Infobox Disease Name Coagulopathy Image Caption DiseasesDB 29158 ICD10 ICD10 D 65 d 65 ICD10 D 68 d 65 ICD9 ICD9 286 ICDO OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID D001778 Coagulopathy also called clotting disorder and bleeding disorder is a condition in which the blood s ability to clot is impaired. This condition can cause prolonged or excessive bleeding, which may occur spontaneously or following an injury or medical and dental procedures. The normal clotting process depends on the interplay of various proteins in the blood. Coagulopathy may be caused by reduced levels or absence of blood clotting proteins, known as clotting factors or coagulation factors. Genetic disorders , such as hemophilia and Von Willebrand s disease , can cause a reduction in clotting factors. Coagulopathy may also occur as a result of dysfunction or reduced levels of platelet platelets small disk shaped bodies in the bloodstream that aid in the clotting process . If someone has coagulopathy, their health care provider may help them manage their symptoms with medications or replacement therapy. In replacement therapy, the reduced or absent clotting factors are replaced with proteins derived from human blood or created in the laboratory. This therapy may be given either to treat bleeding that has already begun or to prevent bleeding from occurring. Coagulopathy may cause uncontrolled internal or external bleeding. Left untreated, uncontrolled bleeding may cause damage to joints, muscles, or internal organs and may be life threatening. Patients should seek immediate medical care for serious symptoms, including heavy external bleeding, blood in the urine or Blood in stool stool , double vision , severe head or neck pain, repeated vomiting , difficulty walking, convulsions, or seizures. They should seek prompt medical care if they experience mild but unstoppable external bleeding or joint swelling and stiffness. ref http www.bettermedicine.com article coagulopathy ref Hypocoagulability ... more details
unreferenced date March 2011 Venom induced consumption coagulopathy VICC is a medical condition caused by the effects of some snake venoms on hemostasis . Important coagulation factors are activated by the specific toxins , and as they become exhausted coagulopathy develops. Category Toxicology Category Coagulopathies med toxic stub ... more details
Triangle of Death may refer to Triangle of Death Algeria , an area south of Algiers during the Algerian Civil War Triangle of Death Iraq , term applied by U.S. and allied forces to a region south of Baghdad Triangle of death Italy , an area in southern Italy with an unusual high number of deaths caused by cancer and other diseases, suspected to be caused by illegal dumping of toxic waste The Triangle of Death documentary The Triangle of Death documentary , 2009 film about the war in Iraq See also Trauma triad of death , the fatal combination of hypothermia, acidosis and coagulopathy disambig ... more details
File Trauma triad of death.svg thumb 280px Triad of death The Trauma triad of death is a medical term describing the combination of hypothermia , acidosis and coagulopathy . ref Citation last Mikhail first J. pmid 10347389 title The trauma triad of death hypothermia, acidosis, and coagulopathy journal AACN Clin Issues year 1999 Feb volume 10 issue 1 pages 85&ndash 94 issn doi ref This combination is commonly seen in patients who have sustained severe traumatic injuries and results in a significant rise in the mortality rate. ref Citation last Lewis first Anne Marie url http findarticles.com p articles mi qa3689 is 200003 ai n8900119 title Trauma triad of death emergency journal Nursing date Mar 2000 issn doi ref The three conditions share a complex relationship each factor can compound the others, resulting in high mortality if the cycle continues uninterrupted. Severe hemorrhage in trauma diminishes oxygen delivery, causing the patient s body temperature to drop hypothermia . This in turn can halt the Coagulation coagulation cascade , preventing blood from clotting coagulopathy . In the absence of blood bound oxygen and nutrients hypoperfusion , the body s cells burn glucose anaerobically for energy lactic acidosis , which in turn increases the blood s acidity metabolic acidosis . Such an increase in acidity can reduce the efficiency of the heart muscles myocardial myocardial performance , further reducing the oxygen delivery and hence triggering a deadly cycle. References Reflist External links Citation first Alicia M. last Mohr first2 Juan A. last2 Asensio first3 Luis M. last3 Garc a N ez first4 Patrizio last4 Petrone first5 Ziad C. last5 Sifri url http www.itaccs.com traumacare archive 05 04 Fall 2005 Fall2005.pdf title Guidelines for the Institution of Damage Control in Trauma Patients journal ITACCS volume 15 issue 4 pages 185&ndash 188 year 2005 issn doi DEFAULTSORT Trauma Triad Of Death Category Blood disorders Category Traumatology he ... more details
Refimprove date December 2009 Interventions infobox Name PAGENAME Image Caption ICD10 ICD9 MeshID D010536 OtherCodes A peritoneovenous shunt also called Denver shunt ref http medical dictionary.thefreedictionary.com Denver shunt thefreedictionary.com Denver shunt Citing McGraw Hill Concise Dictionary of Modern Medicine. 2002 ref is a shunt medical shunt which drains peritoneal fluid from the peritoneum into vein s, usually the internal jugular vein or the superior vena cava . It is sometimes used in patients with refractory ascites . It is a long tube with a non return valve running subcutaneously from the peritoneum to the internal jugular vein in the neck, which allows ascitic fluid to pass directly into the systemic circulation. Possible Complications Infection Superior vena caval thrombosis pulmonary edema bleeding from varices DIC Disseminated intravascular coagulopathy References Reflist DEFAULTSORT Peritoneovenous Shunt Category Implants medicine stub Treatment stub ... more details
Refimprove date December 2009 Prothrombin Complex Concentrate PCC trade name Beriplex or Octaplex ref name fass is a combination of blood clotting factor s II, VII, IX and X, as well as protein C and protein S S . ref name fass http www.fass.se LIF produktfakta artikel produkt.jsp?NplID 20040607006917&DocTypeID 3&UserTypeID 0 FASS.se Farmaceutiska Specialiteter i Sverige the Swedish official drug catalog Ocplex Last updated 2009 09 03 ref It reverses the effect of warfarin a coumarin anti coagulant and is used in cases of significant bleeding in patients with a coagulopathy INR 8.0, prolonged prothrombin time, raised d dimer . Examples include gastrointestinal haemorrhage or intracranial haemorrhage. PCC is effective but expensive. In the UK is prescribed in discussion with a senior haematologist. See also Beriplex Cofact References Reflist DEFAULTSORT Prothrombin Complex Concentrate Category Blood products Category Coagulation system blood drug stub de PPSB ... more details
wikt damage control Damage control is the emergency control of situations that may hazard the sinking of the ship. Damage Control may also refer to Damage control news , efforts to stop damaging stories in journalism Damage control surgical procedure , emergency surgery designed to stabilize the patient and control acidosis, hypothermia, and coagulopathy, allowing surgeons to later perform definitive surgery Damage Control TV series Damage Control TV series , a reality television series airing on MTV Damage Control play Damage Control play , by David Auburn Damage Control comics Damage Control comics , comic book limited series published by Marvel Comics, featuring a fictitious company by the same name Damage Control company , manufacturer of guitar effects pedals and preamps. Damage Control ROM , Popular modification for HTC Evo 4g See also lookfrom damage control intitle damage control Damage disambiguation Control disambiguation disambig ... more details
Infobox Disease Name Bleeding diathesis Image Caption DiseasesDB 1442 ICD10 ICD10 D 69 9 d 65 ICD9 ICD9 287.9 ICDO OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID D006474 In medicine hematology , bleeding diathesis or bleeding tendency or predisposition or haemorrhagic diatheses is an unusual susceptibility to bleeding hemorrhage mostly due to hypocoagulability , in turn caused by a coagulopathy a defect in the system of coagulation . Several types are distinguished, ranging from mild to lethal. Also, bleeding diathesis can be caused by thinning of the skin or impaired wound healing . Hypocoagulability Hypocoagulability is a bleeding diathesis caused by coagulopathy . Causes While there are several possible causes, they generally result in excessive bleeding and a lack of clotting. Acquired Acquired causes of coagulopathy include anticoagulation with warfarin , liver failure , Vitamin K deficiency and disseminated intravascular coagulation . Additionally, the hemotoxic haemotoxic venom from certain species of snake s can cause this condition e.g. Bothrops , rattlesnakes and other species of Viperidae viper . Viral hemorrhagic fever s include dengue hemorrhagic fever and Dengue Shock Syndrome Leukemia may also cause coagulopathy. Autoimmune causes of acquired coagulation disorders There are autoimmune causes of coagulation disorders. They include acquired antibodies to coagulation factors, termed inhibitors of coagulation. The main inhibitor is directed against clotting Factor VIII. Another example is antiphospholipid syndrome . Genetic Some people lack gene s that typically produce the protein coagulation factors that allow normal clotting. Various types of Hemophilia and von Willebrand disease are the major genetic disorders associated with coagulopathy. Rare examples are Bernard Soulier syndrome , Wiskott Aldrich syndrome and Glanzmann s thrombasthenia . Symptoms class wikitable Symptom Disorders Petechiae red spots Wiskott Aldrich syndrome , where they may r ... more details
had a recurrent coagulopathy due to envenomation, which required re hospitalisation and additional antivenin administration. In clinical trials, recurrent coagulopathy the return of a coagulation abnormality ... studied. Recurrent coagulopathy may persist for one to two weeks or more. One patient discontinued ... more details
Infobox Disease Name PAGENAME Image Caption DiseasesDB ICD10 ICD10 O 72 o 60 ICD9 ICD9 666 ICDO OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID Hemorrhage after delivery, or postpartum hemorrhage , is the loss of greater than 500 ml of blood following vaginal delivery, or 1000 ml of blood following cesarean section. It is the most common cause of perinatal maternal death in the developed world and is a major cause of maternal morbidity worldwide. ref name anderson cite journal author Anderson JM, Etches D title Prevention and management of postpartum hemorrhage journal American Family Physician volume 75 issue 6 pages 875 82 year 2007 month March pmid 17390600 doi url ref Causes class wikitable style float right margin 10px Causes of postpartum hemorrhage and their incidence ref name anderson Cause Incidence Uterine atony 70 Trauma 20 Retained tissue 10 Coagulopathy 1 Causes of postpartum hemorrhage are uterine atony , physical trauma trauma , retained placenta , and coagulopathy , commonly referred to as the four Ts ref name anderson Muscle tone Tone uterine atony is the inability of the uterus to contract and may lead to continuous bleeding. Retained placental tissue and infection may contribute to uterine atony. Physical trauma Trauma trauma from the delivery may tear tissue and vessels leading to significant postpartum bleeding. Tissue biology Tissue retention of tissue from the placenta or fetus may lead to bleeding. Thrombin a bleeding disorder occurs when there a failure of clotting , such as with diseases known as coagulopathy coagulopathies . Management Medication Intravenous oxytocin is the drug of choice for postpartum hemorrhage. Misoprostol may also be effective if oxytocin is not available. ref cite web url http www.thelancet.com journals lancet article PIIS0140 6736 2809 2961924 3 abstract title Treatment of post partum haemorrhage with sublingual misoprostol versus oxytocin in women not exposed to oxytocin during labour a double blind, randomise ... more details
Infobox Disease Name PAGENAME Image Hepaticfailure.jpg Caption A person with massive ascites and caput medusae due to cirrhotic liver failure DiseasesDB 5728 ICD10 ICD10 K 72 9 k 70 ICD9 ICD9 573.8 ICDO OMIM MedlinePlus eMedicineSubj med eMedicineTopic 990 MeshID D017093 Liver failure is the inability of the liver to perform its normal protein synthesis synthetic and metabolism metabolic function as part of normal physiology. Two forms are recognised, acute and chronic. ref cite journal author O Grady JG, Schalm SW, Williams R title Acute liver failure redefining the syndromes journal Lancet volume 342 issue 8866 pages 273 5 year 1993 pmid 8101303 doi 10.1016 0140 6736 93 91818 7 url http linkinghub.elsevier.com retrieve pii 0140 6736 93 91818 7 ref Acute Acute liver failure is defined as the rapid development of hepatocellular dysfunction, specifically coagulopathy and mental status changes encephalopathy in a patient without known prior liver disease . ref name Sleisenger cite book last Sleisenger first edited by Mark Feldman, Lawrence S. Friedman, Lawrence J. Brandt consulting editor, Marvin H. title Sleisenger & Fordtran s gastrointestinal and liver disease pathophysiology, diagnosis, management year 2009 publisher MD Consult location St. Louis, Mo. isbn 978 1 4160 6189 2 url http www.mdconsult.com das book pdf 307505734 5 978 1 4160 6189 2 4 u1.0 B978 1 4160 6189 2..00093 7..DOCPDF.pdf?isbn 978 1 4160 6189 2&eid 4 u1.0 B978 1 4160 6189 2..00093 7..DOCPDF edition 9th ed. ref sup 1557 sup The diagnosis of acute liver failure is based on physical exam, laboratory findings, patient history, and past medical history to establish mental status changes, coagulopathy, rapidity of onset, and absence of known prior liver disease respectively. ref name Sleisenger sup 1557 sup The exact definition of rapid is somewhat questionable, and different sub divisions exist which are based on the time from onset of first hepatic symptoms to onset of encephalopathy. One scheme defin ... more details
Infobox symptom Name Grey Turner& 39 s sign Background Image Hemorrhagic pancreatitis Grey Turner s sign.jpg Caption Grey Turner s sign ICD10 ICD9 ICDO OMIM DiseasesDB 17313 MedlinePlus eMedicineSubj eMedicineTopic Grey Turner s sign refers to bruise bruising of the flanks . This sign takes 24 48 hours. It can predict a severe attack of acute pancreatitis , ref name pmid19332225 cite journal author Bosmann M, Schreiner O, Galle PR title Coexistence of Cullen s and Grey Turner s signs in acute pancreatitis journal Am. J. Med. volume 122 issue 4 pages 333 4 year 2009 month April pmid 19332225 doi 10.1016 j.amjmed.2008.08.032 url http linkinghub.elsevier.com retrieve pii S0002 9343 08 01059 0 ref with mortality rising from 8 10 to 40 . Citation needed date October 2009 It is a sign of retroperitoneal hemorrhage. It may be accompanied by Cullen s sign , which may then be indicative of pancreatic necrosis with retroperitoneal or intraabdominal bleeding. It is named for British surgeon George Grey Turner . ref WhoNamedIt synd 3347 ref ref G. G. Turner. Local discoloration of abdominal wall as a sign of acute pancreatitis. British Journal of Surgery, London, 1920, 7 394 395. ref Causes Causes include acute pancreatitis , whereby methemalbumin formed from digested blood tracks subcutaneous ly around the abdomen from the inflamed pancreas blunt abdominal Blunt force trauma trauma ruptured abdominal aortic aneurysm . Ruptured hemorrhagic ectopic pregnancy . spontaneous bleeding secondary to coagulopathy congenital or acquired References reflist External links GPnotebook 1382416365 http www.surgical tutor.org.uk pictures images hepatobiliary grey turners.jpg Photo http www.fmed.ulaval.ca med 18654 prive Cours 2014.htm 1 Photo Eponymous medical signs for digestive system and general abdominal signs General injuries Category Medical signs med sign stub de Grey Turner Zeichen es Signo de Grey Turner pl Objaw Greya Turnera pt Sinal de Grey Turner ... more details
Infobox Disease Name Platelet storage pool deficiency Image Caption DiseasesDB ICD10 ICD10 D 69 1 d 50 ICD9 ICDO OMIM 185050 MedlinePlus eMedicineSubj eMedicineTopic MeshID D010981 Platelet storage pool deficiency is a type of coagulopathy characterized by defects in the granules in platelet s. ref name isbn0 12 369367 5 cite book author Alan D. Michelson title Platelets publisher Academic Press Elsevier location Burlington, MA year 2007 pages 313 isbn 0 12 369367 5 oclc doi accessdate ref It may involve the alpha granules or the dense granules. ref name ColemanTsongalis2009 cite book author1 William B. Coleman author2 Gregory J. Tsongalis title Molecular pathology the molecular basis of human disease url http books.google.com books?id btloapOq85wC&pg PA258 accessdate 2 November 2010 year 2009 publisher Academic Press isbn 9780123744197 pages 258 ref Conditions Examples include Platelet alpha granule s Gray platelet syndrome ref name pmid11442477 cite journal author Hayward CP, Weiss HJ, Lages B, et al. title The storage defects in grey platelet syndrome and alphadelta storage pool deficiency affect alpha granule factor V and multimerin storage without altering their proteolytic processing journal Br. J. Haematol. volume 113 issue 4 pages 871 7 year 2001 month June pmid 11442477 doi 10.1046 j.1365 2141.2001.02833.x url http www3.interscience.wiley.com resolve openurl?genre article&sid nlm pubmed&issn 0007 1048&date 2001&volume 113&issue 4&spage 871 ref Quebec platelet disorder Dense granule s Hermansky Pudlak syndrome ref name pmid11590544 cite journal author Huizing M, Anikster Y, Fitzpatrick DL, et al. title Hermansky Pudlak syndrome type 3 in Ashkenazi Jews and other non Puerto Rican patients with hypopigmentation and platelet storage pool deficiency journal Am. J. Hum. Genet. volume 69 issue 5 pages 1022 32 year 2001 month November pmid 11590544 pmc 1274349 doi 10.1086 324168 url http linkinghub.elsevier.com retrieve pii S0002 9297 07 61318 4 ref Chediak Higashi ... more details
rate No coagulopathy No fetal distress Class 2 moderate and represents approximately 27 of all cases ... mg dL Coagulopathy Fetal death Pathophysiology Physical trauma Trauma , hypertension , or coagulopathy ... more details
and facial areas. ref name Hall2001 This consumptive coagulopathy also uses up clotting factors , such as fibrinogen which may worsen bleeding. The coagulopathy can progress to disseminated intravascular ... hemorrhage . The thrombocytopenia and coagulopathy are managed with platelet transfusions and fresh ... more details
Infobox disease Name Disseminated intravascular coagulation or Disseminated intravascular coagulopathy Image Thrombotic microangiopathy very high mag.jpg Caption Micrograph showing a thrombotic microangiopathy , as may be seen in DIC. Kidney biopsy . PAS stain . DiseasesDB 3765 ICD10 ICD10 D 65 d 65 ICD9 ICD9 286.6 ICDO OMIM MedlinePlus eMedicineSubj med eMedicineTopic 577 eMedicine mult eMedicine2 emerg 150 MeshID D004211 Disseminated intravascular coagulation DIC , also known as disseminated intravascular coagulopathy or consumptive coagulopathy , is a pathological activation of coagulation blood clotting mechanisms that happens in response to a variety of diseases. DIC leads to the formation of small blood clots inside the blood vessels throughout the body. ref Churchill Livingstone Pocket Medical Dictionary 14th Edition. ref As the small clots consume coagulation proteins and platelets, normal coagulation is disrupted and abnormal bleeding occurs from the skin e.g. from sites where blood samples were taken , the gastrointestinal tract , the respiratory tract and surgical wounds. The small clots also disrupt normal blood flow to organs such as the kidney s , which may malfunction as a result. ref ISBN 0 443 07036 9 Davidson s Principles and Practice of Medicine 19th Edition. Churchill Livingstone. Page 200 ref DIC can occur acutely but also on a slower, chronic basis, depending on the underlying problem. ref name isbn0 7216 7335 X cite book author Robbins, Stanley L. Cotran, Ramzi S. Kumar, Vinay Collins, Tucker title Robbins Pathologic Basis of Disease edition 6 publisher Saunders location Philadelphia year 1999 isbn 0 7216 7335 X ref It is common in the critically ill, and may participate in the development of Multiple organ dysfunction syndrome multiple organ failure ... coagulopathy of sepsis. Nat. Med., 14, 648 655. ref By removing pro thrombotic components before they participate in the coagulopathy of DIC, the Ashwell Morell receptor lessens the severity of DIC ... more details
thrombocytopenia and coagulopathy , which prevents blood clotting Fever and infection from lack of normal ... Disseminated Intravascular Coagulopathy in Acute Promyelocytic Leukemia work Clinical Journal ... of leukemia. APL most distinguishable trait is the presence of overt coagulopathy disseminated ... more details
refimprove date August 2011 Infobox disease Name Pasteurellosis Image Caption DiseasesDB ICD10 ICD10 A 28 0 a 20 ICD9 ICD9 027.2 ICDO OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID D010326 Pasteurellosis is an infection with a species of the bacteria genus Pasteurella , ref name KuhnertChristensen cite book author Kuhnert P Christensen H editors . title Pasteurellaceae Biology, Genomics and Molecular Aspects publisher Caister Academic Press year 2008 url http www.horizonpress.com past id http www.horizonpress.com past ISBN 978 1 904455 34 9 ref which is found in human s and animal s. Pasteurella multocida P. septica is carried in mouth and respiratory tract of several animals, notably cats. It is a small Gram negative bacillus with bipolar staining by Wayson stain . In animals it can originate fulminant septicaemia chicken cholera , but is also a common commensal. Pasteurellosis in humans is associated with a close animal contact, and may be transmitted by cat bite. Types There are several forms of the infection Cutaneous Skin Subcutaneous subcutaneous tissue disease is a septic phlegmon that develops classically in the hand and forearm after cat bite. Inflammatory signs are very rapid to develop in 1 or 2 hours, edema , severe pain and serosanguineous exudate appear. Fever , moderate or very high can be seen along with vomit ing, headache and diarrhea . Lymphangitis is usual. Complications are possible, in the form of septic arthritis , osteitis or evolution to chronicity . Septicaemia Sepsis is very rare, but can be as fulminant as septicaemic plague, with high fever, Rigor medicine rigors and vomiting, followed by Shock circulatory shock and coagulopathy . Pneumonic Pneumonia disease is also rare and appears in patients with some chronic pulmonary pathology . It usually presents as bilateral consolidating pneumonia , sometimes very severe. Other locations are possible, such as septic arthritis, meningitis and acute endocarditis , but are very rare. Pasteure ... more details
Infobox disease Name Glanzmann s thrombasthenia Image Caption DiseasesDB 5224 ICD10 ICD10 D 69 1 d 65 ICD9 ICD9 287.1 ICDO OMIM 187800 OMIM mult OMIM2 273800 MedlinePlus eMedicineSubj med eMedicineTopic 872 MeshID D013915 Glanzmann s thrombasthenia is an abnormality of thrombocyte platelets . ref DorlandsDict eight 000108489 Glanzmann thrombasthenia ref It is an extremely rare coagulopathy Blood diseases disorder of the blood , in which the platelets lack GpIIb IIIa glycoprotein IIb IIIa GpIIb IIIa . As a result, no fibrinogen bridging of platelets to other platelets can occur, and the bleeding time is significantly prolonged. Pathophysiology GpIIb IIIa Glycoprotein IIb IIIa GpIIb IIIa is an integrin Platelet Adhesion and aggregation aggregation receptor on thrombocytes platelets . This receptor is activated when the platelet is stimulated by ADP, epinephrine , collagen or thrombin. GpIIb IIIa is essential to blood coagulation since the activated receptor has the ability to bind fibrinogen as well as fibronectin and vitronectin , which is required for fibrinogen dependent platelet platelet interaction aggregation. In contrast, Glanzmann s thrombasthenia has normal glycoprotein Ib receptors, the role of which is to enable platelets to be activated by contact with the von Willebrand factor collagen complex that is exposed when the endothelial blood vessel lining is damaged. Understanding of the role of GpIIb IIIa in Glanzmann s thrombasthenia led to the development of GpIIb IIIa inhibitors , a class of powerful antiplatelet agent s. ref name seligsohn cite journal author Seligsohn U title Glanzmann thrombasthenia a model disease which paved the way to powerful therapeutic agents journal Pathophysiol. Haemost. Thromb. volume 32 issue 5 6 pages 216 7 year 2002 pmid 13679645 doi 10.1159 000073569 url http content.karger.com ProdukteDB produkte.asp?Aktion ShowPDF&ArtikelNr 73569&ProduktNr 224034&Ausgabe 229381&filename 73569.pdf format PDF ref Cause Glanzmann s thrombasth ... more details
Drugbox Verifiedfields changed verifiedrevid 456688274 IUPAC name 6 aminohexanoic acid image 6 Aminocaproic acid.png Clinical data tradename Amicar Drugs.com drugs.com monograph aminocaproic acid MedlinePlus a608023 pregnancy category legal status routes of administration Pharmacokinetic data bioavailability protein bound metabolism Renal elimination half life 2 hours Identifiers CASNo Ref cascite correct CAS CAS number Ref cascite correct ?? CAS number 60 32 2 ATC prefix B02 ATC suffix AA01 ATC supplemental PubChem 564 DrugBank Ref drugbankcite changed drugbank DrugBank APRD00791 ChemSpiderID Ref chemspidercite correct chemspider ChemSpiderID 548 UNII Ref fdacite correct FDA UNII U6F3787206 KEGG Ref keggcite correct kegg KEGG D00160 ChEBI Ref ebicite correct EBI ChEBI 16586 ChEMBL Ref ebicite correct EBI ChEMBL 1046 Chemical data C 6 H 13 N 1 O 2 molecular weight 131.173 g mol smiles O C O C N CCCC InChI 1 C6H13NO2 c1 2 3 4 5 7 6 8 9 h5H,2 4,7H2,1H3, H,8,9 InChIKey LRQKBLKVPFOOQJ UHFFFAOYAT StdInChI Ref stdinchicite correct chemspider StdInChI 1S C6H13NO2 c7 5 3 1 2 4 6 8 9 h1 5,7H2, H,8,9 StdInChIKey Ref stdinchicite correct chemspider StdInChIKey SLXKOJJOQWFEFD UHFFFAOYSA N Aminocaproic acid also known as Amicar, amino caproic acid, Ahx, or 6 aminohexanoic acid is a derivative and analogue of the amino acid lysine , which makes it an effective enzyme inhibitor inhibitor for enzyme s that bind that particular residue. Such enzymes include proteolytic enzymes like plasmin , the enzyme responsible for fibrinolysis . For this reason it is effective in treatment of certain coagulopathy bleeding disorders especially fibrogenemia and is marketed as Amicar. Aminocaproic acid is also an intermediate in the polymerization of Nylon 6, where it is formed by ring opening hydrolysis of caprolactam . Clinical use Aminocaproic acid is used to treat excessive postoperative bleeding, especially after procedures in which a great amount of bleeding is indicated, such as cardiac ... more details
Infobox disease Name Haemobilia Image Caption DiseasesDB ICD10 ICD10 K 83 8 k 80 ICD9 ICD9 576.8 ICDO OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID style padding 0.3em float right margin left 15px border 1px solid A3B1BF background f5faff text align center font size 90 line height 1.5em style background eed padding 0.3em text align center Alternative names Haemobilia Haemorrhage in bile br Hematobilia br Hemobilia br Hemobilia disorder br Hemorrhage in bile Implies bleeding into biliary tree . Can present as acute upper gastrointestinal UGI bleeding. It should be considered in upper abdominal pain presenting with UGI bleeding especially when there is a history of liver injury or instrumentation. First recorded in 1654 by Francis Glisson, a university of cambridge Cambridge professor. ref cite book author Francis Glisson, title From Anatomia hepatis the Anatomy of the liver , 1654 Cambridge Wellcome texts and documents publisher Wellcome Unit for the History of Medicine location Cambridge year 1993 pages isbn 0 9516693 3 8 oclc 33046433 doi ref Haemobilia occurs when there is a fistula between a vessel of the splanchnic circulation and the intrahepatic or extrahepatic biliary system. Causes Physical trauma Trauma , accidental or iatrogenic e.g. due to procedures like cholecystectomy Instrumentation e.g. after ERCP Gallstone Inflammation Inflammatory conditions ranging from ascariasis to Polyarteritis nodosa PAN Vascular malformation Tumor Coagulopathy Clinical feature Quinke s triad of upper abdominal pain, Upper gastrointestinal bleeding upper gastrointestinal haemorrhage and jaundice ref cite journal author Quincke, H. title Ein Fall von Aneurysma der Leberarterie journal Berl Klin Wochenschr volume 30 issue pages 349 352 year 1871 pmid ref is classical but only present in 22 cases. ref name green cite journal author Green M, Duell R, Johnson C, Jamieson N title Haemobilia journal The British journal of surgery volume 88 issue 6 pages 773 86 year 2001 pmid 1 ... more details
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