cannabinoid families. See also List of JWH cannabinoids HU 210 Other HU Cannabinoids List of HU cannabinoids CP 47,497 See also List of CP cannabinoids Further reading A more complete list can ... &db query 0 0 0 &markupType all References references Category AM cannabinoids Category Cannabinoids ... more details
of 5.44nM at CB sub 2 sub and 20.9nM at CB sub 1 sub . See also List of AM cannabinoids HU 210 Other HU Cannabinoids List of HU cannabinoids CP 47,497 See also List of CP cannabinoids References references Category JWH cannabinoids Category Cannabinoids ... more details
CBND may refer to Cannabinodiol, a cannabinoid see Cannabinoids Table of natural cannabinoids . Compagnie B ninoise de N goce et de Distribution , a retail and trading company in Benin. disambig ... more details
AM 251 may refer to USS Inflict AM 251 AM251 a Cannabinoid receptor type 1 CB1 Cannabinoids cannabinoid receptor antagonist Letter NumberCombDisambig ... more details
Drugbox verifiedrevid 435602295 IUPAC name 6aR,10aR 6a,7,10,10a Tetrahydro 3 5 1H imidazol 1 yl 1,1 dimethylpentyl 6,6,9 trimethyl 6H dibenzo b,d pyran 1 ol image O 2545.svg width 240 Clinical data tradename legal status Unscheduled routes of administration Pharmacokinetic data metabolism elimination half life excretion Identifiers CAS number 874745 42 3 PubChem Chemical data C 26 H 36 N 2 O 2 molecular weight 408.575 g mol smiles CC C CCCCn1ccnc1 c3cc2OC C C C H 4C C C C C C H 4c2c O c3 O 2545 is an analgesic cannabinoid derivative created by Organix Inc. for use in scientific research. Unlike most cannabinoids discovered to date, it is water soluble, which gives it considerable advantages over many related cannabinoids. It has high affinity for both cannabinoid receptor 1 CB sub 1 sub and cannabinoid receptor 2 CB sub 2 sub Receptor biochemistry receptors , with Dissociation constant Ki values of 1.5nM at CB sub 1 sub and 0.32nM at CB sub 2 sub . ref Martin BR, Wiley JL, Beletskaya I, Sim Selley LJ, Smith FL, Dewey WL, Cottney J, Adams J, Baker J, Hill D, Saha B, Zerkowski J, Mahadevan A, Razdan RK. Pharmacological characterization of novel water soluble cannabinoids. Journal of Pharmacology and Experimental Therapeutics . 2006 Sep 318 3 1230 9. PMID 16757541 ref See also O 2372 Tropoxane References references cannabinoids cannabinoid stub Category Cannabinoids Category Benzochromenes Category Phenols Category Imidazoles ... more details
Drugbox verifiedrevid 354916523 IUPAC name 6a R ,10a R 6,6,9 trimethyl 3 butyl 6a,7,8,10a tetrahydro 6 H benzo c chromen 1 ol image Delta 9 tetrahydrocannabinol C4.png drug name sup 9 sup Tetrahydrocannabinol C4 Clinical data tradename pregnancy category legal status ? routes of administration Pharmacokinetic data bioavailability metabolism elimination half life excretion Identifiers CAS number ATC prefix none ATC suffix PubChem Chemical data C 20 H 28 O 2 molecular weight 300.43 g mol smiles Tetrahydrocannabinol C4 , also known as THC C4 and butyl THC , is a homolog chemistry homologue of tetrahydrocannabinol THC , the active component of Cannabis drug Cannabis . They are only different by the pentyl sidechain being replaced by a butyl sidechain. It is unknown whether THC C4 is an agonist , partial agonist , or receptor antagonist antagonist at the cannabinoid receptor s. The propyl anolog, THCV is a known antagonist while THC itself is an agonist. See also Cannabinoids Cannabis Cannabinoids cannabinoid stub Category Phenols Category Cannabinoids Category Diterpenes Category Benzochromenes ... more details
Drugbox Watchedfields changed verifiedrevid 444058373 IUPAC name 3,6,6,9 tetramethyl 7,8,9,10 tetrahydrobenzo c chromen 1 yl acetate image Pirnabine structure.png width 200 Clinical data tradename legal status routes of administration Pharmacokinetic data metabolism elimination half life excretion Identifiers CAS number 68298 00 0 PubChem 50137 DrugBank Ref drugbankcite correct drugbank UNII Ref fdacite correct FDA UNII S3FHL03F60 Chemical data C 19 H 24 O 3 molecular weight 300.391 g mol smiles O C C Oc1cc C cc OC2 C C c1C C3 C2CCC3C Pirnabine SP 304 is a synthetic cannabinoid receptor ligand, which was developed for the treatment of glaucoma . ref http jama.ama assn.org cgi reprint 241 1 65.pdf ref References reflist cannabinoids Category Cannabinoids Category Benzochromenes Category Phenols Category Acetate esters ... more details
JWH may refer to John Wesley Hardin , an American gun fighter from the 18th century John W. Henry , futures trader and owner of the Boston Red Sox John Howard John Winston Howard , former Prime Minister of Australia JWH 133 , a medication used to prevent Alzheimer s disease John W. Huffman , creator of the JWH cannabinoids Jared Waerea Hargreaves New Zealand rugby league player for the Manly Sea Eagles disambig it JWH ... more details
CB1 may refer to CB1 Cheese Burger 1r Oner Famous Graffiti Artist in Cudahy who graffed the streets from early 2005 present CB1, a postcode district in the CB postcode area Cannabinoid receptor 1 a receptor for cannabinoids in the brain Crash Bandicoot video game Crash Bandicoot , the first game in the Crash Bandicoot series Letter NumberCombDisambig ... more details
Drugbox verifiedrevid 437389159 IUPAC name 3 5 cyano 1 ,1 dimethylpentyl 1 4 N morpholinobutyryloxy 8 tetrahydrocannabinol image O 1057 molecular geometry.svg width 240 Clinical data tradename legal status routes of administration Pharmacokinetic data metabolism elimination half life excretion Identifiers CAS number PubChem Chemical data C 32 H 46 N 2 O 4 molecular weight 522.717 g mol smiles N CCCCCC c3cc1OC C H 4C C C CC4c1c OC O CCCN2CCOCC2 c3 C C C C C O 1057 is an analgesic cannabinoid derivative created by Organix Inc. for use in scientific research. Unlike most cannabinoids discovered to date, it is water soluble, which gives it considerable advantages over many related cannabinoids. It has moderate affinity for both cannabinoid receptor 1 CB sub 1 sub and cannabinoid receptor 2 CB sub 2 sub Receptor biochemistry receptors , with Dissociation constant K sub i sub values of 8.36nM at CB sub 1 sub and 7.95nM at CB sub 2 sub . ref Pertwee RG, Gibson TM, Stevenson LA, Ross RA, Banner WK, Saha B, Razdan RK, Martin BR. O 1057, a potent water soluble cannabinoid receptor agonist with antinociceptive properties. British Journal of Pharmacology . 2000 Apr 129 8 1577 84. PMID 10780961 ref See also AM 2232 O 1812 O 2694 References references cannabinoids cannabinoid stub Category Cannabinoids Category Benzochromenes Category Butyrates Category Morpholines Category Nitriles ... more details
Drugbox Watchedfields changed verifiedrevid 437691572 IUPAC name 1 1E 3 pentylinden 1 ylidine methyl naphthalene image JWH 171.png width 180 Clinical data tradename pregnancy AU A B1 B2 B3 C D X pregnancy US A B C D X pregnancy category legal AU Unscheduled S2 S3 S4 S5 S6 S7 S8 S9 legal CA Schedule I, II, III, IV, V, VI, VII, VIII legal UK GSL P POM CD Class A, B, C legal US OTC Rx only Schedule I, II, III, IV, V legal status Legal routes of administration Pharmacokinetic data bioavailability protein bound metabolism elimination half life excretion Identifiers CAS number Ref cascite correct ?? CAS number ATC prefix ATC suffix PubChem DrugBank Ref drugbankcite correct drugbank DrugBank Chemical data C 25 H 24 molecular weight 324.457 g mol smiles CCCCCc c3 c1ccccc1c3 Cc2cccc4ccccc24 JWH 171 is an analgesic drug which acts as a cannabinoid receptor agonist . Its Dissociation constant Protein ligand binding binding affinity at the CB sub 1 sub receptor is only 51.0nM, making it slightly less potent than THC itself, ref Huffman JW, Padgett LW. Recent Developments in the Medicinal Chemistry of Cannabimimetic Indoles, Pyrroles and Indenes. Current Medicinal Chemistry , 2005 12 1395 1411. ref however JWH 171 is particularly notable in that it is a hydrocarbon containing no heteroatom s. This demonstrates that reasonably high affinity cannabinoid binding and agonist effects can be produced by compounds with no hydrogen bonding capacity at all, relying merely on Van der Waals force Van der Waals interactions to bind to the receptor. ref Roger Pertwee. Cannabinoids. Handbook of Experimental Pharmacology Volume 168, p 269. Springer. ISBN 3 540 22565 X ref It was discovered by, and named after, Dr. John W. Huffman . See also JWH 175 References references Cannabinoids cannabinoid stub Category Cannabinoids Category JWH cannabinoids Category Naphthalenes Category Indenes Category Polycyclic aromatic hydrocarbons ... more details
Drugbox verifiedrevid 435604466 IUPAC name 6aR,10aR 6,6,9 trimethyl 3 2 methyl 7 morpholin 4 yl 7 oxoheptan 2 yl 6a,7,10,10a tetrahydrobenzo c chromen 1 yl 4 di propan 2 yl amino butanoate image O 2694.png width 240 Clinical data tradename legal status routes of administration Pharmacokinetic data metabolism elimination half life excretion Identifiers CAS number PubChem 11714280 Chemical data C 38 H 60 N 2 O 5 molecular weight 624.891 g mol smiles CC C N C C C CCCC O Oc c1C2CC 3C cc C C C CCCCC O N4CCOCC4 cc1OC C C C2CC 3 O 2694 is a drug which is a cannabinoid derivative. It has analgesic effects and is used in scientific research. Unlike most cannabinoids discovered to date, it is highly water soluble, which gives it considerable advantages over many related drugs. It has high affinity for both cannabinoid receptor 1 CB sub 1 sub and cannabinoid receptor 2 CB sub 2 sub Receptor biochemistry receptors , with Dissociation constant Ki values of 3.7nM at CB sub 1 sub and 2.8nM at CB sub 2 sub . However it has complex pharmacokinetics as most of the administered dose is metabolised by hydrolysis of the ester link to the water insoluble compound O 2372 , thus producing a biphasic effects profile which is less suitable for research purposes than the related compound O 2545 . ref Martin BR, Wiley JL, Beletskaya I, Sim Selley LJ, Smith FL, Dewey WL, Cottney J, Adams J, Baker J, Hill D, Saha B, Zerkowski J, Mahadevan A, Razdan RK. Pharmacological characterization of novel water soluble cannabinoids. Journal of Pharmacology and Experimental Therapeutics . 2006 Sep 318 3 1230 9. PMID 16757541 ref See also O 1057 O 2372 References references cannabinoids cannabinoid stub Category Cannabinoids Category Benzochromenes Category Butyrates Category Morpholines Category Amides ... more details
In 1975, Munson discovered that cannabinoids suppress Lewis lung carcinoma cell growth. The mechanism of this action was shown to be inhibition of DNA synthesis ref cite journal pmid 616322 year 1977 title In vivo effects of cannabinoids on macromolecular biosynthesis in Lewis lung carcinomas. journal Cancer Biochem Biophys. ref Cannabinoids increase the life span of mice carrying Lewis lung tumors and decrease primary tumor size. ref cite journal pmid 16250836 year 2005 title Cannabinoids and cancer. journal Mini Rev Med Chem. doi 10.2174 138955705774329555 ref There are multiple modes of action. ref cite journal pmid 12958205 year 2003 title Inhibitory effects of cannabinoid CB1 receptor stimulation on tumor growth and metastatic spreading actions on signals involved in angiogenesis and metastasis. journal FASEB J ref A carcinoma discovered by Dr. Margaret R. Lewis of the Wistar Institute in 1951. This tumor originated spontaneously as a carcinoma of the lung of a C57BL mouse. The tumor does not appear to be grossly hemorrhagic and the majority of the tumor tissue is a semifirm homogeneous mass. ref Cancer Chemother Rep 2 1972 Nov 3 1 325 ref It is also called 3LL and LLC and is used as a transplantable malignancy. It has been used in many studies. ref name TeicherAndrews2004 cite book last1 Teicher first1 Beverly A. last2 Andrews first2 Paul A. title Anticancer drug development guide preclinical screening, clinical trials, and approval url http books.google.com books?id k4jWvlQ2CCcC&pg PA197 accessdate 31 July 2011 year 2004 publisher Humana Press isbn 9781588292285 pages 197 ref References reflist Category Cancer research Medical stub ... more details
, most potent cannabis product I ve ever tested. Marijuana contains various cannabinoids, Hornby explains ... had an ounce of it, only a tiny fraction of a gram would be anything other than cannabinoids. We also ... none. It s essentially just pure cannabinoids. I ve tested a lot of cannabis materials, but this is the most impressive. Hornby s tests also found Budder contains 80 to 90 of its cannabinoids as THC. It contains much smaller percentages of two other cannabinoids cannabidiol and cannabinol. Of these two ... more details
LS, Martin BR. Pharmacology and stereoselectivity of structurally novel cannabinoids in mice. Journal ... it is widely used in research into the potential therapeutic applications of cannabinoids. ref Tramer MR, Carroll D, Campbell FA, Reynolds DJ, Moore RA, McQuay HJ. Cannabinoids for control of chemotherapy ... 7 323 7303 16 21. ref ref Campbell FA, Tramer MR, Carroll D, Reynolds DJ, Moore RA, McQuay HJ. Are cannabinoids ... review. British Medical Journal . 2001 Jul 7 323 7303 13 6. ref ref Ben Amar M. Cannabinoids in medicine ... 2 1 25. ref See also CP 47,497 References references Cannabinoids pharma stub cannabinoid stub Category Cannabinoids Category Phenanthridines Category Phenol ethers Category Acetate esters es Levonantradol ... more details
or sedative , ref Archer RA. The cannabinoids therapeutic potentials. Annual Reports in Medicinal ... it is sometimes used in research into the potential therapeutic applications of cannabinoids. References references Cannabinoids Category Cannabinoids Category Synthetic chromenes Category Alkynes ... more details
cannabinoids but may be useful for treating pain and chronic inflammatory conditions where nausea ... the CB1 receptor CB sub 1 sub receptor in a different way to psychoactive cannabinoids. Studies ... references Cannabinoids Category Cannabinoids Category Benzochromenes Category Carboxylic acids Category Phenols Category HU cannabinoids it Acido ajulemico ... more details
Drugbox verifiedrevid 424752055 IUPAC name 6 6aR,10aR 1 hydroxy 6,6,9 trimethyl 6a,7,10,10a tetrahydrobenzo c chromen 3 yl N,N,6 trimethylheptanamide image O 1125.svg width 240 Clinical data tradename legal status routes of administration Pharmacokinetic data metabolism elimination half life excretion Identifiers CAS number PubChem 9909689 Chemical data C 26 H 39 N 1 O 3 molecular weight 413.591 g mol smiles CC3 C C1CC C C CC1c2c O cc cc2O3 C C C CCCCC O N C C O 1125 3 1,1 dimethylhexyl 6 dimethylcarboxamide 8 tetrahydrocannabinol is a drug which is a cannabinoid derivative. It has analgesic effects and is used in scientific research. It is a potent CB sub 1 sub full agonist with a Dissociation constant Ki of 1.16nM. ref Griffin G, Wray EJ, Martin BR, Abood ME. Cannabinoid agonists and antagonists discriminated by receptor binding in rat cerebellum. British Journal of Pharmacology . 1999 Oct 128 3 684 8. DOI 10.1038 sj.bjp.0702806 PMID 10516649 ref References references cannabinoids Category Cannabinoids Category Benzochromenes Category Phenols Category Amides cannabinoid stub ... more details
Drugbox verifiedrevid 419853319 IUPAC name 2S,4S,4aS,6R,8aR 6 hydroxymethyl 4 2 hydroxy 4 2 methyloctan 2 yl phenyl 1,2,3,4,4a,5,6,7,8,8a decahydronaphthalen 2 ol image CP 55,244.svg width 240 Clinical data tradename legal status routes of administration Pharmacokinetic data metabolism elimination half life excretion Identifiers CAS number 79678 32 3 PubChem 133254 Chemical data C 26 H 42 O 3 molecular weight 402.608 g mol smiles C13CC CO CCC3CC O CC1c2ccc C C C CCCCCC cc2O CP 55,244 is a compound which is a cannabinoid receptor agonist. It has analgesic effects and is used in scientific research. It is an extremely potent Cannabinoid receptor 1 CB sub 1 sub full agonist with a Dissociation constant K sub i sub of 0.21nM, making it more potent than the commonly used full agonist HU 210 . ref Griffin G, Wray EJ, Martin BR, Abood ME. Cannabinoid agonists and antagonists discriminated by receptor binding in rat cerebellum. British Journal of Pharmacology . 1999 Oct 128 3 684 8. DOI 10.1038 sj.bjp.0702806 PMID 10516649 ref See also CP 47,497 References references cannabinoids Category Cannabinoids Category Decalins Category Alcohols Category Phenols Category Pfizer cannabinoid stub ... more details
Drugbox verifiedrevid 424985016 IUPAC name naphthalen 1 yl 1 pentylpyrrol 3 yl methanone image JWH 030.svg width 150 Clinical data tradename legal status routes of administration Pharmacokinetic data metabolism elimination half life excretion Identifiers CAS number 162934 73 8 PubChem 9971539 Chemical data C 20 H 21 N 1 O 1 molecular weight 291.386 g mol smiles CCCCCn3cc cc3 C O c1cccc2ccccc12 JWH 030 is a research chemical which is a cannabinoid receptor agonist. ref Lainton JAH, Huffman JW, Martin BR, Compton DR. Tetrahedron Letters . 1995 36 1401. ref It has analgesic effects and is used in scientific research. ref Pertwee RG, Griffin, G, Lainton JAH, Huffman JW. European Journal of Pharmacology . 1995 284 241. ref It is a partial agonist at CB sub 1 sub receptors, with a Dissociation constant Ki of 87nM, making it roughly half the potency of THC . ref Cite pmid 9580597 ref It was discovered and named after Dr. John W. Huffman . See also JWH 147 References reflist cannabinoids cannabinoid stub Category Naphthoylpyrroles Category JWH cannabinoids ... more details
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