Infobox Disease LOLHAHHHAHAHAILOVESEANLUVYOUHUN 3 Name Autoimmunepolyendocrinesyndrome Image Caption DiseasesDB 29212 DiseasesDB mult DiseasesDB2 29690 ICD10 ICD10 E 31 0 e 20 ICD9 ICD9 258.1 ICDO OMIM 240300 OMIM mult OMIM2 269200 MedlinePlus eMedicineSubj med eMedicineTopic 1867 eMedicine mult eMedicine2 med 1868 MeshID D016884 In medicine , autoimmunepolyendocrine syndromes are a heterogeneous group ref cite journal author Eisenbarth GS, Gottlieb PA title Autoimmunepolyendocrine syndromes journal New England Journal of Medicine N. Engl. J. Med. volume 350 issue 20 pages 2068 79 year 2004 pmid 15141045 doi 10.1056 NEJMra030158 url ref of rare disease s characterised by autoimmune activity against more than one endocrine organ s, although non endocrine organs can be affected. There are three autoimmunepolyendocrine syndromes , and a number of other diseases which have endocrine autoimmunity as one of their features. The syndromes Autoimmunepolyendocrinesyndrome type 1 Autoimmunepolyendocrinesyndrome type 2 Schmidt s syndrome APECED Syndromeautoimmune polyendocrinopathy APE , candidiasis C , and ectodermal dystrophy ED The most serious but rarest form is the Sex linkage X linked polyendocrinopathy, immunodeficiency and diarrhea syndrome, also called IPEX syndrome XLAAD X linked autoimmunity and allergic dysregulation or IPEX syndrome IPEX immune dysfunction, polyendocrinopathy ... Type 2 autoimmunepolyendocrinesyndrome but no features of Addison s disease , regular screening ... and many die due to autoimmune activity against many organs. Boys are affected, while girls are carriers and might suffer mild disease. Other diseases Other diseases featuring polyendocrine autoimmunity Chromosomal abnormalities Down s syndrome increase the risk of endocrine autoimmunity POEMS syndrome the E is for endocrinopathy the cause is a paraprotein excreted by a plasmacytoma or multiple ... pathology Hypersensitivity and autoimmune diseases Category Endocrine diseases Category Autoimmune ... more details
Infobox Disease Name Autoimmunepolyendocrinesyndrome type 1 Image Caption DiseasesDB 29212 DiseasesDB mult ICD10 ICD10 E 31 0 e 20 ICD9 ICD9 258.1 ICDO OMIM 240300 MedlinePlus eMedicineSubj med eMedicineTopic 1867 MeshID D016884 Autoimmunepolyendocrinesyndrome type 1 , also known as autoimmune polyendocrinopathy candidiasis ectodermal dystrophy APECED , or Whitaker syndrome , ref cite web url http emedicine.medscape.com article 124183 overview title Polyglandular AutoimmuneSyndrome, Type I eMedicine Endocrinology publisher Medscape accessdate 2009 04 17 ref is a form of autoimmunepolyendocrinesyndrome . Autoimmunepolyendocrinesyndrome, type 1 is also known as candidiasis hypoparathyroidism Addison s disease syndrome, Autoimmune Polyglandular Syndrome I, ref name greenspan Cite book author Greenspan, Francis S. Gardner, David C. authorlink coauthors title Basic clinical endocrinology year 2004 publisher McGraw Hill location New York isbn 0 07 140297 7 pages 103 ref APECED, or APS I. Its main features include A mild immune deficiency , leading to persistent mucosal and cutaneous infections with Candida genus candida yeasts. There is also decreased function of the spleen asplenism . Autoimmune dysfunction of the parathyroid gland leading to hypocalcaemia and the adrenal gland ... baldness malabsorption pernicious anemia Autoimmune hepatitis chronic active autoimmune hepatitis As opposed to Autoimmunepolyendocrinesyndrome type 2 type 2 , this syndrome inherits in an autosomal recessive fashion and is due to a defect in the autoimmune regulator AIRE ref name pmid17215373 cite journal author Bensing S, Fetissov SO, Mulder J, et al title Pituitary autoantibodies in autoimmunepolyendocrinesyndrome type 1 journal Proc. Natl. Acad. Sci. U.S.A. volume 104 issue 3 pages 949 ... research on this condition Endocrine pathology Hypersensitivity and autoimmune diseases Transcription factor deficiencies Category Endocrine diseases Category Autoimmune diseases Category Transcription ... more details
See also Autoimmunepolyendocrinesyndrome type 1 Infobox Disease Name Autoimmunepolyendocrinesyndrome type 2 Image Caption DiseasesDB 29690 ICD10 ICD10 E 31 0 e 20 ICD9 ICD9 258.1 ICDO OMIM 269200 MedlinePlus eMedicineSubj med eMedicineTopic 1868 MeshID D016884 Autoimmunepolyendocrinesyndrome type 2 is a form of autoimmunepolyendocrinesyndrome . Autoimmunepolyendocrinesyndrome, type 2 also known as Schmidt s syndrome , ref name pmid7643982 cite journal author Heuss D, Engelhardt A, G bel H, Neund rfer B title Myopathological findings in interstitial myositis in type II polyendocrineautoimmunesyndrome Schmidt s syndrome journal Neurol. Res. volume 17 issue 3 pages 233 7 year 1995 month June pmid 7643982 doi url accessdate 2008 07 25 ref or APS II is the most common form of the polyglandular failure syndromes. ref name greenspan Cite book author Greenspan, Francis S. Gardner, David C. authorlink coauthors title Basic clinical endocrinology year 2004 publisher McGraw Hill location New York isbn 0 07 140297 7 pages 103 ref It is more heterogeneous and has not been linked to one gene . Rather, patients are at a higher risk when they carry a particular human leukocyte antigen genotype DQ2, DQ8 and DRB1 0404 . APS II affects women to a greater degree than men 75 of cases occur in women . ref name greenspan Features of this syndrome are Addison s disease ref name pmid12817789 cite journal author Betterle C, Zanchetta R title Update on autoimmunepolyendocrine syndromes APS journal Acta Biomed volume 74 issue 1 pages 9 33 year 2003 month April pmid 12817789 doi url accessdate 2008 07 25 ref hypothyroidism diabetes mellitus type 1 less common associations hypogonadism vitiligo ... in Addison s disease and autoimmunepolyendocrinesyndrome type III journal Eur. J. Endocrinol ... Some researchers favour splitting this syndrome into three distinct syndromes numbering 2, 3 ref name ... pathology Hypersensitivity and autoimmune diseases Category Endocrine diseases Category Autoimmune diseases ... more details
Infobox Disease Name Autoimmune lymphoproliferative syndrome Image Caption DiseasesDB 33425 DiseasesDB ... eMedicineTopic MeshID Autoimmune lymphoproliferative syndrome is a form of lymphoproliferative disorder . It affects lymphocyte apoptosis . ref name pmid18193364 It is a RASopathy . Introduction Autoimmune ... title Causes and consequences of the autoimmune lymphoproliferative syndrome year 2006 last1 Rao ... in the management and understanding of autoimmune lymphoproliferative syndrome ALPS year 2010 last1 ... response reveal autoimmune lymphoproliferative syndrome ALPS year 2005 last1 Teachey first1 ... with Autoimmune Lymphoproliferative Syndrome year 2002 last1 Bleesing first1 Jack J.H. last2 Brown ... TCR sup sup T cells are reliable markers of autoimmune lymphoproliferative syndrome ALPS associated ... autoimmune lymphoproliferative syndrome in children with Evans syndrome A multi institutional study ... title Autoimmune lymphoproliferative syndrome year 2003 last1 Sneller first1 Michael C. last2 Dale first2 ... in the Human Autoimmune Lymphoproliferative Syndrome year 2011 last1 Kuehn first1 H. S. last2 ... NEJMoa040036 title Autoimmune Lymphoproliferative Syndrome with SomaticFasMutations year 2004 last1 ..., refractory immune cytopenias in children with autoimmune lymphoproliferative syndrome year ... in murine autoimmune lymphoproliferative syndrome ALPS year 2006 last1 Teachey first1 D. T. journal ... in patients with autoimmune lymphoproliferative syndrome year 2009 last1 Teachey first1 David T. last2 ... treatment in a child with autoimmune lymphoproliferative syndrome pages 1117 9 pmid 19588524 year ... disease in MRL lpr mice or in patients with autoimmune lymphoproliferative syndrome pages 1049 55 pmid ... 88 doi 10.1046 j.1365 2141.2002.03357.x title Reversion of autoimmune lymphoproliferative syndrome ... 2011 07 325217 pmc 3228494 title How I treat autoimmune lymphoproliferative syndrome year 2011 ... of 90 patients with autoimmune lymphoproliferative syndrome related to TNFRSF6 mutation year 2011 last1 ... more details
polyendocrinesyndrome Accepted Unknown or multiple APS 1 see Addison s Disease Autoimmune progesterone ... and 17alpha hydroxylase in Addison s disease and autoimmunepolyendocrinesyndrome type III journal ... of Medicine year 1993 ref Autoimmune lymphoproliferative syndrome Accepted TNFRSF6 defective Fas CD95 ...expert subject 1 Medicine date November 2011 Infobox disease Name Autoimmune diseases Image Caption DiseasesDB ... eMedicineTopic MeshID D001327 Autoimmune diseases arise from an overactive immune response of the body ... to certain organ anatomy organ s e.g. in autoimmune thyroiditis or involve a particular tissue in different ... . The treatment of autoimmune diseases is typically with immunosuppression &mdash medication which decreases the immune response. Criteria For a disease to be regarded as an autoimmune disease ... author Rose NR, Bona C title Defining criteria for autoimmune diseases Witebsky s postulates revisited ... T cells Indirect evidence based on reproduction of the autoimmune disease in experimental animals, and Circumstantial evidence from clinical clues Classification It is possible to classify autoimmune ... type III , or Type IV hypersensitivity type IV . No type of autoimmune disease mimics ... accessdate ref There is an on going discussion about when a disease should be considered autoimmune ... ADEM Accepted ref name Mesh MeshName Autoimmune Diseases ref Addison s Disease interferon ... MK title Diagnostic Value of HLA B27 Testing in Ankylosing Spondylitis and Reiter s Syndrome journal ... reply 76 year 1982 pmid 7053711 doi ref ANCA ? CD8 HLA B27 Antiphospholipid syndrome Accepted ref ... Annexin A5 HLA DR7 , HLA B8 , HLA DR2 , HLA DR3 Antisynthetase syndrome Atopic allergy I Atopic dermatitis I Autoimmune aplastic anemia Autoimmune cardiomyopathy Accepted Autoimmune enteropathy Autoimmune hemolytic anemia Accepted II complement activation Autoimmune hepatitis Accepted cell mediated ... liver antigen Autoimmune inner ear disease Accepted ref name urlAutoimmune Inner Ear Disease cite ... more details
cite journal author Ruan QG, She JX title Autoimmune polyglandular syndrome type 1 and the autoimmune ...PBB geneid 326 The autoimmune regulator AIRE is a protein that in humans is encoded by the AIRE gene . ref name pmid9398840 cite journal author title An autoimmune disease, APECED, caused by mutations .... When AIRE is defective, T cells can attack the body, resulting in autoimmune disease . Function In the thymus, the autoimmune regulator causes Transcription genetics transcription of a wide selection ... self proteins and create an autoimmune reaction. So the expression of non local proteins by AIRE reduces ... organs, thereby suppressing autoimmune disease. ref name pmid12612579 The AIRE gene is expressed ... Gene Portal System publisher accessdate 2009 12 19 ref Pathology The autoimmune regulator is mutated in the rare autoimmunesyndromeAutoimmune Polyendocrinopathy Syndrome type 1 APECED Type 1 APS 1 , also known as Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy APECED . Disruption of AIRE results in the development of a range of autoimmune diseases, the most common clinical conditions in the syndrome are hypoparathyroidism, primary adrenocortical failure and chronic mucocutaneous ... 2002 pmid 11854172 doi 10.1093 hmg 11.4.397 ref Interactions Autoimmune regulator has been shown ..., Ollila J, Vihinen M, Scott HS, Antonarakis SE, Kudoh J, Shimizu N, Krohn K, Peterson P title The autoimmune ... P, Kudoh J, Shimizu N, Antonarakis SE, Scott HS, Krohn K title APECED mutations in the autoimmune regulator ... with autoimmune polyendocrinopathy, candidiasis and ectodermal dystrophy APECED , accompanied ... J, Peltonen L title An autosomal locus causing autoimmune disease autoimmune polyglandular disease ... mapping of the autoimmune polyendocrinopathy candidiasis ectodermal dystrophy locus on chromosome ... SE title Common mutations in autoimmune polyendocrinopathy candidiasis ectodermal dystrophy patients ... of the autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein journal Am. J. Hum ... more details
Refimprove date November 2009 Autoimmune pancreatitis AIP is an increasingly recognized type of chronic pancreatitis that can be difficult to distinguish from pancreatic carcinoma but which responds to treatment with corticosteroids , particularly prednisone . ref cite book title The autoimmune diseases publisher Academic Press first1 Noel R. last1 Rose first2 Ian R. last2 Mackay edition 4 year 2006 ISBN 0125959613 pages 783 ref It is increasingly regarded as a form of hyper IgG4 disease . Clinical features AIP is characterized by the following features 1 mild symptoms abdominal pain, weight loss, nausea , usually without acute attacks of pancreatitis, 2 increased serum levels of gamma globulins, immunoglobulin G IgG , or IgG4, 3 the presence of serum autoantibodies such as anti nuclear antibody ANA , anti lactoferrin antibody, anti carbonic anhydrase II antibody, and rheumatoid factor RF , 4 a diffusely enlarged pancreas, 5 diffuse irregular narrowing of the main pancreatic duct and stenosis of the intrapancreatic bile duct on endoscopic retrograde cholangiopancreatography ERCP , 6 rare pancreatic calcification or cyst formation, and 7 marked responsiveness to treatment with corticosteroids. AIP is sometimes associated with other autoimmune disorders, most commonly Sj gren s syndrome , primary sclerosing cholangitis PSC , and inflammatory bowel disease . AIP occurring in association with an autoimmune disorder has been referred to as secondary or syndromic AIP. Diagnostic criteria In 2002, the Japanese Pancreas Society proposed the following diagnostic criteria for autoimmune pancreatitis I. Pancreatic imaging studies show diffuse narrowing of the main pancreatic duct with irregular .... Terms frequently encountered are autoimmune or autoimmune related pancreatitis, lymphoplasmacytic ... associated with Sj gren s syndrome , primary sclerosing cholangitis , or inflammatory bowel ... Autoimmune diseases ja fi Autoimmuunipankreatiitti ... more details
Infobox Disease Name PAGENAME Image Caption DiseasesDB ICD10 ICD10 E 06 3 e 00 ICD9 ICDO OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID D013967 Autoimmune thyroiditis is a form of thyroiditis associated with an autoimmune disease where the body treats the thyroid gland and sometimes the hormones it produces as foreign bodies, therefore rejecting and attacking both. Symptoms Causes Treatment Thyroid hormone supplementation may help with symptoms and prevent further conditions like goitre and thyroid gland failure from happening. Consequences Goiter may result from Autoimmune Thyroiditis as a result of an increase in thyroid gland size. As well, the thyroid s ability to produce hormones for the body becomes impaired. Hypothyroidism can develop from the condition. Types It can refer to Hashimoto s thyroiditis Postpartum thyroiditis endocrine disease stub Endocrine pathology Category Thyroid disease ... more details
Infobox disease Name Autoimmune hepatitis Image Autoimmune hepatitis cropped very high mag.jpg Caption ... of autoimmune hepatitis. Liver biopsy . H&E stain . DiseasesDB 1150 ICD10 ICD10 K 75 4 k 70 ICD9 ICD9 571.42 ICDO OMIM MedlinePlus 000245 eMedicineSubj med eMedicineTopic 366 MeshID D019693 Autoimmune ... liver infection , causes a cell mediated immune response against the body s own liver, resulting in autoimmune ... lead to further complications, including cirrhosis . ref name urlDigestive Disease Autoimmune Hepatitis ... Autoimmune Hepatitis author National Digestive Diseases Information Clearinghouse accessdate October 9, 2010 , ref Autoimmune hepatitis has an incidence of 1 2 per 100,000 per year, and a prevalence of 10 20 100,000. As with most other autoimmune disease s, it affects women much more often than men ... title Autoimmune Hepatitis work accessdate ref Liver enzyme s are elevated, as may be bilirubin . Classification ... IR, Vergani D title Autoimmune liver serology Current diagnostic and clinical challenges journal ... ref name urlautoimmune hepatitis cite web url http www.meddean.luc.edu Lumen MedEd orfpath autoimmune 20hepatitis.htm title autoimmune hepatitis work accessdate ref this group behaves like group 1 ref ... diagnosis of autoimmune hepatitis is best achieved with a combination of clinical trial clinical , laboratory ... are of use, as is finding an increased IgG Immunoglobulin G level. However, the diagnosis of autoimmune ... determine if a patient has autoimmune hepatitis, which combines clinical and laboratory features ... International Autoimmune Hepatitis Group Report review of criteria for diagnosis of autoimmune ... sholland contrivances aihcalc.html title Autoimmune Hepatitis Calculator work accessdate 2008 05 ... been observed. ref name pmid17486048 cite journal author Washington MK title Autoimmune liver disease ... Autoimmune hepatitis classification, heterogeneity, and treatment journal Am. J. Med. volume 96 issue ... ref References reflist 2 Gastroenterology Hypersensitivity and autoimmune diseases DEFAULTSORT Autoimmune ... more details
Orphan date February 2009 Infobox Disease Name Autoimmune neutropenia Image Caption DiseasesDB 32421 ICD10 ICD9 ICDO OMIM MedlinePlus eMedicineSubj ped eMedicineTopic 184 MeshID Autoimmune neutropenia is a form of neutropenia which is most common in infants and young children ref name pmid9414283 cite journal author Bux J, Behrens G, Jaeger G, Welte K title Diagnosis and clinical course of autoimmune neutropenia in infancy analysis of 240 cases journal Blood volume 91 issue 1 pages 181 6 year 1998 pmid 9414283 doi url http www.bloodjournal.org cgi pmidlookup?view long&pmid 9414283 ref where the body identifies the neutrophils as enemies and makes antibodies antibody to destroy them. Primary autoimmune neutropenia AIN is an autoimmune disorder first reported in 1975 that primarily occurs in infancy. In autoimmune neutropenia, the immune system produces autoantibodies directed against the neutrophilic protein antigens in white blood cells known as granulocytic neutrophils granulocytes, segmented neutrophils, segs, polysegmented neutrophils, polys . These antibodies destroy granulocytic neutrophils. Consequently, patients with autoimmune neutropenia have low levels of granulocytic neutrophilic white blood cells causing a condition of neutropenia. Neutropenia causes an increased risk of infection from organisms that the body could normally fight easily. Who is Affected? Primary autoimmune ... conditions occur, including other autoimmune diseases, infections, and malignancies. Neutropenia ... is severe. Ear infections otitis media are the most common infection seen in autoimmune neutropenia .... Studies of children studied for up to six years showed that most cases of autoimmune neutropenia ... for 7 to 24 months. Diagnosis Patients with autoimmune neutropenia are diagnosed on the basis of blood ... Bruin M, Dassen A, Pajkrt D, Buddelmeyer L, Kuijpers T, de Haas M title Primary autoimmune neutropenia ... References reflist DEFAULTSORT Autoimmune Neutropenia Category Monocyte and granulocyte disorders ... more details
about the Meat Beat Manifesto album autoimmune Infobox album See Wikipedia WikiProject Albums Name Autoimmune Type studio Artist Meat Beat Manifesto Cover Autoimmune MBM 2008.jpg Released 2008 April 08 Recorded Room 5 Genre Dubstep Length US version 1 05 45 br UK version 50 27 Label Metropolis Records small MET531 small br Planet Mu small ZIQ202 small Producer Jack Dangers Last album At the Center 2005 This album Autoimmune 2008 Next album Answers Come in Dreams 2010 Album ratings rev1 Allmusic rev1score Rating 4.5 5 ref Allmusic class album id r1340586 pure url yes Allmusic review ref rev2 PopMatters rev2score Rating 6 10 ref http www.popmatters.com pm review 56200 meat beat manifesto autoimmune PopMatters review ref Automatically generated by DASHBot Autoimmune is an album by Meat Beat Manifesto . Originally announced as a twenty track 2xCD release, ref cite web title MBM News page at Brainwashed url http brainwashed.com mbm date 21 May 2007 accessdate 2009 04 05 ref Dangers decided to shorten the album down ref name igloomag cite web url http igloomag.com profiles 1693 MEAT BEAT MANIFESTO Its all about the rhythm title MEAT BEAT MANIFESTO It s all about the rhythm publisher Igloo Magazine date 1 April 2008 accessdate 2010 02 07 ref to a single disc with different track listings between the US and European releases ref cite web title Autoimmune url http brainwashed.com common htdocs discog met531.php?site mbm07 accessdate 2008 04 02 ref . Stylistically, it steps up the pace a bit from other recent MBM albums, flirting with elements of dub, hip hop, industrial, breakbeat and more ... news 2008 04 meat beat title Autoimmune review Jack Dangers interview publisher Wired date 7 April ... released on an EP available only on the Autoimmune tour ref cite web url http brainwashed.com common ... These tracks appeared on an exclusive tour EP after the release of Autoimmune and would have originally ... DEFAULTSORT Autoimmune Album Category Meat Beat Manifesto albums Category 2008 albums ... more details
Infobox disease Name Autoimmune hypophysitis Image Caption DiseasesDB 34426 ICD10 ICD9 ICDO OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID Autoimmune hypophysitis or Lymphocytic hypophysitis is defined as Hypopituitarism below normal production of one or more hormones by the pituitary gland due to autoimmunity . Signs and symptoms The symptoms depend on what part of the pituitary is effected. Lymphocytic adenohypophysitis LAH is when the anterior pituitary ACTH producing cells are effected resulting in adrenal insufficiency . Lymphocytic Infundibuloneurohypophysitis LINH is when the posterior pituitary is effected resulting in diabetes insipidus and symptoms of an intracranial mass. Lymphocytic Infudibulopanhypophysitis LIPH is involvement of both the posterior pituitary and anterior ... years for autoimmune destruction to present symptoms. ref name pmid9691980 However, there have been ... pmc 166236 ref ref HEPATITIS WEEKLY, Autoimmune Diseases, Cytotoxic Antigen Induces Hypophysitis ... hormones. ref name pmid9691980 Likewise, 20 of autoimmune thyroid patients also have pituitary antibodies ... to autoimmune hypophysitis. Recent research has focused on a defect at the CTLA 4 gene which, coupled ... that perhaps as much as 5 of the population experiences some amount of autoimmune pituitary destruction .... History Autoimmune attack of the pituitary gland resulting in reduced hormone production ... and thyroid consistent with autoimmune attack and included atrophy of the adrenal glands. ref THE AUTOIMMUNE DISEASES, by Noel R. Rose and Ian R. Mack Chapter 40, Hypophysitis, by Patrizio Caturegli ... prevalent than is diagnosed. ref name pmid17554056 cite journal author Caturegli P title Autoimmune ... cgi pmidlookup?view long&pmid 17554056 ref Nevertheless, autoimmune hypophysitis ... pmidlookup?view long&pmid 9691980 ref References reflist 2 Endocrine pathology Hypersensitivity and autoimmune diseases Category Pituitary disorders Category Autoimmune diseases ... more details
Other uses In medicine and psychology , a syndrome is the association of several clinically recognizable features, sign medicine signs observed by someone other than the patient , symptom s reported by the patient ... in association. Some syndromes, such as Down syndrome , have only one cause others, such as Parkinsonian syndrome , have multiple possible causes. In other cases, the cause of the syndrome is unknown. The term syndrome derives from the Greek language Greek sundrom and means concurrence of symptoms ..., A Greek English Lexicon , on Perseus ref A familiar syndrome name often continues to be used even ... severe than a defined syndrome, but that nevertheless can be identified and related to the full blown syndrome. A culture bound syndrome is a set of symptoms where there is no evidence of an underlying ... and associated conditions The description of a syndrome usually includes a number of essential characteristics ... and minor findings typical of the syndrome, there may be an association with other conditions, meaning that in persons with the specified syndrome these associated conditions occur more frequently than would be expected by chance. While the syndrome and the associated conditions may be correlation .... An example would be Down syndrome , which has the associated condition of diabetes mellitus ... of the syndrome. Examples One recent case study is AIDS acquired immune deficiency syndrome ..., finally explaining the hitherto mysterious syndrome . Severe acute respiratory syndrome SARS severe acute respiratory syndrome is an even more recent example of a syndrome in medicine that was later ..., 980 1037 , in The Canon of Medicine , pioneered the idea of a syndrome in the diagnosis of specific ... 0 19 513580 6. ref Verify source date September 2010 The concept of a medical syndrome was further ... Toxidrome Withdrawal Withdrawal syndrome References Reflist External links Wiktionary syndrome ... ca S ndrome cs Syndrom de Syndrom et S ndroom es S ndrome eo Simptomaro eu Sindrome fa fr Syndrome ... more details
Latent Autoimmune Diabetes of Adults LADA , also known as, Diabetes Type 1.5 , is a term coined by Tuomi et al. in 1993 Diabetes 42 359 362 to describe slow onset Type 1 autoimmune diabetes in adults. The Expert ... LADA in the definition of Type 1 diabetes Type 1 autoimmune diabetes Type 1 diabetes results from a cellular mediated apoptosis autoimmune destruction of the beta cell s of the pancreas. In Type 1 diabetes ... autoimmune disorder that results in the body mistaking the pancreas as foreign and responding ... stated, autoimmune disorders, including LADA, are an allergy to self. Adults with LADA are frequently ... for LADA LADA may be diagnosed using any of the following terms latent autoimmune diabetes of adulthood late onset autoimmune diabetes of adulthood latent autoimmune diabetes of aging ref Diabetes mellitus ... autoimmune diabetes It is estimated that 20 of persons diagnosed as having non obesity related type ... www.annalsnyas.org cgi content full 958 1 112 Latent Autoimmune Diabetes in Adults Mona Landin Olsson ... December 2009 MEDRS date August 2010 ref Moreover, it is now becoming evident that autoimmune diabetes ... levels may have rather limited use in connections with latent autoimmune diabetes. ref cite journal author Landin Olsson M title Latent autoimmune diabetes in adults journal Annals of the New York Academy ... 2003 12 Latent autoimmune diabetes in adults LADA .pdf lada antibodies&hl en&gl us&ct clnk&cd 4 Latent Autoimmune Diabetes in Adults David Leslie, Cristina Valerie DiabetesVoice.org 2003 ref ref name ... latent autoimmune diabetes lada 1.html Latent Autoimmune Diabetes in Adults Symptoms, Diagnosis ... author Leslie RD, Williams R, Pozzilli P title Clinical review Type 1 diabetes and latent autoimmune ... for type 2 diabetes is sometimes involved regarding a latent autoimmune diabetic adult ref name ... E, et al. title Genetic similarities between latent autoimmune diabetes in adults, type 1 diabetes ... title Latent Autoimmune Diabetes of Adults and Pregnancy Foretelling the Future year ... more details
Infobox Disease Name CNS demyelinating autoimmune diseases Image Caption DiseasesDB ICD10 ICD9 ICDO OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID D020278 CNS demyelinating autoimmune diseases are autoimmune disease s which primarily affect the central nervous system . Examples include Diffuse cerebral sclerosis of Schilder Acute disseminated encephalomyelitis Acute hemorrhagic leukoencephalitis Multiple sclerosis though ethiology is unknown, it is sure that immune system is involved Transverse myelitis Neuromyelitis optica See also Idiopathic inflammatory demyelinating diseases A wider group of diseases which includes also the non autoimmune demyelinating diseases. Demyelinating disease s Group including them all, regardless of their autoimmunity or idiopathic and inflammatory status. CNS diseases of the nervous system disease stub Category Autoimmune diseases Category Demyelinating diseases of CNS ... more details
Autoimmune inner ear disease is a suspected autoimmune disease characterized by rapidly progressive bilateral sensorineural hearing loss. ref http www.emedicine.com ent TOPIC496.HTM Inner Ear, Autoimmune eMedicine, 2006 ref It occurs when the body s immune system attacks cells in the inner ear that are mistaken for a virus or bacteria. Autoimmune inner ear disease was first described by Dr. Brian McCabe of the University of Iowa in 1979. Causes AIED is generally caused by either antibodies or immune cells that cause damage to the inner ear. There are several autoimmune disorders to which AIED is related Bystander damage Cross reactions Genetic factors Drug Use opiate based painkillers like OxyContin http www.medicalnewstoday.com articles 121790.php http abcnews.go.com GMA story?id 128270&page 1&page 1 http www.foxnews.com story 0,2933,99731,00.html Research has found that long term abuse of opiate based painkillers such as OxyContin and Hydrocodone can lead to profound hearing loss caused by damage to the inner ear, according to Dr. Gail Ishiyama, an assistant professor at the UCLA department of neurology. http www.foxnews.com story 0,2933,99731,00.html Treatment AIED treatment is a rapidly changing field. Steroids are often used in the treatment of AIED, as well as Cytotoxic agents such as Cyclophosphamide and Methotrexate . More recently, in order to avoid many of the side effects of steroids, alternative medications and surgical procedures are used. Since these change quite frequently, it is a good idea to check many sources in locating the most cutting edge procedure for treating autoimmune inner ear disesase. ref http www.american hearing.org disorders autoimmune autoimmune.html treated Autoimmune inner ear disease at the American Hearing Research Foundation , Chicago, Illinois 2008. ref Notes reflist External links http entmd.org healthinfo hearing autoimmune.cfm Autoimmune inner ear disease at American Academy of Otolaryngology immunology stub Category Autoimmune ... more details
Summary album cover fur REQUIRED Article Autoimmune album Use Infobox HIGHLY RECOMMENDED Source http www.amazon.com Autoimmune dp B0016OAQH6 ADDITIONAL INFORMATION Name Artist Meat Beat Manifesto Label Metropolis records Graphic Artist Rich Borge Item Type Website Owner Commentary OVERRIDE FIELDS Description Portion Low resolution Purpose Replaceability other information Licensing Non free album cover ... more details
Autoimmune progesterone dermatitis may appear as urticarial papules, deep gyrate lesions, papulovesicular lesions, an eczematous eruption, or as targetoid lesions. ref name Andrews James, William Berger, Timothy Elston, Dirk 2005 . Andrews Diseases of the Skin Clinical Dermatology . 10th ed. . Saunders. ISBN 0 7216 2921 0. ref rp 82 Autoimmune progesterone dermatitis initially manifests with eye symptoms, e.g. burning, and progresses into rashes. Its relapsing remitting pattern in women correspond to the progesterone levels durning the menstrual cycle, which spike twice a month. It is an extremely rare disease, only perhaps 50 cases have ever been reported. See also Skin lesion References reflist Cutaneous condition stub Category Eczema ar ... more details
Infobox disease Name Warm antibody autoimmune hemolytic anemia ICD10 ICD10 D 59 1 d 55 ICD9 ICD9 283.0 Image Caption ICDO OMIM DiseasesDB 29723 MedlinePlus eMedicineSubj eMedicineTopic Warm Antibody Autoimmune Hemolytic Anemia AIHA is the most common of the Autoimmune diseases autoimmune Hemolysis hemolytic diseases. ref name isbn0 7216 0187 1 cite book author Cotran, Ramzi S. Kumar, Vinay Fausto, Nelson Nelso Fausto Robbins, Stanley L. Abbas, Abul K. title Robbins and Cotran pathologic basis of disease publisher Elsevier Saunders location St. Louis, Mo year 2005 pages 637 isbn 0 7216 0187 1 oclc doi accessdate ref About half of the cases are idiopathic , with the other half attributable to a predisposing condition or medications being taken. Pathophysiology The most common antibody involved in warm antibody AIHA is IgG , though sometimes IgA is found. The IgG antibodies attach to a red blood cell, leaving their F sub C sub portion exposed. The F sub C sub region is recognized and grabbed onto by F sub C sub receptors found on monocytes and macrophages in the spleen . These cells will pick off portions of the red cell membrane, almost like they are taking a bite. The loss of membrane causes the red blood cells to become spherocyte s. Spherocytes are not as flexible as normal RBCs ... warm autoimmune hemolytic anemia resulting from IgM autoagglutinins in an infant with severe combined ... autoimmune.pdf AUTOIMMUNE HEMOLYTIC ANEMIA AIHA By J.L. Jenkins. The Regional Cancer Center. 2001 ref ... M, Luppi M, Potenza L, et al. title Mixed warm and cold autoimmune hemolytic anemia complete recovery ... A, et al. title Efficacy and safety of rituximab in adults warm antibody autoimmune haemolytic anemia ... 2003 06 hemoglobin 42 due to autoimmune.html warm antibody autoimmune hemolytic anemia with typical laboratory findings. Clinical Cases and Images. Hematology DEFAULTSORT Warm Autoimmune Hemolytic Anemia Category Autoimmune diseases Category Acquired hemolytic anemia Category Hematopathology ... more details
Autoimmune estrogen dermatitis presents as a cyclic skin disorder that may appear eczematous, papular, bullous, or urticarial. with pruritus typically present, skin eruptions that may be chronic but which are exacerbated premenstrually or occur immediately following menses. ref name Andrews James, William Berger, Timothy Elston, Dirk 2005 . Andrews Diseases of the Skin Clinical Dermatology . 10th ed. . Saunders. ISBN 0 7216 2921 0. ref rp 83 See also Skin lesion References reflist Cutaneous condition stub Category Eczema ... more details
Maternal autoimmune bullous disease is a blistering skin condition that presents at birth. ref name Bolognia cite book author Rapini, Ronald P. Bolognia, Jean L. Jorizzo, Joseph L. title Dermatology 2 Volume Set publisher Mosby location St. Louis year 2007 pages isbn 1 4160 2999 0 oclc doi accessdate ref See also Accessory nail of the fifth toe List of cutaneous conditions References reflist Dermatology stub Category Cutaneous congenital anomalies ... more details
Autoimmunity Autoimmune heart disease s are the effects of the body s own Immunity medical immune defense system mistaking cardiac antigens as foreign and attacking them leading to inflammation of the heart as a whole, or in parts. The commonest form of autoimmune heart disease is rheumatic heart disease or rheumatic fever . Mechanism and Etiology These are the typical mechanisms of autoimmunity . Autoantibody Autoantibodies or auto toxic T cell T lymphocyte mediated tissue destruction. The process is aided by neutrophil s, the complement system , tumor necrosis factor alpha , etc. Etiologically, these are most commonly seen in children with a history of sore throat caused by a streptococcus streptococcal infection . This is similar to the post streptococcal glomerulonephritis . Here, the anti bacterial antibodies cross react with the heart antigens causing inflammation. Inflammatory damage leads to the following Pericarditis Here the pericardium gets inflamed. Acutely, it can cause pericardial effusion leading to cardiac tamponade and death. After healing, there may be fibrosis and adhesion of the pericardium with the heart leading to constriction of the heart and reduced cardiac function. Myocarditis Here the muscle bulk of the heart gets inflamed. Inflamed muscles have reduced functional capacity. This may be fatal, if left untreated as is in a case of pancarditis . On healing, there will be fibrosis and reduced functional capacity. Endocarditis Here the inner lining of the heart is inflamed, including the heart valves . This may cause a Valvular heart disease valve prolapse , adhesion of the adjacent cusps of these valves and occlusion of the flow tracts of blood through the heart causing diseases called Valvular heart disease valve stenosis . Specific Clinical Manifestations These depend on the amount of inflammation . These are covered in their relevant articles .... ISBN 1416025340 Also Read Autoimmunity Heart Glomerulonephritis DEFAULTSORT Autoimmune Heart Disease ... more details
cases. ref cite book last Shoenfield first Y, et al title Diagnostic Criteria in Autoimmune Disease ... PB title Disease associated autoimmune hemolytic anemia journal Bull N Y Acad Med volume 46 issue 6 ... RC title Autoimmune hemolytic anemia journal Am. J. Hematol. volume 69 issue 4 pages 258 71 ... ambiguous. Although Medical Subject Headings MeSH uses the term autoimmune hemolytic anemia , ref MeshName Autoimmune hemolytic anemia ref some sources prefer the term immunohemolytic anemia so ... anemia , autoimmune hemolytic anemia , and immune complex hemolytic anemia to all be synonyms ... AIHA is classified as either warm autoimmune hemolytic anemia or cold autoimmune hemolytic anemia ... author Gupta S, Szerszen A, Nakhl F, et al. title Severe refractory autoimmune hemolytic anemia with both ... lymphocytic leukemia , lymphoma and other autoimmune disorders e.g. systemic lupus erythematosis ... be caused by concomitant autoimmune disorders. ref name Sokol81 Drug induced AIHA, though rare, can ... Sokol81 cite journal author Sokol RJ, Hewitt S, Stamps BK title Autoimmune haemolysis an 18 year ... anemias, and laid the foundation for the clear distinction of autoimmune from congenital hemolytic ... type of antigen antibody reaction may be termed autoimmune , and hemolytic anemias so produced are autoimmune ... Zecca M, Nobili B, Ramenghi U, et al. title Rituximab for the treatment of refractory autoimmune ... 2003 06 hemoglobin 42 due to autoimmune.html Autoimmune Hemolytic Anemia with typical laboratory findings. Clinical Cases and Images. Hematology Autoimmune diseases Category Acquired hemolytic anemia Category Autoimmune diseases ar ca An mia hemol tica autoimmunit ria ... more details
Experimental autoimmune encephalomyelitis , sometimes Experimental Allergic Encephalomyelitis EAE is an animal model of brain inflammation . It is an inflammatory demyelinating disease of the central nervous system CNS . It is mostly used with rodent s and is widely studied as an animal model of the human CNS demyelinating diseases, including the disease s multiple sclerosis and acute disseminated encephalomyelitis ADEM . EAE is also the prototype for T cell mediated autoimmune disease in general. EAE was motivated by observations during the convalescence from virus viral diseases by Thomas M. Rivers, D. H. Sprunt and G. P. Berry in 1933. Their findings upon a transfer of inflamed patient tissue to primate s was published in the Journal of Experimental Medicine article Vol. 58, No. 1, pp. 39 56 ref Rivers TM, Spunt DH & Berry GP 1933 . OBSERVATIONS ON ATTEMPTS TO PRODUCE ACUTE DISSEMINATED ENCEPHALOMYELITIS IN MONKEYS. Journal of Experimental Medicine 58 39 53. ref ref Rivers TM & Schwentker FF. 1935 . Encephalomyelitis accompanied by myelin destruction experimentally produced in monkeys. Journal of Experimental Medicine 61 689 701. ref . An acute monophasic illness, it has been suggested that EAE is far more similar to ADEM than MS ref Sriram S & Steiner I 2005 Experimental Allergic Encephalomyelitis A misleading model of Multiple Sclerosis. Annals of Neurology 58 939 945. ref . EAE can be induced in a number of species, including mice, rats, guinea pigs, rabbits and primates. The most commonly used antigens in rodents are spinal cord homogenate SCH , purified myelin, myelin ... and pathology ref MANNIE, M., R. H. SWANBORG and J. A. STEPANIAK, 2009 Experimental autoimmune .... J. KARPUS, 2007 Experimental autoimmune encephalomyelitis in the mouse. Curr Protoc Immunol Chapter ... Autoimmune Encephalomyelitis Category Demyelinating diseases of CNS Category Animal testing cs Experiment ln autoimunitn encefalomyelitida de Experimentelle autoimmune Enzephalomyelitis el ... more details
Infobox Disease Name IPEX syndrome Image Caption DiseasesDB 33417 ICD10 ICD9 ICDO OMIM 304790 MedlinePlus eMedicineSubj eMedicineTopic MeshID IPEX immunodysregulation polyendocrinopathy enteropathy X linked syndrome is a rare disease linked to the dysfunction of the transcriptional activator FoxP3 . ref name pmid18481161 cite journal author Yong PL, Russo P, Sullivan KE title Use of Sirolimus in IPEX and IPEX Like Children journal J. Clin. Immunol. volume 28 issue 5 pages 581 year 2008 month May pmid 18481161 doi 10.1007 s10875 008 9196 1 ref It leads to the dysfunction of regulatory T cells and the subsequent autoimmunity . ref name Bolognia cite book author Rapini, Ronald P. Bolognia, Jean L. Jorizzo, Joseph L. title Dermatology 2 Volume Set publisher Mosby location St. Louis year 2007 pages 72 isbn 1 4160 2999 0 oclc doi accessdate ref The disorder manifests with psoriasis psoriasiform or eczema eczematous dermatitis , nail dystrophy , autoimmune endocrinopathy autoimmune endocrinopathies overlapping with those seen in APECED syndrome , and autoimmune skin conditions such as alopecia universalis and bullous pemphigoid . ref name Bolognia This autoimmunity is called IPEX and it is the attack from the body s own immune system against the body s own tissues and organs. Early age onset of this disease in males causes severe enlargement of the secondary lymphoid organs , insulin dependent diabetes , eczema, food allergy food allergies , and infections. There has been limited success in treating the syndrome by bone marrow transplant ation. ref cite journal pmid 12161590 pmc 1735203 ... of the immunodysregulation, polyendocrinopathy, enteropathy, X linked IPEX syndrome ref See also Autoimmunepolyendocrinesyndrome FOXP3 External links http www.ncbi.nlm.nih.gov bookshelf br.fcgi?book gene&part ipex GeneReview NIH UW entry on IPEX Syndrome References reflist X linked disorders Transcription factor deficiencies Category Autoimmune diseases Category Transcription factor deficiencies ... more details
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