- Cyclopyrrolones
Cyclopyrrolones are a family of hypnotic and anxiolytic nonbenzodiazepine drugs with similar pharmacological profiles to the benzodiazepine derivatives. Although cyclopyrrolones are chemically unrelated to benzodiazepines, they function via the benzodiazepine receptor Gamma aminobutyric acid GABA neurotransmitter . The best known cyclopyrrolone derivatives are zopiclone Imovane and its enantiomer eszopiclone Lunesta , which are used to treat insomnia , and have a known potential for abuse. Other cyclopyrrolone derivatives include suriclone , pagoclone , pazinaclone and suproclone . Cyclopyrrolone s eszopiclone hypnotic Lunesta zopiclone hypnotic Imovane pagoclone anxiolytic suriclone anxiolytic pazinaclone anxiolytic suproclone anxiolytic External links http bmj.bmjjournals.com cgi content full 316 7125 117 British Medical Journal Anxiolytics Hypnotics and sedatives Category Sedatives Category Hypnotics Category Cyclopyrrolones nervous system drug stub ... more details
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- Pazinaclone
Cyclopyrrolones Category Sedatives Category Isoindolines Category Lactams Category Amides Category ... more details
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- Suriclone
ref References references Hypnotics and sedatives Category Cyclopyrrolones Category Sedatives ... more details
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- Suproclone
References references Hypnotics and sedatives Category Cyclopyrrolones Category Sedatives Category ... more details
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- Pagoclone
Cyclopyrrolones Category Ketones Category Organochlorides Category Isoindolines Category 1,8 Naphthyridines ... more details
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- Eszopiclone
of zopiclone , and belongs to the class of drugs known as cyclopyrrolones . Eszopiclone is a short ... Hypnotics and sedatives Category Cyclopyrrolones Category Carbamates Category Enantiopure ... more details
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- Nonbenzodiazepine
reviews articles nonbenzodiazepine.html Anxiolytics Hypnotics and sedatives GABAergics Category Cyclopyrrolones ... more details
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- Flunitrazepam
the non benzodiazepine families Cyclopyrrolones , Imidazopyridine s, and Pyrazolopyrimidine s are also ... more details
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- Zopiclone
Howto section date March 2011 Drugbox Verifiedfields changed verifiedrevid 458773669 IUPAC name RS 6 5 chloropyridin 2 yl 7 oxo 6,7 dihydro 5H pyrrolo 3,4 b pyrazin 5 yl 4 methylpiperazine 1 carboxylate image Zopiclone.svg width 180 imagename Zopiclone drug name Zopiclone Clinical data tradename Imovane, Zimovane Drugs.com drugs.com international zopiclone pregnancy US C legal UK POM legal US Schedule IV routes of administration Oral tablets, 3.75mg UK , 5 or 7.5 mg Pharmacokinetic data bioavailability 52 59 bound to plasma protein metabolism Various cytochrome P450 liver enzymes elimination half life 6 hours br 9 hours for over 65 excretion Urine Identifiers CASNo Ref cascite correct CAS CAS number Ref cascite correct ?? CAS number 43200 80 2 ATC prefix N05 ATC suffix CF01 PubChem 5735 DrugBank Ref drugbankcite changed drugbank DrugBank APRD00356 ChemSpiderID Ref chemspidercite correct chemspider ChemSpiderID 5533 UNII Ref fdacite correct FDA UNII 03A5ORL08Q KEGG Ref keggcite correct kegg KEGG D01372 ChEBI Ref ebicite correct EBI ChEBI 32315 ChEMBL Ref ebicite correct EBI ChEMBL 135400 Chemical data C 17 H 17 Cl 1 N 6 O 3 molecular weight 388.808 g mol smiles O C OC3c1nccnc1C O N3c2ncc Cl cc2 N4CCN C CC4 InChI 1 C17H17ClN6O3 c1 22 6 8 23 9 7 22 17 26 27 16 14 13 19 4 5 20 14 15 25 24 16 12 3 2 11 18 10 21 12 h2 5,10,16H,6 9H2,1H3 InChIKey GBBSUAFBMRNDJC UHFFFAOYAX StdInChI Ref stdinchicite correct chemspider StdInChI 1S C17H17ClN6O3 c1 22 6 8 23 9 7 22 17 26 27 16 14 13 19 4 5 20 14 15 25 24 16 12 3 2 11 18 10 21 12 h2 5,10,16H,6 9H2,1H3 StdInChIKey Ref stdinchicite correct chemspider StdInChIKey GBBSUAFBMRNDJC UHFFFAOYSA N this ref was in the drugbox template for the US legal bit, but seems to have been braking the template. put here for safe keeping. ref name pmid15806735 cite journal author title Schedules of controlled substances placement of zopiclone into schedule IV. Final rule journal Fed Regist volume 70 issue 63 pages 16935 7 year 2005 month April pmid 15 ... more details
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