PBB geneid 675 Infobox protein family Symbol BRCA2 Name BRCA2 repeat image PDB 1n0w EBI.jpg width caption crystal structure of a rad51 brca2 brc repeat complex Pfam PF00634 Pfam clan InterPro IPR002093 ... 2 helical Name BRCA 2 helical image PDB 1miu EBI.jpg width caption structure of a brca2 dss1 complex ... CAZy CDD Infobox protein family Symbol BRCA 2 OB1 Name BRCA2, oligonucleotide oligosaccharide binding, domain 1 image PDB 1miu EBI.jpg width caption structure of a brca2 dss1 complex Pfam PF09103 ... protein family Symbol BRCA 2 OB3 Name BRCA2, oligonucleotide oligosaccharide binding, domain 3 image PDB 1miu EBI.jpg width caption structure of a brca2 dss1 complex Pfam PF09104 Pfam clan InterPro ... Symbol Tower Name Tower domain image PDB 1miu EBI.jpg width caption structure of a brca2 dss1 ... protein CAZy CDD Unsourced image removed Image BRCA Genes location of BRCA1 and BRCA2 on chromosomes 13 and 17.gif thumb right Location of the genes BRCA1 and BRCA2 on chromosomes 13 and 17 BRCA2 Breast Cancer 2 susceptibility protein is a protein that in humans is encoded by the BRCA2 gene . ref name ..., BRCA2, to chromosome 13q12 13 journal Science volume 265 issue 5181 pages 2088 90 year 1994 month September pmid 8091231 doi 10.1126 science.8091231 url ref BRCA2 orthologs have been identified in most ... phylogenetic marker BRCA2 coding sequence url http www.orthomam.univ montp2.fr orthomam data cds detailMarkers ENSG00000139618 BRCA2.xml ref BRCA2 belongs to the tumor suppressor gene family ref name pmid10193517 cite journal author Duncan JA, Reeves JR, Cooke TG title BRCA1 and BRCA2 proteins roles ... 51 5 237 ref ref name pmid15546503 cite journal author Yoshida K, Miki Y title Role of BRCA1 and BRCA2 ... ref The BRCA2 gene is located on the long q arm of chromosome 13 human chromosome 13 at position ... of the BRCA1 and BRCA2 genes are very different, at least some functions are interrelated. The protein s made by both gene s are essential for repairing damaged DNA. The BRCA2 protein binds to and regulates ... more details
wiktionarypar BRCA BRCA may refer to BRCA mutation , mutations in two genes which produce a hereditary breast ovarian cancer syndrome BRCA1 BRCA2 British Radio Car Association , an organisation governing all types of radio controlled car racing in the United Kingdom. disambig pl BRCA ... more details
PBB geneid 79728 Partner and localizer of BRCA2 , also known as PALB2 , is a protein which in humans is encoded by the PALB2 gene . ref name entrez cite web title Entrez Gene PALB2 partner and localizer of BRCA2 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 79728 accessdate ref ref name pmid16793542 cite journal author Xia B, Sheng Q, Nakanishi K, Ohashi A, Wu J, Christ N, Liu X, Jasin M, Couch FJ, Livingston DM title Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2 journal Mol. Cell volume 22 issue 6 pages 719 29 year 2006 month June pmid 16793542 doi 10.1016 j.molcel.2006.05.022 url ref ref name pmid17200672 cite journal author Xia B, Dorsman JC, Ameziane N, de Vries Y, Rooimans MA, Sheng Q, Pals G, Errami A, Gluckman E, Llera ... in the BRCA2 partner PALB2 journal Nat. Genet. volume 39 issue 2 pages 159 61 year 2007 month February ... with the breast cancer 2 early onset protein BRCA2 in nuclear foci and likely permits the stable intranuclear localization and accumulation of BRCA2. ref name entrez PALB2 binds the single ... A.M, et al. title Cooperation of breast cancer proteins PALB2 and piccolo BRCA2 in stimulating homologous ... pmid 20871615 volume 17 issue 10 pages 1247 54 ref PALB2 can function synergistically with a BRCA2 ... BRCA2 in stimulating homologous recombination. journal Nature Structural & molecular biology ... of breast cancer proteins PALB2 and piccolo BRCA2 in stimulating homologous recombination. journal ... Biallelic mutations in PALB2 also known as FANCN , similar to biallelic BRCA2 mutations, cause Fanconi ... gr.4039406 pmc 1356129 cite journal author Xia B, Sheng Q, Nakanishi K, et al. title Control of BRCA2 ... N, Seal S, Thompson D, et al. title PALB2, which encodes a BRCA2 interacting protein, is a breast cancer ... author Xia B, Dorsman JC, Ameziane N, et al. title Fanconi anemia is associated with a defect in the BRCA2 ... journal author Oliver AW, Swift S, Lord CJ, et al. title Structural basis for recruitment of BRCA2 ... more details
original research date October 2010 unreferenced date October 2010 Microcalcifications are tiny specks of mineral deposit s calcium , that can be scattered throughout the mammary gland , or occur in clusters. When found on a mammogram , a radiologist will then decide whether the specks are of concern usually, this is not the case. Commonly, they simply indicate the presence of tiny benign cyst s, but can signify the presence of early breast cancer for this reason, it is important to attend regular screening sessions, as recommended by your health service. They are caused by a number of reasons Aging the majority of diagnoses are made in women over 50 Benign causes Genetic involving the BRCA1 and BRCA2 genes Depending on what pattern the microcalcifications present determines the future course of the action, whether it be further investigatory techniques as part of the triple assessment , or more regular screening. Category Medical signs Med sign stub ... more details
PBB geneid 56647 BRCA2 and CDKN1A interacting protein is a protein that in humans is encoded by the BCCIP gene . ref name pmid11313963 cite journal author Liu J, Yuan Y, Huan J, Shen Z title Inhibition of breast and brain cancer cell growth by BCCIPalpha, an evolutionarily conserved nuclear protein that interacts with BRCA2 journal Oncogene volume 20 issue 3 pages 336 45 year 2001 month Apr pmid 11313963 pmc doi 10.1038 sj.onc.1204098 ref ref name pmid10878006 cite journal author Ono T, Kitaura H, Ugai H, Murata T, Yokoyama KK, Iguchi Ariga SM, Ariga H title TOK 1, a novel p21Cip1 binding protein that cooperatively enhances p21 dependent inhibitory activity toward CDK2 kinase journal J Biol Chem volume 275 issue 40 pages 31145 54 year 2000 month Oct pmid 10878006 pmc doi 10.1074 jbc.M003031200 ref ref name entrez cite web title Entrez Gene BCCIP BRCA2 and CDKN1A interacting protein url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 56647 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple ... may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity .... ref name entrez Interactions BCCIP has been shown to Protein protein interaction interact with BRCA2 ... conserved nuclear protein that interacts with BRCA2 journal Oncogene volume 20 issue 3 ... Machackova E, Damborsky J, Valik D, Foretova L title Novel germline BRCA1 and BRCA2 mutations in breast ... A, Konstantopoulou I, et al. title BRCA2 gene mutations in Greek patients with familial breast cancer ... cite journal author Robson M, Scheuer L, Nafa K, et al. title Unique de novo mutation of BRCA2 in a woman ... The BRCA2 interacting protein BCCIP functions in RAD51 and BRCA2 focus formation and homologous recombinational ... more details
is also found to interact with BRCA1 and BRCA2 , which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. ref cite journal author Daniel DC title Highlight BRCA1 and BRCA2 ... cancer susceptibility protein BRCA2 controls the function of Rad51 in the pathway for DNA repair ... of a RAD51 BRCA2 complex journal Nature volume 420 issue 6913 pages 287 93 year 2002 pmid 12442171 ... ref ref cite journal author Klopfleisch R, Gruber AD. title Increased expression of BRCA2 ... month Nov. title Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome ... ref BRCC3 , ref name pmid14636569 BARD1 , ref name pmid14636569 BRCA2 , ref name pmid14636569 ref ... lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2 journal Nature journal ... specific phosphorylation of BRCA2 by Polo like kinase 1 correlates with the dissociation of the BRCA2 ... by self association and interaction with BRCA2 journal Mol. Cell volume 12 issue 4 pages 1029 ... W H year 1998 month Apr. title The BRC repeats in BRCA2 are critical for RAD51 binding and resistance ... J, Ha S I, Chodosh L A year 2001 month Oct. title Analysis of murine Brca2 reveals conservation of protein ... BRC motifs in the human breast cancer susceptibility gene brca2 journal J. Biol. Chem. volume ... A, Ogawa H, Kamada N, Nakamura Y, Miki Y year 1998 month Mar. title Multiple possible sites of BRCA2 ... Nov. title Insights into DNA recombination from the structure of a RAD51 BRCA2 complex journal Nature ... nuclear protein that interacts with BRCA2 journal Oncogene volume 20 issue 3 pages 336 45 publisher ... between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells journal ... Ouchi T, Aaronson S A year 1998 month Nov. title The BRCA2 gene product functionally interacts ... more details
A BRCA mutation is a mutation in either of the genes BRCA1 and BRCA2 . Harmful mutations in these genes produce a hereditary breast ovarian cancer syndrome in affected families. Mutations in BRCA1 and BRCA2 ... BRCA1 or BRCA2 have risk of breast cancer that is about five times the normal risk, and a risk ... Institute url http www.cancer.gov cancertopics factsheet Risk BRCA title BRCA1 and BRCA2 Cancer Risk ... and ovarian cancer in women than BRCA2 mutations. Having a high risk mutation does not guarantee that the woman ... K, Miki Y title Role of BRCA1 and BRCA2 as regulators of DNA repair, transcription, and cell cycle ... that it produces. The cancer risk caused by BRCA1 and BRCA2 mutations are inherited in a Dominance ... McCredie, MR author9 Hopper, JL title After BRCA1 and BRCA2 what next? Multifactorial segregation ... disclosed positive test results, then a full test that checks the entire sequence of both BRCA1 and BRCA2 ... cancer risk See BRCA1 BRCA2 Women with deleterious mutations in either the BRCA1 or BRCA2 genes have ... with a deleterious mutation in BRCA2 will develop breast cancer by age 70, and 13 to 23 will develop ... Parmigiani first2 G. title Meta analysis of BRCA1 and BRCA2 penetrance. journal J Clin Oncol volume ... Morris5 BRCA2 is associated primarily with post menopausal breast cancer, although the risk of pre ... . ref name Morris13 BRCA1 related ovarian cancer appears at younger ages, but the risk for women with BRCA2 ... blue Caption 77 of women with a BRCA1 mutation and 56 of women with a BRCA2 mutation and no screening ... 20 width units em data max 85 label1 BRCA1 mutation data1 53 label2 BRCA2 mutation data2 71 label3 ... Kurian 2009 Women with high risk BRCA2 mutations, with screening but with no prophylactic medical ... to 2 of men with a BRCA1 mutation will develop breast cancer by age 70. Approximately 6 of men with a BRCA2 ... with a BRCA mutation, especially a BRCA2 mutation, may benefit from professional and self breast exam s. Medical imaging is not usually recommended, but because male BRCA2 carriers have a risk of breast ... more details
NCN Route 11 is a Sustrans National Cycle Route connecting Harlow in Essex to King s Lynn in Norfolk . Route Harlow to Cambridge Image National Cycle Route 11 at Great Shelford.jpg thumb NCR 11 near Great Shelford, showing a double helix and a small part of the BRCA2 gene. Harlow Bishop Stortford Hinxton Sawston Cambridge Intersects with NCR 51 in Cambridge. A section of path, about two kilometres long, from Great Shelford to Addenbrookes Hospital in Cambridge, is decorated with over 10,000 lines of four colours representing the nucleotide sequence of the BRCA2 gene. This gene, implicated in early onset breast cancer, was discovered in 1994 the discoverers included scientists from nearby Addenbrookes Hospital and The Sanger Centre, Hinxton. This section of path also includes and commemorates the 10,000th mile of the National Cycle Network. Cambridge to King s Lynn Cambridge Burwell, Cambridgeshire Burwell Wicken, Cambridgeshire Wicken Ely, Cambridgeshire Ely Downham Market Watlington, Norfolk Watlington King s Lynn Intersects with National Cycle Route 1 near King s Lynn Expand section date June 2008 Proposed development Wicken Fen Vision Spine Route main Wicken Fen Lodes Way Route 11 between Cambridge and Ely had a gap in the route, due to the difficulties of crossing the many waterways of the Cambridgeshire Fens. In 2011, the new bridge over Swaffham Bulbeck Lode, and surfacing of several sections of cycle path enables complete use of the route. This section of route 11 had been called the the Wicken Fen Vision Spine Route, but in 2011 was named the Lodes Way. The project involves the construction of 18 km of cycleway and of a number of bridges over the man made waterways known as Cambridgeshire Lodes lodes . ref name WFV2 cite web url http www.wicken.org.uk vision lodesway.htm title The Wicken Vision Spine Route publisher National Trust for Places of Historic Interest or Natural Beauty National Trust date accessdate 2011 12 30 ref The Lodes Way still has a fo ... more details
2010 Cancer In tumours with BRCA1 , BRCA2 or PALB2 ref name Buisson 2010 cite journal author Buisson R, Dion C t A.M, et al. title Cooperation of breast cancer proteins PALB2 and piccolo BRCA2 in stimulating ... cause multiple double strand breaks to form in this way, and because of the BRCA1 or BRCA2 or PALB2 ... cancer proteins PALB2 and piccolo BRCA2 in stimulating homologous recombination. journal Nature ... more details
high throughput sequencing by Myriad 1995 BRCA2 was resequenced based on unpublished insider ... First BRCA2 patent filed in the U.S. by the University of Utah and other institutions 1996 Myriad ... First BRCA2 patent was granted in the U.S. to the University of Utah, NIEHS and Myriad Genetics 2000 ... for Sick Children University of Toronto University of Tokyo Myriad Genetics, Inc. BRCA2 Co discoverers ... first John last Timmer accessdate 2009 11 10 ref Parts of the company s patents on the BRCA1 and BRCA2 ... more details
Image Roxana Moslehi 2006.jpg right thumb Roxana Moslehi, Ph.D. is a genetic epidemiology genetic epidemiologist . Most of her research is dedicated to the study of cancer and cancer precursors. Born in Iran and raised in Canada , she is currently an assistant professor http www.albany.edu cancergenomics people moslehi.html in Epidemiology and Biostatistics at the State University of New York SUNY , where she has developed multiple courses related to genetic and molecular epidemiology and genomics based public health and medicine. Through her research she has been contributing to the understanding of hereditary causes of diseases as well as the influence of gene environment interactions on the risk of developing disease. Education Roxana received her B.Sc. with honors, M.Sc. and Ph.D. degrees from the University of British Columbia UBC in Vancouver , Canada. Following her Ph.D., she completed a postdoctoral fellowship at the National Institutes of Health NIH , Division of Cancer Epidemiology and Genetics DCEG under the supervision of Dr. Mitchell Gail. While being a postdoctoral fellow at the NIH, she also received an adjunct assistant professor position at George Washington University GWU , where she developed a course entitled controversies in cancer epidemiology with Dr. Paul Levine. Research Image Moslehi SUNY Abany.jpg right thumb Working with Drs. Steven Narod and J.M. Friedman, she was first to estimate the penetrance of BRCA1 and BRCA2 mutations for breast cancer breast , ovarian cancer ovarian and other cancers in a study of Jewish women with ovarian cancer, ref BRCA1 and BRCA2 Mutation Analysis of 208 Ashkenazi Jewish Women with Ovarian Cancer http www.journals.uchicago.edu AJHG journal issues v66n4 990518 990518.html ref now the most studied hereditary cancer predisposing genes in the human genome . In 2009, Roxana proposed the possibility of positive selection for BRCA mutations and conducted the first study into the impact of mutations in the BRCA1 and ... more details
rectum BRCA1 gene br BRCA1 protein BRCA1 breast cancer 1 a human gene and its protein BRCA2 gene br BRCA2 protein BRCA2 breast cancer 2 a human gene and its protein BRP bathroom privileges BS breath ... more details
hand split foot malformation type 1. In addition, it has been shown to directly interact with BRCA2 ... been shown to Protein protein interaction interact with BRCA2 . ref name pmid10373512 cite journal ... gene BRCA2 and DSS1, a protein functionally conserved from yeast to mammals journal Mol. Cell. Biol ... Nikola P year 2002 month Sep. title BRCA2 function in DNA binding and recombination from a BRCA2 ... of the breast cancer susceptibility gene BRCA2 and DSS1, a protein functionally conserved from ... first4 D last5 Marshall first5 CJ last6 Ashworth first6 A cite journal author Yang H title BRCA2 function in DNA binding and recombination from a BRCA2 DSS1 ssDNA structure journal Science volume ... more details
Chembox ImageFile Rucaparib.svg ImageSize 200px IUPACName 8 Fluoro 2 4 methylamino methyl phenyl 1,3,4,5 tetrahydro 6 H azepino 5,4,3 cd indol 6 one OtherNames AG014699 Section1 Chembox Identifiers CASNo 283173 50 2 CASNo Ref cascite correct CAS PubChem 9931954 ChemSpiderID 8107584 SMILES Fc4cc2c1c nc c1CCNC2 O c3ccc cc3 CNC c4 InChI InChI 1S C19H18FN3O c1 21 10 11 2 4 12 5 3 11 18 14 6 7 22 19 24 15 8 13 20 9 16 23 18 17 14 15 h2 5,8 9,21,23H,6 7,10H2,1H3, H,22,24 Section2 Chembox Properties C 19 H 18 F 1 N 3 O 1 Appearance Density MeltingPt BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition Rucaparib AG 014699 is a PARP inhibitor being investigated as a potential anti cancer agent. Rucaparib inhibits the contraction of isolated vascular smooth muscle, including that from the tumours of cancer patients. It also reduces the migration of some cancer and normal cells in culture. ref http www.qub.ac.uk schools SchoolofPharmacy Filestore Filetoupload,121186,en.pdf ref It has undergone phase I clinical trial s for patients with advanced solid tumour s. ref http meeting.ascopubs.org cgi content abstract 23 16 suppl 3065 ref It is in phase II clinical trials for metastatic breast cancer breast and ovarian cancer with known BRCA1 or BRCA2 mutation. ref http science.cancerresearchuk.org research loc newcastle newcastle univ plummerr plummerrfr plummerrfrp2 ?version 1 ref References reflist Category PARP inhibitors Category Indoles Category Lactams antineoplastic drug stub ... more details
Olufunmilayo I. Olopade born 1957 Nigeria is an hematology oncologist , Associate Dean for Global Health and Walter L. Palmer Distinguished Service Professor in Medicine and Human Genetics at the University of Chicago . ref http www.uchospitals.edu physicians olufunmilayo olopade.html ref ref http www.genes.uchicago.edu olopade.html ref She also serves as director of the University of Chicago Hospital s Cancer Risk Clinic. She graduated from University of Ibadan , Nigeria, with a MD, in 1980. She has performed extensive clinical work surrounding the role of the BRCA1 and BRCA2 genes in the incidence of breast cancer in women of African descent. She a member of the American Association for Cancer Research, the American College of Physicians, and the Nigerian Medical Association and works closely with the Breast Cancer Research Foundation. ref http www.bcrfcure.org action 0708grantees olopade.html ref ref http www.bcrfcure.org action 0910grantees olopade.html ref She is a member of the Institute of Medicine . ref http www.iom.edu Global Directory Detail.aspx?id 0020018661 ref She married Christopher Sola Olopade, also a physician at the University of Chicago, in 1983 they have two daughters, and one son. ref http www.notablebiographies.com newsmakers2 2006 Le Ra Olopade Olufunmilayo.html ref Awards 2005 MacArthur Fellows Program ref http www.macfound.org site c.lkLXJ8MQKrH b.1076861 apps nl content2.asp?content id D26D83CB 8210 4530 868D 92480C62AEA0 ¬oc 1 ref References reflist External links http scicom.ucsc.edu QandA AAAS08 Olopade The SciCom Interview Olufunmilayo Olopade http www.pbs.org kcet tavissmiley archive 200907 20090710 olopade.html Dr. Olufunmilayo Olopade , Tavis Smiley , July 10, 2009 http www.portofharlem.net archives coverstories febapr2008.html Is the Answer in Your Genes? , Port of Harlem , Feb Apr 2008 http www.sciencedaily.com releases 2008 03 080317164342.htm Breast Cancer In Black Women May Be Connected To Neighborhood Conditions, Study Sugg ... more details
Infobox scientist name Bruce Ponder image Replace this image male.svg Freely licenced images only. Please do not put a fair use image here, it will be deleted see WP NONFREE image size caption Do you have a picture of Bruce Ponder? Please, post here. birth name birth date birth place nationality British field work institution University of Cambridge alma mater doctoral advisor Lionel Crawford doctoral students notable students other names known for occupation prizes Knight Bachelor , Fellow of the Royal Society FRS Professor Sir Bruce Ponder is the Director and Professor of Oncology at the Cambridge Bio Medical Campus Cancer Research UK Cambridge Research Institute Cancer Research UK Cambridge Research Institute . Ponder s team helped to identify the breast cancer susceptibility genes BRCA1 and BRCA2 . He carried out his PhD studies with Lionel Crawford in London working on chromatin organisation and DNA sequence specificity using polyoma virus . ref name pmid202734 cite journal author Ponder BA, Crew F, Crawford LV title Comparison of nuclease digestion of polyoma virus nucleoprotein complex and mouse chromatin journal J. Virol. volume 25 issue 1 pages 175 86 year 1978 month January pmid 202734 pmc 353914 doi url ref External references http www.jesus.cam.ac.uk contacts fellows profiles ponder.html Page at Jesus college Cambridge http info.cancerresearchuk.org cancerandresearch ourcurrentresearch researchbygrantee prof bruce ponder Page at Cancer Research UK References Reflist Persondata Metadata see Wikipedia Persondata . NAME Ponder, Bruce ALTERNATIVE NAMES SHORT DESCRIPTION DATE OF BIRTH PLACE OF BIRTH DATE OF DEATH PLACE OF DEATH DEFAULTSORT Ponder, Bruce Category Fellows of the Royal Society Category Knights Bachelor Category Cancer research Category Living people ... more details
mergeto Susan G. Komen for the Cure date June 2011 primarysources date November 2009 The Komen Brinker Award for Scientific Distinction was established by Susan G. Komen for the Cure in 1992 to recognize leading scientists for their significant work in advancing research concepts or clinical application in the fields of breast cancer research, screening or treatment. The intent of the award is to recognize scholars for a specific contribution, a consistent pattern of contributions, or leadership in the field that has had a substantial impact on the fight against breast cancer. The awardees are nominated and selected by a panel of their peers. Recipients are also invited to present their work in a lecture at the annual San Antonio Breast Cancer Symposium SABCS . Past recipients of the Komen Brinker Award for Scientific Distinction include V. Craig Jordan 1992 , Ph.D., OBE a pioneer in the use of tamoxifen Leland Hartwell 1998 , Ph.D., winner of the 2001 Nobel Prize for medicine or physiology who was recognized for his achievements in the understanding the cell cycle in the development of cancer Dr. Mary Claire King 1999 , Ph.D., whose research isolated the BRCA1 and BRCA2 gene mutations associated with genetic forms of breast cancer Larry Norton, M.D. 2004 , whose dose density approach to the administration of chemotherapy has revolutionized breast cancer treatment Dr. Anita Roberts 2005 , who co discovered the TGF beta molecule Professor Benita S. Katzenellenbogan 2009 of the UIUC College of Liberal Arts and Sciences University of Illinois , ref name Aronson Citation last Aronson first Deb date Spring 2010 year 2010 archivedate 22 August 2010 accessdate 22 August 2010 title MCB breast cancer researchers are focusing on the estrogen pathway periodical mcb publisher School of Molecular and Cellular Biology, University of Illinois issue 4 page 5 url http mcb.illinois.edu alumni downloads MCB4.pdf archiveurl http www.webcitation.org 5sAoKM9u5 ref for her work on the rol ... more details
that localized BRCA2 , a major breast cancer susceptibility gene that repairs chromosomal damage, to chromosome ... Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12 13 journal Science ..., Bignell G, Lancaster J, et al. title Identification of the breast cancer susceptibility gene BRCA2 ... cancer due to CHEK2 1100delC in noncarriers of BRCA1 or BRCA2 mutations journal Nat. Genet. volume 31 ... encodes a BRCA2 interacting protein, is a breast cancer susceptibility gene journal Nat. Genet ... more details
PBB geneid 56946 Protein EMSY is a protein that in humans is encoded by the C11orf30 gene . ref name entrez cite web title Entrez Gene C11orf30 chromosome 11 open reading frame 30 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 56946 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text Interactions C11orf30 has been shown to Protein protein interaction interact with ZMYND11 , ref name pmid14651845 cite journal last Hughes Davies first Luke authorlink coauthors Huntsman David, Ruas Margarida, Fuks Francois, Bye Jacqueline, Chin Suet Feung, Milner Jonathon, Brown Lindsay A, Hsu Forrest, Gilks Blake, Nielsen Torsten, Schulzer Michael, Chia Stephen, Ragaz Joseph, Cahn Anthony, Linger Lori, Ozdag Hilal, Cattaneo Elena, Jordanova E S, Schuuring Edward, Yu David S, Venkitaraman Ashok, Ponder Bruce, Doherty Aidan, Aparicio Samuel, Bentley David, Theillet Charles, Ponting Chris P, Caldas Carlos, Kouzarides Tony year 2003 month Nov. title EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer journal Cell volume 115 issue 5 pages 523 35 publisher location United States issn 0092 8674 pmid 14651845 bibcode oclc id url language format accessdate laysummary laysource laydate quote doi 10.1016 S0092 8674 03 00930 9 ref BRCA2 ref name pmid14651845 and CBX1 . ref name pmid14651845 References reflist Further reading refbegin 2 PBB Further reading citations cite journal author Strausberg RL, Feingold EA, Grouse LH, et al. title Generation and initial analysis of more than 15,000 full length human and mouse cDNA sequences journal Proc. Natl. Acad. Sci. U.S.A. volume 99 issue 26 pages 16899 903 year 2003 pmid 12477932 doi 10.1073 pnas.242603899 pmc 139241 cite journal author Hughes Davies L, Huntsman D, Ruas M, et al. title EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer journal Cell volume 115 issue 5 pag ... more details
and Life ref It acts against cancers in people with hereditary BRCA1 or BRCA2 mutations, which includes ... Poly ADP ribose polymerase 1 inhibitor treatment regresses autochthonous Brca2 p53 mutant mammary tumors ... of the BRCA1 and BRCA2 genes. In 12 of the patients, none of whom had responded to other therapies ... with ovarian cancer. 7 responses in 17 patients with BRCA1 or BRCA2 mutations and 11 responses ... more details
BRCA2, which is linked to an increased risk of some types of cancers ref http www.nature.com nature ... mutated BRCA 1 or BRCA2, leading to a new approach to cancer treatment. Cancer cells that carry mutant forms of BRCA1 or BRCA2 are highly sensitive to a class of drugs known as PARP inhibitors. Early ... more details
O, Cummings S, Garber J, Bernhardt B, Antman K, et al Sequence analysis of BRCA1 and BRCA2 Correlation ... Jewish women for BRCA1 and BRCA2. J Clin Oncol 1999 17 494 500. Antman K, Heitjan D, Hortobagy Gabriel ... in both BRCA1 and BRCA2 Clin Genet 2000 57 70 73. Antman, K, S Lagakos, J Drazen. Designing and Funding ... more details
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