP glucose pyrophosphorylase , cytidine diphosphoglucose pyrophosphorylase , cytidine diphosphate glucose pyrophosphorylase , cytidine diphosphate D glucose pyrophosphorylase , and CTP D glucose 1 phosphate cytidylyltransferase . This enzyme participates in starch and sucrose metabolism and nucleotide sugars metabolism . ref cite journal author MAYER RM, GINSBURG V year 1965 title PURIFICATION AND PROPERTIES OF CYTIDINE DIPHOSPHATE D GLUCOSE PYROPHOSPHORYLASE FROM SALMONELLA PARATYPHI A journal J. Biol. Chem. volume 240 pages 1900&ndash 4 pmid 14299608 ref St ... more details
PBB geneid 57379 Activation induced cytidine deaminase , also known as AICDA and AID, is an enzyme which in humans is encoded by the AICDA gene . ref name entrez cite web title Entrez Gene AICDA activation induced cytidine deaminase url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 57379 accessdate ref Function This gene encodes a RNA editing deaminase that is a member of the cytidine deaminase family. The protein is involved in somatic hypermutation, gene conversion, and class switch recombination of immunoglobulin genes. ref name entrez Recently, AICDA has been implicated in active DNA demethylation. AICDA can deaminate 5 methylcytosine, which can then be replaced with cytosine by base excision repair. ref cite journal author Morgan HD, Dean W, Coker HA, Reik W, Petersen Mahrt SK year 2004 title Activation induced Cytidine Deaminase Deaminates 5 Methylcytosine ... IgM syndrome type 2 . See also Activation Induced Cytidine Deaminase References reflist Further ... First AID activation induced cytidine deaminase is needed to produce high affinity isotype switched ... distribution, and chromosomal localization of the human activation induced cytidine deaminase AID ... cite journal author Revy P, Muto T, Levy Y, et al. title Activation induced cytidine deaminase ... induced cytidine deaminase in patients with hyper IgM syndrome journal Clin. Immunol. volume ... M, Inudou M, et al. title Association between a new polymorphism in the activation induced cytidine ... cite journal author Martin A, Bardwell PD, Woo CJ, et al. title Activation induced cytidine deaminase ... of activation induced cytidine deaminase in human B cell non Hodgkin lymphomas journal Blood ... journal author Bransteitter R, Pham P, Scharff MD, Goodman MF title Activation induced cytidine deaminase ... syndrome caused by mutation in activation induced cytidine deaminase journal J. Med. Dent. Sci. volume ... M, et al. title Human activation induced cytidine deaminase causes transcription dependent, strand ... more details
enzyme Name CTP synthase EC number 6.3.4.2 CAS number 9023 56 7 IUBMB EC number 6 3 4 2 GO code 0003883 image width caption CTP synthase or CTP synthetase is an enzyme involved in pyrimidine biosynthesis . ref name pmid13367044 cite journal author Lieberman I title Enzymatic amination of uridine triphosphate to cytidine triphosphate journal J. Biol. Chem. volume 222 issue 2 pages 765 75 year 1956 month October pmid 13367044 doi url issn ref ref name pmid5411547 cite journal author Long CW, Levitzki A, Koshland DE title The subunit structure and subunit interactions of cytidine triphosphate synthetase journal J. Biol. Chem. volume 245 issue 1 pages 80 7 year 1970 month January pmid 5411547 doi url issn ref It intraconverts Uridine triphosphate UTP and Cytidine triphosphate CTP . The source of the amine amino group in Cytidine triphosphate CTP is glutamine . CTP synthase is activated by Guanosine triphosphate GTP , a purine . This acts to balance the relative amounts of purine and pyrimidine nucleotides. CTP synthase is inhibited by reversible by Cytidine triphosphate CTP and irreversible for example by the glutamine analogon 6 Diazo 5 oxo L norleucine DON . ref name pmid2108451 cite journal author Ahluwalia GS, Grem JL, Hao Z, Cooney DA title Metabolism and action of amino acid analog anti cancer agents journal Pharmacol. Ther. volume 46 issue 2 pages 243 71 year 1990 pmid 2108451 doi 10.1016 0163 7258 90 90094 I url issn ref gallery Image Uridintriphosphat2.svg Uridine triphosphate UTP Image CTP chemical structure.png Cytidine triphosphate CTP Note nitrogen in upper right. Ignore rotation. gallery Isozymes The following human genes encode proteins that possess CTP synthase activity CTP synthase 1 CTPS CTP synthase 1 CTPS2 CTP synthase 2 Cytoophidium The cytoophidium Greek cyto , meaning cell, and ophidium , meaning serpent is a snake like filamentary structure containing CTP synthase. It was first reported in the fruit flies Drosophila melanogaster D. melanogaster , ... more details
journal author Kuzuyama T, Takagi M, Kaneda K, Dairi T and Seto H year 2000 title Formation of 4 cytidine ... K, Eisenreich W, Bacher A, Zenk MH year 1999 title Cytidine 5 triphosphate dependent biosynthesis ... more details
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