chembox verifiedrevid 443554099 ImageFile Ref chemboximage correct ?? ImageFile Cysteamine 2D skeletal.png ImageName Skeletal formula ImageFile1 Cysteamine 3D balls.png ImageName1 Ball and stick model IUPACName 2 aminoethanethiol OtherNames mercaptoethylamine br 2 aminoethanethiol br 2 mercaptoethylamine br decarboxycysteine br thioethanolamine Section1 Chembox Identifiers ChemSpiderID Ref chemspidercite correct chemspider ChemSpiderID 5834 ChEMBL Ref ebicite correct EBI ChEMBL 602 UNII Ref fdacite correct FDA UNII 5UX2SD1KE2 KEGG Ref keggcite correct kegg KEGG D03634 InChI 1 C2H7NS c3 1 2 4 h4H,1 3H2 InChIKey UFULAYFCSOUIOV UHFFFAOYAX StdInChI Ref stdinchicite correct chemspider StdInChI 1S C2H7NS c3 1 2 4 h4H,1 3H2 StdInChIKey Ref stdinchicite correct chemspider StdInChIKey UFULAYFCSOUIOV UHFFFAOYSA N CASNo 60 23 1 CASNo Ref cascite correct CAS CASNo1 156 57 0 CASNo1 Comment hydrochloride HCl PubChem 6058 DrugBank Ref drugbankcite correct drugbank DrugBank DB00847 ChEBI Ref ebicite correct EBI ChEBI 17141 SMILES SCCN Section2 Chembox Properties C 2 H 7 N 1 S 1 Appearance Density MeltingPt 95 97 ° C BoilingPt Solubility Section3 Chembox Hazards EUClass Hazchem Xn ExternalMSDS http msds.chem.ox.ac.uk CY cysteamine.html External MSDS SPhrases S26 S36 Autoignition Cysteamine is the chemical compound with the formula HSCH sub 2 sub CH sub 2 sub NH sub 2 sub . It is the simplest ... Under the trade name Cystagon, cysteamine is used in the treatment of disorders of cystine excretion. Cysteamine cleaves the disulfide bond with cystine to produce molecules that can escape the metabolic ... protective effectiveness of low doses of cysteamine, heparin, and naphtizine in experiments ... nauk volume 41 issue 3 pages 310 2 year 2001 pmid 11458646 doi ref Cysteamine is used in the body to form ... of cysteamine bitartrate for Huntington s disease . DR Cysteamine is also being investigated ... nl Cysteamine ja pl Cysteamina ... more details
enzyme Name cysteamine dioxygenase EC number 1.13.11.19 CAS number 9033 41 4 IUBMB EC number 1 13 11 19 GO code 0047800 image width caption In enzymology , a cysteamine dioxygenase EC number 1.13.11.19 is an enzyme that catalysis catalyzes the chemical reaction 2 aminoethanethiol O sub 2 sub math rightleftharpoons math hypotaurine Thus, the two substrate biochemistry substrates of this enzyme are 2 aminoethanethiol and oxygen O sub 2 sub , whereas its product chemistry product is hypotaurine . This enzyme belongs to the family of oxidoreductase s, specifically those acting on single donors with O sub 2 sub as oxidant and incorporation of two atoms of oxygen into the substrate oxygenases . The oxygen incorporated need not be derived from O sub 2 sub . The systematic name of this enzyme class is 2 aminoethanethiol oxygen oxidoreductase . Other names in common use include persulfurase , cysteamine oxygenase , and cysteamine oxygen oxidoreductase . This enzyme participates in taurine and hypotaurine metabolism . It employs one cofactor biochemistry cofactor , iron . References reflist 1 cite journal author Cavallini D, De Marco C, Scandurra R, Dupre S, Graziani MT date 1966 title The enzymatic oxidation of cysteamine to hypotaurine. Purification and properties of the enzyme journal J. Biol. Chem. volume 241 pages 3189&ndash 96 pmid 5912113 issue 13 cite journal author Wood JL, Cavallini D date 1967 title Enzymic oxidation of cysteamine to hypotaurine in the absence of a cofactor journal Arch. Biochem. Biophys. volume 119 pages 368&ndash 72 pmid 6052430 doi 10.1016 0003 9861 67 90467 5 issue 1 cite journal author Cavallini D, Federici G, Ricci G, Dupre S, Antonucci A date 1975 title The specificity of cysteamine oxygenase journal FEBS Lett. volume 56 pages 348&ndash 51 pmid 1157952 doi 10.1016 0014 5793 75 81124 0 issue 2 cite journal author Richerson RB, Ziegler DM date 1987 ... doi 10.1016 0076 6879 87 43071 1 chapter Cysteamine dioxygenase series Methods in Enzymology isbn ... more details
ref Treatment Cystinosis is normally treated with a drug called cysteamine brand name Cystagon . ref ..., James J. Schlesselman, Ph.D., Brian J. Corden, M.D., and Jerry A. Schneider, M.D. title Cysteamine ... of cysteamine can reduce the intracellular cystine content. Cysteamine concentrates inside the lysosomes and reacts with cystine to form both cysteine and a cysteine cysteamine complex, which are able to leave the lysosomes. When administered regularly, cysteamine decreases the amount of cystine stored ... Cysteamine eyedrops remove the cystine crystals in the cornea that can cause photophobia if left ... more details
selfref In Wikipedia, MEA can refer to Wikipedia WikiProject Missing encyclopedic articles MEA or Mea may refer to Manx Electricity Authority Materials and Equipment Acceptance, an agency that examines and provides approval for certain manufactured equipment for use in New York City Membrane Electrode Assembly , part of a PEM fuel cell Cysteamine Mercaptoethylamine 2 , an organic chemical compound Urban Employment Area Top 100 Urban Employment Areas in Japan Metropolitan Employment Area , a type of Urban Employment Area as defined by the Center for Spatial Information Service, the University of Tokyo Michigan Education Association Middle East Airlines , flag carrier of Lebanon Middle East & Africa Region Little League World Series Middle East & Africa Region of Little League World Series in baseball Middle East and Asia Millennium Ecosystem Assessment Minimum Enroute Altitude , the recommended minimum altitude for a segment of an Airway aviation airway Ministry of External Affairs Minnesota Education Association Monoethanolamine , an organic chemical compound Multielectrode array or multi electrode array to record activity from populations of neuron s Multilateral Environmental Agreement People Ivan Della Mea Mea, Ivan Della 1940 2009 , Italian singer Fictional characters Mea, a maid for three sisters in the anime & eroge game List of Popotan characters Popotan disambig de MEA es MEA eo MEA fa MEA fr MEA ko MEA it MEA ja MEA pl MEA sr MEA ... more details
distinguish pantethine Unreferenced stub auto yes date December 2009 Chembox verifiedrevid 400841488 ImageFile Pantetheine structure.png ImageSize IUPACName 2R 2,4 Dihydroxy 3,3 dimethyl N 2 2 sulfanylethylcarbamoyl ethyl butanamide OtherNames R Pantetheine Section1 Chembox Identifiers InChI 1 C11H22N2O4S c1 11 2,7 14 9 16 10 17 13 4 3 8 15 12 5 6 18 h9,14,16,18H,3 7H2,1 2H3, H,12,15 H,13,17 InChIKey ZNXZGRMVNNHPCA UHFFFAOYAV StdInChI Ref stdinchicite correct chemspider StdInChI 1S C11H22N2O4S c1 11 2,7 14 9 16 10 17 13 4 3 8 15 12 5 6 18 h9,14,16,18H,3 7H2,1 2H3, H,12,15 H,13,17 StdInChIKey Ref stdinchicite correct chemspider StdInChIKey ZNXZGRMVNNHPCA UHFFFAOYSA N CASNo 496 65 1 PubChem 479 ChemSpiderID Ref chemspidercite correct chemspider ChemSpiderID 466 SMILES O C NCCS CCNC O C O C C C CO Section2 Chembox Properties Formula C sub 11 sub H sub 22 sub N sub 2 sub O sub 4 sub S MolarMass 278.369 g mol Appearance Density MeltingPt BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition Pantetheine is the cysteamine amide analog chemistry analogue of pantothenic acid vitamin B sub 5 sub . The dimer of this compound, pantethine is more commonly known, and is considered to be a more potent form of vitamin B sub 5 sub than pantothenic acid. Pantetheine is an intermediate in the production of coenzyme A by the body. Vitamin Category Amides Category Thiols Category Vitamins Category Alcohols fr Pant th ine alcohol stub ... more details
distinguish cysteamine Orphan date February 2009 chembox Watchedfields changed verifiedrevid 409739949 ImageFile cystamine.svg ImageSize 200px IUPACName 2,2 Dithiobis ethylamine OtherNames 2,2 Dithiobisethanamine br 2 Aminoethyl disulfide br Decarboxycystine Section1 Chembox Identifiers Abbreviations AED UNII Ref fdacite correct FDA UNII R110LV8L02 InChIKey APQPRKLAWCIJEK UHFFFAOYAQ ChEMBL Ref ebicite correct EBI ChEMBL 61350 StdInChI Ref stdinchicite correct chemspider StdInChI 1S C4H12N2S2 c5 1 3 7 8 4 2 6 h1 6H2 StdInChIKey Ref stdinchicite correct chemspider StdInChIKey APQPRKLAWCIJEK UHFFFAOYSA N CASNo Ref cascite correct CAS CASNo 51 85 4 ChemSpiderID Ref chemspidercite correct chemspider ChemSpiderID 2812 EINECS PubChem 2915 SMILES S SCCN CCN InChI 1 C4H12N2S2 c5 1 3 7 8 4 2 6 h1 6H2 RTECS MeSHName ChEBI Ref ebicite correct EBI ChEBI KEGG Ref keggcite correct kegg KEGG ATCCode prefix ATCCode suffix ATC Supplemental Section2 Chembox Properties Formula C sub 4 sub H sub 12 sub N sub 2 sub S sub 2 sub MolarMass 152.28 g mol ref Merck Index , 12th Edition, 2846 . ref Appearance Viscous oil Density MeltingPt Melting notes BoilingPt Decomposes Boiling notes Solubility Miscible SolubleOther Soluble Solvent Ethanol pKa pKb Section7 Chembox Hazards EUClass EUIndex MainHazards NFPA H NFPA F NFPA R NFPA O RPhrases SPhrases RSPhrases FlashPt Autoignition ExploLimits PEL Cystamine is an organic disulfide bond disulfide . It is formed when cystine is heated, the result of decarboxylation . Cystamine is an unstable liquid and is generally handled as the dihydrochloride salt, C sub 4 sub H sub 12 sub N sub 2 sub S sub 2 sub 2HCl, which is stable to 203 214 C at which point it decomposes. Cystamine is toxic if swallowed or inhaled and potentially harmful by contact. References Reflist Category Amines Category Organic disulfides organic compound stub ca Cistamina ja ru sr Cistamin zh ... more details
italictitle taxobox name Lithocarpus glaber image Lithocarpus glaber SZ89.png image caption Lithocarpus glaber illustration in Flora Japonica, Sectio Prima Tafelband regnum Plant ae unranked divisio Angiosperms unranked classis Eudicots unranked ordo Rosids ordo Fagales familia Fagaceae genus Lithocarpus species L. glaber binomial Lithocarpus glaber binomial authority Carl Peter Thunberg Thunb. Takenoshin Nakai Nakai subdivision ranks Subspecies synonyms Pasania glabra Thunb. Oerst. br Quercus glabra Thunb Lithocarpus glaber , the Japanese oak, is a tree species in the genus Lithocarpus found in Japan, China and Ta wan. Mitami Shrine , a Shinto shrine in Sakai, Osaka Prefecture, Japan, is famous locally for its comparatively large population of Lithocarpus glaber, known as Shiribukagashi . In China, it is called ke . Condensed tannin s from L. glaber leaves have been analysed through acid catalyzed degradation in the presence of cysteamine and have a potent free radical scavenging activity. ref http www.mdpi.com 1420 3049 13 12 2986 pdf HPLC, NMR and MALDI TOF MS analysis of condensed tannins from Lithocarpus glaber leaves with potent free radical scavenging activity. Liang Liang Zhang and Yi Ming Lin, 2008 ref References reflist External links wikispecies commons http www.ars grin.gov cgi bin npgs html taxon.pl?22407 Lithocarpus glaber on www.ars grin.gov Category Lithocarpus glaber Category Plants described in 1916 Fagales stub de Lithocarpus glaber ja zh ... more details
Infobox protein family Symbol ACPS Name ACPS image PDB 1qr0 EBI.jpg width caption crystal structure of the 4 phosphopantetheinyl transferase sfp coenzyme a complex Pfam PF01648 Pfam clan InterPro IPR008278 SMART PROSITE MEROPS SCOP 1qr0 TCDB OPM family OPM protein CAZy CDD In molecular biology, the 4 phosphopantetheinyl transferase superfamily of protein s ACPS transfer the 4 phosphopantetheine 4 PP moiety from coenzyme A CoA to the invariant serine of pp binding. This post translational modification renders holo ACP capable of acyl group activation via thioesterification of the cysteamine thiol of 4 PP. ref name pmid7559576 cite journal author Lambalot RH, Walsh CT title Cloning, overproduction, and characterization of the Escherichia coli holo acyl carrier protein synthase journal J. Biol. Chem. volume 270 issue 42 pages 24658 61 year 1995 month October pmid 7559576 doi 10.1074 jbc.270.42.24658 url ref This superfamily consists of two subtypes The ACPS type such as E. coli ACPS and the Sfp type such as B. subtilis SFP. The secondary structure structure of the Sfp type is known, ref name pmid10581256 cite journal author Reuter K, Mofid MR, Marahiel MA, Ficner R title Crystal structure of the surfactin synthetase activating enzyme sfp a prototype of the 4 phosphopantetheinyl transferase superfamily journal EMBO J. volume 18 issue 23 pages 6823 31 year 1999 month December pmid 10581256 pmc 1171745 doi 10.1093 emboj 18.23.6823 url ref which shows the active site accommodates a magnesium ion . The most highly conservation genetics conserved regions of the protein are involved in Binding molecular binding the magnesium ion . References reflist InterPro content IPR008278 Category Protein families ... more details
chembox verifiedrevid 448615665 ImageFile 4,5 Dihydrothiazole.svg ImageSize 100px IUPACName 4,5 dihydro 1,3 thiazole OtherNames 4,5 Dihydrothiazole Section1 Chembox Identifiers CASNo Ref cascite correct ?? CASNo 504 79 0 PubChem 120269 SMILES C1CSC N1 Section2 Chembox Properties Formula C sub 3 sub H sub 5 sub NS MolarMass Appearance colourless liquid Density MeltingPt BoilingPt 135 8 C Solubility Section3 Chembox Hazards MainHazards FlashPt NFPA H NFPA F NFPA R Autoignition Thiazoline is a heterocyclic compound containing both sulfur and nitrogen in the ring. Although thiazoline itself is rarely encountered, its derivatives are often bioactive. For example, in a common post translational modification , cysteine residues are converted into thiazolines. ref Walsh, Christopher T. Nolan, Elizabeth M. Morphing peptide backbones into heterocycles Proceedings of the National Academy of Sciences USA 2008, volume 105, 5655 5656. doi 10.1073 pnas.0802300105 ref Synthesis Thiazolines were first prepared by di alkylation of thioamide s. ref Richard Willst tter , Theodor Wirth ber Thioformamid Chem. Ber. 1909, volume 42, 1908 1922. DOI 10.1002 cber.19090420267 ref More commonly, they are prepared from derivatives of 2 aminoethanethiol cysteamine . File 2 Thiazoline, 3 Thiazoline und 4 Thiazoline.png thumb right 300px Isomeric heterocyclic compounds 2 thiazoline, 3 thiazoline and 4 thiazoline from left to right . R is an organyl residue. Related compounds Three related classes of C sub 3 sub NS heterocycles are well studied, 1,3 thiazoles parent C sub 3 sub H sub 3 sub NS , 1,3 thiazolines parent C sub 3 sub H sub 5 sub NS , and 1,3 thiazolidines parent C sub 3 sub H sub 7 sub NS . The naming is analogous to the C3N2 heterocycles, imidazoles, imidazolines, and imidazolidines. Substituted thiazolines Many molecules contain thiazoline rings, one example being luciferin , the light emitting molecule in fireflies . The amino acid cysteine is produced industrially from substituted t ... more details
DISPLAYTITLE BDTH sub 2 sub Chembox verifiedrevid 399537633 Name BDTH sub 2 sub ImageFile BDTH2.png ImageSize 200px ImageAlt Central benzene ring, with two identical strings of CNCCCS attached to non adjacent carbon atoms in the ring the first C in each string is double bonded to an O. IUPACName N , N&prime bis 2 mercaptoethyl isophthalamide OtherNames BDET BDETH sub 2 sub N , N&prime Bis 2 mercaptoethyl 1,3 benzenedicarboxamide Section1 Chembox Identifiers MeSHName 1,3 benzenediamidoethanethiol InChI 1 C12H16N2O2S2 c15 11 13 4 6 17 9 2 1 3 10 8 9 12 16 14 5 7 18 h1 3,8,17 18H,4 7H2, H,13,15 H,14,16 InChIKey JUTBAVRYDAKVGQ UHFFFAOYAW SMILES1 O C NCCS c1cccc c1 C O NCCS StdInChI Ref stdinchicite correct chemspider StdInChI 1S C12H16N2O2S2 c15 11 13 4 6 17 9 2 1 3 10 8 9 12 16 14 5 7 18 h1 3,8,17 18H,4 7H2, H,13,15 H,14,16 StdInChIKey Ref stdinchicite correct chemspider StdInChIKey JUTBAVRYDAKVGQ UHFFFAOYSA N CASNo Ref cascite correct ?? CASNo 351994 94 0 ChemSpiderID Ref chemspidercite correct chemspider ChemSpiderID 19238563 PubChem SMILES O C NCCS C1 CC C NCCS O CC C1 Section2 Chembox Properties C 12 H 16 N 2 O 2 S 2 Appearance Density MeltingPt 132 135 C ref name Blue BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition BDTH sub 2 sub also called BDET and BDETH sub 2 sub trade names B9 , MetX and OSR 1 is an organosulfur compound that is used as a chelation agent. It is a colourless solid. The molecule consists of two thiol functional group groups and linked via a pair of amide groups. The compound is banned in the US as a treatment of autism , ref name Tsouderos despite a marketing campaign aimed at parents of children with this disorder. Preparation This compound is prepared by treating cysteamine with isophthalic acid isophthaloyl dichloride to give the desired amide ref name Blue File Preparation of BDTH2.png frameless upright 2 Isophthaloyl dichloride 2 cysteamine BDTH2 Potential applications Like most thiols, BDTH sub 2 sub binds to ... more details
reaction called phloroglucinolysis , thioglycolic acid thioglycolysis , benzyl mercaptan or cysteamine ... C. title Chromatographic characterization of proanthocyanidins after thiolysis with cysteamine journal ... mercaptan reaction called thiolysis , thioglycolic acid reaction called thioglycolysis or cysteamine ... through acid catalyzed degradation in the presence of cysteamine . ref name Liang HPLC, NMR and MALDI ... more details
. Part Xvi. On the Protective Effects of Cysteamine on Acute Radiation Mortality of Mice In German , Strahlentherapie ... Protective Screen. XVII. The Effect on Radiation Protection of Cysteamine Administered after ... to Radiation and Cysteamine Protection of Male Mice after Gonadectomy In German , Strahlentherapie ... more details
Encyclopedia
top
