see also Cyclin D PBB geneid 595 G1 S specific cyclinD1 is a protein that in humans is encoded by the CCND1 ... title Entrez Gene CCND1 cyclinD1 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch ... 125px Micrograph of cyclinD1 staining in a mantle cell lymphoma . Immunohistochemical staining of cyclinD1 antibodies is used to diagnose mantle cell lymphoma . Interactions CyclinD1 has been shown ... Aug. title CyclinD1 Is a Ligand independent Co repressor for Thyroid Hormone Receptors journal J ... Jan. title A central domain of cyclinD1 mediates nuclear receptor corepressor activity journal Oncogene ... and nuclear accumulation of cyclinD1 Cdk4 during G1 journal J. Biol. Chem. volume 273 issue 50 pages ... K R year 1997 month Jul. title Identification of CDK4 sequences involved in cyclinD1 and p16 binding ... P D year 1999 month Jan. title CyclinD1 associates with the TBP associated factor TAF II 250 ..., Leiter Andrew B year 2002 month Mar. title CyclinD1 represses the basic helix loop helix transcription ... independent recruitment of steroid receptor coactivators to estrogen receptor by cyclinD1 journal Genes ... year 1997 month Feb. title CDK independent activation of estrogen receptor by cyclinD1 journal Cell ... cite journal author Chung DC title CyclinD1 in human neuroendocrine tumorigenesis journal Ann. N. Y ..., location, location the role of cyclinD1 nuclear localization in cancer journal J. Cell. Biochem ... Walker JL, Assoian RK title Integrin dependent signal transduction regulating cyclinD1 expression ..., Gugger M, et al. title CyclinD1 in non small cell lung cancer a key driver of malignant transformation ... cite journal author Li Z, Wang C, Prendergast GC, Pestell RG title CyclinD1 functions in cell ... CyclinD1 and CDK4 Binding and Induces Cell Cycle Arrest journal J. Biol. Chem. volume 284 issue 9 ... T, Arnold A title PRAD1 cyclinD1 proto oncogene genomic organization, 5 DNA sequence, and sequence ... JV, Kronenberg HM, Arnold A title A novel cyclin encoded by a bcl1 linked candidate oncogene journal ... more details
, Cyclin B3 CCNB3 align center C Cyclin C CCNC align center Cyclin D D CyclinD1 CCND1 , Cyclin D2 CCND2 ... cycle by activating cyclin dependent kinase Cdk enzyme s. ref name pmid12910258 cite journal title ... FP author3 Giordano A author separator , ref Function Image Cyclin Expression.svg thumb left 400px ... according to their conserved cyclin box structure, and not all these cyclins alter in level through ... ref . The oscillations of the cyclins, namely fluctuations in cyclin gene expression and destruction by proteolysis, induce oscillations in Cdk activity to drive the cell cycle. A cyclin forms a complex ... Cdk1 cdc2 or Cyclin dependent kinase 1 cdk1 proteins, form the maturation promoting factor . MPFs ... in late G1 and fall in early S phase. The Cdk G1 S cyclin complex begins to induce the initial processes ... early events in mitosis. M cyclin concentrations rise as the cell begins to enter mitosis and the concentrations ... spindles and alignment of sister chromatids along the spindles are induced by M cyclin Cdk complexes ..., or amino acid sequence. The similarity between members of the cyclin family are similar in the 100 amino acids that make up the cyclin box. Cyclins contain two protein domain domains of similar all .... The first of which is the conserved cyclin box, outside of which cyclins are divergent. For example ... for proteolysis in mitosis. valign top Pfam box Symbol Cyclin N Name Cyclin, N terminal domain image PDB 1vin EBI.jpg width caption Structure of bovine cyclin A. ref name pmid8591034 cite journal author Brown NR, Noble ME, Endicott JA, et al. title The crystal structure of cyclin A journal ... Cyclin C Name Cyclin, C terminal domain image PDB 1e9h EBI.jpg width caption Structure of CDK2 cyclin ... L, et al. title Inhibitor binding to active and inactive CDK2 the crystal structure of CDK2 cyclin ... for which no Cdk partner has been identified. For example, cyclin F is an orphan cyclin that is essential ... sub 1 sub S transition , Cyclin A Cyclin dependent kinase 2 CDK2 active in S sub sub phase. Cyclin D ... more details
protein Name CCNA1 cyclin A1 caption image width HGNCid 1577 Symbol CCNA1 AltSymbols EntrezGene 8900 OMIM 604036 RefSeq NM 003914 UniProt P78396 PDB ECnumber Chromosome 13 Arm q Band 12.3 LocusSupplementaryData q13 protein Name cyclin A2 caption image width HGNCid 1578 Symbol CCNA2 AltSymbols CCNA, CCN1 EntrezGene 890 OMIM 123835 RefSeq NM 001237 UniProt P20248 PDB ECnumber Chromosome 4 Arm q Band 27 LocusSupplementaryData Cyclin A is a member of the cyclin family. Cyclin A binds to S phase Cdk2 and is required for the cell to progress through the S phase . Cyclin A Cdk2 is inhibited by the complex p21CIP. Image Cyclinexpression waehrend Zellzyklus.png center 422px Expression of cyclins through the cell cycle . External links http www.sdbonline.org fly newgene cyclina1.htm Drosophila Cyclin A The Interactive Fly MeshName Cyclin A Cell biology stub Cell cycle proteins Category Cell cycle Category Proteins es Ciclina A ... more details
TOCright D1 , D01 , D.I , D.1 or D 1 can refer to Science and technology D1 Sony , an early digital video recording format D1 building , a 80 floor residential building currently under construction in Dubai ... Classification System Dopamine receptor D1 Dopamine receptor D sub 1 sub Haplogroup D1 Y DNA Mercedes D.I , a 1913 German 6 cylinder, water cooled, inline engine for use in aircraft Nikon D1 , a digital single lens reflex DSLR camera Vitamin D Vitamin D sub 1 sub and also D1 , a hexadecimal value equal to the decimal value 209 T D1 , the German T Mobile mobile phone network former name D01, Carcinoma ... STS 61 A D 1 , a West German funded and controlled Space Shuttle STS mission. D1, an abbreviation for DOCSIS DOCSIS 1.0 , an international telecommunications standard. Transport D1 class Melbourne tram D1 multiple unit , a train developed at Torzhoksky car building factory in Russia in 2007 D1 road Croatia , a state route in Croatia D1 motorway Czech Republic , a highway in the Czech Republic D1 motorway ... aircraft LB&SCR D1 class , a 1873 British powerful 0 4 2 suburban passenger tank locomotive NCC Class D1 , a Northern Counties Committee Template Ireland Steam Locomotives Irish steam locomotive PRR D1 , a 1968 American steam locomotive model the first model type of the BSA Bantam Military ..., single seater fighter biplane Char D1 , a French tank Daimler D.I , a 1918 German fighter aircraft ... NCAA Division I NCAA Division I , the highest division of American collegiate sports The D1 Grand ... that use d the D1 moniker, related or not D1NZ , from New Zealand D1 IRL, known now as Prodrift Irish ... Championship in the United Kingdom Other Dublin 1 D1 , a Dublin , Republic of Ireland Ireland postcode D 1 guitar , a guitar model by C. F. Martin & Company D1 Music , a record label by Jay Paul Gordon D1 Recordings , an Irish techno record label d1 , an ironic reference to one sided dice die which ... planning in the UK , D1 is the code for permission to use specific land or premises for non residential ... more details
protein Name cyclinD1 caption Crystal structure of human cyclinD1 blue green in complex with cyclin ... pnas.0809645106 url issn ref image CyclinD.jpg width HGNCid 1582 Symbol cyclinD1 CCND1 AltSymbols ... have been identified. These human proteins, called cyclinD1 , cyclin D2 , and cyclin D3 are expressed ... It has been shown that the inhibition of cyclin D cyclinD1 and 2, in particular could result from the induction ... There are two ways in which DNA damage affects Cdks. Following DNA damage, cyclin D cyclinD1 is rapidly ... would place expression of cyclin D more specifically, cyclinD1 under an inappropriate Promoter ... Takahashi Yanaga F, Sasaguri T title GSK 3beta regulates cyclinD1 expression a new target for chemotherapy ... ref name Auto81 2 http www.scbt.com datasheet 20044 cyclind1 dcs 6 antibody.html ref ref name Auto81 ..., Sicinski P title Deletion of the p27Kip1 gene restores normal development in cyclinD1 deficient ... Crystal structure of human CDK4 in complex with a D type cyclin journal Proc. Natl. Acad. Sci. U.S.A. ... 11 Arm q Band 13 LocusSupplementaryData protein Name CCND2 cyclin D2 caption image width HGNCid ... Chromosome 12 Arm p Band 13 LocusSupplementaryData protein Name CCND3 cyclin D3 caption image width ... ECnumber Chromosome 6 Arm p Band 21 LocusSupplementaryData Cyclin D is a member of the cyclin protein family that is involved in regulating cell cycle progression. The synthesis of cyclin D is initiated during G1 and drives the G1 S phase transition. Cyclin D protein is anywhere from 155 in zebra mussel ... by cyclin Cdk complexes which are periodically expressed and partially redundant in function. Cyclins are eukaryotic proteins that form holoenzymes with cyclin dependent protein kinases Cdk , which ... through an APC c dependent pathway. Cyclin D is one of the major cyclins produced in terms of its functional importance. It interacts with four Cdks Cdk2, 4, 5, and 6. In proliferating cells, cyclin D Cdk4 6 complex accumulation is of great importance for cell cycle progression. Namely, cyclin ... more details
Kitagawa M, Higashi H, Jung HK, et al. title The consensus motif for phosphorylation by cyclinD1 Cdk4 is different from that for phosphorylation by cyclin A E Cdk2. journal EMBO J. volume 15 issue ...PBB geneid 894 G1 S specific cyclin D2 is a protein that in humans is encoded by the CCND2 gene . ref name pmid1386335 cite journal author Inaba T, Matsushime H, Valentine M, Roussel MF, Sherr CJ, Look AT title Genomic organization, chromosomal localization, and independent expression of human cyclin ... by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic ... of cyclin dependent kinases. Different cyclins exhibit distinct Gene expression expression and degradation patterns which contribute to the temporal coordination of each mitosis mitotic event. This cyclin ... web title Entrez Gene CCND2 cyclin D2 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch ..., Roussel MF, Kato JY, et al. title Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin ... kinase activity for cdk6, a novel cyclin D partner. journal Mol. Cell. Biol. volume 14 issue 3 ... AJ, et al. title Cyclins D1 and D2 are differentially expressed in human B lymphoid cell lines. journal ... AR, Shiffman D, Chan CS, et al. title Functional analysis of the human cyclin D2 and cyclin D3 promoters ... Cyclin D2 is an FSH responsive gene involved in gonadal cell proliferation and oncogenesis. journal ... title Cyclin D2 interacts with cdk 5 and modulates cellular cdk 5 p35 activity. journal J. Neurochem ... journal author G mez Lahoz E, Liegeois NJ, Zhang P, et al. title Cyclin D and E dependent kinases ... 2 H cite journal author Bouchard C, Thieke K, Maier A, et al. title Direct induction of cyclin ... cite journal author Choi D, Lee EY, Yoon S, et al. title Clinical correlation of cyclin ... of assembled cyclin D3 cdk4 complexes in B 1 and B 2 lymphocyte subsets. journal J. Immunol. volume ... E, et al. title The expression of pseudogene cyclin D2 mRNA in the human ovary may be a novel marker ... more details
, Kronenberg HM, Arnold A title Cloning and characterization of human cyclin D3, a cDNA closely related in sequence to the PRAD1 cyclinD1 proto oncogene. journal J. Biol. Chem. volume 267 issue 28 pages ...PBB geneid 896 G1 S specific cyclin D3 is a protein that in humans is encoded by the CCND3 gene . ref ... AT title Genomic organization, chromosomal localization, and independent expression of human cyclin ... by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic ... to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions ... protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell ... CCND3 cyclin D3 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 896 accessdate ref See also CyclinCyclin D Interactions Cyclin D3 has been shown to Protein protein ... Alexandra, Rochette Egly C cile, Chomienne Christine, Delva Laurent year 2003 month Feb. title Cyclin ... kinase, with cyclin D3 journal J. Biol. Chem. volume 277 issue 38 pages 35314 22 publisher location ... format accessdate laysummary laysource laydate quote ref CRABP2 , ref name pmid12482873 Cyclin ... last Lin first J authorlink coauthors Jinno S, Okayama H year 2001 month Apr. title Cdk6 cyclin D3 ... X, Wolgemuth D J year 1999 month Jun. title Developmentally regulated expression of cyclin D3 and its ... en.140.6.2790 ref Cyclin dependent kinase 6 , ref name pmid11360184 ref name pmid8114739 cite journal ... of G1 kinase activity for cdk6, a novel cyclin D partner journal Mol. Cell. Biol. volume 14 issue 3 ... of eukaryotic initiation factor 3 eIF3k as a new interaction partner of cyclin D3 journal FEBS Lett ... journal author Motokura T, Yi HF, Kronenberg HM, et al. title Assignment of the human cyclin D3 gene ... cyclin binding regions of proliferating cell nuclear antigen. journal J. Biol. Chem. volume 269 issue ... of G1 kinase activity for cdk6, a novel cyclin D partner. journal Mol. Cell. Biol. volume ... more details
Image 2B9R.png thumb alt Structure of PDB 2B9R human cyclin B rendered with PyMol DeLano Scientific Freeware . Structure of human cyclin B. ref name pmid17495533 cite journal author Petri, E.T., Errico, A., Escobedo, L., Hunt, T., and Basavappa, R. title The crystal structure of human cyclin B journal Cell Cycle volume 11 issue 11 pages 1342 9 year 2007 pmid 17495533 ref protein Name cyclin B1 caption image width HGNCid 1579 Symbol cyclin B1 CCNB1 AltSymbols CCNB EntrezGene 891 OMIM 123836 RefSeq NM 031966 UniProt P14635 PDB ECnumber Chromosome 5 Arm q Band 12 LocusSupplementaryData protein Name cyclin B2 caption image width HGNCid 1580 Symbol cyclin B2 CCNB2 AltSymbols EntrezGene 9133 OMIM 602755 RefSeq NM 004701 UniProt O95067 PDB ECnumber Chromosome 15 Arm q Band 21.3 LocusSupplementaryData protein Name cyclin B3 caption image width HGNCid 18709 Symbol CCNB3 AltSymbols EntrezGene 85417 OMIM 300456 RefSeq NM 033670 UniProt Q8WWL7 PDB ECnumber Chromosome X Arm p Band 11 LocusSupplementaryData Cyclin B is a member of the cyclin family. Cyclin B is a mitosis mitotic cyclin. The amount of cyclin B which binds to Cdk1 and the activity of the cyclin B Cdk complex rise through the cell cycle ref name pmid11089869 cite journal author Ito M title Factors controlling cyclin B expression journal Plant Mol. Biol. volume 43 issue 5 6 pages 677 90 year 2000 month August pmid 11089869 doi 10.1023 A 1006336005587 url http www.kluweronline.com art.pdf?issn 0167 4412&volume 43&page 677 issn ref until mitosis, where they fall abruptly due to degradation of cyclin B Cdk1 is constitutively present ... of cyclin B journal Philos. Trans. R. Soc. Lond., B, Biol. Sci. volume 354 issue 1389 pages ... url issn ref The complex of Cdk and cyclin B is called maturation promoting factor or mitosis ... through the cell cycle . See also Cyclin B1 Cyclin B2 References Reflist External links MeshName Cyclin B http www.sdbonline.org fly newgene cyclinb1.htm Drosophila Cyclin B The Interactive Fly Cell ... more details
protein Name CCNE1 cyclin E1 caption image width HGNCid 1589 Symbol CCNE1 AltSymbols CCNE EntrezGene 898 OMIM 123837 RefSeq NM 001238 UniProt P24864 PDB ECnumber Chromosome 19 Arm q Band 12 LocusSupplementaryData protein Name CCNE2 cyclin E2 caption image width HGNCid 1590 Symbol CCNE2 AltSymbols EntrezGene 9134 OMIM 603775 RefSeq NM 057749 UniProt O96020 PDB ECnumber Chromosome 8 Arm q Band 22.1 LocusSupplementaryData Cyclin E is a member of the cyclin family. Cyclin E binds to G1 phase G sub 1 sub phase Cdk2 , which is required for the transition from G sub 1 sub to S phase . The Cyclin E CDK2 complex phosphorylation phosphorylates p27 sup Kip1 sup an Enzyme inhibitor inhibitor of Cyclin D , tagging it for degradation, thus promoting expression of Cyclin A , allowing progression to S phase. Image Cyclinexpression waehrend Zellzyklus.png center 422px Expression of cyclins through the cell cycle . External links MeshName Cyclin E Cell biology stub Cell cycle proteins Category Cell cycle Category Proteins es Ciclina E ... more details
The Cyclin D Cdk4 complex is a compound structure of Cyclin D and Cdk4 , regulated by the GATA1 GATA 1 transcription factor . ref cite journal author Muntean A, Pang L, Poncz M, Dowdy S, Blobel G, Crispino J title Cyclin D Cdk4 is regulated by GATA 1 and required for megakaryocyte growth and polyploidization journal Blood volume 109 issue 12 pages 5199 207 year 2007 pmid 17317855 doi 10.1182 blood 2006 11 059378 pmc 1890844 ref See also Human papillomavirus References references biochemistry stub Category Cell cycle Category Human proteins Category Papillomavirus Category Protein complexes Category Transcription factors es Ciclina D Cdk4 ... more details
PBB geneid 8900 Cyclin A1 is a protein that in humans is encoded by the CCNA1 gene . ref name pmid9041194 cite journal author Yang R, Morosetti R, Koeffler HP title Characterization of a second human cyclin ... section title summary text The protein encoded by this gene belongs to the highly conserved cyclin ... complex together with cyclin dependent kinases cyclin dependent kinases CDKs . Different cyclins ... of cell cycle events. Cyclin A1 was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of meiosis . This cyclin ..., the other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind ... Cip family of CDK inhibitor proteins. ref name entrez Cite web title Entrez Gene CCNA1 cyclin ... ref Interactions Cyclin A1 Protein protein interaction interacts with E2F1 , ref name pmid10022926 ... H P year 1999 month Mar. title Functions of cyclin A1 in the cell cycle and its interactions ... S, Hatakeyama M year 2000 month Feb. title Human p55 CDC Cdc20 associates with cyclin A and is phosphorylated by the cyclin A Cdk2 complex journal Biochem. Biophys. Res. Commun. volume 268 issue ... protein , ref name pmid10022926 Cyclin dependent kinase 2 , ref name pmid9041194 cite journal quotes ... Characterization of a second human cyclin A that is highly expressed in testis and in several leukemic ... A distinct cyclin A is expressed in germ cells in the mouse journal Development volume 122 issue 1 ... W E, Serve H, Saville M, Watson R, Koeffler H P year 2001 month Apr. title Cyclin A1 directly interacts with B myb and cyclin A1 cdk2 phosphorylate B myb at functionally important serine and threonine ... peptides for cyclin dependent kinases journal Nat. Cell Biol. volume 1 issue 7 pages 438 43 publisher ... month Aug. title Identification of interaction partners and substrates of the cyclin A1 CDK2 complex ... M, Bates S, Peters G title Evidence for different modes of action of cyclin dependent kinase inhibitors ... more details
PBB geneid 891 G2 mitotic specific cyclin B1 is a protein that in humans is encoded by the CCNB1 gene ... 92 90190 4 ref Function Cyclin B1 is a regulatory protein involved in mitosis . The gene product complexes ... web title Entrez Gene CCNB1 cyclin B1 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 891 accessdate ref Cyclin B1 contributes to the switch like all or none behavior ... loops ensure that once the cyclin B1 Cdk1 complex is activated it is not deactivated. Cyclin B1 ... breakdown, and spindle pole assembly. Once activated, cyclin B1 Cdk1 promotes several of the events .... Another important function of the cyclin B1 Cdk1 complex is to break down the nuclear envelope ... of Lamin nuclear lamins . Phosphorylation of the lamins by cyclin B1 Cdk1 causes them to dissociate ... Image Nsp cellcycle 5 3 5 8.jpg thumb 300px left Cyclin B1 accumulates throughout the cell ... cell cycle. Like all cyclins, levels of cyclin B1 oscillate over the course of the cell cycle. Just prior to mitosis, a large amount of cyclin B1 is present in the cell, but it is inactive due to phosphorylation .... A possible trigger for activation is phosphorylation by cyclin A Cdk, which functions before cyclin B1 Cdk in the cell cycle. Active Cdk1 is also capable of phosphorylating and activating Cdc25 and thus promote its own activation, resulting in a positive feedback loop. Once cyclin B1 Cdk1 is activated, it remains stably active for the rest of mitosis. Another mechanism by which cyclin B1 Cdk1 activity is regulated is through subcellular localization. Before mitosis almost all cyclin ... by the phosphorylation of cyclin B1, in contrast to phosphorylation of Cdk1 regulating the activity of the complex. Phosphorylation of cyclin B1 causes it to be imported to the nucleus ... of cyclin B1 to the nucleus at prophase requires a phosphorylation dependent nuclear import signal ... ES, Kornbluth S title Combinatorial control of cyclin B1 nuclear trafficking through phosphorylation ... more details
PBB geneid 890 Cyclin A2 is a protein that in humans is encoded by the CCNA2 gene . ref name pmid1675006 ... in the human cyclin A gene journal Nucleic Acids Res volume 19 issue 9 pages 2516 date July 1991 ... summary text The protein encoded by this gene belongs to the highly conserved cyclin family, whose members ... patterns which contribute to the temporal coordination of each mitotic event. In contrast to cyclin A1, which is present only in germ cells, this cyclin is expressed in all tissues tested. This cyclin .... ref name entrez cite web title Entrez Gene CCNA2 cyclin A2 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 890 accessdate ref See also Cyclin A Interactions Cyclin A2 has been shown to Protein protein interaction interact with ITGB3BP , ref name pmid10673397 ... M date January 2000 title beta3 endonexin as a novel inhibitor of cyclin A associated kinase ... K A, Peng C Y, Yee A S, Piwnica Worms H date December 1994 title Cyclin A CDK2 binds directly ... C S, Bartek J, Helin K date January 1999 title Phosphorylation of mammalian CDC6 by cyclin A CDK2 ... J D, Dutta A date May 1998 title Human CDC6 Cdc18 Associates with Orc1 and Cyclin cdk and Is Selectively ... Koundrioukoff St phane, H bscher Ulrich date July 2003 title Phosphorylation of human Fen1 by cyclin ... F, et al. title Cyclin A is required at two points in the human cell cycle journal EMBO J. volume 11 ... T, Bornens M title Cytoplasmic accumulation of cyclin B1 in human cells association with a detergent ... between human cyclin A and adenovirus E1A associated p107 protein journal Science volume 255 ... LR, Adamczewski JP, Hunt T, La Thangue NB title Cyclin A and the retinoblastoma gene product complex ... Assignment of a human cyclin A gene to 4q26 q27 journal Genomics volume 8 issue 3 pages 595 7 year ... B, Br chot C title Hepatitis B virus integration in a cyclin A gene in a hepatocellular carcinoma ... 7630397 doi 10.1038 376313a0 cite journal author Xu M, Sheppard KA, Peng CY, et al. title Cyclin ... more details
PBB geneid 8812 Cyclin K is a protein that in humans is encoded by the CCNK gene . ref name pmid9632813 cite journal author Edwards MC, Wong C, Elledge SJ title Human Cyclin K, a Novel RNA Polymerase II Associated Cyclin Possessing Both Carboxy Terminal Domain Kinase and Cdk Activating Kinase Activity journal Mol Cell Biol volume 18 issue 7 pages 4291 300 year 1998 month Jul pmid 9632813 pmc 109013 doi ref ref name pmid10574912 cite journal author Fu TJ, Peng J, Lee G, Price DH, Flores O title Cyclin K functions as a CDK9 regulatory subunit and participates in RNA polymerase II transcription journal J Biol Chem volume 274 issue 49 pages 34527 30 year 2000 month Feb pmid 10574912 pmc doi 10.1074 jbc.274.49.34527 ref ref name entrez cite web title Entrez Gene CCNK cyclin K url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 8812 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text The protein encoded by this gene is a member of the transcription cyclin family. These cyclins may regulate transcription through their association with and activation of cyclin dependent kinases CDK that phosphorylate the C terminal domain CTD of the large subunit of RNA polymerase II. This gene product may play a dual role in regulating CDK and RNA polymerase II activities. ref name entrez Interactions Cyclin K has been shown to Protein protein interaction ... J, Lee G, Price D H, Flores O year 1999 month Dec. title Cyclin K functions as a CDK9 regulatory subunit ... R, Fujinaga K, Peterlin BM title P TEFb containing cyclin K and Cdk9 can activate transcription via ... jbc.M200117200 cite journal author Mori T title Cyclin K as a Direct Transcriptional Target of the p53 ... author Baek K, Brown RS, Birrane G, Ladias JA title Crystal Structure of Human Cyclin K, a Positive Regulator of Cyclin dependent Kinase 9 journal J. Mol. Biol. volume 366 issue 2 pages 563 73 year ... more details
PBB geneid 905 Cyclin T2 is a protein that in humans is encoded by the CCNT2 gene . ref name pmid9499409 cite journal author Peng J, Zhu Y, Milton JT, Price DH title Identification of multiple cyclin subunits of human P TEFb journal Genes Dev volume 12 issue 5 pages 755 62 year 1998 month Apr pmid 9499409 ... Gene CCNT2 cyclin T2 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch ... by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic ... to the temporal coordination of each mitotic event. This cyclin and its kinase partner CDK9 were found to be subunits of the transcription elongation factor p TEFb. The p TEFb complex containing this cyclin ..., have been described. ref name entrez cite web title Entrez Gene CCNT2 cyclin T2 url http www.ncbi.nlm.nih.gov ... Cyclin T2 has been shown to Protein protein interaction interact with CDK9 ref name pmid9499409 ... D H year 1998 month Mar. title Identification of multiple cyclin subunits of human P TEFb journal ... and human immunodeficiency virus replication are facilitated by human cyclin T1 but not cyclins ... cyclin T proteins in regulating HIV 1 tat activation. journal J. Mol. Biol. volume 288 issue 1 pages ... TA, Bogerd HP, Cullen BR title Analysis of the effect of natural sequence variation in Tat and in cyclin T on the formation and RNA binding properties of Tat cyclin T complexes. journal J. Virol. volume ... MA title The Cdk9 and cyclin T subunits of TAK P TEFb localize to splicing factor rich nuclear ... to and inhibits the activity of CDK9 cyclin T complexes. journal Nature volume 414 issue 6861 pages ... author Michels AA, Nguyen VT, Fraldi A, et al. title MAQ1 and 7SK RNA interact with CDK9 cyclin T complexes ... BM title Transcriptional activity and substrate recognition of cyclin T2 from P TEFb. journal Gene ... is a novel partner of cyclin T2a in muscle differentiation. journal J. Cell. Physiol. volume 207 issue ... A title Abrogation of signal dependent activation of the cdk9 cyclin T2a complex in human RD rhabdomyosarcoma ... more details
Cleanup date November 2007 PBB geneid 898 G1 S specific cyclin E1 is a protein that in humans is encoded ... of three novel human cyclins by rescue of G1 cyclin Cln function in yeast journal Cell volume ... conserved cyclin family, whose members are characterized by a dramatic periodicity in protein ... of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2 ... is not yet available. ref name entrez Cite web title Entrez Gene CCNE1 cyclin E1 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 898 accessdate ref See also cyclin E Interactions Cyclin E1 has been shown to Protein protein interaction interact with Retinoblastoma ... Seghezzi W, Parry D, Mahony D, Lees E year 1999 month Feb. title Cyclin E associates with BAF155 and BRG1 ... and activation of a cyclin E cdk2 complex during the G1 phase of the human cell cycle journal Science ... oclc id url language format accessdate laysummary laysource laydate quote ref Cyclin dependent ... 3 targets cyclin E for ubiquitination and controls S phase in mammalian cells journal Genes Dev. volume ... doi Cite journal author Mazumder S, DuPree EL, Almasan A title A dual role of cyclin E in cell ... D, et al. title Formation and activation of a cyclin E cdk2 complex during the G1 phase of the human ... science.1388288 Cite journal author Koff A, Cross F, Fisher A, et al. title Human cyclin E, a new cyclin that interacts with two members of the CDC2 gene family. journal Cell volume 66 issue 6 pages ... cyclin C CCNC , cyclin E CCNE , p21 CDKN1 and KAP CDKN3 . journal Cytogenet. Cell Genet. volume 69 ... AM, Schumacher J, et al. title Human cyclin E, a nuclear protein essential for the G1 to S phase ... cyclin E. series 107 journal J. Cell. Sci. volume Pt 2 issue pages 581 8 year 1994 pmid 8207080 ... of the cyclin E gene by transcription factor E2F1. journal Proc. Natl. Acad. Sci. U.S.A. volume ... journal author Geng Y, Eaton EN, Pic n M, et al. title Regulation of cyclin E transcription by E2Fs ... more details
PBB geneid 9133 G2 mitotic specific cyclin B2 is a protein that in humans is encoded by the CCNB2 gene . The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text Cyclin B2 is a member of the cyclin family, specifically the B type cyclins. The B type cyclins, B1 and B2, associate with p34cdc2 and are essential components of the cell cycle regulatory machinery. B1 and B2 differ in their subcellular localization. Cyclin B1 co localizes with microtubules, whereas cyclin B2 is primarily associated with the Golgi region. Cyclin B2 also binds to transforming growth factor beta RII and thus cyclin B2 cdc2 may play a key role in transforming growth factor beta mediated cell cycle control. ref name entrez cite web title Entrez Gene CCNB2 cyclin B2 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 9133 accessdate ref See also Cyclin B Interactions Cyclin B2 has been shown to Protein protein interaction interact with TGF beta receptor 2 . ref name pmid9926943 cite journal last Liu first J H authorlink coauthors Wei S, Burnette P K, Gamero A M, Hutton M, Djeu J Y year 1999 month Jan. title Functional association of TGF beta receptor II with cyclin B journal Oncogene volume 18 issue 1 pages 269 75 publisher location ENGLAND issn 0950 9232 pmid 9926943 doi 10.1038 sj.onc.1202263 bibcode oclc id url language format accessdate laysummary laysource laydate quote ref References reflist Further reading refbegin 2 PBB Further reading citations cite journal author He ... the activation of p34cdc2 cyclin B. journal J. Virol. volume 69 issue 11 pages 6859 64 year 1995 ... localization of human cyclins A and B is due to a cytoplasmic retention signal in cyclin B. journal ... al. title Cyclin B2 null mice develop normally and are fertile whereas cyclin B1 null mice die in utero ... association of TGF beta receptor II with cyclin B. journal Oncogene volume 18 issue 1 pages ... more details
PBB geneid 902 Cyclin H is a protein that in humans is encoded by the CCNH gene . ref name pmid9465303 cite journal author Eki T, Okumura K, Abe M, Kagotani K, Taguchi H, Murakami Y, Pan ZQ, Hanaoka F title Mapping of the human genes encoding cyclin H CCNH and the CDK activating kinase CAK assembly factor ... cite web title Entrez Gene CCNH cyclin H url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ... The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized ... which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex ... kinases, thus functions as a CDK activating kinase CAK . This cyclin and its kinase partner are components ... and the cell cycle machinery. ref name entrez Interactions Cyclin H has been shown to Protein ... laydate quote ref Cyclin dependent kinase 7 ref name pmid8078587 cite journal last M kel first ... Sep. title A cyclin associated with the CDK activating kinase MO15 journal Nature journal Nature ... R, Xiong Y year 1995 month Dec. title Molecular cloning of CDK7 associated human MAT1, a cyclin ... interacts with MAT1, a cyclin dependent kinase activating kinase complex ring finger factor, and regulates ... X cite journal author Fisher RP, Morgan DO title A novel cyclin associates with MO15 CDK7 to form ... 0092 8674 94 90535 5 cite journal author M kel TP title A cyclin associated with the CDK activating ... TW cite journal author Tassan JP title In vitro assembly of a functional human CDK7 cyclin H complex ... Adamczewski JP title MAT1, cdk7 and cyclin H form a kinase complex which is UV light sensitive upon ... cite journal author Drapkin R title Human cyclin dependent kinase activating kinase exists in three ... HM, Morgan DO, Kim SH title Three dimensional structure of human cyclin H, a positive regulator ... Poterszman A title Expression in Escherichia coli purification and characterization of cyclin H, a subunit ... Andersen G title The structure of cyclin H common mode of kinase activation and specific features ... more details
PBB geneid 904 Cyclin T1 is a protein that in humans is encoded by the CCNT1 gene . ref name pmid9491887 cite journal author Wei P, Garber ME, Fang SM, Fischer WH, Jones KA title A novel CDK9 associated C type cyclin interacts directly with HIV 1 Tat and mediates its high affinity, loop specific binding to TAR RNA journal Cell volume 92 issue 4 pages 451 62 year 1998 month Mar pmid 9491887 pmc doi 10.1016 S0092 8674 00 80939 3 ref ref name pmid9499409 cite journal author Peng J, Zhu Y, Milton JT, Price DH title Identification of multiple cyclin subunits of human P TEFb journal Genes Dev volume ... conserved cyclin family, whose members are characterized by a dramatic periodicity in protein ... mitotic event. This cyclin tightly associates with CDK9 kinase, and was found to be a major subunit of the transcription elongation factor p TEFb. The kinase complex containing this cyclin and the elongation ... transcription. This cyclin and its kinase partner were also found to be involved in the phosphorylation ... cite web title Entrez Gene CCNT1 cyclin T1 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 904 accessdate ref Interactions Cyclin T1 has been shown to Protein protein ..., Lania Luigi, Bensaude Olivier year 2003 month Jul. title MAQ1 and 7SK RNA interact with CDK9 cyclin ... interacts with cyclin T1 and modulates P TEFb dependent transcription journal Mol. Cell. Biol. volume .... title Identification of multiple cyclin subunits of human P TEFb journal Genes Dev. volume 12 issue ... Sep. title The human I mfa domain containing protein, HIC, interacts with cyclin T1 and modulates ... J C, Lorca T, Nakayama Ki K, Benkirane M year 2001 month Dec. title Interaction between cyclin ... Peng J, Lee G, Price D H, Flores O year 1999 month Dec. title Cyclin K functions as a CDK9 regulatory ... of human cyclin T1 to nuclear bodies through direct interaction with the PML protein journal ... cite journal author Romano G, Kasten M, De Falco G, et al. title Regulatory functions of Cdk9 and of cyclin ... more details
Infobox building name Dubai Number One image Deleted image removed File Mohammad nabil rais D 1 Tower.JPG 250px D1 Tower in October 2007 caption D1 under construction in 2009 building type Residential location latd 25 latm 13 lats 37.90 latNS N longd 55 longm 20 longs 26.52 longEW E iso region AE coordinates display title roof convert 284 m ft abbr on floor count 80 start date 2007 est completion 2011 opening elevator count floor area developer ENSHAA PSC and Sunland Group architect D1 meaning Dubai Number One is an 80 Storey floor residential skyscraper currently under construction in Dubai , United Arab Emirates . The tower has a total structural height of convert 284 m ft abbr on , but the design originally included a spire that would bring the total height to convert 350 m ft abbr on . Construction of D1 is expected to be completed in 2011. The tower is the sister of the world s tallest residential building, Q1 building Q1 in Gold Coast, Queensland Gold Coast , Australia . Although they will look similar, D1 will be structurally shorter, whilst having a taller roof height. This is because Q1 has a roof height of convert 275 m ft abbr on with a spire increasing the total height to convert 323 m ft abbr on . D1 will feature skyrise lounge, private cinema, indoor pool, gymnasium and concierge services. D1 is adjacent to the Palazzo Versace Dubai. See also List of tallest buildings in Dubai Q1 building Q1 External links http www.d1tower.com Official website http skyscraperpage.com cities ?buildingID 57011 SkyscraperPage entry http www.emporis.com en wm bu ?id d1tower dubai unitedarabemirates Emporis entry Future Dubai skyscrapers DEFAULTSORT D1 Building Category Residential skyscrapers in Dubai Category Buildings and structures under construction in Dubai UAE struct stub es D1 Rascacielo fr D1 Tower id D1 Tower ja D1 pl D1 Tower pt D1 Tower ru D1 Tower ... more details
PBB geneid 10309 Cyclin O is a protein that in humans is encoded by the CCNO gene . ref name entrez cite web title Entrez Gene CCNO cyclin O url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 10309 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text Interactions Cyclin O has been shown to Protein protein interaction interact with RPA2 ref name pmid10393198 cite journal last Otterlei first M authorlink coauthors Warbrick E, Nagelhus T A, Haug T, Slupphaug G, Akbari M, Aas P A, Steinsbekk K, Bakke O, Krokan H E year 1999 month Jul. title Post replicative base excision repair in replication foci journal EMBO J. volume 18 issue 13 pages 3834 44 publisher location ENGLAND issn 0261 4189 pmid 10393198 doi 10.1093 emboj 18.13.3834 bibcode oclc id url language format accessdate laysummary laysource laydate quote pmc 1171460 ref and PCNA . ref name pmid10393198 ref name pmid12171929 cite journal last Ohta first Satoshi authorlink coauthors Shiomi Yasushi, Sugimoto Katsunori, Obuse Chikashi, Tsurimoto Toshiki year 2002 month Oct. title A proteomics approach to identify proliferating cell nuclear antigen PCNA binding proteins in human cell lysates. Identification of the human CHL12 RFCs2 5 complex as a novel PCNA binding protein journal J. Biol. Chem. volume 277 issue 43 pages 40362 7 publisher location United States issn 0021 9258 pmid 12171929 doi 10.1074 jbc.M206194200 bibcode oclc id url language format accessdate laysummary laysource laydate quote ref References reflist Further reading refbegin 2 PBB Further reading citations cite journal title The nature of enzymes involved in uracil DNA repair isoform characteristics of proteins ... title Cell cycle regulation of a human cyclin like gene encoding uracil DNA glycosylase journal J. Biol ... Rasooly first9 R pmc 528928 cite journal title The cyclin like uracil DNA glycosylase UDG of murine ... more details
Infobox camera model Nikon D1 image File Nikon D1 8373.jpg 300px kind Digital single lens reflex camera ... II, 2GB maximum weight Approx. 1.1 kg without battery or lens madeIn Japan The Nikon D1 is a digital ... image.com eng news release 1999 D1.html title The Nikon D1 publisher Nikon Corporation date ... SLR cameras to quickly become proficient in using the camera. Autofocus speed on the D1 series bodies ... digital SLR cameras for several years prior, the D1 was the first professional digital SLR that displaced ... reviews nikond1 title Nikon D1 Review 1. Intro first Phil last Askey publisher Digital Photography Review date 2000 11 27 accessdate 2009 10 25 ref Unusual for a DSLR, the D1 uses the NTSC color space instead of the conventional sRGB or Adobe RGB color spaces. The resulting color on the D1 ... available. ref cite web url http www.bythom.com d1series.htm title The Nikon D1, D1h, and D1x ... ivo photography NikonD1 nikond1 workflow.htm title Nikon D1 digital workflow first Ivo last Kwee ... D1 Review 16. Image Quality first Phil last Askey publisher Digital Photography Review date 2000 ... The D1 was replaced by the D1H and D1X on February 5, 2001. ref cite press release url http www.nikon ... was oriented towards fast action photography, keeping the same 2.7 megapixels image sensor as the D1 ... the sRGB AdobeRGB color spaces, which is an improvement over the original D1. Development and its significance plus its Sensor Design Development began on the D1 in 1996, when digital imaging was in its ... in the D1 was for a 23.7 15.6 mm CCD producing images with a final resolution of 2000 1312 pixels ... for and used in the D1, and subsequently the D1H, actually utilised 10.8 million photosites rather ... products imaging lineup digitalcamera slr d1 index.htm Nikon D1 Product Page Nikon Global Website ... review of the D1, D1h and D1x http www.naturfotograf.com d1 rev00.html top The End of The Beginning The Beginning of The End A review of D1 by Bj rn R rslett http www.naturfotograf.com D1X review.html ... more details
Infobox Ship Begin Infobox Ship Image Ship image Image HMS D1 WWI .jpg 300px Ship caption HMS D1 Infobox Ship Career Hide header Ship country Ship flag Image Naval Ensign of the United Kingdom.svg 60px RN Ensign Ship class Ship name HMS D1 Ship ordered Ship awarded Ship builder Vickers Armstrongs Vickers Armstrong , Barrow in Furness Ship laid down 14 May 1907 Ship launched 16 May 1908 Ship christened Ship acquired Ship commissioned September 1909 Ship recommissioned Ship decommissioned Ship in service Ship out of service Ship renamed Ship reclassified Ship refit Ship captured Ship struck Ship reinstated Ship fate Sunk as a target on 23 October 1918 Ship status Ship homeport Infobox Ship Characteristics Hide header Header caption Ship class D class submarine Ship displacement Surfaced 483 tons Submerged 595 tons Ship length convert 163.0 ft m abbr on oa Ship beam convert 13.6 ft m abbr on oa Ship draught Ship draft Ship propulsion 550hp electric 1750hp diesel twin screws Ship speed Surfaced 14.0 kts Dived 10.0 design 9.0 service Ship range Surface 2500nm at 10 kts Submerged 45nm at 5knots Ship endurance Ship test depth Ship complement 25 Ship sensors Ship EW Ship armament 3x18 in 46 cm torpedo tube s 2 forward, one aft, 6 torpedo es ref Fitzsimons, Bernard. Illustrated Encyclopedia of 20th Century Weapons and Warfare London Phoebus, 1978 , Volume 7, p.674, D.1 . ref 1x12 pdr 76 mm British ordnance terms QF QF gun ref Fitzsimons, p.674. ref Ship notes HMS D1 was a British D class submarine built by Vickers , Barrow in Furness Barrow . D1 was laid down on 14 May 1907 and was launched on 16 May 1908 at Barrow. She was commissioned in September 1909. In 1910, D1 took part in the Annual Manoevures. She torpedoed 2 blue fleet cruisers off Colonsay . This showed that the D class could operate a considerable away from their base at Fort Blockhouse . D1 was sunk as a target on 23 October 1918. External links http www.maritimequest.com warship directory great britain submarines ... more details
Infobox Locomotive name PRR D1 powertype Steam image PRR D1 28.jpg caption D1 28 builder PRR Altoona Works builddate 1868 1872 totalproduction 13 whytetype 4 4 0 uicclass 2 B gauge RailGauge ussg leadingdiameter convert 26 in mm 0 abbr on ref name dredge driverdiameter convert 68 in mm 0 abbr on ref name dredge wheelbase convert 22 ft 5 5 8 in m 2 abbr on locomotive br convert 44 ft 11 5 8 in abbr on overall ref name diagram length convert 54 ft 6.44 in abbr on ref name diagram cite web title Class D1 diagram url http prr.railfan.net diagrams PRRdiagrams.html?diag d1.gif&sel ste&sz sm&fr author Pennsylvania Railroad publisher PRR.Railfan.net accessdate 2008 08 19 ref width convert 9 ft 0.94 in m 2 abbr on ref name diagram height convert 14 ft 8 in m 2 abbr on ref name diagram weightondrivers convert 42370 lb t 1 abbr in ref name diagram locoweight convert 77700 lb t 1 abbr in ref name diagram tenderweight convert 51400 lb t 1 abbr in ref name diagram locotenderweight convert 129100 lb t 1 abbr in ref name diagram tendertype Eight wheel with water scoop fueltype Soft coal fuelcap convert 8000 lb t 1 abbr in ref name diagram watercap convert 2400 usgal abbr on ref name diagram The Pennsylvania Railroad s steam locomotive class D1 formerly Class A , pre 1895 comprised thirteen 4 4 0 locomotives for express passenger train passenger service , constructed at the railroad s own Altoona Works during 1868 1872. ref name prr roster cite web title PRR Steam Roster url http www.northeast.railfan.net prr steam2.html work Northeast Rails accessdate 2007 12 31 ref They were the first standardized class of locomotives on the railroad and shared many parts with other standard classes. ref name dredge cite book title The Pennsylvania Railroad first James last Dredge year 1879 publisher Engineering magazine location London ref Image PRR D1 AirBrake.jpg thumb none PRR D1 fitted with experimental Westinghouse air brake equipment during the trials of September 1869. The PRR was the first ... more details
PBB geneid 5337 Phospholipase D1 is an enzyme that in humans is encoded by the PLD1 gene . ref name pmid9858822 cite journal author Park SH, Chun YH, Ryu SH, Suh PG, Kim H title Assignment of human PLD1 ... ref name entrez cite web title Entrez Gene PLD1 phospholipase D1, phosphatidylcholine specific url ... Interactions Phospholipase D1 has been shown to Protein protein interaction interact with RALA , ref ... with the Arf responsive, PIP2 dependent phospholipase D1 journal Biochem. Biophys. Res. Commun. volume ... Jul. title Activation of phospholipase D1 by direct interaction with ADP ribosylation factor 1 and RalA .... title Regulation of expression of phospholipase D1 and D2 by PEA 15, a novel protein that interacts ... Klaus, Just Ingo year 2003 month Feb. title Activation of phospholipase D1 by ADP ribosylated RhoA ... J H year 2001 month May. title Determination of interaction sites of phospholipase D1 for RhoA journal ... regulates phospholipase D1 through direct interaction journal J. Biol. Chem. volume 276 issue 21 pages ... H A year 2000 month May. title Activation of phospholipase D1 by Cdc42 requires the Rho insert ... S, et al. title Characterization of two alternately spliced forms of phospholipase D1. Activation ... phospholipase D1. journal Biochem. Biophys. Res. Commun. volume 235 issue 3 pages 854 9 year 1997 ... JH, Lee SD, Han JM, et al. title Activation of phospholipase D1 by direct interaction with ADP ribosylation ... al. title Phospholipase D1 in caveolae regulation by protein kinase Calpha and caveolin 1. journal ... author Kim Y, Han JM, Park JB, et al. title Phosphorylation and activation of phospholipase D1 ... SJ, Wu WJ, Cerione RA, Brown HA title Activation of phospholipase D1 by Cdc42 requires the Rho ... author Zhang Y, Redina O, Altshuller YM, et al. title Regulation of expression of phospholipase D1 ... D1 through direct interaction. journal J. Biol. Chem. volume 276 issue 21 pages 18096 101 ... of interaction sites of phospholipase D1 for RhoA. journal Biochem. J. volume 355 issue Pt ... more details
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