protein Skip past these infobox fields to edit article body Name peptidylprolyl isomerase A cyclophilin A caption Ribbon diagram of cyclophilin A in complex with ciclosporin yellow . From PDB 1CWA . image Cyclophilin A cyclosporin complex 1CWA.png width 200 HGNCid 9253 Symbol PPIA AltSymbols EntrezGene 5478 OMIM 123840 RefSeq NM 203430 UniProt Q3KQW3 PDB ECnumber 5.2.1.8 Chromosome 7 Arm p Band 13 LocusSupplementaryData Infobox protein family Symbol Pro isomerase Name Pro isomerase image PDB 1w74 EBI.jpg width caption x ray structure of peptidyl prolyl cis trans isomerase a, ppia, rv0009, from mycobacterium tuberculosis. Pfam PF00160 Pfam clan CL0475 InterPro IPR002130 SMART PROSITE PDOC00154 MEROPS SCOP 1cyh TCDB OPM family OPM protein CAZy CDD Cyclophilins are a family of protein s from vertebrates and other organism s that bind to cyclosporine , an immunosuppressant which is usually used to suppress Transplant rejection rejection after internal organ transplant s ref name pmid14731520 cite journal author Stamnes MA, Rutherford SL, Zuker CS title Cyclophilins a new family of proteins ... form to cis form at proline residues and facilitates protein folding . Cyclophilin A is a cytoplasm ... B and C, and natural killer Cell biology cell cyclophilin related protein. ref name pmid1464374 ... the ER, and some are even secreted . Cyclophilin A CycA Peptidylprolyl isomerase A Cyclophilin A also ... alpha helix alpha helices and a beta sheet . Other cyclophilins have similar structures to cyclophilin A. The ciclosporin cyclophilin A complex inhibits a calcium calmodulin dependent phosphatase ... of the pro inflammatory molecules TNF alpha and interleukin 2 . Cyclophilin A is also known ... virus particles is essential for HIV 1 infectivity. Cyclophilin D PPID Cyclophilin D , which is located ... disorder, so the opening of the pore plays an important role in cell death . Cyclophilin D is thought ... the pore opening. Examples Human genes encoding proteins containing the cyclophilin type peptidyl prolyl ... more details
Cis trans isomerase is a type of isomerase which catalyzes the isomerization of geometric isomers . Examples include photoisomerase and immunophilins such as cyclophilin . External links MeshName cis trans Isomerases br Enzymes Topoisomerases enzyme stub Category Isomerases ... more details
PBB geneid 5478 Peptidylprolyl isomerase A also known as cyclophilin A or rotamase A is an enzyme that in humans is encoded by the PPIA gene . ref name entrez ref name pmid2197089 cite journal author Haendler B, Hofer E title Characterization of the human cyclophilin gene and of related processed pseudogenes journal Eur. J. Biochem. volume 190 issue 3 pages 477 82 year 1990 month July pmid 2197089 doi 10.1111 j.1432 1033.1990.tb15598.x ref ref name pmid1989998 cite journal author Holzman TF, Egan DA, Edalji R, Simmer RL, Helfrich R, Taylor A, Burres NS title Preliminary characterization of a cloned neutral isoelectric form of the human peptidyl prolyl isomerase cyclophilin journal J. Biol. Chem. volume 266 issue 4 pages 2474 9 year 1991 month February pmid 1989998 doi ref Function This gene encodes a member of the peptidyl prolyl cis trans isomerase PPIase family. PPIases catalyze the cis trans isomerization of proline imidic peptide bond s in oligopeptide s and accelerates the folding of protein s. The encoded protein is a cyclosporin binding protein and may play a role in cyclosporin A mediated immunosuppression . The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virion s. Multiple pseudogene s that map to different chromosome s have been reported. ref name entrez cite web title Entrez Gene PPIA peptidylprolyl isomerase A cyclophilin A url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 5478 accessdate ref Interactions Peptidylprolyl ... prolyl isomerase cyclophilin A journal PNAS Proc. Natl. Acad. Sci. U.S.A. volume 99 issue ... ref See also Cyclophilin TRIM5alpha References reflist Further reading refbegin 2 cite journal author Franke EK, Luban J title Cyclophilin and gag in HIV 1 replication and pathogenesis journal Adv ... E, Luban J title Cyclophilin, TRIM5, and innate immunity to HIV 1 journal Curr. Opin. Microbiol ... more details
isomerase B cyclophilin B url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch ... of endoplasmic reticulum molecular chaperones, GRP94, ERp72, BiP, calreticulin, and cyclophilin B ... cyclophilin B gene PPIB to chromosome 15. journal Cytogenet. Cell Genet. volume 60 issue 3 4 ... P title s cyclophilin is retained intracellularly via a unique COOH terminal sequence and colocalizes ... JR, Godbout M, Sutcliffe JG title An endoplasmic reticulum specific cyclophilin journal Mol. Cell ... Spik G, Haendler B, Delmas O, et al. title A novel secreted cyclophilin like protein SCYLP journal J ... RJ, Crabtree GR title Calcium signalling in T cells stimulated by a cyclophilin B binding protein journal ... M, Lim D, et al. title Cyclophilin B trafficking through the secretory pathway is altered by binding ... MD title X ray structure of a cyclophilin B cyclosporin complex comparison with cyclophilin A and delineation ... F, Denys A, Spik G title Characterization of surface binding sites for cyclophilin B on a human tumor ... The hydrophobic pocket of cyclophilin is the binding site for the human immunodeficiency virus type ... Distribution of cyclophilin B binding sites in the subsets of human peripheral blood lymphocytes .... title Human cyclophilin has a significantly higher affinity for HIV 1 recombinant p55 than p24 journal ... doi cite journal author Rycyzyn MA, Reilly SC, O Malley K, Clevenger CV title Role of cyclophilin ... V, O Connor M, Dai WW, et al. title CD147 is a signaling receptor for cyclophilin B journal ... more details
CYP is a three letter abbreviation which may refer to CINOP Young Professionals Calbayog , in the Philippines IATA airport code Crystal Palace railway station , the national railway code for a railway station in London, UK Cape York Peninsula , Australia Cyclopentanone Cyclophilin CYP, ISO 3166 1 ISO 3 letter country code for Cyprus Cyprichromis , genus of fishes in the family Cichlidae Cypriot pound , the ISO 4217 code for the former currency of Cyprus Cytochrome P450 , isoenzyme Cypripedium , orchid genus disambig de CYP et CYP eo CYP fr CYP it CYP lt CYP ja CYP fi CYP sv CYP zh CYP ... more details
In molecular biology , immunophilins are endogenous cytosolic peptidyl prolyl isomerases that interconvert between the cis and trans positions. Immunophilins are targeted by immunosuppressive drug s such as sirolimus rapamycin , ciclosporin , and tacrolimus . For these drugs in particular, known immunophilins such as cyclophilin catalyze the cis trans isomerization of peptide bond s, particularly X Pro peptide bonds. This isomerase activity can be inhibited by immunosuppressive drugs. See also FKBP12 FKBP52 FKBP5 FKBP5 FKBP51 External links MeshName Immunophilins http pmb.berkeley.edu faculty faculty pages Luan.html Plant immunophilins and signal transduction at berkeley.edu Immune receptors Category EC 5.2 enzyme stub immunology stub de Immunophiline es Inmunofilina ... more details
RS title Regulation of vegetative phase change in Arabidopsis thaliana by cyclophilin 40. journal ... kDa cyclophilin related protein. journal J. Biol. Chem. volume 267 issue 8 pages 5503 7 year 1992 ... of human cyclophilin 40 and the effect of the His141 Trp mutation on catalysis and ciclosporin A binding ... 1033.1995.tb20454.x cite journal author Kieffer LJ, Seng TW, Li W, et al. title Cyclophilin 40 ... nucleotide sequence of the human cyclophilin 40 PPID gene. journal Genomics volume 35 issue 3 pages ... PJ, Ward BK, Kumar P, et al. title Human cyclophilin 40 is a heat shock protein that exhibits altered ... journal author Ward BK, Allan RK, Mok D, et al. title A structure based mutational analysis of cyclophilin ... year 2004 pmid 12665801 doi 10.1038 nbt810 cite journal author Schubert A, Grimm S title Cyclophilin ... author Machida K, Osada H title Molecular interaction between cyclophilin D and adenine nucleotide ... of the Hsp90 cochaperone cyclophilin 40 with Hsc70. journal Cell Stress Chaperones volume 9 issue ... by cyclophilin D via stabilization of hexokinase II mitochondrial binding in cancer cells. journal ... cite journal author Mok D, Allan RK, Carrello A, et al. title The chaperone function of cyclophilin ... more details
Orphan date February 2009 PBB geneid 819 Calcium signal modulating cyclophilin ligand is a protein that in humans is encoded by the CAMLG gene . ref name pmid8824814 cite journal author Bram RJ, Valentine V, Shapiro DN, Jenkins NA, Gilbert DJ, Copeland NG title The gene for calcium modulating cyclophilin ligand CAMLG is located on human chromosome 5q23 and a syntenic region of mouse chromosome 13 journal Genomics volume 31 issue 2 pages 257 60 year 1997 month Mar pmid 8824814 pmc doi 10.1006 geno.1996.0044 ref ref name entrez cite web title Entrez Gene CAMLG calcium modulating ligand url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 819 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text The immunosuppressant drug cyclosporin A blocks a calcium dependent signal from the T cell receptor TCR that normally leads to T cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium . This integral ... cyclophilin B in calcium signaling, even in the absence of cyclosporin. ref name entrez ... modulating cyclophilin ligand References reflist Further reading refbegin 2 PBB Further reading citations cite journal author Bram RJ, Crabtree GR title Calcium signalling in T cells stimulated by a cyclophilin ... Holloway MP, Bram RJ title Co localization of calcium modulating cyclophilin ligand with intracellular ... modulating cyclophilin ligand desensitizes hormone evoked calcium release. journal Biochem. Biophys ... herpesvirus mitochondrial K7 protein targets a cellular calcium modulating cyclophilin ligand to modulate ... author Guo S, Lopez Ilasaca M, Dzau VJ title Identification of calcium modulating cyclophilin ligand ... more details
FK506 has peptidyl prolyl isomerase activity but is distinct from cyclophilin ... folding chaperone protein chaperone s for proteins containing proline residues. Along with cyclophilin ... a related treatment, the drug ciclosporin , which binds cyclophilin. ref name pmid9275110 cite journal ... 199708150 00012 url ref Both the FKBP tacrolimus complex and the ciclosporin cyclophilin complex ... I, Schreiber SL title Calcineurin is a common target of cyclophilin cyclosporin A and FKBP ... more details
CQ, et al. title Structure of recombinant human cyclophilin J, a novel member of the cyclophilin family ... studies of human cyclophilin J journal Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. volume ... more details
al. title The human nuclear SRcyp is a cell cycle regulated cyclophilin. journal J. Biol. Chem. volume ..., Leu S, Lu MC, Ouyang P title Over expression of SR cyclophilin, an interaction partner of nuclear ... more details
chembox Verifiedfields changed verifiedrevid 444021522 ImageFile NIM811.png ImageSize 200px IUPACName OtherNames Section1 Chembox Identifiers CASNo Ref cascite correct ?? CASNo 143205 42 9 PubChem 6473876 UNII Ref fdacite correct FDA UNII 96262S4I14 ChEMBL Ref ebicite changed EBI ChEMBL 1688529 SMILES CC C H 1C O N CC O N C H C O N C H C O N C H C O N C H C O N C H C O N C H C O N C H C O N C H C O N C H C O N1 C H C H C C C C C O C C C C C CC C C C CC C C C C C CC C C C C C C C H C CC C C Section2 Chembox Properties Formula C sub 62 sub H sub 111 sub N sub 11 sub O sub 12 sub MolarMass 1202.61 Appearance Density MeltingPt BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition NIM811 is a mitochondrial permeability transition inhibitor. Also known as N methyl 4 isoleucine cyclosporin, it is a four substituted cyclosporine that does not bind to cyclophilin A and therefore lacks immunosuppressive activity. Rather, NIM811 binds and inhibits cyclophilin. Category Peptides Category Macrocycles biochem stub ... more details
particle specific SnuCyp 20, a nuclear cyclophilin journal J. Biol. Chem. volume 275 issue 11 pages ... R cite journal author Horowitz DS, Lee EJ, Mabon SA, Misteli T title A cyclophilin functions in pre ... cyclophilin H and a U4 U6 snRNP 60K peptide journal J. Mol. Biol. volume 331 issue 1 pages 45 56 ... associated human cyclophilin CypH journal Nucleic Acids Res. volume 31 issue 16 pages ... more details
by affinity for a new cyclophilin one in the presence and one in the absence of CsA journal Cell ... author Price ER title Cyclophilin B trafficking through the secretory pathway is altered by binding ... Friedman J, Trahey M, Weissman I title Cloning and characterization of cyclophilin C associated protein a candidate natural cellular ligand for cyclophilin C journal Proc. Natl. Acad. Sci. U.S.A. volume ... doi 10.1074 jbc.272.10.6677 cite journal author Trahey M, Weissman IL title Cyclophilin C associated ... more details
Orphan date February 2009 PBB geneid 85313 Peptidyl prolyl cis trans isomerase like 4 is an enzyme that in humans is encoded by the PPIL4 gene . ref name entrez cite web title Entrez Gene PPIL4 peptidylprolyl isomerase cyclophilin like 4 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 85313 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text This gene is a member of the cyclophilin family of peptidylprolyl isomerases. The cyclophilins are a highly conserved family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV 1 virions. ref name entrez cite web title Entrez Gene PPIL4 peptidylprolyl isomerase cyclophilin like 4 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 85313 accessdate ref References reflist Further reading refbegin 2 PBB Further reading citations cite journal author Zeng L, Zhou Z, Xu J, et al. title Molecular cloning, structure and expression of a novel nuclear RNA binding cyclophilin like gene PPIL4 from human fetal brain. journal Cytogenet. Cell Genet. volume 95 issue 1 2 pages 43 7 year 2002 pmid 11978968 doi 10.1159 000057015 cite journal author Strausberg RL, Feingold EA, Grouse LH, et al. title Generation and initial analysis of more than 15,000 full length human and mouse cDNA sequences journal Proc. Natl. Acad. Sci. U.S.A. volume 99 issue 26 pages 16899 903 year 2003 pmid 12477932 doi 10.1073 pnas.242603899 pmc 139241 cite journal author Scanlan MJ, Gout I, Gordon CM, et al. title Humoral immunity to human breast cancer antigen definition and quantitative analysis of mRNA expression journal Cancer Immun. volume 1 issue pages 4 year 2003 pmid 12747765 doi cite journal author Mungall AJ, Palmer SA, Sims SK, et al. title The DNA sequence and analysis of human chromosome 6 journal Nature volume 425 ... more details
italic title Taxobox name Cypa image image width 250px image caption regnum Animal ia phylum Arthropod a classis Insect a ordo Lepidoptera familia Sphingidae subfamilia Smerinthinae tribus genus Cypa genus authority Francis Walker entomologist Walker , 1865 range map range map width subdivision ranks Species subdivision See text. CypA may also refer to Peptidylprolyl isomerase A Cyclophilin A , enzyme Cypa is a genus of moth s in the Sphingidae family. Species Cypa bouyeri small Cadiou 1998 small Cypa claggi small Clark 1935 small Cypa decolor small Walker 1856 small Cypa duponti small Roepke 1941 small Cypa enodis small Jordan 1931 small Cypa ferruginea small Walker 1865 small Cypa kitchingi small Cadiou 1997 small Cypa latericia small Inoue 1991 small Cypa luzonica small Brechlin, 2009 small Cypa terranea small Butler 1876 small Cypa uniformis small Mell 1922 small Category Cypa Category Smerinthini wikispecies Cypa Smerinthini stub nl Cypa pt Cypa vi Cypa ... more details
Parvulin , a 92 amino acid protein discovered in E. coli in 1994, ref name Rahfeld Rahfeld JU, Schierhorn A, Mann KH. 1994 . A novel peptidyl prolyl cis trans isomerase from Escherichia coli. FEBS Lett 343 65. ref is the smallest known protein with prolyl isomerase activity, which catalyzes the Cis trans isomerism cis trans isomerization of proline peptide bonds. Although parvulin has no homology biology homology with larger prolyl isomerases such as cyclophilin and FKBP , it does share structural features with subdomains of other proteins involved in preparing secrete d proteins for export from the cell biology cell . ref name Balbach Balbach J, Schmid FX. 2000 . Proline isomerizarion and its catalysis in protein folding. In Mechanisms of Protein Folding 2nd ed. Ed. RH Pain. Frontiers in Molecular Biology series. Oxford University Press Oxford, UK. ref Although parvulin is as active as the larger prolyl isomerases against a short proline containing test peptide , it has lower relative activity against biological substrates, possibly because the larger molecules have a higher ability to bind the substrate peptide. ref name Scholz Scholz C, Rahfeld J, Fischer G, Schmid FX. 1997 . Catalysis of protein folding by parvulin. J Mol Biol 273 3 752 62. ref Parvulin itself contains proline residues and its protein folding folding can be accelerated by the presence of cyclophilin parvulin folding can also be autocatalytic . A eukaryotic homolog of parvulin known as Pin1 is required to execute the transition from G2 phase to M phase in the cell cycle . ref name Gothel Gothel SF, Marahiel MA. 1999 . Peptidyl prolyl cis trans isomerases, a superfamily of ubiquitous folding catalysts. Cell Mol Life Sci 55 3 423 36. ref Absence of Pin1 activity in humans has also been implicated in the folding and processing of the amyloid precursor protein , whose degradation product is the cytotoxic peptide amyloid beta implicated in Alzheimer s disease . ref name Pastorino Pastorino L, Sun A, L ... more details
, or UNIL 025 is a cyclophilin inhibitor. ref name pmid18641676 cite journal author Reutenauer J, Dorchies OM, Patthey Vuadens O, Vuagniaux G, Ruegg UT title Investigation of Debio 025, a cyclophilin ... cyclophilin D . Alisporivir is not immunosuppressive. ref name pmid18212100 cite journal author ... in human cells by Debio 025, a novel cyclophilin binding agent journal Antimicrob. Agents Chemother ... author Coelmont L, Kaptein S, Paeshuyse J, et al. title Debio 025, a cyclophilin binding molecule, is highly ... more details
Orphan date February 2009 PBB geneid 51645 Peptidyl prolyl cis trans isomerase like 1 is an enzyme that in humans is encoded by the PPIL1 gene . ref name pmid10072585 cite journal author Mann SS, Pettenati MJ, von Kap herr C, Hart TC title Reassignment of peptidyl prolyl isomerase like 1 gene PPIL1 to human chromosome region 6p21.1 by radiation hybrid mapping and fluorescence in situ hybridization journal Cytogenet Cell Genet volume 83 issue 3 4 pages 228 9 year 1999 month Mar pmid 10072585 pmc doi 10.1159 000015186 ref ref name pmid8978786 cite journal author Ozaki K, Fujiwara T, Kawai A, Shimizu F, Takami S, Okuno S, Takeda S, Shimada Y, Nagata M, Watanabe T, Takaichi A, Takahashi E, Nakamura Y, Shin S title Cloning, expression and chromosomal mapping of a novel cyclophilin related gene PPIL1 from human fetal brain journal Cytogenet Cell Genet volume 72 issue 2 3 pages 242 5 year 1997 month Jan pmid 8978786 pmc doi 10.1159 000134199 ref ref name entrez cite web title Entrez Gene PPIL1 peptidylprolyl isomerase cyclophilin like 1 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 51645 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text This gene is a member of the cyclophilin family of peptidylprolyl isomerases PPIases . The cyclophilins are a highly conserved, ubiquitous family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV 1 virions. Based on similarity to other PPIases, this protein could accelerate the folding of proteins and might catalyze the cis trans isomerization of proline imidic peptide bonds in oligopeptides. ref name entrez cite web title Entrez Gene PPIL1 peptidylprolyl isomerase cyclophilin like 1 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 51645 accessdate ref References reflist Further reading ... more details
title A new cyclophilin and the human homologues of yeast Prp3 and Prp4 form a complex associated with U4 ... particle specific SnuCyp 20, a nuclear cyclophilin journal J. Biol. Chem. volume 275 issue 11 ... SA, Misteli T title A cyclophilin functions in pre mRNA splicing journal EMBO J. volume 21 issue ... structure of a complex between human spliceosomal cyclophilin H and a U4 U6 snRNP 60K peptide journal ... more details
in cyclophilin B, or peptidyl prolyl isomerase B PPIB , was published on May 11, 2007. ref cite ... mutation in equine cyclophilin B PPIB associated with HERDA in the American Quarter Horse journal ... a cyclophilin B SNP associated with HERDA. http patft.uspto.gov netacgi nph Parser?Sect1 PTO1 ... more details
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