enzyme Name ADPribosediphosphatase EC number 3.6.1.13 CAS number 9024 83 3 IUBMB EC number 3 6 1 13 GO code 0047631 image width caption ADPribosediphosphatase EC number 3.6.1.13 is an enzyme that catalysis ... in complex by the enzyme. Image ADPRiboseDiphosphatase Pocket shown for the substrate .png thumb This shows the full enzyme with ADPRibose bound in the active site pocket. Blue and red areas on the surface ... pdb explore.do?structureId 1KHZ From PDB 1KHZ . The C terminal domain of ADPribosediphosphatase ... 72 2001 . ref ADPribose hydrolases in general act as protective agents against excessive intracellular accumulation of ADPribose, as high intracellular levels of ADPribose can be damaging to the cell. ADPribosediphosphatase, in particular, hydrolyzes ADPribose into AMP and D ribose 5 phosphate ... with the attachment and coordination of H sub 2 sub O, Mg sup 2 sup , and the ADPribose substrate. ref name Gabelliet.al.2001 Image ADPRiboseDiphosphatase Mechanism Glutamate 162 as catalyst .png ... ADPribose to produce Adenosine monophosphate AMP and D ribose 5 phosphate. Enzyme hydrolysis .... ref name Gabelliet.al.2001 Gabelli, Sandra B. et al. The structure of ADPribose pyrophosphatase reveals ... placenta hydrolases active on free ADPribose an ADP sugar pyrophosphatase and a specific ADPribose pyrophosphatase. Biochimica et Biophysica Acta 1526 86 94 2001 . ref Other common names for ADPribosediphosphatase include ADPribose pyrophosphatase and ADPRase. ADPribose is commonly referred to as ADPR. Structure Image How ADPribose is Held in Complex by H bonds and Mg2 coordination.jpg thumb ... sup 2 sup bridges the two phosphates on ADPribose. Distances between the Mg sup 2 sup and the substrate ... in complex with AMPCPR and Mg sup 2 sup . AMPCPR is a nonhydrolyzable analog of ADPribose, and thus .... This evidence is a refutation of a previous study that suggested that hydrolysis of ADPribose could ... Gabelliet.al.2002 Gabelli, Sandra B., et al. Mechanism of the Escheirichia coli ADPribose pyrophosphatase ... more details
ADP , further connected to another ribose at the 5 position, which, in turn, closes the cycle by glycosidic ... of cyclic ADPribose journal Nat. Struct. Biol. volume 1 issue 3 pages 143 4 year 1994 pmid 7656029 ... from ADPribose ADPR , the non cyclic analog. cADPR is produced from nicotinamide adenine dinucleotide NAD sup sup by ADP ribosyl cyclases EC 3.2.2.5 as part of a second messenger system . Function ... MJ, Cameselle JC title Hydrolysis of the phosphoanhydride linkage of cyclic ADPribose by the Mn sup 2 sup dependent ADPribose CDP alcohol pyrophosphatase journal FEBS Lett. volume 583 year 2009 ... IP3 ADPribose References reflist External links http www.hku.hk physio hclee index.html The web page of Dr. Hon Cheung Lee, the discoverer of cyclic ADPribose. http books.google.es books?id UfUpyJZW0roC&printsec frontcover&source gbs summary r&cad 0 Cyclic ADPribose and NAADP. The first ...chembox verifiedrevid 424586166 ImageFile Cyclic ADP Ribose.PNG ImageSize 175px IUPACName OtherNames Section1 Chembox Identifiers CASNo 119340 53 3 PubChem 123847 IUPHAR ligand 2445 SMILES MeSHName Cyclic ADPRibose Section2 Chembox Properties Formula C15H21N5O13P2 MolarMass 541.301 Appearance Density MeltingPt BoilingPt Section3 Chembox Hazards Solubility MainHazards FlashPt Autoignition Cyclic ADPRibose , frequently abbreviated as cADPR , is a cyclic adenine nucleotide like Cyclic adenosine monophosphate ... has the glycosidic bond to the other ribose ref cite journal author Lee HC, Walseth TF, Bratt GT, Hayes ... family also includes the GPI anchored CD157 and the specific, monofunctional ADP ribosyl cyclase ..., Stout CD title Crystal structure of Aplysia ADP ribosyl cyclase, a homolog of the bifunctional ectozyme ... Category Nucleotides ca Difosfat d adenosina de ribosa c clic fr Ad nosine diphosphate ribose cyclique gl ADP ribosa c clico nl Cyclisch ADPribose ja ru sr Cikli na ADP riboza zh ADP ... more details
for the sound Parp onomatopoeic Image Adenosine diphosphate ribose.svg thumb Adenosine diphosphate riboseADPribose Image NADplus.png thumb Nicotinamide adenine dinucleotide Poly ADPribose polymerase PARP is a family of protein s involved in a number of cell biology cell ular processes involving mainly DNA repair and programmed cell death . Members of PARP family The PARP family comprises 17 members 10 putative . They have all very different structures and functions in the cell. PARP1 , PARP2 , VPARP PARP4 , Tankyrase 1 and 2 PARP 5a or TNKS , and PARP 5b or TNKS2 have a confirmed PARP activity ... the synthesis of a poly ADPribose chain PAR as a signal for the other DNA repairing enzymes such as DNA ... complementing gene 1 XRCC1 . After repairing, the PAR chains are degraded via Poly ADPribose glycohydrolase .... journal Proteome Sci. 8 22. date 2010 04 13 ref It is interesting to note that NAD diphthamide ADP ribosyltransferase NAD is required as substrate for generating ADPribose monomers. The overactivation ... year 2008 title Deficiency in Poly ADPribose Polymerase 1 PARP 1 Accelerates Aging and Spontaneous ... ADPribose polymerase 1 activity regulates JP 8 induced sustained cytokine expression in alveolar macrophages ... 17993261 pmc 2278030 ref Activity The catalytic domain is responsible for Poly ADPribose polymerization ... factor mediates poly ADPribose PAR polymer induced cell death journal Proceedings of the National ... methyltransferase DNMT 1 after attaching poly ADPribose chains to itself after interaction with CTCF ... content parp.asp PARP Poly ADPribose polymerase at inotekcorp.com http parplink.u strasbg.fr index.html The PARP Link Homepage at parplink.u strasbg.fr MeshName Poly ADPRibose Polymerase http ... group linking riboseribose sugars . PAR is synthesized using nicotinamide NAM as the leaving group. This leaves a pyrophosphate as the linking group between ribose sugars rather than single phosphate ... Category DNA repair it Poli ADP ribosio polimerasi ru ... more details
enzyme Name ADP sugar diphosphatase EC number 3.6.1.21 CAS number 37289 32 0 IUBMB EC number 3 6 1 21 GO code 0019144 image width caption In enzymology , an ADP sugar diphosphatase EC number 3.6.1.21 is an enzyme that catalysis catalyzes the chemical reaction ADP sugar H sub 2 sub O math rightleftharpoons math AMP alpha D aldose 1 phosphate Thus, the two substrate biochemistry substrates of this enzyme are ADP sugar and water H sub 2 sub O , whereas its two product chemistry products are adenosine monophosphate AMP and alpha D aldose 1 phosphate . This enzyme belongs to the family of hydrolase s, specifically those acting on acid anhydrides in phosphorus containing anhydrides. The systematic name of this enzyme class is ADP sugar sugarphosphohydrolase . Other names in common use include ADP sugar pyrophosphatase , and adenosine diphosphosugar pyrophosphatase . This enzyme participates in 3 metabolism metabolic pathways fructose and mannose metabolism , purine metabolism , and starch and sucrose metabolism . References reflist 1 cite journal author Rodriguez P, Bass ST, Hansen RG date 1968 title A pyrophosphatase from mammalian tissues specific for derivatives of ADP journal Biochim. Biophys. Acta. volume 167 pages 199&ndash 201 pmid 5686292 issue 1 hydrolase stub Category EC 3.6.1 Category Enzymes of unknown structure ... more details
Summary This shows how H bonds and Mg2 coordinate and hold the ADPribose substrate in complex with the enzyme. Active site amino acids are shown, as well as two important active site water molecules Licensing PD self date May 2008 Copy to Wikimedia Commons bot Fbot priority true ... more details
chembox Verifiedfields changed verifiedrevid 412792499 Name small D small Ribose ImageFileL1 D Ribose.png ... Ribose OtherNames Section1 Chembox Identifiers CASNo 50 69 1 CASNo Ref cascite correct CAS EC number ... br Lyxose Function Pentose aldopentoses OtherCpds Deoxyribose Ribose is an organic compound with the formula ... . The term may refer to any of two enantiomer s almost always to small D small ribose , which occurs widely in nature and is discussed here or to its synthetic mirror image small L small ribose , which is not found in nature and is of limited interest. small D small Ribose was first reported ... small arabinose both isomers of which are named for their source, gum arabic and ribose itself is named ... 42 pages 463 year 1958 doi 10.1002 sce.3730420523 ref Ribose comprises the backbone of RNA , a biopolymer ... , as found in DNA . Once phosphorylated , ribose can become a subunit of Adenosine triphosphate ... Cyclic adenosine monophosphate cAMP and Cyclic guanosine monophosphate cGMP . Structure Ribose is an aldopentose ..., found in DNA, differs from ribose by having a hydrogen atom in place of the hydroxyl group in carbon C2 . Like many monosaccharides, ribose occurs in water as the linear form H C O CHOH sub 4 sub H and any ... in the name small D small ribose refers to the stereochemistry of the Chirality chemistry chiral carbon atom farthest away from the aldehyde group C4 . In small D small ribose, as in all small D ... . Phosphorylation In biology, small D small ribose must be phosphorylated by the cell before it can be used. Ribokinase catalyzes this reaction by converting small D small ribose to Ribose 5 phosphate small D small ribose 5 phosphate . Once converted, small D small ribose 5 phosphate is available ... phosphate pathway . The absorption of small D small ribose is 88 100 in the small intestines up to 200 ... ca Ribosa cs Rib za da Ribose de Ribose el es Ribosa eo Ribozo fr Ribose fy Riboaze gl ... nl Ribose ja no Ribose oc Rib sa pl Ryboza pt Ribose ru simple Ribose sl Riboza sr ... more details
ADP may refer to Organizations and companies Automatic Data Processing , global provider of integrated computing and business outsourcing A roports de Paris , airport authority for the Parisian region in France Aeropuertos del Per , airport operator for airports in northern Peru Alaska Democratic Party , the local branch of the Democratic Party in the state of Alaska California Department of Alcohol and Drug Programs , Californian agency dealing with substance abuse prevention and treatment Alpha Delta Phi , a fraternal organization on college campuses Alpha Delta Pi , a sorority organization on college campuses American Democracy Project AASCU initiative , a project of the AASCU to promote understanding of civic engagement among college students American Democracy Project 527 group in Florida Arab Democratic Party Israel , a former political party in Israel Arab Democratic Party Lebanon , a political party in Lebanon Association for the Development of Pakistan , a Boston based non profit organization Azerbaijan Democratic Party Computing Android Dev Phone , a device sold by Google for Android developers Automatic data processing online payroll software People ADP, a nickname for Alessandro Del Piero , Italian footballer AdP, a nickname for Adrian Peterson , an American football player for the Minnesota Vikings. Science and Technology Adenosine diphosphate , an important molecule resulting from the transfer of energy from ATP Ammonium dihydrogen phosphate , an optical crystal Other Andorran peseta , a former currency of Andorra ADP, the IATA airport code for SLAF Anuradhapura , an airport in Sri Lanka Actual deferral percentage, a 401 k test for highly compensated employees Austin Danger Powers, the full name of film character Austin Powers character Antidepressant ... , a method to determine the percentage of body fat Disambig de ADP eo ADP fr ADP it ADP hu ADP egy rtelm s t lap nl ADP ja ADP pt ADP sr ADP ... more details
enzyme Name ribose isomerase EC number 5.3.1.20 CAS number 57534 76 6 IUBMB EC number 5 3 1 20 GO code 0050261 image width caption In enzymology , a ribose isomerase EC number 5.3.1.20 is an enzyme that catalysis catalyzes the chemical reaction D ribose math rightleftharpoons math D ribulose Hence, this enzyme has one substrate biochemistry substrate , D ribose , and one product chemistry product , D ribulose . This enzyme belongs to the family of isomerase s, specifically those intramolecular oxidoreductase s interconverting aldose s and ketose s. The systematic name of this enzyme class is D ribose aldose ketose isomerase . Other names in common use include D ribose isomerase , and D ribose ketol isomerase . References reflist 1 cite journal author Izumori K, Rees AW, Elbein AD date 1975 title Purification, crystallization, and properties of D ribose isomerase from Mycobacterium smegmatis journal J. Biol. Chem. volume 250 pages 8085&ndash 7 pmid 240851 issue 20 isomerase stub Category EC 5.3.1 Category Enzymes of unknown structure ... more details
chembox Verifiedfields changed Watchedfields changed verifiedrevid 464382183 ImageFile Ribose 5 phosphate.png ImageSize IUPACName 2,3,4 Trihydroxy 5 oxo pentoxy phosphonic acid OtherNames Section1 Chembox Identifiers InChI 1 C5H9O8P c6 1 3 7 5 9 4 8 2 13 14 10,11 12 h1,3 5,7 9H,2H2, H2,10,11,12 p 2 t3 ,4 ,5 m0 s1 InChIKey PPQRONHOSHZGFQ QRUISDQRBJ StdInChI Ref stdinchicite changed chemspider StdInChI 1S C5H9O8P c6 1 3 7 5 9 4 8 2 13 14 10,11 12 h1,3 5,7 9H,2H2, H2,10,11,12 p 2 t3 ,4 ,5 m0 s1 StdInChIKey Ref stdinchicite correct chemspider StdInChIKey PPQRONHOSHZGFQ LMVFSUKVSA L CASNo Ref cascite changed ?? CASNo 3615 55 2 PubChem 230 ChemSpiderID Ref chemspidercite correct chemspider ChemSpiderID 19971025 ChEBI Ref ebicite correct EBI ChEBI 58273 SMILES O P O O OC C H O C H O C H O C O MeSHName ribose 5 phosphate Section2 Chembox Properties Formula C sub 5 sub H sub 9 sub O sub 8 sub P MolarMass 230.110 Appearance Density MeltingPt BoilingPt Section3 Chembox Hazards Solubility MainHazards FlashPt Autoignition Ribose 5 phosphate is both a product and an intermediate of the pentose phosphate pathway . The last step of the oxidative reactions in the pentose phosphate pathway is the production of ribulose 5 phosphate . Depending on the body s state, ribulose 5 phosphate can reversibly isomerize to ribose 5 phosphate. Ribulose 5 phosphate can alternatively undergo a series of isomerizations as well as transaldolations and transketolations that result in the production of other pentoses phosphates as well as fructose 6 phosphate and glyceraldehyde 3 phosphate both intermediates in glycolysis . The enzyme ribose phosphate diphosphokinase converts ribose 5 phosphate into phosphoribosyl pyrophosphate . Pentose phosphate pathway intermediates Nucleotide metabolism intermediates Category Organophosphates Category Monosaccharide derivatives biochem stub de Ribose 5 phosphat es Ribosa 5 fosfato fr Ribose 5 phosphate it Ribosio 5 fosfato ja 5 pl Rybozo 5 fosforan pt Ribose ... more details
enzyme Name nucleoside diphosphatase EC number 3.6.1.6 CAS number 9027 69 4 IUBMB EC number 3 6 1 6 GO code 0017110 image width caption In enzymology , a nucleoside diphosphatase EC number 3.6.1.6 is an enzyme that catalysis catalyzes the chemical reaction a nucleoside diphosphate H sub 2 sub O math rightleftharpoons math a nucleotide phosphate Thus, the two substrate biochemistry substrates of this enzyme are nucleoside diphosphate and water H sub 2 sub O , whereas its two product chemistry products are nucleotide and phosphate . This enzyme belongs to the family of hydrolase s, specifically those acting on acid anhydrides in phosphorus containing anhydrides. The systematic name of this enzyme class is nucleoside diphosphate phosphohydrolase . Other names in common use include thiaminpyrophosphatase , UDPase , inosine diphosphatase , adenosine diphosphatase , IDPase , ADPase , adenosinepyrophosphatase , guanosine diphosphatase , guanosine 5 diphosphatase , inosine 5 diphosphatase , uridine diphosphatase , uridine 5 diphosphatase , nucleoside diphosphate phosphatase , type B nucleoside diphosphatase , GDPase , CDPase , nucleoside 5 diphosphatase , type L nucleoside diphosphatase , NDPase , and nucleoside diphosphate phosphohydrolase . This enzyme participates in purine metabolism and pyrimidine metabolism . Structural studies As of late 2007, two tertiary structure structures have been solved for this class of enzymes, with Protein Data Bank PDB accession codes PDB link 2H2N and PDB link 2H2U . References reflist 1 cite journal author GIBSON DM, AYENGAR P, SANADI DR date 1955 title A phosphatase specific for nucleoside diphosphates journal Biochim. Biophys. Acta. volume 16 pages 536&ndash 8 pmid 14389272 doi 10.1016 0006 3002 55 90275 4 issue 4 cite journal author Horecker BL, Hurwitz J and Heppel LA date 1957 title The synthesis of ribose 5 pyrophosphate and ribose 5 triphosphate journal J. Am. Chem. Soc. volume 79 pages 701&ndash 702 doi 10.1021 ja01560a054 issue 3 ... more details
riboseADPriboseADP ribosylation is the addition of one or more ADPribose moieties to a protein ... ref These reactions are reversible for example, when arginine is modified, the ADP ribosylarginine produced can be removed by ADP ribosylarginine hydrolases. ref cite journal author Takada T, Okazaki IJ, Moss J title ADP ribosylarginine hydrolases journal Mol. Cell. Biochem. volume 138 issue 1 2 pages 119 22 year 1994 pmid 7898453 doi 10.1007 BF00928452 ref Multiple groups of ADPribose ... ADP ribosyl ation. ref name Diefenbach cite journal author Diefenbach J, B rkle A title Introduction to poly ADPribose metabolism journal Cell. Mol. Life Sci. volume 62 issue 7 8 pages 721 30 year ... ADPribose polymerase poly ADPribose polymerase s PARPs , which are found in most eukaryote s, but not prokaryote ... Poly ADPribose . The most elaborate metabolite of NAD journal FEBS J. volume 272 issue 18 pages 4576 89 year 2005 pmid 16156780 doi 10.1111 j.1742 4658.2005.04864.x ref The poly ADPribose structure ... ADP ribosylation journal EMBO J. volume 22 issue 9 pages 1953 8 year 2003 pmid 12727863 doi 10.1093 emboj cdg209 pmc 156081 ref ADP ribosylation enzymes One way this protein modification can be produced is by NAD diphthamide ADP ribosyltransferase NAD sup sup diphthamide ADP ribosyltransferase enzymes, which transfer the ADPribose group from nicotinamide adenine dinucleotide NAD sup sup onto acceptors such as arginine , glutamic acid , or aspartic acid . In human s, one type of ADP ribosyltransferases is Type is subject predicate does not agree with its complement. the NAD arginine ADP ribosyltransferases, which modify amino acid residues in proteins such as histone s by adding a single ADPribose group. ref cite journal author Okazaki IJ, Moss J title Characterization of glycosylphosphatidylinositiol anchored, secreted, and intracellular vertebrate mono ADP ribosyltransferases journal ... , in processes such as DNA repair and telomere maintenance. ref name Burkle Bacterial toxins ADP ... more details
enzyme Name guanosine diphosphatase EC number 3.6.1.42 CAS number 98037 56 0 IUBMB EC number 3 6 1 42 GO code 0004382 image width caption In enzymology , a guanosine diphosphatase EC number 3.6.1.42 is an enzyme that catalysis catalyzes the chemical reaction GDP H sub 2 sub O math rightleftharpoons math GMP phosphate Thus, the two substrate biochemistry substrates of this enzyme are guanosine diphosphate GDP and water H sub 2 sub O , whereas its two product chemistry products are guanosine monophosphate GMP and phosphate . This enzyme belongs to the family of hydrolase s, specifically those acting on acid anhydrides in phosphorus containing anhydrides. The systematic name of this enzyme class is GDP phosphohydrolase . This enzyme is also called GDPase . References reflist 1 cite journal author Raychaudhuri P, Ghosh S, Maitra U date 1985 title Purification and characterization of a guanosine diphosphatase activity from calf liver microsomal salt wash proteins journal J. Biol. Chem. volume 260 pages 8306&ndash 11 pmid 2989286 issue 14 hydrolase stub Category EC 3.6.1 Category Enzymes of unknown structure ... more details
enzyme Name undecaprenyl diphosphatase EC number 3.6.1.27 CAS number 9077 80 9 IUBMB EC number 3 6 1 27 GO code 0050380 image width caption In enzymology , an undecaprenyl diphosphatase EC number 3.6.1.27 is an enzyme that catalysis catalyzes the chemical reaction undecaprenyl diphosphate H sub 2 sub O math rightleftharpoons math undecaprenyl phosphate phosphate Thus, the two substrate biochemistry substrates of this enzyme are undecaprenyl diphosphate and water H sub 2 sub O , whereas its two product chemistry products are undecaprenyl phosphate and phosphate . This enzyme belongs to the family of hydrolase s, specifically those acting on acid anhydrides in phosphorus containing anhydrides. The systematic name of this enzyme class is undecaprenyl diphosphate phosphohydrolase . Other names in common use include C55 isoprenyl diphosphatase , C55 isoprenyl pyrophosphatase , and isoprenyl pyrophosphatase . This enzyme participates in peptidoglycan biosynthesis . References reflist 1 cite journal author Goldman R, Strominger JL date 1972 title Purification and properties of C 55 isoprenylpyrophosphate phosphatase from Micrococcus lysodeikticus journal J. Biol. Chem. volume 247 pages 5116&ndash 22 pmid 4341539 issue 16 hydrolase stub Category EC 3.6.1 Category Enzymes of unknown structure ... more details
enzyme Name dCTP diphosphatase EC number 3.6.1.12 CAS number 9024 87 7 IUBMB EC number 3 6 1 12 GO code 0047840 image width caption lowercase In enzymology , a dCTP diphosphatase EC number 3.6.1.12 is an enzyme that catalysis catalyzes the chemical reaction dCTP H sub 2 sub O math rightleftharpoons math dCMP diphosphate Thus, the two substrate biochemistry substrates of this enzyme are dCTP and water H sub 2 sub O , whereas its two product chemistry products are dCMP and diphosphate . This enzyme belongs to the family of hydrolase s, specifically those acting on acid anhydrides in phosphorus containing anhydrides. The systematic name of this enzyme class is dCTP nucleotidohydrolase . Other names in common use include deoxycytidine triphosphatase , dCTPase , dCTP pyrophosphatase , deoxycytidine triphosphatase , deoxy CTPase , and dCTPase . This enzyme participates in pyrimidine metabolism . References reflist 1 cite journal author Zimmerman SB and Kornberg A year 1961 title Deoxycytidine di and triphosphate cleavage by an enzyme formed in bacteriophage infected Escherichia coli journal J. Biol. Chem. volume 236 pages 1480&ndash 1486 pmid 13788541 Category EC 3.6.1 Category Enzymes of unknown structure hydrolase stub ... more details
enzyme Name monoterpenyl diphosphatase EC number 3.1.7.3 CAS number IUBMB EC number 3 1 7 3 GO code 0050108 image width caption In enzymology , a monoterpenyl diphosphatase EC number 3.1.7.3 is an enzyme that catalysis catalyzes the chemical reaction monoterpenyl diphosphate H sub 2 sub O math rightleftharpoons math monoterpenol diphosphate Thus, the two substrate biochemistry substrates of this enzyme are monoterpenyl diphosphate and water H sub 2 sub O , whereas its two product chemistry products are monoterpenol and diphosphate . This enzyme belongs to the family of hydrolase s, specifically those acting on diphosphoric ester monoester bonds. The systematic name of this enzyme class is monoterpenyl diphosphate diphosphohydrolase . Other names in common use include bornyl pyrophosphate hydrolase , and monoterpenyl pyrophosphatase . References reflist 1 cite journal author Croteau R, Karp F date 1979 title Biosynthesis of monoterpenes hydrolysis of bornyl pyrophosphate, an essential step in camphor biosynthesis, and hydrolysis of geranyl pyrophosphate, the acyclic precursor of camphor, by enzymes from sage Salvia officinalis journal Arch. Biochem. Biophys. volume 198 pages 523&ndash 32 pmid 42357 doi 10.1016 0003 9861 79 90527 7 issue 2 hydrolase stub Category EC 3.1.7 Category Enzymes of unknown structure ... more details
enzyme Name prenyl diphosphatase EC number 3.1.7.1 CAS number 37288 33 8 IUBMB EC number 3 1 7 1 GO code 0050210 image width caption In enzymology , a prenyl diphosphatase EC number 3.1.7.1 is an enzyme that catalysis catalyzes the chemical reaction prenyl diphosphate H sub 2 sub O math rightleftharpoons math prenol diphosphate Thus, the two substrate biochemistry substrates of this enzyme are prenyl diphosphate and water H sub 2 sub O , whereas its two product chemistry products are prenol and diphosphate . This enzyme belongs to the family of hydrolase s, specifically those acting on diphosphoric ester monoester bonds. The systematic name of this enzyme class is prenyl diphosphate diphosphohydrolase . Other names in common use include prenyl pyrophosphatase , prenol pyrophosphatase , and prenylphosphatase . References reflist 1 cite journal author Tsai SC, Gaylor JL date 1966 title Testicular sterols. V. Preparation and partial purification of a microsomal prenol pyrophosphate pyrophosphohydrolase journal J. Biol. Chem. volume 241 pages 4043&ndash 50 pmid 4288361 issue 17 hydrolase stub Category EC 3.1.7 Category Enzymes of unknown structure ... more details
enzyme Name ATP diphosphatase EC number 3.6.1.8 CAS number 37289 25 1 IUBMB EC number 3 6 1 8 GO code 0047693 image width caption In enzymology , an ATP diphosphatase EC number 3.6.1.8 is an enzyme that catalysis catalyzes the chemical reaction ATP H sub 2 sub O math rightleftharpoons math AMP diphosphate Thus, the two substrate biochemistry substrates of this enzyme are adenosine triphosphate ATP and water H sub 2 sub O , whereas its two product chemistry products are adenosine monophosphate AMP and diphosphate . This enzyme belongs to the family of hydrolase s, specifically those acting on acid anhydrides in phosphorus containing anhydrides. The systematic name of this enzyme class is ATP diphosphohydrolase diphosphate forming . Other names in common use include ATPase , ATP pyrophosphatase , adenosine triphosphate pyrophosphatase , and ATP diphosphohydrolase ambiguous . This enzyme participates in purine metabolism and pyrimidine metabolism . References reflist 1 cite journal author HEPPEL LA, HILMOE RJ date 1953 title Mechanism of enzymatic hydrolysis of adenosinetriphosphate journal J. Biol. Chem. volume 202 pages 217&ndash 26 pmid 13061448 issue 1 cite journal author JOHNSON M, KAYE MA, HEMS R, KREBS HA date 1953 title Enzymic hydrolysis of adenosine phosphates by cobra venom journal Biochem. J. volume 54 pages 625&ndash 9 pmid 13058963 issue 4 pmc 1269107 hydrolase stub Category EC 3.6.1 Category Enzymes of unknown structure ... more details
enzyme Name FAD diphosphatase EC number 3.6.1.18 CAS number 37289 30 8 IUBMB EC number 3 6 1 18 GO code 0047884 image width caption In enzymology , a FAD diphosphatase EC number 3.6.1.18 is an enzyme that catalysis catalyzes the chemical reaction FAD H sub 2 sub O math rightleftharpoons math AMP FMN Thus, the two substrate biochemistry substrates of this enzyme are FAD and water H sub 2 sub O , whereas its two product chemistry products are adenosine monophosphate AMP and flavin mononucleotide FMN . This enzyme belongs to the family of hydrolase s, specifically those acting on acid anhydrides in phosphorus containing anhydrides. The systematic name of this enzyme class is FAD nucleotidohydrolase . Other names in common use include FAD pyrophosphatase , riboflavin adenine dinucleotide pyrophosphatase , flavin adenine dinucleotide pyrophosphatase , riboflavine adenine dinucleotide pyrophosphatase , and flavine adenine dinucleotide pyrophosphatase . This enzyme participates in riboflavin metabolism . References reflist 1 cite journal author Ravindranath SD, Rao NA date 1969 title Nucleotidases in plants. 3. Effect of metabolites on the enzyme hydrolyzing flavine adenine dinucleotide FAD from Phaseolus radiatus journal Arch. Biochem. Biophys. volume 133 pages 54&ndash 9 pmid 5810832 doi 10.1016 0003 9861 69 90487 1 issue 1 cite journal author Shin HJ, Mego JL date 1988 title A rat liver lysosomal membrane flavin adenine dinucleotide phosphohydrolase purification and characterization journal Arch. Biochem. Biophys. volume 267 pages 95&ndash 103 pmid 2848456 doi 10.1016 0003 9861 88 90012 4 issue 1 hydrolase stub Category EC 3.6.1 Category Enzymes of unknown structure ... more details
enzyme Name NAD sup sup diphosphatase EC number 3.6.1.22 CAS number 37289 33 1 IUBMB EC number 3 6 1 22 GO code 0000210 image width caption In enzymology , a NAD sup sup diphosphatase EC number 3.6.1.22 is an enzyme that catalysis catalyzes the chemical reaction NAD sup sup H sub 2 sub O math rightleftharpoons math AMP NMN Thus, the two substrate biochemistry substrates of this enzyme are nicotinamide adenine dinucleotide NAD sup sup and water H sub 2 sub O , whereas its two product chemistry products are adenosine monophosphate AMP and NMN . This enzyme belongs to the family of hydrolase s, specifically those acting on acid anhydrides in phosphorus containing anhydrides. The systematic name of this enzyme class is NAD sup sup phosphohydrolase . Other names in common use include nicotinamide adenine dinucleotide pyrophosphatase , NADP pyrophosphatase , and NADH pyrophosphatase . This enzyme participates in nicotinate and nicotinamide metabolism . Structural studies As of late 2007, only one tertiary structure structure has been solved for this class of enzymes, with the Protein Data Bank PDB accession code PDB link 2GB5 . References reflist 1 cite journal author Anderson BM, Lang CA date 1966 title Nicotinamide adenine dinucleotide pyrophosphatase in the growing and aging mosquito journal Biochem. J. volume 101 pages 392&ndash 6 pmid 4381708 issue 2 pmc 1270119 cite journal author Nakajima Y, Fukunaga N, Sasaki S, Usami S date 1973 title Purification and properties of NADP pyrophosphatase from Proteus vulgaris journal Biochim. Biophys. Acta. volume 293 pages 242&ndash 55 pmid 4405504 issue 1 hydrolase stub Category EC 3.6.1 Category NADH dependent enzymes Category Enzymes of known structure ... more details
enzyme Name nucleotide diphosphatase EC number 3.6.1.9 CAS number 9032 64 8 IUBMB EC number 3 6 1 9 GO code 0004551 image width caption In enzymology , a nucleotide diphosphatase EC number 3.6.1.9 is an enzyme that catalysis catalyzes the chemical reaction a dinucleotide H sub 2 sub O math rightleftharpoons math 2 mononucleotides Thus, the two substrate biochemistry substrates of this enzyme are dinucleotide and water H sub 2 sub O , whereas its product chemistry product is Nucleotide mononucleotide . This enzyme belongs to the family of hydrolase s, specifically those acting on acid anhydrides in phosphorus containing anhydrides. The systematic name of this enzyme class is dinucleotide nucleotidohydrolase . Other names in common use include nucleotide pyrophosphatase , and nucleotide sugar pyrophosphatase . This enzyme participates in 5 metabolism metabolic pathways purine metabolism , starch and sucrose metabolism , riboflavin metabolism , nicotinate and nicotinamide metabolism , and pantothenate and coa biosynthesis . Structural studies As of 2007 alt As of late 2007 , 5 tertiary structure structures have been solved for this class of enzymes, with Protein Data Bank PDB accession codes PDB link 1NQY , PDB link 1NQZ , PDB link 2GSN , PDB link 2GSO , and PDB link 2GSU . References reflist 1 cite journal author Jacobson JB and Kaplan NO date 1957 title A reduced pyridine nucleotide pyrophosphatase journal J. Biol. Chem. volume 226 pages 427&ndash 437 pmid 13428775 cite journal author Kornberg A and Pricer WE date 1950 title Nucleotide pyrophosphatase journal J. Biol. Chem. volume 182 pages 763&ndash 778 cite journal author Kumar SA, Rao NA, Vaidyanathan CS date 1965 title Nucleotidases in plants. I. Partial purification and properties of the enzyme hydrolyzing flavine adenine dinucleotide from mung bean seedlings Phaseolus radiatus journal Arch. Biochem. Biophys. volume 111 pages 646&ndash 52 pmid 5862212 doi 10.1016 0003 9861 65 90246 8 issue 3 cite journal author Swartz ... more details
Orphan date August 2011 Infobox protein family Symbol ADP ribosyl GH Name ADP ribosylglycohydrolase image PDB 1t5j EBI.jpg width caption crystal structure of ribosylglycohydrolase mj1187 from methanococcus jannaschii Pfam PF03747 Pfam clan InterPro IPR005502 SMART PROSITE MEROPS SCOP 1t5j TCDB OPM family OPM protein CAZy CDD In molecular biology, ADP ribosylglycohydrolase is a family of enzymes which catalysis catalyses Adenosine diphosphate ADP ribosylations. This family includes enzyme s such as ADP ribosylarginine hydrolase EC number 3.2.2.19. which Bond cleavage cleaves ADPribose L arginine. ref name pmid8349667 cite journal author Takada T, Iida K, Moss J title Cloning and site directed mutagenesis of human ADP ribosylarginine hydrolase journal J. Biol. Chem. volume 268 issue 24 pages 17837 43 year 1993 month August pmid 8349667 doi url ref The family also includes dinitrogenase reductase activating glycohydrolase, ref name pmid2506427 cite journal author Fitzmaurice WP, Saari LL, Lowery RG, Ludden PW, Roberts GP title Genes coding for the reversible ADP ribosylation system of dinitrogenase reductase from Rhodospirillum rubrum journal Mol. Gen. Genet. volume 218 issue 2 pages 340 7 year 1989 month August pmid 2506427 doi 10.1007 BF00331287 url ref and most surprisingly jellyfish crystallin s, ref name pmid2506427 although these protein s appear to have lost the presumed active site residue chemistry residues . References reflist InterPro content IPR005502 Category Protein families ... more details
enzyme Name inorganic diphosphatase EC number 3.6.1.1 CAS number 9024 82 2 IUBMB EC number 3 6 1 1 GO code 0004427 image width caption Infobox protein family Symbol H PPase Name Inorganic H pyrophosphatase image width caption Pfam PF03030 Pfam clan InterPro IPR004131 SMART PROSITE MEROPS SCOP TCDB 3.A.10 OPM family OPM protein CAZy CDD In enzymology , an inorganic diphosphatase EC number 3.6.1.1 is an enzyme that catalysis catalyzes the chemical reaction diphosphate H sub 2 sub O math rightleftharpoons math 2 phosphate Thus, the two substrate biochemistry substrates of this enzyme are diphosphate and water H sub 2 sub O , whereas its product chemistry product is phosphate . This enzyme belongs to the family of hydrolase s, specifically those acting on acid anhydrides in phosphorus containing anhydrides. The systematic name of this enzyme class is diphosphate phosphohydrolase . This enzyme participates in oxidative phosphorylation . It employs one cofactor biochemistry cofactor , metal . Two types of inorganic diphosphatase, very different in terms of both amino acid sequence and Protein structure, secondary structure , have been characterised to date soluble and membrane bound proton pumping pyrophosphatases sPPases and H sup sup PPases, respectively . sPPases are ubiquitous protein proteins that hydrolyse PPi to release heat, whereas H sup sup PPases, so far unidentified in animal and fungus fungal cells, couple the energy of PPi hydrolysis to proton movement across biology biological Cell membrane membrane s. ref name pmid12451180 cite journal author Perez Castineira JR, Lopez Marques RL, Villalba JM, Losada M, Serrano A title Functional complementation of yeast cytosolic pyrophosphatase by bacterial and plant H translocating pyrophosphatases journal Proc. Natl. Acad. Sci. U.S.A. volume 99 issue 25 pages 15914 9 year 2002 month December pmid 12451180 pmc 138539 doi 10.1073 pnas.242625399 url ref ref name pmid10523139 cite journal author Baltscheffsky M, Schultz A, Baltscheffsky ... more details
enzyme Name dUTP diphosphatase EC number 3.6.1.23 CAS number 37289 34 2 IUBMB EC number 3 6 1 23 GO code 0004170 image width caption Infobox protein family Symbol dUTPase Name dUTPase image PDB 1f7o EBI.jpg width caption crystal structures of feline immunodeficiency virus dutp pyrophosphatase and its nucleotide complexes in three crystal forms. Pfam PF00692 Pfam clan CL0153 InterPro IPR008180 SMART PROSITE MEROPS SCOP 1dup TCDB OPM family OPM protein CAZy CDD Infobox protein family Symbol dUTPase 2 Name dUTPase 2 image PDB 1w2y EBI.jpg width caption the crystal structure of a complex of campylobacter jejuni dutpase with substrate analogue dupnhp Pfam PF08761 Pfam clan CL0231 InterPro IPR014871 SMART PROSITE MEROPS SCOP 1w2y TCDB OPM family OPM protein CAZy CDD lowercase In enzymology , a dUTP diphosphatase EC number 3.6.1.23 is an enzyme that catalysis catalyzes the chemical reaction dUTP H sub 2 sub O math rightleftharpoons math dUMP diphosphate Thus, the two substrate biochemistry substrates of this enzyme are dUTP and water H sub 2 sub O , whereas its two product chemistry products are dUMP and diphosphate . This enzyme belongs to the family of hydrolase s, specifically those acting on acid anhydrides in phosphorus containing anhydrides. The systematic name of this enzyme class is dUTP nucleotidohydrolase . Other names in common use include deoxyuridine triphosphatase , dUTPase , dUTP pyrophosphatase , desoxyuridine 5 triphosphate nucleotidohydrolase , and desoxyuridine 5 triphosphatase . This enzyme participates in pyrimidine metabolism . The main function of this enzyme is to remove dUTP from the nucleotide deoxynucleotide pool, which reduces the probability of this base being mistakenly incorporated into DNA by DNA polymerase s, which is a cause of mutation s. ref cite journal author Vassylyev DG, Morikawa K title Precluding uracil from DNA journal Structure volume 4 issue 12 pages 1381 5 year 1996 pmid 8994964 doi 10.1016 S0969 2126 96 00145 1 ref Structural studies ... more details
Encyclopedia
top
