chembox Verifiedfields changed verifiedrevid 460110426 Name Cycloheximide ImageFile Ref chemboximage correct ?? ImageFile Cycloheximide.png ImageName Cycloheximide IUPACName 4 2 R 2 1 S ,3 S ,5 S 3,5 Dimethyl 2 oxocyclohexyl 2 hydroxyethyl piperidine 2,6 dione OtherNames naramycin a, hizarocin br actidione, actispray br kaken, U 4527 Section1 Chembox Identifiers UNII Ref fdacite correct FDA UNII 98600C0908 SMILES O C2NC O CC C C H O C H 1C O C H C C C H C C1 C2 ChemSpiderID Ref chemspidercite correct chemspider ChEBI Ref ebicite correct EBI ChEBI 27641 ChemSpiderID 5962 ChEMBL Ref ebicite correct EBI ChEMBL 123292 InChI 1 C15H23NO4 c1 8 3 9 2 15 20 11 4 8 12 17 5 10 6 13 18 16 14 19 7 10 h8 12,17H,3 7H2,1 2H3, H,16,18,19 t8 ,9 ,11 ,12 m0 s1 InChIKey YPHMISFOHDHNIV FSZOTQKABD StdInChI Ref stdinchicite ... msds.chem.ox.ac.uk CY cycloheximide.html Oxford MSDS RPhrases R26 R27 R28 Cycloheximide is an Enzyme ... Streptomyces griseus . Cycloheximide exerts its effect by interfering with the translocation ... Translation genetics translational elongation . Cycloheximide is widely used in biomedical research ... ref http toxnet.nlm.nih.gov index.html TOXNET Bot generated title ref , cycloheximide is generally ... decreasing as the health risks have become better understood. Cycloheximide is degraded by alkali pH ... alkali solution such as soap. Since cycloheximide is an effective inhibitor of protein biosynthesis ... will not be expressed in the presence of cycloheximide. Conversely, translation using mitochondrial ribosomes is unaffected by cycloheximide, and mitochondrial genes will continue to be expressed. Experimental applications Cycloheximide can be used as an experimental tool in molecular biology to determine the half life of a protein . Treating cells with cycloheximide in a time course experiment ... in protein half life. Cycloheximide treatment provides the ability to observe the half life of a protein ... Cycloheximide nl Cycloheximide ja pl Cykloheksymid sv Cykloheximid zh ... more details
Bacterivores are free living, generally heterotrophic organisms, exclusively microscopic , which obtain energy and nutrients primarily or entirely from the consumption of bacteria . Many species of amoeba are bacterivores, as well as other types of protozoans . In common all species of bacteria will be prey. But spores of some species like Clostridium perfringens will never be prey, because of their cellular attributes. Microbiology In microbiology of water some samples were collected to give some information about inhabitant microorganisms. Most of the probes of freshwater can be contaminated with bacterivores. By adding cycloheximide , the bacteriovores will be inhibited and the bacteria will raise up normally. For bacteria adsorbed to sediment 2 g cycloheximide per 100 g sediment will be added. For experiments with spores for example spores of C. perfringens , it is not necessesary to add cycloheximide to the samples. Examples Ceriodaphnia quadrangula Diaphanosoma brachyura Vorticella Paramecium Many species of Protozoan Protozoa References Davies, Cheryl M. et al. Survival of Fecal Microorganisms in Marine and Freshwater Sediments , 1995, http www.pubmedcentral.nih.gov picrender.fcgi?artid 167451&blobtype pdf PDF feeding modelling ecosystems Category Ecological definitions Category Trophic ecology ecology stub de Bakterivore nl Bacterivoor ... more details
Chx may refer to Chicago Stock Exchange Charing Cross railway station National Rail code in London Chlorhexidine A disinfectant and topical anti infective agent used also as mouthwash to prevent oral plaque Cycloheximide An inhibitor of protein biosynthesis in eukaryotic cells The IATA airport code airport code for Bocas del Toro Province Changuinola Airport in Panama disambig de CHX fr CHX it CHX ... more details
Unreferenced date December 2009 Image DTM positive.jpg thumb DTM plate on the right showing color change after two day s growth Microsporum canis Dermatophyte Test Medium DTM is a specialized agar used in medical mycology . It is based on Sabouraud s dextrose agar with added cycloheximide to inhibit saprotrophic growth, antibiotic to inhibit bacterial growth, and phenol red a pH indicator. The pH indicator is useful in distinguishing a dermatophyte fungus , which utilizes nitrogen ous material for preferred metabolism, producing alkaline by products, imparting a red color change to the medium. Typical saprotrophic fungi utilized carbohydrate s in the medium producing acidic by products and no red color change. Growth media DEFAULTSORT Dermatophyte Test Medium Category Mycology Category Microbiological media Fungus stub ar th ... more details
Chembox ImageFile Glutarimide ifa.png ImageSize IUPACName piperidine 2,6 dione OtherNames 2,6 diket opiperidi ne Section1 Chembox Identifiers CASNo 1121 89 7 PubChem 70726 ChemSpiderID 63891 SMILES O C1NC O CCC1 InChI InChI 1S C5H7NO2 c7 4 2 1 3 5 8 6 4 h1 3H2, H,6,7,8 Section2 Chembox Properties Formula C sub 5 sub H sub 7 sub NO sub 2 sub MolarMass 113.11 g mol Appearance Density MeltingPt BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition Glutarimide is a chemical compound featuring a piperidine functional group ring with two ketone s attached next to the nitrogen . It is a structural component of cycloheximide , a very potent inhibitor of protein synthesis. See also Piperidine Cyclohexane Imide Ketone organic compound stub Category Glutarimides fr Glutarimide ... more details
Italic title Taxobox name Cryptococcus adeliensis image image caption regnum Fungi phylum Basidiomycota classis Tremellomycetes ordo Tremellales familia Tremellaceae genus Cryptococcus fungus Cryptococcus species C. adeliensis binomial Cryptococcus adeliensis binomial authority synonyms Cryptococcus adeliensis is a species of Cryptococcus fungus Cryptococcus that when plated on agar produces colonies that are cream colored, with a smooth, glossy appearance. The colonies frequently appear to have a soft texture. The optimal growth range for this species is at 25 degrees Celsius . Cryptococcus adeliensis is incapable of fermentation, as is typical of the Cryptococcus species. This species is able to use sucrose , maltose , cellbiose , trehalose , raffinose , citric acid citrate , inositol ethanol , soluble starch , melezitose , xylitol , saccharate, salicin as well as many other compounds as sole carbon sources. Cryptococcus adeliensis is able to use nitrate, nitrite and cadaverine , a protein created when animals decay which produces the putrid smell associated with said decay, as sources of Nitrogen. This species forms starch as it grows. Cryptococcus adeliensis also grows on 0.01 cycloheximide. ref Cryptococcus adeliensis sp. nov., a xylanase producing basidiomycetous yeast from Antarctica. Antonie van Leeuwenhoek. Scorzetti et al. 2000 , 77, pages 153 157 ref References reflist External links wikispecies commons Category Tremellomycetes fungus stub ... more details
italic title Taxobox name Lactobacillus sanfranciscensis regnum Bacteria divisio Firmicutes classis Bacilli ordo Lactobacillales familia Lactobacillaceae genus Lactobacillus species L. sanfranciscensis binomial Lactobacillus sanfranciscensis binomial authority ex Kline & Sugihara 1971 br Weiss & Schillinger 1984 Lactobacillus sanfranciscensis formerly L. sanfrancisco is a species of lactic acid bacteria that helps give San Francisco sourdough bread its characteristic taste. ref name Kulp 2003 cite book author Karel Kulp, Klaus Lorenz title Handbook of Dough Fermentation edition publisher CRC Press year 2003 isbn 0 8247 4264 8 ref Sourdough starter s are leaven ed by a mixture of yeast and lactobacilli in a ratio of about 1 100. The yeast is most commonly Candida milleri . This yeast cannot metabolize the maltose found in the dough, while the Lactobacillus needs maltose. ref name Neubauer 1994 cite journal author Neubauer H, Glaasker E, Hammes WP, Poolman B, Konings WN title Mechanism of maltose uptake and glucose excretion in Lactobacillus sanfrancisco journal J Bacteriol year 1994 pages 3007 12 volume 176 issue 10 pmid 8188601 pmc 205458 ref They therefore act without conflict for Substrate biochemistry substrate , with the Lactobacillus utilizing maltose and the yeast utilizing the other sugars, including the glucose produced by the Lactobacillus . The lactobacilli produce an antibiotic , cycloheximide , which kills many organisms but not Candida spp. Candida tolerates the lactic acid produced by the lactobacilli. For commercial use, specific strains of the L. sanfranciscensis are grown on Growth medium defined media , Freeze dry freeze dried , and shipped to bakeries worldwide. References references Template San Francisco attractions Category Lactobacillaceae es Lactobacillus sanfranciscensis it Lactobacillus sanfranciscensis sv Lactobacillus sanfranciscensis ... more details
Italic title Taxobox name Cryptococcus consortionis image image caption regnum Fungi phylum Basidiomycota classis Tremellomycetes ordo Tremellales familia Tremellaceae genus Cryptococcus fungus Cryptococcus species C. consortionis binomial Cryptococcus consortionis binomial authority synonyms Cryptococcus consortionis is a fungus species. It produces colonies that are cream colored with a glistening, mucoid appearance. When grown in liquid media, this species requires constant agitation. This species growth range is from 4 C to 23 C, with growth at 23 C occurring very slowly. On the microscopic level, C. consortionis appears ovoid, with a thin capsule. Sexual reproduction does not occur in this species, but it asexually reproduces through budding at the birth scar site. Very occasionally, the cells have been observed to produce three celled pseudomycelia. C. consortionis does not ferment. This species produces Amylose, but it is the only basidioblastomycete which does so but is unable to also assimilate cellobiose, D galactose, mannitol, myo inositol and nitrate. C. consortionis is DBB positive. This species required thiamine for proper growth, and its growth is slowed by small amounts of cycloheximide. C. consortionis does not produce urease, and does not produce melanin on DOPA. ref Vishniac H. S. 1985 Cryptococcus socialis sp. nov. and Cryptococcus consotionis sp. nov., Antarctic Basidoblastomycetes. Int. J. Syst. Bacteriol. 35 1 119 122 ref References reflist External links wikispecies commons Category Tremellomycetes fungus stub ... more details
Drugbox verifiedrevid 444252852 IUPAC name 4 3 6 oxo 3,6 dihydro 9 H purin 9 yl propanoyl amino benzoic acid image Leteprinim.png width 240 Clinical data tradename routes of administration Pharmacokinetic data elimination half life Identifiers CAS number Ref cascite correct ?? CAS number 138117 50 7 ATC prefix none ATC suffix PubChem 132123 DrugBank Ref drugbankcite correct drugbank UNII Ref fdacite correct FDA UNII NBY3IU407M Chemical data C 15 H 13 N 5 O 4 molecular weight 327.295 smiles C1 CC CC C1C O O NC O CCN2C NC3 C2NC NC3 O Leteprinim Neotrofin , AIT 082 is a hypoxanthine derivative drug with neuroprotective and nootropic effects. ref Di Iorio P, Virgilio A, Giuliani P, Ballerini P, Vianale G, Middlemiss PJ, Rathbone MP, Ciccarelli R. AIT 082 is neuroprotective against kainate induced neuronal injury in rats. Experimental Neurology . 2001 Jun 169 2 392 9. PMID 11358452 ref ref Lahiri DK, Ge YW, Farlow MR. Effect of a memory enhancing drug, AIT 082, on the level of synaptophysin. Annals of the New York Academy of Sciences . 2000 Apr 903 387 93. PMID 10818529 ref ref Yan R, Nguyen Q, Gonzaga J, Johnson M, Ritzmann RF, Taylor EM. Reversal of cycloheximide induced memory disruption by AIT 082 Neotrofin is modulated by, but not dependent on, adrenal hormones. Psychopharmacology Berlin . 2003 Apr 166 4 400 7. PMID 12605287 ref It stimulates release of nerve growth factor s and enhances survival of neurons in the brain, ref Rathbone MP, Middlemiss PJ, Crocker CE, Glasky MS, Juurlink BH, Ramirez JJ, Ciccarelli R, Di Iorio P, Caciagli F. AIT 082 as a potential neuroprotective and regenerative agent in stroke and central nervous system injury. Expert Opinion in Investigational Drugs . 1999 Aug 8 8 1255 62. PMID 15992149 ref ref Ramirez JJ, Parakh T, George MN, Freeman L, Thomas AA, White CC, Becton A. The effects of Neotrofin on septodentate sprouting after unilateral entorhinal cortex lesions in rats. Restorative Neurology and Neuroscience . 2002 20 1 2 51 9. PMID 12 ... more details
PBB geneid 5997 Regulator of G protein signaling 2 is a protein that in humans is encoded by the RGS2 gene . ref name pmid8179820 cite journal author Siderovski DP, Heximer SP, Forsdyke DR title A human gene encoding a putative basic helix loop helix phosphoprotein whose mRNA increases rapidly in cycloheximide treated blood mononuclear cells journal DNA Cell Biol volume 13 issue 2 pages 125 47 year 1994 month Jun pmid 8179820 pmc doi 10.1089 dna.1994.13.125 ref ref cite web title RGS2 regulator of G protein signaling 2, 24kDa url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 5997 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text Interactions RGS2 has been shown to Protein protein interaction interact with PRKG1 ref name pmid14608379 cite journal last Tang first K Mary authorlink coauthors Wang Guang rong, Lu Ping, Karas Richard H, Aronovitz Mark, Heximer Scott P, Kaltenbronn Kevin M, Blumer Kendall J, Siderovski David P, Zhu Yan, Mendelsohn Michael E, Tang Mary, Wang Guang year 2003 month Dec. title Regulator of G protein signaling 2 mediates vascular smooth muscle relaxation and blood pressure journal Nat. Med. volume 9 issue 12 pages 1506 12 publisher location United States issn 1078 8956 pmid 14608379 doi 10.1038 nm958 bibcode oclc id url language format accessdate laysummary laysource laydate quote ref and ADCY5 . ref name pmid12604604 cite journal last Salim first Samina authorlink coauthors Sinnarajah Srikumar, Kehrl John H, Dessauer Carmen W year 2003 month May. title Identification of RGS2 and type V adenylyl cyclase interaction sites journal J. Biol. Chem. volume 278 issue 18 pages 15842 9 publisher location United States issn 0021 9258 pmid 12604604 doi 10.1074 jbc.M210663200 bibcode oclc id url language format accessdate laysummary laysource laydate quote ref References reflist Further reading refbegin 2 ... more details
. It was later shown that treatment with the protein synthesis inhibitor cycloheximide delayed ... moore kinetic Finally, it was also shown that this delay occurred even with short pulses of cycloheximide ..., DP title Inhibition of DNA synthesis in synchronized Chinese hamster cells treated in G1 with cycloheximide ... more details
ionophore treatment, microinjection of calcium ions, or electrical stimulation. Treatment with cycloheximide ... Mitsuru last6 Yoshida first6 Mitsutoshi last7 Miyoshi first7 Kazuchika title Effects of Cycloheximide ... stimulation. Treatment with cycloheximide, a non specific protein synthesis inhibitor, enhances ... more details
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